We are presenting the design and implementation of a pharmacophore searching tool, Pharmadoop, using the Hadoop framework. Due to its Hadoop implementation, Pharmadoop is a faster approach as compared tothe existing standalone pharmacophore search tools.

Download files and follow the software installation tutorial.

Step 1

Before setting up Hadoop-1.2.1 cluster, all nodes should be configured first. It can be done by following steps in given link: http://www.michael-noll.com/tutorials/running-hadoop-on-ubuntu-linux-single-node-cluster/

Step 2

Hadoop multi node cluster setup is done by following this link: http://www.michael-noll.com/tutorials/running-hadoop-on-ubuntu-linux-multi-node-cluster/

Step 3

Download Eclipse IDE for java EE Developers by following this link: http://www.eclipse.org/downloads/eclipse-packages/

Step 4

Download hadoop plugin by following this link:Download

Step 5

Configure the hadoop plugin with eclipse by following this link: https://www.youtube.com/watch?v=-001hhMk11M&index=12&list=PL2jvR2CemrGomVj6pTLd6726b7CyXGpgc/

Step 6

Start Hadoop Daemons.

Step 7

Import Pharmahadoop in Eclipse.

Step 8

Fill the details which are specified by "<>" symbol in java files. Input file must be in SDF format and the query file must be in xml format.

Step 9

To get the demo of input file use the following link:

Download and to get the demo of xml file use the following link:Download

Step 10

To run programme do right click from main (Driver method) programme and run application as Java application.

Citation: Semwal, R., Aier, I., Raj, U. et al. Netw Model Anal Health Inform Bioinforma (2017) 6: 20.