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| HGNC approved symbol | Pfam domains | Uniprot ID(mouse) | HGNC approved name | Uniprot ID(human) | Function | Modification | Protein complex | Target entity | Product |
|---|---|---|---|---|---|---|---|---|---|
| HGNC approved symbol | Pfam domains | UniProt ID (mouse) | HGNC approved name | UniProt ID (human) | Function | Modification | Protein complex | Target entity | Product |
| # | LEDGF PF11467 472-578 PWWP PF00855 5-87 Pfam-B_32406 PB032406 111-159 | HDGR2_MOUSE | # | HDGR2_HUMAN | Histone modification read | # | # | H3K79me3 H4K20me3 H3K36me3 | # |
| A1CF | DND1_DSRM PF14709 445-523 RRM_1 PF00076 58-127 138-203 RRM_6 PF14259 233-297 | A1CF_MOUSE | APOBEC1 complementation factor | A1CF_HUMAN | RNA modification | RNA deamination | APOB_mRNA_editosome | mRNA mC | U |
| ACTB | Actin PF00022 2-375 | ACTB_MOUSE | actin beta | ACTB_HUMAN | Chromatin remodelling cofactor | # | BAF nBAF npBAF PBAF SWI/SNF-like EPAFB bBAF SWI/SNF BRM-BRG1 NuA4 NuA4-related complex | # | # |
| ACTL6A | Actin PF00022 8-429 | ACL6A_MOUSE | actin-like 6A | ACL6A_HUMAN | Chromatin remodelling cofactor | # | BAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB SWI/SNF BRM-BRG1 Ino80 NuA4 NuA4-related complex SRCAP | # | # |
| ACTL6B | Actin PF00022 8-426 | ACL6B_MOUSE | actin-like 6B | ACL6B_HUMAN | Chromatin remodelling cofactor | # | BAF nBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF BRM-BRG1 | # | # |
| ACTR3B | Actin PF00022 3-412 | ARP3B_MOUSE | ARP3 actin-related protein 3 homolog B (yeast) | ARP3B_HUMAN | Chromatin remodelling | # | # | H2A H3 H4 | # |
| ACTR5 | Actin PF00022 30-570 | ARP5_MOUSE | ARP5 actin-related protein 5 homolog (yeast) | ARP5_HUMAN | Chromatin remodelling | # | Ino80 | # | # |
| ACTR6 | Actin PF00022 1-395 | ARP6_MOUSE | ARP6 actin-related protein 6 homolog (yeast) | ARP6_HUMAN | Chromatin remodelling cofactor | # | SRCAP | # | # |
| ACTR8 | Actin PF00022 43-621 | ARP8_MOUSE | ARP8 actin-related protein 8 homolog (yeast) | ARP8_HUMAN | Histone modification read | # | Ino80 | # | # |
| ADNP | Homeobox PF00046 765-813 Pfam-B_10803 PB010803 691-762 Pfam-B_21724 PB021724 921-1100 Pfam-B_29916 PB029916 615-646 | ADNP_MOUSE | activity-dependent neuroprotector homeobox | ADNP_HUMAN | Chromatin remodelling cofactor | # | # | # | # |
| AEBP2 | Pfam-B_22101 PB022101 1-79 Pfam-B_8048 PB008048 401-515 zf-H2C2_2 PF13465 315-341 | AEBP2_MOUSE | AE binding protein 2 | AEBP2_HUMAN | Histone modification write cofactor | Histone methylation | PRC2 | # | # |
| AICDA | APOBEC_N PF08210 11-181 | AICDA_MOUSE | activation-induced cytidine deaminase | AICDA_HUMAN | DNA modification | DNA demethylation | APOB_mRNA_editosome | ssDNA hmC | hmU |
| AIRE | PHD PF00628 298-343 Pfam-B_9104 PB009104 481-543 SAND PF01342 189-249 Sp100 PF03172 1-106 | AIRE_MOUSE | autoimmune regulator | AIRE_HUMAN | Histone modification read TF | # # | # | H3K4 H3K4me3 DNA motif | # |
| ALKBH1 | 2OG-FeII_Oxy_2 PF13532 98-344 | ALKB1_MOUSE | alkB alkylation repair homolog 1 (E. coli) | ALKB1_HUMAN | Histone modification | # | # | H2A | # |
| ANKRD32 | Ank_2 PF12796 783-871 845-931 Pfam-B_101142 PB101142 932-1056 Pfam-B_12624 PB012624 231-430 Pfam-B_18156 PB018156 1-229 Pfam-B_81366 PB081366 641-782 | ANR32_MOUSE | ankyrin repeat domain 32 | ANR32_HUMAN | Histone modification read | # | # | H2AXS139 | # |
| ANP32A | LRR_9 PF14580 17-166 | AN32A_MOUSE | acidic (leucine-rich) nuclear phosphoprotein 32 family member A | AN32A_HUMAN | Chromatin remodelling cofactor | # | # | # | # |
| ANP32B | LRR_4 PF12799 88-136 Pfam-B_30686 PB030686 171-249 | AN32B_MOUSE | acidic (leucine-rich) nuclear phosphoprotein 32 family member B | AN32B_HUMAN | Histone chaperone | # | # | H3 H4 | # |
| ANP32E | LRR_4 PF12799 88-133 LRR_8 PF13855 65-125 Pfam-B_38005 PB038005 215-262 Pfam-B_94319 PB094319 171-200 | AN32E_MOUSE | acidic (leucine-rich) nuclear phosphoprotein 32 family member E | AN32E_HUMAN | Histone chaperone Histone modification read | # # | SWR | H2A.Z | # |
| APBB1 | PID PF00640 370-509 543-664 Pfam-B_23321 PB023321 1-215 WW PF00397 255-283 | APBB1_MOUSE | amyloid beta (A4) precursor protein-binding family B member 1 (Fe65) | APBB1_HUMAN | Histone modification | # | # | H2AX | # |
| APEX1 | Exo_endo_phos PF03372 65-309 Pfam-B_21616 PB021616 1-39 | APEX1_MOUSE | APEX nuclease (multifunctional DNA repair enzyme) 1 | APEX1_HUMAN | DNA modification cofactor | DNA demethylation | # | # | # |
| APOBEC1 | APOBEC_N PF08210 17-186 | ABEC1_MOUSE | apolipoprotein B mRNA editing enzyme catalytic polypeptide 1 | ABEC1_HUMAN | DNA modification RNA modification | DNA demethylation mRNA editing | APOB_mRNA_editosome | ssDNA mRNA mC | U |
| APOBEC2 | APOBEC_C PF05240 159-216 Pfam-B_38491 PB038491 1-39 | ABEC2_MOUSE | apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 2 | ABEC2_HUMAN | DNA modification RNA modification | DNA demethylation mRNA editing | # | ssDNA mRNA mC | hmU |
| APOBEC3A | APOBEC_C PF05240 133-187 | # | apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3A | ABC3A_HUMAN | DNA modification RNA modification | DNA demethylation mRNA editing | # | ssDNA mRNA mC | dhU |
| APOBEC3B | APOBEC_C PF05240 316-370 APOBEC_N PF08210 11-190 | ABEC3_MOUSE | apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3B | ABC3B_HUMAN | DNA modification RNA modification | DNA demethylation mRNA editing | # | ssDNA mRNA mC | dhU |
| APOBEC3C | APOBEC_C PF05240 128-182 | # | apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3C | ABC3C_HUMAN | DNA modification RNA modification | DNA demethylation mRNA editing | # | ssDNA mRNA mC | dhU |
| APOBEC3D | APOBEC_C PF05240 140-194 324-378 | # | apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3D | ABC3D_HUMAN | DNA modification RNA modification | DNA demethylation mRNA editing | # | ssDNA mRNA mC | dhU |
| APOBEC3F | APOBEC_N PF08210 3-189 199-373 | # | apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3F | ABC3F_HUMAN | DNA modification RNA modification | DNA demethylation mRNA editing | APOB_mRNA_editosome | ssDNA mRNA mC | dhU |
| APOBEC3G | APOBEC_N PF08210 3-182 202-380 | # | apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G | ABC3G_HUMAN | DNA modification RNA modification | DNA demethylation mRNA editing | APOB_mRNA_editosome | ssDNA mRNA mC | dhU |
| APOBEC3H | APOBEC_C PF05240 116-174 dCMP_cyt_deam_1 PF00383 24-99 | # | apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3H | ABC3H_HUMAN | DNA modification RNA modification | DNA demethylation mRNA editing | APOB_mRNA_editosome | ssDNA mRNA mC | dhU |
| ARID1A | ARID PF01388 1015-1104 DUF3518 PF12031 1975-2231 Pfam-B_16906 PB016906 451-499 Pfam-B_1854 PB001854 281-379 | ARI1A_MOUSE | AT rich interactive domain 1A (SWI-like) | ARI1A_HUMAN | Chromatin remodelling cofactor | # | BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm WINAC bBAF SWI/SNF BRM-BRG1 | DNA motif | # |
| ARID1B | ARID PF01388 1050-1140 DUF3518 PF12031 1926-2182 Pfam-B_60945 PB060945 291-369 Pfam-B_7257 PB007257 371-449 | # | AT rich interactive domain 1B (SWI1-like) | ARI1B_HUMAN | Histone modification write | Histone ubiquitination | BAF nBAF npBAF PBAF SWI/SNF-like_EPAFa SWI/SNF-like EPAFB SWI/SNF BRM-BRG1 | H2BK120 DNA motif | # |
| ARID2 | ARID PF01388 10-101 Pfam-B_11884 PB011884 1660-1747 Pfam-B_14804 PB014804 1051-1098 Pfam-B_649 PB000649 1529-1658 Pfam-B_6603 PB006603 1239-1268 RFX_DNA_binding PF02257 517-604 | # | AT rich interactive domain 2 (ARID RFX-like) | ARID2_HUMAN | Chromatin remodelling cofactor | # | PBAF | DNA motif | # |
| ARID4A | ARID PF01388 306-397 Pfam-B_1988 PB001988 1071-1111 1166-1240 RBB1NT PF08169 168-263 Tudor-knot PF11717 573-630 | # | AT rich interactive domain 4A (RBP1-like) | ARI4A_HUMAN | Histone modification write cofactor | Histone acetylation | mSin3A | DNA motif | # |
| ARID4B | ARID PF01388 304-394 Pfam-B_15110 PB015110 771-828 RBB1NT PF08169 166-264 Tudor-knot PF11717 569-626 | ARI4B_MOUSE | AT rich interactive domain 4B (RBP1-like) | ARI4B_HUMAN | Histone modification write cofactor | Histone acetylation | mSin3A | DNA motif | # |
| ARNTL | HLH PF00010 73-126 PAS PF00989 146-253 PAS_11 PF14598 337-444 Pfam-B_2781 PB002781 455-619 | BMAL1_MOUSE | aryl hydrocarbon receptor nuclear translocator-like | BMAL1_HUMAN | Histone modification write cofactor TF | # TF activator | # | # | # |
| ARRB1 | Arrestin_C PF02752 193-356 Arrestin_N PF00339 18-174 | ARRB1_MOUSE | arrestin beta 1 | ARRB1_HUMAN | Histone modification | # | # | # | # |
| ASF1A | ASF1_hist_chap PF04729 1-154 | ASF1A_MOUSE | anti-silencing function 1A histone chaperone | ASF1A_HUMAN | Histone chaperone | # | # | H3 H4 | # |
| ASF1B | ASF1_hist_chap PF04729 1-154 | ASF1B_MOUSE | anti-silencing function 1B histone chaperone | ASF1B_HUMAN | Histone chaperone | # | # | H3 H4 | # |
| ASH1L | BAH PF01426 2661-2798 Bromodomain PF00439 2453-2538 PHD PF00628 2587-2631 Pfam-B_14208 PB014208 1818-1847 Pfam-B_18246 PB018246 2310-2419 Pfam-B_25586 PB025586 1473-1507 Pfam-B_4663 PB004663 1023-1054 1180-1377 Pfam-B_6310 PB006310 1509-1554 SET PF00856 2156-2261 | ASH1L_MOUSE | ash1 (absent small or homeotic)-like (Drosophila) | ASH1L_HUMAN | Histone modification write | Histone methylation | # | H3K36 | H3K36me |
| ASH2L | Pfam-B_11232 PB011232 499-622 Pfam-B_12412 PB012412 361-417 SPRY PF00622 418-497 | ASH2L_MOUSE | ash2 (absent small or homeotic)-like (Drosophila) | ASH2L_HUMAN | Histone modification write cofactor | Histone methylation | COMPASS Menin-associated_HMT MLL-HCF CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 COMPASS-like MLL3 4 | # | # |
| ASXL1 | ASXH PF13919 231-362 HARE-HTH PF05066 11-83 PHD_3 PF13922 1475-1539 Pfam-B_4087 PB004087 970-1084 | ASXL1_MOUSE | additional sex combs like transcriptional regulator 1 | ASXL1_HUMAN | Histone modification erase Polycomb group (PcG) protein | Histone deubiquitination # | PR-DUB | H2AK119 | H2AK119ub1 |
| ASXL2 | ASXH PF13919 249-381 HARE-HTH PF05066 11-83 PHD_3 PF13922 1370-1433 Pfam-B_4087 PB004087 944-1090 | ASXL2_MOUSE | additional sex combs like transcriptional regulator 2 | ASXL2_HUMAN | Histone modification read | # | # | H3K4 H3K9 | # |
| ASXL3 | ASXH PF13919 229-361 HARE-HTH PF05066 10-81 PHD_3 PF13922 2183-2246 Pfam-B_17129 PB017129 941-1279 Pfam-B_20113 PB020113 751-939 Pfam-B_27498 PB027498 1341-1411 Pfam-B_34336 PB034336 1281-1339 Pfam-B_6874 PB006874 601-669 | ASXL3_MOUSE | additional sex combs like transcriptional regulator 3 | ASXL3_HUMAN | Scaffold protein Polycomb group (PcG) protein | # # | # | # | # |
| ATAD2 | AAA PF00004 463-598 Bromodomain PF00439 993-1075 Pfam-B_11064 PB011064 870-958 Pfam-B_23116 PB023116 1-56 Pfam-B_40477 PB040477 57-79 | ATAD2_MOUSE | ATPase family AAA domain containing 2 | ATAD2_HUMAN | Chromatin remodelling | # | # | # | # |
| ATAD2B | AAA PF00004 437-572 Bromodomain PF00439 967-1050 Pfam-B_11064 PB011064 896-932 Pfam-B_130965 PB130965 330-388 | # | ATPase family AAA domain containing 2B | ATD2B_HUMAN | Histone modification read | # | # | H1.4 H2A H2B H3 and H4 | # |
| ATF2 | bZIP_1 PF00170 349-413 | ATF2_MOUSE | activating transcription factor 2 | ATF2_HUMAN | Histone modification write TF | Histone acetylation TF activator | # | H2B H4 DNA motif | # |
| ATF7IP | Pfam-B_2570 PB002570 450-518 | MCAF1_MOUSE | activating transcription factor 7 interacting protein | MCAF1_HUMAN | Histone modification write cofactor | Histone methylation | # | # | # |
| ATM | FAT PF02259 2096-2489 FATC PF02260 3024-3056 PI3_PI4_kinase PF00454 2711-2962 Pfam-B_10220 PB010220 1575-1713 Pfam-B_13450 PB013450 602-830 Pfam-B_16049 PB016049 1715-1818 Pfam-B_17604 PB017604 1819-1953 Pfam-B_3386 PB003386 861-1458 TAN PF11640 5-166 | ATM_MOUSE | ATM serine/threonine kinase | ATM_HUMAN | Histone modification write | Histone phosphorylation | # | H2AXS139 | # |
| ATN1 | Atrophin-1 PF03154 1-163 349-1190 | ATN1_MOUSE | atrophin 1 | ATN1_HUMAN | Histone modification erase cofactor | # | # | # | # |
| ATR | FAT PF02259 1771-2092 FATC PF02260 2612-2644 PI3_PI4_kinase PF00454 2321-2567 Pfam-B_15857 PB015857 1226-1489 Pfam-B_17853 PB017853 1-129 Pfam-B_20071 PB020071 291-659 Pfam-B_21066 PB021066 131-289 Pfam-B_21726 PB021726 661-1009 Pfam-B_22672 PB022672 1011-1079 UME PF08064 1119-1225 | ATR_MOUSE | ATR serine/threonine kinase | ATR_HUMAN | Histone modification write | Histone phosphorylation | # | H2AX | # |
| ATRX | Helicase_C PF00271 2076-2155 Pfam-B_12326 PB012326 1906-2016 Pfam-B_14952 PB014952 1242-1362 Pfam-B_16104 PB016104 2368-2490 Pfam-B_16400 PB016400 1424-1474 Pfam-B_17163 PB017163 1364-1422 Pfam-B_19720 PB019720 751-889 Pfam-B_24253 PB024253 1181-1239 Pfam-B_3534 PB003534 45-304 SNF2_N PF00176 1563-1889 | ATRX_MOUSE | alpha thalassemia/mental retardation syndrome X-linked | ATRX_HUMAN | Chromatin remodelling | # | # | H3K9me2 H3K9me3 H3K4 | # |
| ATXN7 | Pfam-B_15485 PB015485 781-879 Pfam-B_23658 PB023658 129-174 Pfam-B_6735 PB006735 491-579 SCA7 PF08313 318-397 | ATX7_MOUSE | ataxin 7 | ATX7_HUMAN | Histone modification write cofactor | Histone acetylation | SAGA | # | # |
| ATXN7L3 | Pfam-B_25595 PB025595 276-345 SCA7 PF08313 201-239 Sgf11 PF08209 80-112 | AT7L3_MOUSE | ataxin 7-like 3 | AT7L3_HUMAN | Histone modification erase cofactor | Histone deubiquitination | SAGA | # | # |
| AURKA | Pfam-B_20489 PB020489 1-59 Pkinase PF00069 133-383 | AURKA_MOUSE | aurora kinase A | AURKA_HUMAN | Histone modification write | Histone phosphorylation | # | H3 | H3S10ph |
| AURKB | Pfam-B_34716 PB034716 1-46 Pkinase PF00069 77-327 | AURKB_MOUSE | aurora kinase B | AURKB_HUMAN | Histone modification write | Histone phosphorylation | # | H3S10 H3S28 | # |
| AURKC | Pkinase PF00069 43-293 | AURKC_MOUSE | aurora kinase C | AURKC_HUMAN | Histone modification write | Histone phosphorylation | # | H3S10 H3S28 | # |
| BABAM1 | Pfam-B_4074 PB004074 1-327 | BABA1_MOUSE | BRISC and BRCA1 A complex member 1 | BABA1_HUMAN | Histone modification erase cofactor | Histone deubiquitination | BRISC BRCA1-A | # | # |
| BAHD1 | BAH PF01426 623-779 | BAHD1_MOUSE | bromo adjacent homology domain containing 1 | BAHD1_HUMAN | Chromatin remodelling | # | # | H3K27me3 | # |
| BANP | BEN PF10523 249-322 | BANP_MOUSE | BTG3 associated nuclear protein | BANP_HUMAN | Histone modification write | Histone acetylation | # | H3K9 H4K8 | # |
| BAP1 | Peptidase_C12 PF01088 4-217 Pfam-B_14567 PB014567 441-579 Pfam-B_16218 PB016218 271-439 Pfam-B_4660 PB004660 581-693 | BAP1_MOUSE | BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) | BAP1_HUMAN | Histone modification erase Polycomb group (PcG) protein | Histone deubiquitination # | PR-DUB | H2AK119ub1 | H2AK119 |
| BARD1 | Ank PF00023 427-459 460-491 493-525 BRCT PF00533 568-640 Pfam-B_30184 PB030184 161-239 Pfam-B_32178 PB032178 241-290 Pfam-B_32432 PB032432 291-339 Pfam-B_33025 PB033025 723-775 zf-RING_6 PF14835 41-105 | BARD1_MOUSE | BRCA1 associated RING domain 1 | BARD1_HUMAN | Histone modification write | Histone ubiquitination | BRCC BRCA1-A | H2AX H2A H2B H3 H4 | H2AXub H2Aub H2Bub H3ub H4ub |
| BAZ1A | Bromodomain PF00439 1438-1521 DDT PF02791 422-487 PHD PF00628 1150-1198 Pfam-B_18021 PB018021 670-767 Pfam-B_18567 PB018567 769-877 Pfam-B_19398 PB019398 1210-1430 WAC_Acf1_DNA_bd PF10537 22-122 WHIM1 PF15612 592-640 | BAZ1A_MOUSE | bromodomain adjacent to zinc finger domain 1A | BAZ1A_HUMAN | Histone chaperone | # | ACF CHRAC | # | # |
| BAZ1B | Bromodomain PF00439 1348-1431 PHD PF00628 1186-1234 WAC_Acf1_DNA_bd PF10537 20-120 WHIM1 PF15612 724-773 WHIM2 PF15613 899-936 WHIM3 PF15614 991-1031 | BAZ1B_MOUSE | bromodomain adjacent to zinc finger domain 1B | BAZ1B_HUMAN | Histone modification write | Histone phosphorylation | B-WICH WINAC | H2AXT142 H3 | H2AXY142ph |
| BAZ2A | Bromodomain PF00439 1802-1885 DDT PF02791 848-910 MBD PF01429 546-620 PHD PF00628 1678-1726 Pfam-B_14139 PB014139 1518-1541 Pfam-B_1702 PB001702 2-228 Pfam-B_25722 PB025722 1211-1279 Pfam-B_3124 PB003124 701-789 1085-1136 Pfam-B_32186 PB032186 1484-1516 Pfam-B_6766 PB006766 331-489 WHIM1 PF15612 950-999 WHIM3 PF15614 1439-1480 | BAZ2A_MOUSE | bromodomain adjacent to zinc finger domain 2A | BAZ2A_HUMAN | Chromatin remodelling Histone modification erase | # Histone deacetylation | NoRC | H4K16ac DNA motif | H4K5 H4K8 H4K12 |
| BAZ2B | Bromodomain PF00439 2069-2151 DDT PF02791 1087-1149 MBD PF01429 739-813 PHD PF00628 1933-1981 Pfam-B_10350 PB010350 521-649 Pfam-B_12038 PB012038 1200-1479 Pfam-B_13066 PB013066 91-399 Pfam-B_1587 PB001587 401-519 Pfam-B_17078 PB017078 1618-1728 Pfam-B_17427 PB017427 1-89 Pfam-B_9375 PB009375 1481-1616 | # | bromodomain adjacent to zinc finger domain 2B | BAZ2B_HUMAN | Histone modification read | # | # | H1.4ac H2Aac H2Bac H3ac H4Kac | # |
| BCOR | Ank_2 PF12796 1460-1560 Pfam-B_11277 PB011277 41-289 Pfam-B_26758 PB026758 300-329 Pfam-B_27995 PB027995 1241-1359 Pfam-B_30654 PB030654 1361-1419 Pfam-B_5207 PB005207 421-1239 | BCOR_MOUSE | BCL6 corepressor | BCOR_HUMAN | Polycomb group (PcG) protein | # | BCOR | # | # |
| BCORL1 | Ank_2 PF12796 1410-1486 1426-1519 Pfam-B_1109 PB001109 110-149 Pfam-B_16739 PB016739 560-637 Pfam-B_20248 PB020248 740-800 Pfam-B_31169 PB031169 1-76 Pfam-B_8912 PB008912 383-533 | BCORL_MOUSE | BCL6 corepressor-like 1 | BCORL_HUMAN | Histone modification erase cofactor | Histone deacetylation | BCOR | H3K36me2 | # |
| BMI1 | zf-C3HC4 PF00097 18-56 | BMI1_MOUSE | BMI1 proto-oncogene polycomb ring finger | BMI1_HUMAN | Polycomb group (PcG) protein | # | PRC1 | # | # |
| BPTF | Bromodomain PF00439 2936-3019 DDT PF02791 240-300 PHD PF00628 392-437 2869-2918 Pfam-B_14861 PB014861 2113-2229 Pfam-B_26081 PB026081 91-205 Pfam-B_911 PB000911 1922-2111 Pfam-B_94218 PB094218 1-89 WHIM1 PF15612 339-388 | # | bromodomain PHD finger transcription factor | BPTF_HUMAN | Chromatin remodelling | # | NuRF | # | # |
| BRCA1 | BRCT PF00533 1648-1723 1756-1842 BRCT_assoc PF12820 344-508 EIN3 PF04873 648-978 Pfam-B_17893 PB017893 1404-1493 zf-C3HC4 PF00097 24-64 | BRCA1_MOUSE | breast cancer 1 early onset | BRCA1_HUMAN | Histone modification write cofactor Histone modification write cofactor Histone modification write cofactor TF TF | Histone acetylation Histone methylation Histone ubiquitination TF activator TF repressor | BRCC BRCA1-A | DNA motif | # |
| BRCA2 | BRCA-2_OB1 PF09103 2670-2800 BRCA-2_OB3 PF09104 3052-3190 BRCA-2_helical PF09169 2479-2667 BRCA2 PF00634 1002-1036 1212-1246 1421-1455 1517-1551 1664-1698 1837-1871 1971-2005 2051-2085 Pfam-B_13057 PB013057 2141-2448 Pfam-B_47717 PB047717 2449-2478 Pfam-B_8258 PB008258 651-989 Tower PF09121 2831-2872 | BRCA2_MOUSE | breast cancer 2 early onset | BRCA2_HUMAN | Histone modification write | Histone acetylation | BRCC | H3 H4 ssDNA | # |
| BRCC3 | JAB PF01398 7-148 | BRCC3_MOUSE | BRCA1/BRCA2-containing complex subunit 3 | BRCC3_HUMAN | Histone modification erase | Histone deubiquitination | BRISC BRCA1-A | H2AK63 H2AXK63 | H2A H2AX |
| BRD1 | Bromodomain PF00439 571-654 EPL1 PF10513 46-196 PHD_2 PF13831 228-262 PWWP PF00855 927-1042 zf-HC5HC2H_2 PF13832 269-388 | # | bromodomain containing 1 | BRD1_HUMAN | Histone modification read | # | MOZ/MORF | H3K36me3 H3 | # |
| BRD2 | Bromodomain PF00439 84-168 353-441 Pfam-B_12618 PB012618 624-776 Pfam-B_14336 PB014336 541-613 | BRD2_MOUSE | bromodomain containing 2 | BRD2_HUMAN | Histone modification read | # | # | H3K9me2 H3K14me2 H4K5ac H4K12ac | # |
| BRD3 | Bromodomain PF00439 42-128 315-403 | BRD3_MOUSE | bromodomain containing 3 | BRD3_HUMAN | Histone modification read | # | # | H3K9me2 H3K14me2 H4K5ac H4K12ac | # |
| BRD4 | Bromodomain PF00439 67-152 357-445 Pfam-B_14896 PB014896 1187-1263 Pfam-B_15118 PB015118 509-647 Pfam-B_18611 PB018611 648-667 Pfam-B_24632 PB024632 833-892 Pfam-B_29595 PB029595 1283-1311 Pfam-B_35798 PB035798 1136-1185 Pfam-B_361 PB000361 1324-1357 | BRD4_MOUSE | bromodomain containing 4 | BRD4_HUMAN | Histone modification read | # | # | H3K9 H3K14 H4K5 H4K12 | # |
| BRD7 | Bromodomain PF00439 140-223 DUF3512 PF12024 286-534 Pfam-B_1543 PB001543 591-649 Pfam-B_64177 PB064177 1-49 | BRD7_MOUSE | bromodomain containing 7 | BRD7_HUMAN | Histone modification read | # | SWI/SNF BRM-BRG1 | H3K9ac H3K14ac H3K8ac | # |
| BRD8 | Bromodomain PF00439 713-799 1112-1195 Pfam-B_19676 PB019676 1-69 Pfam-B_55933 PB055933 71-109 | BRD8_MOUSE | bromodomain containing 8 | BRD8_HUMAN | Histone modification read | # | SWR NuA4 NuA4-related complex | # | # |
| BRD9 | Bromodomain PF00439 143-228 DUF3512 PF12024 268-505 Pfam-B_8260 PB008260 511-595 | BRD9_MOUSE | bromodomain containing 9 | BRD9_HUMAN | Histone modification read | # | SWI/SNF BRM-BRG1 | H3 | # |
| BRDT | Bromodomain PF00439 36-121 276-364 Pfam-B_11430 PB011430 710-791 | BRDT_MOUSE | bromodomain testis-specific | BRDT_HUMAN | Histone modification read | # | # | H4K5ac H4K8ac | # |
| BRE | BRE PF06113 1-333 | BRE_MOUSE | brain and reproductive organ-expressed (TNFRSF1A modulator) | BRE_HUMAN | Histone modification write cofactor | Histone ubiquitination | BRISC BRCC BRCA1-A | # | # |
| BRMS1 | Sds3 PF08598 58-229 | BRMS1_MOUSE | breast cancer metastasis suppressor 1 | BRMS1_HUMAN | Chromatin remodelling | # | mSin3A | # | # |
| BRMS1L | Sds3 PF08598 59-227 | BRM1L_MOUSE | breast cancer metastasis-suppressor 1-like | BRM1L_HUMAN | Histone modification erase | Histone deacetylation | mSin3A | # | # |
| BRPF1 | Bromodomain PF00439 637-720 EPL1 PF10513 105-255 PHD_2 PF13831 287-321 PWWP PF00855 1083-1198 zf-HC5HC2H_2 PF13832 328-447 | # | bromodomain and PHD finger containing 1 | BRPF1_HUMAN | Histone modification read | # | MOZ/MORF | H3K36me3 | # |
| BRPF3 | Bromodomain PF00439 598-681 EPL1 PF10513 47-194 PHD_2 PF13831 226-260 PWWP PF00855 1074-1189 Pfam-B_5327 PB005327 751-829 zf-HC5HC2H_2 PF13832 267-386 | # | bromodomain and PHD finger containing 3 | BRPF3_HUMAN | Histone modification write cofactor | Histone acetylation | MOZ/MORF | # | # |
| BRWD1 | Bromodomain PF00439 1166-1252 1322-1405 Pfam-B_18973 PB018973 859-924 Pfam-B_22078 PB022078 2089-2186 Pfam-B_27858 PB027858 1900-2087 Pfam-B_71 PB000071 2238-2318 Pfam-B_8184 PB008184 1821-1898 WD40 PF00400 177-214 218-256 260-302 358-396 458-497 | BRWD1_MOUSE | bromodomain and WD repeat domain containing 1 | BRWD1_HUMAN | Histone modification read | # | # | H3 | # |
| BRWD3 | Bromodomain PF00439 1147-1233 1345-1418 Pfam-B_12397 PB012397 1669-1710 Pfam-B_2569 PB002569 9-97 WD40 PF00400 171-208 212-250 254-296 352-392 455-494 507-540 | BRWD3_MOUSE | bromodomain and WD repeat domain containing 3 | BRWD3_HUMAN | Histone modification read | # | # | H3 | # |
| BUB1 | Mad3_BUB1_I PF08311 4-126 Pkinase PF00069 787-1033 | BUB1_MOUSE | BUB1 mitotic checkpoint serine/threonine kinase | BUB1_HUMAN | Histone modification write | Histone phosphorylation | # | H2AS121 | H2AS121ph |
| C11orf30 | ENT PF03735 16-88 Pfam-B_10468 PB010468 695-833 Pfam-B_10943 PB010943 985-1113 | EMSY_MOUSE | chromosome 11 open reading frame 30 | EMSY_HUMAN | Histone modification write cofactor | Histone methylation | # | # | # |
| C14orf169 | Cupin_4 PF08007 215-557 Pfam-B_41208 PB041208 71-139 Pfam-B_47541 PB047541 1-69 | NO66_MOUSE | # | NO66_HUMAN | Histone modification erase | Histone methylation | # | H3K4me3 H3K4me1 H3K36me2 | H3K4me2 H3K4 H3K36me1 |
| C17orf49 | # | BAP18_MOUSE | chromosome 17 open reading frame 49 | BAP18_HUMAN | Histone modification read | # | CHD8 MLL2/3 MLL4/WBP7 | H3K4me3 | # |
| CARM1 | CARM1 PF11531 26-139 PRMT5 PF05185 143-446 Pfam-B_10255 PB010255 449-469 Pfam-B_13059 PB013059 511-606 | CARM1_MOUSE | coactivator-associated arginine methyltransferase 1 | CARM1_HUMAN | Histone modification write | Histone methylation | # | H3R17 | H3R17me H3R17me2a |
| CBX1 | Chromo PF00385 21-70 Chromo_shadow PF01393 115-172 | CBX1_MOUSE | chromobox homolog 1 | CBX1_HUMAN | Histone modification read | # | # | H3K9me3 H3K27me3 | # |
| CBX2 | Chromo PF00385 12-61 Pfam-B_1400 PB001400 249-295 | CBX2_MOUSE | chromobox homolog 2 | CBX2_HUMAN | Histone modification read | # | PRC1 | H3K9me3 H3K27me3 | # |
| CBX3 | Chromo PF00385 30-79 Chromo_shadow PF01393 119-176 | CBX3_MOUSE | chromobox homolog 3 | CBX3_HUMAN | Histone modification read | # | RING2-L3MBTL2 L3MBTL1 | H3K9me3 | # |
| CBX4 | Chromo PF00385 11-60 Pfam-B_16393 PB016393 481-531 Pfam-B_26041 PB026041 401-479 Pfam-B_8537 PB008537 82-281 | CBX4_MOUSE | chromobox homolog 4 | CBX4_HUMAN | Histone modification read | # | PRC1 | H3K9me3 | # |
| CBX5 | Chromo PF00385 20-69 Chromo_shadow PF01393 119-176 | CBX5_MOUSE | chromobox homolog 5 | CBX5_HUMAN | Histone modification read | # | # | H3K9me H3K27me3 | # |
| CBX6 | Chromo PF00385 11-60 Pfam-B_41557 PB041557 291-379 Pfam-B_49897 PB049897 381-410 | CBX6_MOUSE | chromobox homolog 6 | CBX6_HUMAN | Histone modification read | # | PRC1 | H3K9me3 H3K27me3 | # |
| CBX7 | Chromo PF00385 11-60 | CBX7_MOUSE | chromobox homolog 7 | CBX7_HUMAN | Histone modification read | # | PRC1 | H3K9me3 H3K27me3 | # |
| CBX8 | Chromo PF00385 11-60 | CBX8_MOUSE | chromobox homolog 8 | CBX8_HUMAN | Histone modification read | # | PRC1 | H3K9me3 H3K27me3 | # |
| CCDC101 | DUF1325 PF07039 157-289 | SGF29_MOUSE | coiled-coil domain containing 101 | SGF29_HUMAN | Histone modification read | # | ATAC | H3K4me H3K4me3 | # |
| CDC6 | AAA_22 PF13401 190-322 Cdc6_C PF09079 465-545 | CDC6_MOUSE | cell division cycle 6 | CDC6_HUMAN | Chromatin remodelling | # | # | # | # |
| CDC73 | CDC73 PF05179 233-525 | CDC73_MOUSE | cell division cycle 73 | CDC73_HUMAN | Histone modification write cofactor | Histone methylation | # | # | # |
| CDK1 | Pkinase PF00069 4-287 | CDK1_MOUSE | cyclin-dependent kinase 1 | CDK1_HUMAN | Histone modification write | Histone phosphorylation | # | H1 | H1ph |
| CDK2 | Pkinase PF00069 4-286 | CDK2_MOUSE | cyclin-dependent kinase 2 | CDK2_HUMAN | Histone modification write | Histone phosphorylation | # | H1S H1T | H1Sph H1Tph |
| CDK3 | Pkinase PF00069 4-286 | CDK3_MOUSE | cyclin-dependent kinase 3 | CDK3_HUMAN | Histone modification write | Histone phosphorylation | # | H1 | # |
| CDK5 | Pkinase PF00069 4-286 | CDK5_MOUSE | cyclin-dependent kinase 5 | CDK5_HUMAN | Histone modification write | Histone phosphorylation | # | H1 | # |
| CDK7 | Pfam-B_20206 PB020206 301-344 Pkinase PF00069 12-295 | CDK7_MOUSE | cyclin-dependent kinase 7 | CDK7_HUMAN | Histone modification write | Histone phosphorylation | # | H1 | # |
| CDK9 | Pkinase PF00069 19-315 | CDK9_MOUSE | cyclin-dependent kinase 9 | CDK9_HUMAN | Histone modification cofactor | # | # | # | # |
| CDK17 | Pkinase PF00069 192-473 | CDK17_MOUSE | cyclin-dependent kinase 17 | CDK17_HUMAN | Histone modification write | Histone phosphorylation | # | H1 | # |
| CDY1 | Chromo PF00385 6-57 ECH PF00378 287-535 Pfam-B_51834 PB051834 101-148 | # | chromodomain protein Y-linked 1 | CDY1_HUMAN | Histone modification write | Histone acetylation | # | H4 | # |
| CDY1B | Chromo PF00385 6-57 ECH PF00378 287-535 Pfam-B_51834 PB051834 101-148 | # | chromodomain protein Y-linked 1B | CDY1_HUMAN | Histone modification write | Histone acetylation | # | H4 | # |
| CDY2A | Chromo PF00385 6-57 ECH PF00378 288-536 Pfam-B_51834 PB051834 101-149 | # | chromodomain protein Y-linked 2A | CDY2_HUMAN | Histone modification write | Histone acetylation | # | # | # |
| CDY2B | Chromo PF00385 6-57 ECH PF00378 288-536 Pfam-B_51834 PB051834 101-149 | # | chromodomain protein Y-linked 2B | CDY2_HUMAN | Histone modification write | Histone acetylation | # | # | # |
| CDYL | Chromo PF00385 61-112 ECH PF00378 345-593 Pfam-B_14969 PB014969 136-234 | CDYL_MOUSE | chromodomain protein Y-like | CDYL1_HUMAN | Histone modification write | Histone acetylation | # | H4 | # |
| CDYL2 | Chromo PF00385 7-57 ECH PF00378 253-501 | CDYL2_MOUSE | chromodomain protein Y-like 2 | CDYL2_HUMAN | Histone modification read | # | # | H3K9me3 | # |
| CECR2 | Bromodomain PF00439 443-526 Pfam-B_13010 PB013010 1-329 Pfam-B_18245 PB018245 800-968 Pfam-B_20164 PB020164 331-419 | # | cat eye syndrome chromosome region candidate 2 | CECR2_HUMAN | Histone modification read | # | CERF CERF | H2A H3 | # |
| CENPC | CENP-C_C PF11699 856-940 CENP-C_mid PF15620 296-552 CENP_C_N PF15622 7-292 | CENPC_MOUSE | centromere protein C | CENPC_HUMAN | DNA modification | DNA methylation | # | C | 5mC |
| CHAF1A | CAF-1_p150 PF11600 266-479 CAF1-p150_C2 PF15539 665-956 CAF1-p150_N PF15557 1-229 CAF1A PF12253 557-635 | CAF1A_MOUSE | chromatin assembly factor 1 subunit A (p150) | CAF1A_HUMAN | Chromatin remodelling | # | CAF-1 | H3 H4 | # |
| CHAF1B | CAF-1_p60_C PF15512 381-558 WD40 PF00400 10-45 57-94 119-157 161-199 339-372 | CAF1B_MOUSE | chromatin assembly factor 1 subunit B (p60) | CAF1B_HUMAN | Chromatin remodelling | # | WINAC CAF-1 | H3 H4 | # |
| CHD1 | Chromo PF00385 273-355 389-443 DUF4208 PF13907 1400-1500 Helicase_C PF00271 822-902 Pfam-B_182 PB000182 1646-1708 Pfam-B_91833 PB091833 121-162 SNF2_N PF00176 484-765 | CHD1_MOUSE | chromodomain helicase DNA binding protein 1 | CHD1_HUMAN | Chromatin remodelling | # | # | # | # |
| CHD1L | Helicase_C PF00271 381-459 Pfam-B_2492 PB002492 468-549 SNF2_N PF00176 49-328 | CHD1L_MOUSE | chromodomain helicase DNA binding protein 1-like | CHD1L_HUMAN | Chromatin remodelling | # | # | # | # |
| CHD2 | Chromo PF00385 261-344 378-447 DUF4208 PF13907 1455-1555 Helicase_C PF00271 825-905 Pfam-B_19320 PB019320 1231-1309 Pfam-B_761 PB000761 1111-1229 SNF2_N PF00176 487-768 | CHD2_MOUSE | chromodomain helicase DNA binding protein 2 | CHD2_HUMAN | Chromatin remodelling | # | # | # | # |
| CHD3 | CHDCT2 PF08074 1735-1907 CHDNT PF08073 147-201 Chromo PF00385 539-574 631-683 DUF1086 PF06461 1363-1519 DUF1087 PF06465 1293-1357 Helicase_C PF00271 1094-1174 PHD PF00628 381-426 458-503 SNF2_N PF00176 739-1035 | # | chromodomain helicase DNA binding protein 3 | CHD3_HUMAN | Chromatin remodelling | # | NuRD | # | # |
| CHD4 | CHDCT2 PF08074 1724-1896 CHDNT PF08073 163-217 Chromo PF00385 531-577 622-674 DUF1086 PF06461 1366-1523 DUF1087 PF06465 1289-1353 Helicase_C PF00271 1084-1164 PHD PF00628 372-417 451-496 SNF2_N PF00176 729-1025 | CHD4_MOUSE | chromodomain helicase DNA binding protein 4 | CHD4_HUMAN | Chromatin remodelling | # | NuRD | # | # |
| CHD5 | CHDCT2 PF08074 1731-1903 CHDNT PF08073 146-200 Chromo PF00385 499-537 592-643 DUF1086 PF06461 1377-1531 DUF1087 PF06465 1295-1359 Helicase_C PF00271 1058-1138 PHD PF00628 345-390 418-463 Pfam-B_20089 PB020089 201-334 SNF2_N PF00176 703-999 | CHD5_MOUSE | chromodomain helicase DNA binding protein 5 | CHD5_HUMAN | Chromatin remodelling | # | # | H3K27me3 H3K4 | # |
| CHD6 | BRK PF07533 2400-2441 Chromo PF00385 292-354 375-429 Helicase_C PF00271 817-897 Pfam-B_18962 PB018962 1-49 Pfam-B_23619 PB023619 1691-1909 Pfam-B_71010 PB071010 1911-1953 Pfam-B_761 PB000761 1271-1333 1361-1519 SNF2_N PF00176 464-751 | CHD6_MOUSE | chromodomain helicase DNA binding protein 6 | CHD6_HUMAN | Chromatin remodelling | # | # | # | # |
| CHD7 | BRK PF07533 2562-2612 2640-2685 Chromo PF00385 800-862 882-935 Helicase_C PF00271 1324-1404 Pfam-B_19729 PB019729 1-188 Pfam-B_19848 PB019848 2351-2469 Pfam-B_2227 PB002227 281-449 Pfam-B_2565 PB002565 1722-1920 Pfam-B_6146 PB006146 2041-2259 Pfam-B_761 PB000761 1622-1720 1966-2035 SNF2_N PF00176 971-1258 | CHD7_MOUSE | chromodomain helicase DNA binding protein 7 | CHD7_HUMAN | Chromatin remodelling | # | # | # | # |
| CHD8 | BRK PF07533 2308-2353 Chromo PF00385 642-704 724-778 Helicase_C PF00271 1167-1247 Pfam-B_10410 PB010410 1-109 Pfam-B_12479 PB012479 1721-1779 Pfam-B_13819 PB013819 2211-2279 Pfam-B_20709 PB020709 2031-2169 Pfam-B_2565 PB002565 1781-2029 Pfam-B_6146 PB006146 2171-2209 Pfam-B_6192 PB006192 1481-1669 Pfam-B_7386 PB007386 311-493 Pfam-B_8182 PB008182 1411-1479 Pfam-B_8545 PB008545 111-309 SNF2_N PF00176 814-1101 | CHD8_MOUSE | chromodomain helicase DNA binding protein 8 | CHD8_HUMAN | Chromatin remodelling | # | CHD8 MLL2/3 MLL4/WBP7 | H1 | # |
| CHD9 | BRK PF07533 2480-2530 2554-2599 Chromo PF00385 690-752 773-827 Helicase_C PF00271 1216-1296 Pfam-B_10410 PB010410 1-89 Pfam-B_1107 PB001107 2701-2729 Pfam-B_15117 PB015117 371-579 Pfam-B_24836 PB024836 1774-1901 Pfam-B_6192 PB006192 1530-1675 Pfam-B_7386 PB007386 231-369 Pfam-B_8182 PB008182 1460-1528 Pfam-B_8545 PB008545 91-229 SNF2_N PF00176 863-1150 | CHD9_MOUSE | chromodomain helicase DNA binding protein 9 | CHD9_HUMAN | Chromatin remodelling | # | # | # | # |
| CHEK1 | Pkinase PF00069 9-265 | CHK1_MOUSE | checkpoint kinase 1 | CHK1_HUMAN | Histone modification write | Histone phosphorylation | # | H3.1 | H3.1ph |
| CHRAC1 | CBFD_NFYB_HMF PF00808 17-80 | CHRC1_MOUSE | chromatin accessibility complex 1 | CHRC1_HUMAN | Histone chaperone | # | CHRAC | # | # |
| CHTOP | FoP_duplication PF13865 171-245 | CHTOP_MOUSE | chromatin target of PRMT1 | CHTOP_HUMAN | # | # | # | # | # |
| CHUK | IKKbetaNEMObind PF12179 706-743 Pfam-B_15051 PB015051 300-415 Pkinase PF00069 15-297 | IKKA_MOUSE | conserved helix-loop-helix ubiquitous kinase | IKKA_HUMAN | Histone modification write | Histone phosphorylation | # | H3 | # |
| CIR1 | Cir_N PF10197 13-49 Pfam-B_16354 PB016354 52-448 | CIR1_MOUSE | corepressor interacting with RBPJ 1 | CIR1_HUMAN | Histone modification read | # | # | # | # |
| CIT | CNH PF00780 1597-1868 Pfam-B_11694 PB011694 483-521 Pfam-B_387 PB000387 1354-1412 Pkinase PF00069 97-360 Pkinase_C PF00433 378-424 | CTRO_MOUSE | citron rho-interacting serine/threonine kinase | CTRO_HUMAN | Histone modification write cofactor Histone modification write cofactor | Histone methylation Histone phosphorylation | # | H3K9 | H3K9me |
| CLNS1A | Pfam-B_77655 PB077655 1-34 Voldacs PF03517 35-165 | ICLN_MOUSE | chloride channel nucleotide-sensitive 1A | ICLN_HUMAN | Histone modification write cofactor | Histone methylation | methylosome | # | # |
| CLOCK | HLH PF00010 35-85 PAS PF00989 109-188 PAS_11 PF14598 273-381 Pfam-B_3081 PB003081 721-839 Pfam-B_7827 PB007827 571-719 Pfam-B_8264 PB008264 382-429 | CLOCK_MOUSE | clock circadian regulator | CLOCK_HUMAN | Histone modification write | Histone acetylation | # | H3 H4 | # |
| CRB2 | EGF PF00008 112-142 150-180 227-257 324-354 362-392 811-841 1060-1090 Laminin_G_2 PF02210 465-588 900-1033 Pfam-B_3557 PB003557 1199-1283 Pfam-B_79172 PB079172 1119-1197 hEGF PF12661 305-317 | CRUM2_MOUSE | crumbs family member 2 | CRUM2_HUMAN | Histone modification read | # | # | H4K20 | # |
| CREBBP | Bromodomain PF00439 1094-1180 Creb_binding PF09030 2016-2115 DUF902 PF06001 1191-1232 KAT11 PF08214 1342-1648 KIX PF02172 587-667 Pfam-B_2669 PB002669 2188-2217 Pfam-B_817 PB000817 2353-2401 ZZ PF00569 1701-1742 zf-TAZ PF02135 352-432 1770-1843 | CBP_MOUSE | CREB binding protein | CBP_HUMAN | Histone modification write | Histone acetylation | # | # | # |
| CSNK2A1 | Pkinase PF00069 39-324 | CSK21_MOUSE | casein kinase 2 alpha 1 polypeptide | CSK21_HUMAN | Histone modification | # | RING2-FBRS | # | # |
| CSRP2BP | Acetyltransf_1 PF00583 678-752 Pfam-B_6449 PB006449 351-435 Pfam-B_8520 PB008520 1-129 | CSR2B_MOUSE | CSRP2 binding protein | CSR2B_HUMAN | Histone modification write | Histone acetylation | ATAC | H4 | # |
| CTBP1 | 2-Hacid_dh PF00389 30-352 2-Hacid_dh_C PF02826 133-317 | CTBP1_MOUSE | C-terminal binding protein 1 | CTBP1_HUMAN | Chromatin remodelling | # | LSD-CoREST | # | # |
| CTBP2 | 2-Hacid_dh PF00389 36-358 2-Hacid_dh_C PF02826 139-323 | CTBP2_MOUSE | C-terminal binding protein 2 | CTBP2_HUMAN | Histone modification write cofactor | Histone methylation | # | H3K9 | H3K9me H3K9me2 |
| CTCF | Pfam-B_18810 PB018810 671-725 zf-C2H2 PF00096 437-460 zf-C2H2_4 PF13894 555-578 zf-H2C2_2 PF13465 280-305 308-333 336-362 365-389 393-418 481-506 507-534 | CTCF_MOUSE | CCCTC-binding factor (zinc finger protein) | CTCF_HUMAN | Chromatin remodelling TF | # TF activator | # | DNA motif | # |
| CTCFL | Pfam-B_37192 PB037192 1-49 Pfam-B_59982 PB059982 611-659 zf-C2H2 PF00096 428-451 546-568 zf-H2C2_2 PF13465 271-296 299-324 327-353 356-380 384-409 472-497 500-525 | CTCFL_MOUSE | CCCTC-binding factor (zinc finger protein)-like | CTCFL_HUMAN | Chromatin remodelling | # | # | # | # |
| CTR9 | Pfam-B_9491 PB009491 5-42 TPR_1 PF00515 163-196 198-231 306-339 342-374 498-530 531-564 681-710 TPR_2 PF07719 451-483 | CTR9_MOUSE | CTR9 Paf1/RNA polymerase II complex component | CTR9_HUMAN | Histone modification cofactor | # | # | H3K36 | # |
| CUL1 | Cullin PF00888 21-707 Cullin_Nedd8 PF10557 703-770 | CUL1_MOUSE | cullin 1 | CUL1_HUMAN | Chromatin remodelling cofactor | # | # | H3K9me3 H3K36me3 H1.4K26me3 | H3K9 H3K36 H1.4K26 |
| CUL2 | Cullin PF00888 14-645 Cullin_Nedd8 PF10557 672-739 | CUL2_MOUSE | cullin 2 | CUL2_HUMAN | Chromatin remodelling cofactor | # | # | HP1 (Heterochromatin protein 1) | # |
| CUL3 | Cullin PF00888 34-666 Cullin_Nedd8 PF10557 695-762 | CUL3_MOUSE | cullin 3 | CUL3_HUMAN | Histone modification write | Histone ubiquitination | # | MACROH2A | # |
| CUL4A | Cullin PF00888 63-661 Cullin_Nedd8 PF10557 688-753 | CUL4A_MOUSE | cullin 4A | CUL4A_HUMAN | Histone modification write | Histone ubiquitination | # | H3 H4 | # |
| CUL4B | Cullin PF00888 217-815 Cullin_Nedd8 PF10557 842-907 | CUL4B_MOUSE | cullin 4B | CUL4B_HUMAN | Histone modification write | Histone ubiquitination | # | H3 H4 | # |
| CUL5 | Cullin PF00888 19-673 Cullin_Nedd8 PF10557 707-774 | CUL5_MOUSE | cullin 5 | CUL5_HUMAN | DNA modification cofactor | DNA methylation | # | # | # |
| CXXC1 | PHD PF00628 28-76 zf-CXXC PF02008 160-208 zf-CpG_bind_C PF12269 400-636 | CXXC1_MOUSE | CXXC finger protein 1 | CXXC1_HUMAN | Chromatin remodelling TF | # # | COMPASS | CG DNA motif | # |
| DAPK3 | Pkinase PF00069 13-275 | DAPK3_MOUSE | death-associated protein kinase 3 | DAPK3_HUMAN | Histone modification write | Histone phosphorylation | # | H3T11 | # |
| DAXX | Daxx PF03344 1-740 | DAXX_MOUSE | death-domain associated protein | DAXX_HUMAN | # | # | # | H3.3 | # |
| DDB1 | CPSF_A PF03178 788-1099 MMS1_N PF10433 75-546 Pfam-B_431 PB000431 585-732 | DDB1_MOUSE | damage-specific DNA binding protein 1 127kDa | DDB1_HUMAN | Histone modification write | Histone ubiquitination | # | H2A | # |
| DDB2 | WD40 PF00400 112-140 232-271 284-316 | DDB2_MOUSE | damage-specific DNA binding protein 2 48kDa | DDB2_HUMAN | Histone modification write cofactor | Histone ubiquitination | # | # | # |
| DDX21 | DEAD PF00270 210-385 GUCT PF08152 620-716 Helicase_C PF00271 458-532 Pfam-B_47445 PB047445 1-39 | DDX21_MOUSE | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | DDX21_HUMAN | RNA modification | # | B-WICH | # | # |
| DDX50 | DEAD PF00270 161-336 GUCT PF08152 571-666 Helicase_C PF00271 409-483 | DDX50_MOUSE | DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 | DDX50_HUMAN | RNA modification | # | # | # | # |
| DEK | DEK_C PF08766 321-375 Pfam-B_10960 PB010960 191-269 SAP PF02037 149-183 | DEK_MOUSE | DEK proto-oncogene | DEK_HUMAN | Chromatin remodelling | # | B-WICH | H4 | # |
| DMAP1 | DMAP1 PF05499 243-407 | DMAP1_MOUSE | DNA methyltransferase 1 associated protein 1 | DMAP1_HUMAN | Chromatin remodelling | # | NuA4 NuA4-related complex SRCAP | # | # |
| DNAJC1 | DnaJ PF00226 65-126 Myb_DNA-binding PF00249 494-543 Pfam-B_8255 PB008255 367-413 | DNJC1_MOUSE | DnaJ (Hsp40) homolog subfamily C member 1 | DNJC1_HUMAN | Histone modification write cofactor Histone modification erase cofactor | Histone acetylation Histone deacetylation | # | # | # |
| DNAJC2 | DnaJ PF00226 88-158 Myb_DNA-binding PF00249 451-506 552-600 Pfam-B_24524 PB024524 28-59 Pfam-B_30652 PB030652 1-27 | DNJC2_MOUSE | DnaJ (Hsp40) homolog subfamily C member 2 | DNJC2_HUMAN | Histone modification read | # | # | H2A | # |
| DND1 | DND1_DSRM PF14709 253-333 RRM_1 PF00076 60-126 | DND1_MOUSE | DND microRNA-mediated repression inhibitor 1 | DND1_HUMAN | RNA modification | # | # | # | # |
| DNMT1 | BAH PF01426 755-880 931-1100 DMAP_binding PF06464 16-105 DNA_methylase PF00145 1139-1594 DNMT1-RFD PF12047 399-534 zf-CXXC PF02008 645-691 | DNMT1_MOUSE | DNA (cytosine-5-)-methyltransferase 1 | DNMT1_HUMAN | DNA modification | DNA methylation | # | dhC | dhU |
| DNMT3A | DNA_methylase PF00145 634-776 PWWP PF00855 290-375 | DNM3A_MOUSE | DNA (cytosine-5-)-methyltransferase 3 alpha | DNM3A_HUMAN | DNA modification | DNA methylation | # | dhC | dhU |
| DNMT3B | DNA_methylase PF00145 575-725 PWWP PF00855 223-308 | DNM3B_MOUSE | DNA (cytosine-5-)-methyltransferase 3 beta | DNM3B_HUMAN | DNA modification | DNA methylation | # | dhC | dhU |
| DNMT3L | Pfam-B_139748 PB139748 181-229 Pfam-B_41249 PB041249 91-179 | DNM3L_MOUSE | DNA (cytosine-5-)-methyltransferase 3-like | DNM3L_HUMAN | Histone modification read | # | # | H3K4 | # |
| DNTTIP2 | Fcf2 PF08698 635-731 | TDIF2_MOUSE | deoxynucleotidyltransferase terminal interacting protein 2 | TDIF2_HUMAN | Chromatin remodelling | # | # | H2A H2B | # |
| DOT1L | DOT1 PF08123 115-317 Pfam-B_30738 PB030738 501-539 | - | DOT1-like histone H3K79 methyltransferase | DOT1L_HUMAN | Histone modification write | Histone methylation | # | H3K79 | # |
| DPF1 | PHD PF00628 256-311 310-368 Pfam-B_77905 PB077905 1-37 Requiem_N PF14051 38-111 | DPF1_MOUSE | D4 zinc and double PHD fingers family 1 | DPF1_HUMAN | Chromatin remodelling cofactor | # | nBAF SWI/SNF BRM-BRG1 | # | # |
| DPF2 | PHD PF00628 272-330 329-376 Requiem_N PF14051 12-85 | REQU_MOUSE | D4 zinc and double PHD fingers family 2 | REQU_HUMAN | Chromatin remodelling | # | SWI/SNF BRM-BRG1 | # | # |
| DPF3 | PHD PF00628 261-319 318-366 Requiem_N PF14051 12-85 | DPF3_MOUSE | D4 zinc and double PHD fingers family 3 | DPF3_HUMAN | Chromatin remodelling | # | BAF nBAF SWI/SNF BRM-BRG1 | H3 H4 | # |
| DPPA3 | PGC7_Stella PF15549 1-155 | DPPA3_MOUSE | developmental pluripotency associated 3 | DPPA3_HUMAN | Histone modification read | # | # | H3K9me2 | # |
| DPY30 | Dpy-30 PF05186 52-93 Pfam-B_28037 PB028037 1-51 | DPY30_MOUSE | dpy-30 homolog (C. elegans) | DPY30_HUMAN | Histone modification write cofactor | Histone methylation | COMPASS Menin-associated_HMT MLL-HCF CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 COMPASS-like MLL3 4 | # | # |
| DR1 | CBFD_NFYB_HMF PF00808 11-75 | NC2B_MOUSE | down-regulator of transcription 1 TBP-binding (negative cofactor 2) | NC2B_HUMAN | Histone chaperone | # | ATAC | # | # |
| DTX3L | Pfam-B_11420 PB011420 311-389 706-737 zf-RING_2 PF13639 559-600 | DTX3L_MOUSE | deltex 3 like E3 ubiquitin ligase | DTX3L_HUMAN | Histone modification write | Histone ubiquitination | # | H4K91 | # |
| DZIP3 | Pfam-B_10362 PB010362 531-619 Pfam-B_5525 PB005525 201-419 Pfam-B_5636 PB005636 1-199 Pfam-B_8501 PB008501 621-773 Pfam-B_8729 PB008729 421-529 zf-RING_2 PF13639 1146-1188 | DZIP3_MOUSE | DAZ interacting zinc finger protein 3 | DZIP3_HUMAN | Histone modification write | Histone ubiquitination | # | H2AK119 | H2AK119ub |
| E2F6 | E2F_TDP PF02319 63-128 | E2F6_MOUSE | E2F transcription factor 6 | E2F6_HUMAN | TF | TF repressor | RING2-L3MBTL2 CHD8 MLL2/3 MLL4/WBP7 | DNA motif | # |
| EED | Pfam-B_26038 PB026038 1-39 Pfam-B_6684 PB006684 265-359 WD40 PF00400 180-219 231-264 | EED_MOUSE | embryonic ectoderm development | EED_HUMAN | Polycomb group (PcG) protein | # | PRC2 | # | # |
| EHMT1 | Ank_2 PF12796 742-836 810-903 910-998 Ank_4 PF13637 773-826 839-893 Pfam-B_28560 PB028560 1-98 Pre-SET PF05033 1013-1118 SET PF00856 1137-1243 | EHMT1_MOUSE | euchromatic histone-lysine N-methyltransferase 1 | EHMT1_HUMAN | Histone modification write | Histone methylation | # | H3K9 | H3K9me1 H3K9me2 |
| EHMT2 | Ank PF00023 684-716 717-748 750-783 784-816 818-849 850-882 Pfam-B_9355 PB009355 34-359 Pre-SET PF05033 925-1030 SET PF00856 1049-1155 | EHMT2_MOUSE | euchromatic histone-lysine N-methyltransferase 2 | EHMT2_HUMAN | Histone modification write | Histone methylation | # | H3K9 | H3K9me1 H3K9me2 |
| EID1 | Pfam-B_5729 PB005729 1-159 | EID1_MOUSE | EP300 interacting inhibitor of differentiation 1 | EID1_HUMAN | Histone modification write cofactor | Histone acetylation | # | # | # |
| EID2 | Pfam-B_42536 PB042536 111-199 Pfam-B_7728 PB007728 1-109 201-234 | EID2_MOUSE | EP300 interacting inhibitor of differentiation 2 | EID2_HUMAN | Histone modification write cofactor | Histone acetylation | # | # | # |
| EID2B | # | # | EP300 interacting inhibitor of differentiation 2B | EID2B_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| ELP2 | WD40 PF00400 48-91 99-143 197-237 274-320 378-416 557-587 604-642 662-697 | ELP2_MOUSE | elongator acetyltransferase complex subunit 2 | ELP2_HUMAN | Histone modification write cofactor | Histone acetylation | Pol2 elongator | # | # |
| ELP3 | Acetyltransf_1 PF00583 441-536 Pfam-B_13823 PB013823 1-49 Radical_SAM PF04055 96-305 | ELP3_MOUSE | elongator acetyltransferase complex subunit 3 | ELP3_HUMAN | Histone modification write | Histone acetylation | Pol2 elongator | H3 H4? | # |
| ELP4 | PAXNEB PF05625 27-424 | ELP4_MOUSE | elongator acetyltransferase complex subunit 4 | ELP4_HUMAN | Histone modification write cofactor | Histone acetylation | Pol2 elongator | # | # |
| ELP5 | Elong_Iki1 PF10483 17-298 | ELP5_MOUSE | elongator acetyltransferase complex subunit 5 | ELP5_HUMAN | Histone modification write cofactor | Histone acetylation | Pol2 elongator | H3K14 H4K8 | # |
| ELP6 | DUF2348 PF09807 1-251 | ELP6_MOUSE | elongator acetyltransferase complex subunit 6 | ELP6_HUMAN | Histone modification write cofactor | Histone acetylation | Pol2 elongator | # | # |
| ENY2 | EnY2 PF10163 11-96 | ENY2_MOUSE | enhancer of yellow 2 homolog (Drosophila) | ENY2_HUMAN | Histone modification erase cofactor | Histone ubiquitination | SAGA | # | # |
| EP300 | Bromodomain PF00439 1058-1144 Creb_binding PF09030 1990-2099 DUF902 PF06001 1155-1196 KAT11 PF08214 1306-1612 KIX PF02172 566-646 Pfam-B_15526 PB015526 1-129 Pfam-B_817 PB000817 2317-2349 ZZ PF00569 1664-1705 zf-TAZ PF02135 336-416 1733-1806 | EP300_MOUSE | E1A binding protein p300 | EP300_HUMAN | Histone modification write | Histone acetylation | # | H2A H2B H3 H4 | # |
| EP400 | HSA PF07529 800-871 Helicase_C PF00271 1932-2014 Pfam-B_18422 PB018422 1887-1923 SNF2_N PF00176 1094-1374 | EP400_MOUSE | E1A binding protein p400 | EP400_HUMAN | Chromatin remodelling Histone modification write | # Histone acetylation | SWR NuA4 NuA4-related complex | # | # |
| EPC1 | EPL1 PF10513 6-149 E_Pc_C PF06752 582-836 | EPC1_MOUSE | enhancer of polycomb homolog 1 (Drosophila) | EPC1_HUMAN | Polycomb group (PcG) protein | # | NuA4 Piccolo_NuA4 NuA4-related complex | # | # |
| EPC2 | EPL1 PF10513 6-149 E_Pc_C PF06752 577-807 Pfam-B_18248 PB018248 432-544 Pfam-B_19406 PB019406 370-415 | EPC2_MOUSE | enhancer of polycomb homolog 2 (Drosophila) | EPC2_HUMAN | Chromatin remodelling | # | # | # | # |
| ERBB4 | Furin-like PF00757 176-335 GF_recep_IV PF14843 502-634 Pfam-B_10445 PB010445 1236-1306 Pkinase_Tyr PF07714 718-974 Recep_L_domain PF01030 55-167 358-478 | ERBB4_MOUSE | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 | ERBB4_HUMAN | Histone modification cofactor | # | # | H3K9me3 | # |
| ERCC6 | Helicase_C PF00271 873-952 Pfam-B_58020 PB058020 1-49 SNF2_N PF00176 510-812 | # | excision repair cross-complementation group 6 | ERCC6_HUMAN | Chromatin remodelling | # | B-WICH | # | # |
| EXOSC1 | ECR1_N PF14382 7-41 EXOSC1 PF10447 64-135 | EXOS1_MOUSE | exosome component 1 | EXOS1_HUMAN | Scaffold protein RNA modification | # RNA degradation | RNA exosome | # | # |
| EXOSC2 | ECR1_N PF14382 26-64 | EXOS2_MOUSE | exosome component 2 | EXOS2_HUMAN | Scaffold protein RNA modification | # RNA degradation | RNA exosome | # | # |
| EXOSC3 | Pfam-B_7181 PB007181 221-267 | EXOS3_MOUSE | exosome component 3 | EXOS3_HUMAN | Scaffold protein RNA modification | # RNA degradation | RNA exosome | # | # |
| EXOSC4 | Pfam-B_25613 PB025613 221-243 RNase_PH PF01138 21-152 RNase_PH_C PF03725 155-220 | EXOS4_MOUSE | exosome component 4 | EXOS4_HUMAN | Scaffold protein RNA modification | # RNA degradation | RNA exosome | # | # |
| EXOSC5 | RNase_PH PF01138 27-147 RNase_PH_C PF03725 150-216 | EXOS5_MOUSE | exosome component 5 | EXOS5_HUMAN | Scaffold protein RNA modification | # RNA degradation | RNA exosome | # | # |
| EXOSC6 | RNase_PH PF01138 35-175 | EXOS6_MOUSE | exosome component 6 | EXOS6_HUMAN | Scaffold protein RNA modification | # RNA degradation | RNA exosome | # | # |
| EXOSC7 | RNase_PH PF01138 31-166 RNase_PH_C PF03725 196-262 | EXOS7_MOUSE | exosome component 7 | EXOS7_HUMAN | Scaffold protein RNA modification | # RNA degradation | RNA exosome | # | # |
| EXOSC8 | RNase_PH PF01138 31-166 RNase_PH_C PF03725 191-258 | EXOS8_MOUSE | exosome component 8 | EXOS8_HUMAN | Scaffold protein RNA modification | # RNA degradation | RNA exosome | # | # |
| EXOSC9 | RNase_PH PF01138 31-163 RNase_PH_C PF03725 189-256 | EXOS9_MOUSE | exosome component 9 | EXOS9_HUMAN | Scaffold protein RNA modification | # RNA degradation | RNA exosome | # | # |
| EYA1 | Pfam-B_10178 PB010178 530-586 Pfam-B_3150 PB003150 209-513 | EYA1_MOUSE | EYA transcriptional coactivator and phosphatase 1 | EYA1_HUMAN | Histone modification erase | Histone phosphorylation | # | H2AXT142 | # |
| EYA2 | # | EYA2_MOUSE | EYA transcriptional coactivator and phosphatase 2 | EYA2_HUMAN | Histone modification erase | Histone phosphorylation | # | H2AXT142 | # |
| EYA3 | # | EYA3_MOUSE | EYA transcriptional coactivator and phosphatase 3 | EYA3_HUMAN | Histone modification erase | Histone phosphorylation | # | H2AXT142 | # |
| EYA4 | Pfam-B_6035 PB006035 96-142 | EYA4_MOUSE | EYA transcriptional coactivator and phosphatase 4 | EYA4_HUMAN | Histone modification erase | Histone phosphorylation | # | H2AXY142ph | H2AXY142 |
| EZH1 | EZH2_WD-Binding PF11616 39-68 SET PF00856 624-728 | EZH1_MOUSE | enhancer of zeste 1 polycomb repressive complex 2 subunit | EZH1_HUMAN | Histone modification write Polycomb group (PcG) protein | Histone methylation # | PRC2 | H3K27 | H3K27me1 H3K27me2 H3K27me3 |
| EZH2 | EZH2_WD-Binding PF11616 39-68 SET PF00856 623-727 | EZH2_MOUSE | enhancer of zeste 2 polycomb repressive complex 2 subunit | EZH2_HUMAN | Histone modification write Polycomb group (PcG) protein | Histone methylation # | PRC2 | H3K27 | H3K27me1 H3K27me2 H3K27me3 |
| FAM175A | Pfam-B_8506 PB008506 1-175 | F175A_MOUSE | family with sequence similarity 175 member A | F175A_HUMAN | Scaffold protein | # | BRCA1-A | # | # |
| FAM175B | Pfam-B_24421 PB024421 331-390 | F175B_MOUSE | family with sequence similarity 175 member B | F175B_HUMAN | Histone modification erase cofactor | Histone ubiquitination | BRISC | H2AK63 | H2AK63ub |
| FBL | Fibrillarin PF01269 88-315 | FBRL_MOUSE | fibrillarin | FBRL_HUMAN | Histone modification write | Histone methylation | # | H2AQ104 | H2AQ104me |
| FBRS | Auts2 PF15336 82-282 Pfam-B_58582 PB058582 283-359 | FBRS_MOUSE | fibrosin | FBRS_HUMAN | Histone modification | # | RING2-FBRS | # | # |
| FBRSL1 | Auts2 PF15336 587-791 Pfam-B_17807 PB017807 439-487 Pfam-B_187339 PB187339 41-131 Pfam-B_52362 PB052362 164-412 | # | fibrosin-like 1 | FBSL_HUMAN | Histone modification | # | RING2-FBRS | # | # |
| FOXA1 | Fork_head PF00250 170-265 Fork_head_N PF08430 17-169 HNF_C PF09354 397-461 | FOXA1_MOUSE | forkhead box A1 | FOXA1_HUMAN | Chromatin remodelling TF | # # | # | DNA motif | # |
| FOXO1 | Fork_head PF00250 127-268 Pfam-B_12765 PB012765 601-653 Pfam-B_39024 PB039024 1-49 | FOXO1_MOUSE | forkhead box O1 | FOXO1_HUMAN | TF | # | # | DNA motif H3 H4 | # |
| FOXP1 | Fork_head PF00250 465-555 Pfam-B_24123 PB024123 1-79 | FOXP1_MOUSE | forkhead box P1 | FOXP1_HUMAN | TF | # | # | DNA motif | # |
| FOXP2 | Fork_head PF00250 504-593 Pfam-B_4008 PB004008 240-308 | FOXP2_MOUSE | forkhead box P2 | FOXP2_HUMAN | TF | # | # | DNA motif | # |
| FOXP3 | Fork_head PF00250 337-426 | FOXP3_MOUSE | forkhead box P3 | FOXP3_HUMAN | TF | # | # | DNA motif | # |
| FOXP4 | Fork_head PF00250 467-555 Pfam-B_22084 PB022084 1-155 Pfam-B_23482 PB023482 569-647 Pfam-B_4008 PB004008 201-230 | FOXP4_MOUSE | forkhead box P4 | FOXP4_HUMAN | TF | # | # | DNA motif | # |
| GADD45A | Ribosomal_L7Ae PF01248 21-123 | GA45A_MOUSE | growth arrest and DNA-damage-inducible alpha | GA45A_HUMAN | Chromatin remodelling | # | # | H2A H2B H3 H4 | # |
| GADD45B | Ribosomal_L7Ae PF01248 21-121 | GA45B_MOUSE | growth arrest and DNA-damage-inducible beta | GA45B_HUMAN | Chromatin remodelling | # | # | H2A H2B H3 H4 | # |
| GADD45G | Ribosomal_L7Ae PF01248 24-113 | GA45G_MOUSE | growth arrest and DNA-damage-inducible gamma | GA45G_HUMAN | Chromatin remodelling | # | # | H2A H2B H3 H4 | # |
| GATAD1 | GATA PF00320 9-36 Pfam-B_13145 PB013145 175-216 Pfam-B_17231 PB017231 235-263 | GATD1_MOUSE | GATA zinc finger domain containing 1 | GATD1_HUMAN | Histone modification read | # | # | H3K4me3 | # |
| GATAD2A | Pfam-B_2058 PB002058 1-79 | P66A_MOUSE | GATA zinc finger domain containing 2A | P66A_HUMAN | Histone modification read | # | NuRD | H2A H2B H3 H4 | # |
| GATAD2B | GATA PF00320 420-454 | P66B_MOUSE | GATA zinc finger domain containing 2B | P66B_HUMAN | Histone modification read | # | NuRD | H2A H2B H3 H4 | # |
| GFI1 | LIM PF00412 228-283 287-342 346-401 405-460 Paxillin PF03535 6-135 | GFI1_MOUSE | growth factor independent 1 transcription repressor | GFI1_HUMAN | Chromatin remodelling | # | # | # | # |
| GFI1B | zf-C2H2 PF00096 220-242 zf-H2C2_2 PF13465 177-203 262-287 290-314 | GFI1B_MOUSE | growth factor independent 1B transcription repressor | GFI1B_HUMAN | Histone modification cofactor | # | # | # | # |
| GLYR1 | NAD_binding_11 PF14833 430-551 NAD_binding_2 PF03446 267-429 PWWP PF00855 6-89 | GLYR1_MOUSE | glyoxylate reductase 1 homolog (Arabidopsis) | GLYR1_HUMAN | Histone modification read | # | # | H3K4me3 | # |
| GSE1 | DUF3736 PF12540 70-203 731-874 | GSE1_MOUSE | Gse1 coiled-coil protein | GSE1_HUMAN | Histone modification erase | Histone acetylation | BHC LSD-CoREST | # | # |
| GSG2 | DUF3635 PF12330 708-797 Pfam-B_41097 PB041097 111-310 Pfam-B_49843 PB049843 1-109 Pkinase PF00069 484-699 | HASP_MOUSE | germ cell associated 2 (haspin) | HASP_HUMAN | Histone modification write | Histone phosphorylation | # | H3T3 | H3T3ph |
| GTF2I | GTF2I PF02946 112-187 361-436 466-541 571-646 733-808 868-943 | GTF2I_MOUSE | general transcription factor IIi | GTF2I_HUMAN | TF | # | BHC | DNA motif | # |
| GTF3C4 | TFIIIC_delta PF12657 61-254 zf-TFIIIC PF12660 733-822 | TF3C4_MOUSE | general transcription factor IIIC polypeptide 4 90kDa | TF3C4_HUMAN | Histone modification write | Histone acetylation | # | H3 | # |
| HAT1 | Hat1_N PF10394 26-187 | HAT1_MOUSE | histone acetyltransferase 1 | HAT1_HUMAN | Histone modification write | Histone acetylation | # | H4 H2A | # |
| HCFC1 | Kelch_1 PF01344 32-71 Kelch_3 PF13415 91-145 146-208 215-263 264-330 Pfam-B_49758 PB049758 381-598 | HCFC1_MOUSE | host cell factor C1 | HCFC1_HUMAN | Chromatin remodelling | # | NSL COMPASS MLL-HCF CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 | # | # |
| HCFC2 | Kelch_1 PF01344 244-301 Kelch_3 PF13415 205-253 Kelch_5 PF13854 312-356 | HCFC2_MOUSE | host cell factor C2 | HCFC2_HUMAN | Histone modification write cofactor Histone modification write cofactor | Histone methylation Histone acetylation | MLL-HCF CHD8 MLL2/3 MLL4/WBP7 | H3 | # |
| HDAC1 | Hist_deacetyl PF00850 18-320 Pfam-B_22185 PB022185 444-478 | HDAC1_MOUSE | histone deacetylase 1 | HDAC1_HUMAN | Histone modification erase | Histone acetylation | SWI/SNF_Brm NuRD BHC MeCP1 mSin3A core HDAC mSin3A-like complex RING2-L3MBTL2 CREST-BRG1 LSD-CoREST | H3 H4 | # |
| HDAC2 | Hist_deacetyl PF00850 19-321 Pfam-B_46198 PB046198 351-449 | HDAC2_MOUSE | histone deacetylase 2 | HDAC2_HUMAN | Histone modification erase | Histone acetylation | SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm NuRD BHC MeCP1 mSin3A core HDAC mSin3A-like complex RING2-L3MBTL2 LSD-CoREST | H2AKac H2BKac H3Kac H4Kac | H2AK H2BK H3K H4K |
| HDAC3 | Hist_deacetyl PF00850 11-315 Pfam-B_3137 PB003137 353-383 | HDAC3_MOUSE | histone deacetylase 3 | HDAC3_HUMAN | Histone modification erase | Histone acetylation | # | H2AKac H2BKac H3Kac H4Kac | H2AK H2BK H3K H4K |
| HDAC4 | Arb2 PF09757 1000-1059 HDAC4_Gln PF12203 61-152 Hist_deacetyl PF00850 664-993 | HDAC4_MOUSE | histone deacetylase 4 | HDAC4_HUMAN | Histone modification erase | Histone acetylation | # | H2AKac H2BKac H3Kac H4Kac | H2AK H2BK H3K H4K |
| HDAC5 | HDAC4_Gln PF12203 66-133 Hist_deacetyl PF00850 693-1023 | HDAC5_MOUSE | histone deacetylase 5 | HDAC5_HUMAN | Histone modification erase | Histone acetylation | # | H2AKac H2BKac H3Kac H4Kac | H2AK H2BK H3K H4K |
| HDAC6 | Hist_deacetyl PF00850 95-403 489-799 zf-UBP PF02148 1133-1195 | HDAC6_MOUSE | histone deacetylase 6 | HDAC6_HUMAN | Histone modification erase | Histone acetylation | # | H2AKac H2BKac H3Kac H4Kac | H2AK H2BK H3K H4K |
| HDAC7 | Hist_deacetyl PF00850 530-860 Pfam-B_5922 PB005922 1-148 | HDAC7_MOUSE | histone deacetylase 7 | HDAC7_HUMAN | Histone modification erase | Histone acetylation | # | H2AKac H2BKac H3Kac H4Kac | H2AK H2BK H3K H4K |
| HDAC8 | Hist_deacetyl PF00850 21-323 Pfam-B_15628 PB015628 324-375 | HDAC8_MOUSE | histone deacetylase 8 | HDAC8_HUMAN | Histone modification erase | Histone acetylation | # | H2AKac H2BKac H3Kac H4Kac | H2AK H2BK H3K H4K |
| HDAC9 | HDAC4_Gln PF12203 36-124 Hist_deacetyl PF00850 643-973 Pfam-B_5353 PB005353 577-624 | HDAC9_MOUSE | histone deacetylase 9 | HDAC9_HUMAN | Histone modification erase | Histone acetylation | # | H3Kac H4Kac | H3K H4K |
| HDAC10 | Hist_deacetyl PF00850 13-322 | HDA10_MOUSE | histone deacetylase 10 | HDA10_HUMAN | Histone modification erase | Histone acetylation | # | H2AKac H2BKac H3Kac H4Kac | H2AK H2BK H3K H4K |
| HDAC11 | Hist_deacetyl PF00850 23-320 | HDA11_MOUSE | histone deacetylase 11 | HDA11_HUMAN | Histone modification erase | Histone acetylation | # | H2AKac H2BKac H3Kac H4Kac | H2AK H2BK H3K H4K |
| HDGF | PWWP PF00855 10-92 | HDGF_MOUSE | hepatoma-derived growth factor | HDGF_HUMAN | Chromatin remodelling TF | # TF repressor | # | DNA motif | # |
| HELLS | Helicase_C PF00271 633-712 SNF2_N PF00176 226-577 | HELLS_MOUSE | helicase lymphoid-specific | HELLS_HUMAN | Chromatin remodelling | # | # | # | # |
| HIF1AN | Cupin_8 PF13621 48-302 | HIF1N_MOUSE | hypoxia inducible factor 1 alpha subunit inhibitor | HIF1N_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| HINFP | Pfam-B_17110 PB017110 1-103 zf-C2H2 PF00096 255-278 345-368 zf-C2H2_4 PF13894 229-254 zf-H2C2_2 PF13465 185-210 | HINFP_MOUSE | histone H4 transcription factor | HINFP_HUMAN | Histone modification read TF TF | # TF activator TF repressor | # | H4 DNA motif | # |
| HIRA | HIRA_B PF09453 448-471 Hira PF07569 763-962 Pfam-B_18560 PB018560 963-1015 WD40 PF00400 5-44 60-98 121-159 164-202 258-312 | HIRA_MOUSE | histone cell cycle regulator | HIRA_HUMAN | Histone modification read | # | # | H2B H4 | # |
| HIRIP3 | CHZ PF09649 484-520 | HIRP3_MOUSE | HIRA interacting protein 3 | HIRP3_HUMAN | Histone modification read | # | # | H2A H3 | # |
| HJURP | HJURP_C PF12347 409-471 554-614 HJURP_mid PF12346 271-386 Pfam-B_631 PB000631 682-746 Scm3 PF10384 16-77 | HJURP_MOUSE | Holliday junction recognition protein | HJURP_HUMAN | Histone chaperone | # | # | H4 | # |
| HLCS | BPL_C PF02237 669-718 BPL_LplA_LipB PF03099 471-603 Pfam-B_33359 PB033359 244-405 Pfam-B_35799 PB035799 407-469 | BPL1_MOUSE | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) | BPL1_HUMAN | Histone modification write | # | # | H1 H2A H2B H4 | # |
| HLTF | HIRAN PF08797 60-155 Helicase_C PF00271 870-950 SNF2_N PF00176 243-722 zf-RING_2 PF13639 758-801 | HLTF_MOUSE | helicase-like transcription factor | HLTF_HUMAN | Chromatin remodelling cofactor | # | # | # | # |
| HMG20A | HMG_box PF00505 103-171 | HM20A_MOUSE | high mobility group 20A | HM20A_HUMAN | Chromatin remodelling cofactor | # | LSD-CoREST | H3K4 | # |
| HMG20B | HMG_box PF00505 70-138 Pfam-B_10576 PB010576 211-315 | HM20B_MOUSE | high mobility group 20B | HM20B_HUMAN | Chromatin remodelling | # | BHC LSD-CoREST | # | # |
| HMGB1 | HMG_box PF00505 95-163 HMG_box_2 PF09011 6-79 | HMGB1_MOUSE | high mobility group box 1 | HMGB1_HUMAN | Chromatin remodelling | # | # | # | # |
| HMGN1 | HMG14_17 PF01101 2-96 | HMGN1_MOUSE | high mobility group nucleosome binding domain 1 | HMGN1_HUMAN | Chromatin remodelling | # | # | H1 | # |
| HMGN2 | HMG14_17 PF01101 2-90 | HMGN2_MOUSE | high mobility group nucleosomal binding domain 2 | HMGN2_HUMAN | Chromatin remodelling | # | # | H1 | # |
| HMGN3 | HMG14_17 PF01101 2-98 | HMGN3_MOUSE | high mobility group nucleosomal binding domain 3 | HMGN3_HUMAN | Chromatin remodelling | # | # | H1 | # |
| HMGN4 | HMG14_17 PF01101 2-90 | # | high mobility group nucleosomal binding domain 4 | HMGN4_HUMAN | Chromatin remodelling | # | # | H1 | # |
| HMGN5 | HMG14_17 PF01101 2-102 | HMGN5_MOUSE | high mobility group nucleosome binding domain 5 | HMGN5_HUMAN | Chromatin remodelling | # | # | H1 | # |
| HP1BP3 | Linker_histone PF00538 157-232 260-330 341-412 | HP1B3_MOUSE | heterochromatin protein 1 binding protein 3 | HP1B3_HUMAN | Chromatin remodelling | # | # | # | # |
| HR | JmjC PF02373 1026-1140 Pfam-B_40014 PB040014 312-431 Pfam-B_80075 PB080075 181-289 | HAIR_MOUSE | hair growth associated | HAIR_HUMAN | Histone modification erase | Histone methylation | # | H3K9me1 H3K9me2 | H3K9 |
| HSPA1A | HSP70 PF00012 6-612 | HS71A_MOUSE | heat shock 70kDa protein 1A | HSP71_HUMAN | Histone modification write cofactor Histone modification write cofactor | Histone methylation Histone acetylation | CHD8 MLL2/3 MLL4/WBP7 | # | # |
| HSPA1B | HSP70 PF00012 6-612 | HS71A_MOUSE | heat shock 70kDa protein 1B | HSP71_HUMAN | Histone modification write cofactor Histone modification write cofactor | Histone methylation Histone acetylation | CHD8 MLL2/3 MLL4/WBP7 | # | # |
| HUWE1 | DUF4414 PF14377 2968-3079 DUF908 PF06012 89-370 DUF913 PF06025 429-815 HECT PF00632 4067-4374 Pfam-B_13571 PB013571 3944-3965 Pfam-B_15798 PB015798 3091-3191 Pfam-B_20712 PB020712 2429-2459 Pfam-B_6870 PB006870 3966-4021 UBA PF00627 1317-1352 WWE PF02825 1611-1679 | HUWE1_MOUSE | HECT UBA and WWE domain containing 1 E3 ubiquitin protein ligase | HUWE1_HUMAN | Histone modification write | Histone ubiquitination | # | H3K9 | # |
| IKBKAP | IKI3 PF04762 1-954 Pfam-B_8846 PB008846 1048-1212 | ELP1_MOUSE | inhibitor of kappa light polypeptide gene enhancer in B-cells kinase complex-associated protein | ELP1_HUMAN | Scaffold protein | # | Pol2 elongator | RNA | # |
| IKZF1 | zf-H2C2_2 PF13465 131-156 159-184 187-212 | IKZF1_MOUSE | IKAROS family zinc finger 1 (Ikaros) | IKZF1_HUMAN | Chromatin remodelling TF | # # | # | DNA motif | # |
| IKZF3 | Pfam-B_2031 PB002031 67-110 zf-C2H2_4 PF13894 480-504 zf-H2C2_2 PF13465 132-157 160-183 188-213 | IKZF3_MOUSE | IKAROS family zinc finger 3 (Aiolos) | IKZF3_HUMAN | TF | # | # | DNA motif | # |
| ING1 | ING PF12998 173-256 PHD PF00628 355-402 Pfam-B_837 PB000837 51-89 | ING1_MOUSE | inhibitor of growth family member 1 | ING1_HUMAN | Histone modification read | # | # | H3K4me3 | # |
| ING2 | ING PF12998 26-125 PHD PF00628 214-261 | ING2_MOUSE | inhibitor of growth family member 2 | ING2_HUMAN | Histone modification read | # | mSin3A-like complex | H3K4me3 | # |
| ING3 | ING PF12998 2-104 PHD PF00628 362-409 | ING3_MOUSE | inhibitor of growth family member 3 | ING3_HUMAN | Chromatin remodelling Histone modification write cofactor | # Histone acetylation | SWR NuA4 Piccolo_NuA4 | H2A H4 | # |
| ING4 | ING PF12998 5-107 PHD PF00628 198-245 | ING4_MOUSE | inhibitor of growth family member 4 | ING4_HUMAN | Histone modification read | # | HBO1 | H3K4me3 | # |
| ING5 | ING PF12998 5-107 PHD PF00628 188-235 | ING5_MOUSE | inhibitor of growth family member 5 | ING5_HUMAN | Histone modification read | # | HBO1 MOZ/MORF | H3K4me3 H3K4me2 | # |
| INO80 | DBINO PF13892 270-410 Helicase_C PF00271 1135-1214 Pfam-B_16799 PB016799 1435-1475 SNF2_N PF00176 521-822 | INO80_MOUSE | INO80 complex subunit | INO80_HUMAN | Chromatin remodelling | # | Ino80 | # | # |
| INO80B | PAPA-1 PF04795 211-293 zf-HIT PF04438 305-336 | IN80B_MOUSE | INO80 complex subunit B | IN80B_HUMAN | Chromatin remodelling cofactor | # | Ino80 | # | # |
| INO80C | YL1_C PF08265 141-170 | IN80C_MOUSE | INO80 complex subunit C | IN80C_HUMAN | Chromatin remodelling cofactor | # | Ino80 CHD8 MLL2/3 MLL4/WBP7 | # | # |
| INO80D | Pfam-B_14282 PB014282 588-622 zf-C3Hc3H PF13891 16-80 446-512 | IN80D_MOUSE | INO80 complex subunit D | IN80D_HUMAN | Chromatin remodelling cofactor | # | Ino80 | # | # |
| INO80E | # | # | INO80 complex subunit E | IN80E_HUMAN | Chromatin remodelling cofactor | # | # | # | # |
| JADE1 | EPL1 PF10513 29-181 PHD_2 PF13831 217-251 zf-HC5HC2H_2 PF13832 256-368 | JADE1_MOUSE | jade family PHD finger 1 | JADE1_HUMAN | Histone modification write | Histone acetylation | HBO1 | H3 H4 | H3ac H4ac |
| JADE2 | EPL1 PF10513 39-177 PHD_2 PF13831 213-247 Pfam-B_23296 PB023296 631-669 zf-HC5HC2H_2 PF13832 252-364 | JADE2_MOUSE | jade family PHD finger 2 | JADE2_HUMAN | Histone modification write | Histone acetylation | HBO1 | H3 H4 | H3ac H4ac |
| JADE3 | EPL1 PF10513 30-178 PHD PF00628 202-249 zf-HC5HC2H_2 PF13832 253-365 | JADE3_MOUSE | jade family PHD finger 3 | JADE3_HUMAN | Histone modification write | Histone acetylation | HBO1 | H3 H4 | H3ac H4ac |
| JAK2 | Pkinase_Tyr PF07714 545-805 849-1123 SH2 PF00017 400-481 | JAK2_MOUSE | Janus kinase 2 | JAK2_HUMAN | Histone modification write | Histone phosphorylation | # | H3T41 | H3T41ph |
| JARID2 | ARID PF01388 618-709 JmjC PF02373 916-1031 JmjN PF02375 558-591 Pfam-B_728 PB000728 1-122 zf-C5HC2 PF02928 1139-1193 | JARD2_MOUSE | jumonji AT rich interactive domain 2 | JARD2_HUMAN | Histone modification write cofactor | Histone methylation | PRC2 | H3K27 H3K9 | # |
| JDP2 | bZIP_1 PF00170 70-131 | JDP2_MOUSE | Jun dimerization protein 2 | JDP2_HUMAN | Chromatin remodelling Histone modification erase cofactor | # Histone acetylation | # | # | # |
| JMJD1C | JmjC PF02373 2381-2481 Pfam-B_14856 PB014856 2090-2122 Pfam-B_15350 PB015350 2148-2224 Pfam-B_16501 PB016501 1889-1927 Pfam-B_17329 PB017329 541-947 Pfam-B_19453 PB019453 1929-2023 Pfam-B_2770 PB002770 220-524 Pfam-B_63706 PB063706 1-119 | JHD2C_MOUSE | jumonji domain containing 1C | JHD2C_HUMAN | Histone modification erase | Histone methylation | # | H3K9me | H3K9 |
| JMJD6 | JmjC PF02373 174-288 Pfam-B_22969 PB022969 1-39 | JMJD6_MOUSE | jumonji domain containing 6 | JMJD6_HUMAN | Histone modification erase | Histone methylation | # | H3R2me H4R3me | H3R2 H4R3 |
| KANSL1 | PEHE PF15275 885-1035 Pfam-B_14811 PB014811 571-639 Pfam-B_19390 PB019390 431-469 Pfam-B_2194 PB002194 135-403 Pfam-B_6892 PB006892 471-569 | KANL1_MOUSE | KAT8 regulatory NSL complex subunit 1 | KANL1_HUMAN | Histone modification write cofactor Histone modification write cofactor | Histone methylation Histone acetylation | NSL CHD8 MLL2/3 MLL4/WBP7 | H4 | H4ac |
| KANSL2 | Pfam-B_21577 PB021577 1-25 zf-C3Hc3H PF13891 27-93 300-365 | KANL2_MOUSE | KAT8 regulatory NSL complex subunit 2 | KANL2_HUMAN | Histone modification write cofactor | Histone acetylation | NSL | H5 | H4ac |
| KANSL3 | Abhydrolase_5 PF12695 287-436 Pfam-B_10092 PB010092 521-544 Pfam-B_8995 PB008995 545-589 | KANL3_MOUSE | KAT8 regulatory NSL complex subunit 3 | KANL3_HUMAN | Histone modification write cofactor | Histone acetylation | NSL | H6 | H4ac |
| KAT2A | Acetyltransf_1 PF00583 553-628 Bromodomain PF00439 737-820 PCAF_N PF06466 86-337 Pfam-B_10717 PB010717 1-67 | KAT2A_MOUSE | K(lysine) acetyltransferase 2A | KAT2A_HUMAN | Histone modification write | Histone acetylation | TFTC-HAT SAGA ATAC STAGA | # | # |
| KAT2B | Acetyltransf_7 PF13508 541-624 Bromodomain PF00439 732-815 PCAF_N PF06466 74-327 Pfam-B_358817 PB358817 339-381 | KAT2B_MOUSE | K(lysine) acetyltransferase 2B | KAT2B_HUMAN | Histone modification write | Histone acetylation | # | # | # |
| KAT5 | MOZ_SAS PF01853 285-477 Tudor-knot PF11717 7-65 | KAT5_MOUSE | K(lysine) acetyltransferase 5 | KAT5_HUMAN | Histone modification write | Histone acetylation | SWR NuA4 Piccolo_NuA4 | H2AK5 H3K14 H4K5 H4K8 H4K12 H4K16 | H2AK5ac H3K14ac H4K5ac H4K8ac H4K12ac H4K16ac |
| KAT6A | MOZ_SAS PF01853 562-749 PHD PF00628 208-265 264-313 Pfam-B_19382 PB019382 1-84 Pfam-B_21350 PB021350 1011-1048 Pfam-B_25985 PB025985 1056-1116 Pfam-B_3468 PB003468 1648-1699 Pfam-B_6470 PB006470 1487-1601 | KAT6A_MOUSE | K(lysine) acetyltransferase 6A | KAT6A_HUMAN | Histone modification write | Histone acetylation | MOZ/MORF | H3 H4 | H3ac H4ac |
| KAT6B | Linker_histone PF00538 106-175 MOZ_SAS PF01853 773-960 PHD PF00628 271-320 Pfam-B_6470 PB006470 1604-1717 | KAT6B_MOUSE | K(lysine) acetyltransferase 6B | KAT6B_HUMAN | Histone modification write | Histone acetylation | MOZ/MORF | H3 | H3ac |
| KAT7 | MOZ_SAS PF01853 390-577 zf-C2HC PF01530 182-212 | KAT7_MOUSE | K(lysine) acetyltransferase 7 | KAT7_HUMAN | Histone modification write | Histone acetylation | HBO1 | H4 | H4ac |
| KAT8 | MOZ_SAS PF01853 232-418 Tudor-knot PF11717 55-111 | KAT8_MOUSE | K(lysine) acetyltransferase 8 | KAT8_HUMAN | Histone modification write | Histone acetylation | NSL CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 | H2A H3 H4 | H2Aac H3ac H4ac |
| KDM1A | Amino_oxidase PF01593 288-826 SWIRM PF04433 174-264 | KDM1A_MOUSE | lysine (K)-specific demethylase 1A | KDM1A_HUMAN | Histone modification erase | Histone methylation | NuRD BHC SCL | H3K4me1 H3K4me2 H3K9me | H3K4 H3K9 |
| KDM1B | Amino_oxidase PF01593 392-820 zf-CW PF07496 137-192 | KDM1B_MOUSE | lysine (K)-specific demethylase 1B | KDM1B_HUMAN | Histone modification erase | Histone methylation | # | H3K4me1 H3K4me2 | H3K4 |
| KDM2A | F-box PF00646 889-935 JmjC PF02373 199-299 Pfam-B_11167 PB011167 362-470 Pfam-B_6618 PB006618 951-1149 Pfam-B_9841 PB009841 686-744 zf-CXXC PF02008 563-609 | KDM2A_MOUSE | lysine (K)-specific demethylase 2A | KDM2A_HUMAN | Histone modification erase | Histone methylation | # | H3K36me2 | H3K36 |
| KDM2B | Cupin_8 PF13621 23-335 F-box PF00646 1050-1107 Pfam-B_23456 PB023456 441-519 Pfam-B_33113 PB033113 1235-1289 zf-CXXC PF02008 605-651 | KDM2B_MOUSE | lysine (K)-specific demethylase 2B | KDM2B_HUMAN | Histone modification erase | Histone methylation | BCOR | H3K4me3 H3K36me2 | H3K4 H3K36 |
| KDM3A | JmjC PF02373 1151-1264 Pfam-B_14772 PB014772 851-889 Pfam-B_17027 PB017027 351-439 Pfam-B_6147 PB006147 441-539 Pfam-B_7111 PB007111 781-849 | KDM3A_MOUSE | lysine (K)-specific demethylase 3A | KDM3A_HUMAN | Histone modification erase | Histone methylation | # | H3K9me1 H3K9me2 | H3K9 |
| KDM3B | JmjC PF02373 1594-1704 Pfam-B_16202 PB016202 1548-1593 Pfam-B_16670 PB016670 1497-1546 Pfam-B_19299 PB019299 351-469 Pfam-B_22020 PB022020 711-779 Pfam-B_3525 PB003525 571-639 Pfam-B_38652 PB038652 1-39 Pfam-B_6147 PB006147 471-569 Pfam-B_7111 PB007111 781-839 | KDM3B_MOUSE | lysine (K)-specific demethylase 3B | KDM3B_HUMAN | Histone modification erase | Histone methylation | # | H3K9me1 H3K9me2 | H3K9 |
| KDM4A | JmjC PF02373 175-291 JmjN PF02375 15-49 PHD_2 PF13831 732-767 zf-HC5HC2H_2 PF13832 773-884 | KDM4A_MOUSE | lysine (K)-specific demethylase 4A | KDM4A_HUMAN | Histone modification erase | Histone methylation | # | H3K4me3 H3K36me3 | H3K4me2 H3K36me2 |
| KDM4B | JmjC PF02373 176-292 JmjN PF02375 16-50 PHD_2 PF13831 754-789 Pfam-B_12059 PB012059 1021-1094 zf-HC5HC2H_2 PF13832 795-906 | KDM4B_MOUSE | lysine (K)-specific demethylase 4B | KDM4B_HUMAN | Histone modification erase | Histone methylation | # | H3K9me3 | H3K9me1 H3K9me2 |
| KDM4C | JmjC PF02373 177-293 JmjN PF02375 17-51 PHD_2 PF13831 712-747 Pfam-B_10616 PB010616 1021-1054 Pfam-B_14467 PB014467 422-670 Pfam-B_5109 PB005109 891-1019 zf-HC5HC2H_2 PF13832 753-864 | KDM4C_MOUSE | lysine (K)-specific demethylase 4C | KDM4C_HUMAN | Histone modification erase | Histone methylation | # | H3K9me3 H3K36me3 | H3K9me1 H3K9me2 |
| KDM4D | JmjC PF02373 179-295 JmjN PF02375 19-53 Pfam-B_45485 PB045485 324-356 Pfam-B_84013 PB084013 451-521 | KDM4D_MOUSE | lysine (K)-specific demethylase 4D | KDM4D_HUMAN | Histone modification erase | Histone methylation | # | H3K9me3 | H3K9me1 H3K9me2 |
| KDM4E | JmjC PF02373 176-292 JmjN PF02375 16-50 | # | lysine (K)-specific demethylase 4E | KDM4E_HUMAN | Histone modification erase | Histone methylation | # | H3K9me2 H3K9me3 | H3K9 |
| KDM5A | ARID PF01388 81-170 JmjC PF02373 470-586 JmjN PF02375 20-53 PHD PF00628 295-343 1163-1218 PLU-1 PF08429 740-1072 zf-C5HC2 PF02928 676-729 | KDM5A_MOUSE | lysine (K)-specific demethylase 5A | KDM5A_HUMAN | Histone modification erase | Histone methylation | # | H3K4me3 | H3K4 |
| KDM5B | ARID PF01388 94-183 JmjC PF02373 486-602 JmjN PF02375 33-66 PHD PF00628 311-359 1178-1224 1486-1538 PLU-1 PF08429 756-1088 zf-C5HC2 PF02928 692-745 | KDM5B_MOUSE | lysine (K)-specific demethylase 5B | KDM5B_HUMAN | Histone modification erase | Histone methylation | # | H3K4me3 | H3K4 |
| KDM5C | ARID PF01388 76-165 JmjC PF02373 501-617 JmjN PF02375 15-48 PHD PF00628 326-374 1187-1250 PLU-1 PF08429 771-1100 Pfam-B_12821 PB012821 1417-1482 zf-C5HC2 PF02928 707-760 | KDM5C_MOUSE | lysine (K)-specific demethylase 5C | KDM5C_HUMAN | Histone modification erase | Histone methylation | # | H3K4me3 | H3K4me2 H3K4me1 |
| KDM5D | ARID PF01388 76-165 JmjC PF02373 491-607 JmjN PF02375 15-48 PHD PF00628 316-364 1174-1237 PLU-1 PF08429 761-1087 Pfam-B_12821 PB012821 1401-1443 zf-C5HC2 PF02928 697-750 | KDM5D_MOUSE | lysine (K)-specific demethylase 5D | KDM5D_HUMAN | Histone modification erase | Histone methylation | # | H3K4me3 H3K4me2 | H3K4 |
| KDM6A | JmjC PF02373 1133-1241 Pfam-B_604 PB000604 631-769 Pfam-B_972 PB000972 771-1109 TPR_1 PF00515 130-163 318-351 352-380 TPR_17 PF13431 272-304 TPR_8 PF13181 205-238 | KDM6A_MOUSE | lysine (K)-specific demethylase 6A | KDM6A_HUMAN | Histone modification erase | Histone methylation | CHD8 MLL2/3 MLL4/WBP7 COMPASS-like MLL3 4 | H3K27me2. H3K27me3 | H3K27 |
| KDM6B | JmjC PF02373 1377-1485 Pfam-B_5108 PB005108 101-843 Pfam-B_992 PB000992 1-99 | KDM6B_MOUSE | lysine (K)-specific demethylase 6B | KDM6B_HUMAN | Histone modification erase | Histone methylation | # | H3K27me2. H3K27me4 | H3K28 |
| KDM7A | PHD PF00628 39-88 JmjC PF02373 269-369 Pfam-B_18122 PB018122 381-538 Pfam-B_13686 PB013686 541-639 Pfam-B_1060 PB001060 853-939 | KDM7A_MOUSE | lysine (K)-specific demethylase 7A | KDM7A_HUMAN | Histone modification erase | Histone methylation | # | H3K9me2 H3K27me2 H4K20me1 | H3K9 H3K27 H4K20 |
| KDM8 | Cupin_8 PF13621 192-416 | KDM8_MOUSE | lysine (K)-specific demethylase 8 | KDM8_HUMAN | Histone modification erase | Histone methylation | # | H3K36me2 | H3K36 |
| KEAP1 | BACK PF07707 184-286 BTB PF00651 67-179 Kelch_1 PF01344 317-359 361-410 412-457 459-504 506-551 553-598 | KEAP1_MOUSE | kelch-like ECH-associated protein 1 | KEAP1_HUMAN | Chromatin remodelling | # | # | # | # |
| KMT2A | FYRC PF05965 3666-3749 FYRN PF05964 2023-2073 PHD PF00628 1481-1533 1568-1627 Pfam-B_11202 PB011202 1021-1086 SET PF00856 3840-3945 zf-CXXC PF02008 1147-1194 zf-HC5HC2H PF13771 1900-1978 | KMT2A_MOUSE | lysine (K)-specific methyltransferase 2A | KMT2A_HUMAN | Histone modification write | Histone methylation | MLL-HCF CHD8 COMPASS-like MLL1 2 | H3K4 | H3K4me |
| KMT2B | FYRC PF05965 2411-2494 FYRN PF05964 1732-1782 PHD PF00628 1251-1303 1337-1396 Pfam-B_25060 PB025060 1783-1849 Pfam-B_25524 PB025524 1168-1202 Pfam-B_26440 PB026440 701-839 Pfam-B_27348 PB027348 2191-2289 Pfam-B_3353 PB003353 1981-2079 Pfam-B_6332 PB006332 1401-1479 Pfam-B_85509 PB085509 345-387 SET PF00856 2586-2691 zf-CXXC PF02008 958-1005 zf-HC5HC2H PF13771 1608-1686 | KMT2B_MOUSE | lysine (K)-specific methyltransferase 2B | KMT2B_HUMAN | Histone modification write | Histone methylation | Menin-associated_HMT MLL2/3 COMPASS-like MLL3 4 | H3K4 | H3K4me3 |
| KMT2C | FYRC PF05965 4606-4693 FYRN PF05964 4550-4604 PHD PF00628 390-438 959-1010 1009-1060 Pfam-B_16694 PB016694 2536-2572 Pfam-B_19991 PB019991 1874-1906 Pfam-B_43 PB000043 3044-3095 Pfam-B_49476 PB049476 1-159 SET PF00856 4782-4887 zf-HC5HC2H PF13771 252-331 4429-4507 | KMT2C_MOUSE | lysine (K)-specific methyltransferase 2C | KMT2C_HUMAN | Histone modification write | Histone methylation | MLL2/3 COMPASS-like MLL3 4 | H3K4 | H3K4me |
| KMT2D | FYRC PF05965 5236-5323 FYRN PF05964 5180-5234 PHD PF00628 275-323 1379-1429 1429-1477 Pfam-B_26489 PB026489 5016-5050 Pfam-B_29065 PB029065 423-678 Pfam-B_2976 PB002976 1682-1717 Pfam-B_33020 PB033020 3681-3767 SET PF00856 5408-5513 zf-HC5HC2H PF13771 139-218 5059-5137 | KMT2D_MOUSE | lysine (K)-specific methyltransferase 2D | KMT2D_HUMAN | Histone modification write | Histone methylation | COMPASS-like MLL1 2 MLL4/WBP7 COMPASS-like MLL3 4 | H3K4 | H3K4me |
| KMT2E | PHD PF00628 120-166 Pfam-B_13611 PB013611 1791-1856 Pfam-B_19470 PB019470 1301-1369 Pfam-B_19601 PB019601 1131-1179 Pfam-B_20626 PB020626 961-1129 Pfam-B_22469 PB022469 871-959 Pfam-B_24586 PB024586 1261-1299 Pfam-B_7010 PB007010 1651-1789 Pfam-B_7713 PB007713 731-869 SET PF00856 342-447 | KMT2E_MOUSE | lysine (K)-specific methyltransferase 2E | KMT2E_HUMAN | Histone modification write | Histone methylation | # | H3K4 | H3K4me1 H3K4me2 |
| L3MBTL1 | MBT PF02820 242-314 349-421 453-525 SAM_1 PF00536 681-745 zf-C2HC PF01530 551-581 | LMBL1_MOUSE | l(3)mbt-like 1 (Drosophila) | LMBL1_HUMAN | Histone modification read | # | L3MBTL1 | H1BK26 H4K20 | # |
| L3MBTL2 | MBT PF02820 214-290 327-395 432-508 540-610 | LMBL2_MOUSE | l(3)mbt-like 2 (Drosophila) | LMBL2_HUMAN | Histone modification read | # | RING2-L3MBTL2 | H3K4 H3K9 H3K27 H4K20 | # |
| L3MBTL3 | MBT PF02820 268-340 375-447 479-548 Pfam-B_29190 PB029190 1-79 SAM_1 PF00536 706-770 | LMBL3_MOUSE | l(3)mbt-like 3 (Drosophila) | LMBL3_HUMAN | Histone modification read | # | # | H4K20me | # |
| L3MBTL4 | MBT PF02820 88-160 196-268 300-371 SAM_1 PF00536 541-605 zf-C2HC PF01530 376-407 | LMBL4_MOUSE | l(3)mbt-like 4 (Drosophila) | LMBL4_HUMAN | Histone modification read | # | # | HKme | # |
| LAS1L | Las1 PF04031 42-188 Pfam-B_28535 PB028535 671-732 | LAS1L_MOUSE | LAS1-like (S. cerevisiae) | LAS1L_HUMAN | Histone modification write cofactor Histone modification write cofactor | Histone methylation Histone acetylation | CHD8 MLL2/3 MLL4/WBP7 | H3K4 H3 H4 H2A | H3K4me H3K4me2 H3Ac H4Ac H2AAc |
| LBR | ERG4_ERG24 PF01222 183-615 LBR_tudor PF09465 1-55 | LBR_MOUSE | lamin B receptor | LBR_HUMAN | # | # | # | # | # |
| LEO1 | Leo1 PF04004 373-537 Pfam-B_17842 PB017842 1-105 Pfam-B_20153 PB020153 171-239 Pfam-B_6431 PB006431 241-309 | LEO1_MOUSE | Leo1 Paf1/RNA polymerase II complex component homolog (S. cerevisiae) | LEO1_HUMAN | Histone modification write cofactor | Histone ubiquitination | # | # | # |
| LRWD1 | LRR_1 PF00560 48-69 Pfam-B_28625 PB028625 274-344 Pfam-B_39252 PB039252 191-239 WD40 PF00400 382-421 | LRWD1_MOUSE | leucine-rich repeats and WD repeat domain containing 1 | LRWD1_HUMAN | Chromatin remodelling | # | # | H3K9me3 H3K27me3 | # |
| MAP3K7 | Pfam-B_11880 PB011880 521-569 Pkinase_Tyr PF07714 36-284 | M3K7_MOUSE | mitogen-activated protein kinase kinase kinase 7 | M3K7_HUMAN | Histone modification write | # | # | # | # |
| MAPKAPK3 | Pkinase PF00069 44-304 | MAPK3_MOUSE | mitogen-activated protein kinase-activated protein kinase 3 | MAPK3_HUMAN | Chromatin remodelling | # | # | # | # |
| MASTL | Pfam-B_24677 PB024677 271-369 Pfam-B_8409 PB008409 371-489 Pkinase PF00069 35-203 733-835 | GWL_MOUSE | microtubule associated serine/threonine kinase-like | GWL_HUMAN | Histone modification write | Histone phosphorylation | # | H1 H3 | H1p H3p |
| MAX | HLH PF00010 24-75 | MAX_MOUSE | MYC associated factor X | MAX_HUMAN | Histone modification write cofactor Histone modification write cofactor TF TF | Histone methylation Histone acetylation TF activator TF repressor | CHD8 MLL2/3 MLL4/WBP7 | DNA motif | # |
| MAZ | zf-C2H2 PF00096 337-360 zf-C2H2_4 PF13894 190-213 366-388 zf-H2C2_2 PF13465 293-318 | MAZ_MOUSE | MYC-associated zinc finger protein (purine-binding transcription factor) | MAZ_HUMAN | Chromatin remodelling | # | # | # | # |
| MBD1 | MBD PF01429 1-85 Pfam-B_12306 PB012306 468-526 Pfam-B_9691 PB009691 528-587 zf-CXXC PF02008 168-215 217-262 330-377 | MBD1_MOUSE | methyl-CpG binding domain protein 1 | MBD1_HUMAN | Histone modification write cofactor TF | Histone methylation TF repressor | # | mCG DNA motif | # |
| MBD2 | MBD PF01429 145-216 MBD_C PF14048 294-387 | MBD2_MOUSE | methyl-CpG binding domain protein 2 | MBD2_HUMAN | Histone modification write cofactor Histone modification erase cofactor TF | Histone methylation Histone acetylation TF repressor | NuRD MeCP1 | mCG DNA motif | # |
| MBD3 | MBD PF01429 1-72 MBD_C PF14048 150-243 | MBD3_MOUSE | methyl-CpG binding domain protein 3 | MBD3_HUMAN | Histone modification erase cofactor | Histone acetylation | NuRD | # | # |
| MBD4 | HhH-GPD PF00730 461-575 MBD PF01429 76-151 Pfam-B_47325 PB047325 409-460 | MBD4_MOUSE | methyl-CpG binding domain protein 4 | MBD4_HUMAN | DNA modification | # | # | G:T G:U | # |
| MBD5 | Pfam-B_1400 PB001400 981-1140 Pfam-B_19258 PB019258 499-567 Pfam-B_41495 PB041495 438-497 Pfam-B_51737 PB051737 1-119 Pfam-B_5417 PB005417 121-219 Pfam-B_7705 PB007705 221-410 | MBD5_MOUSE | methyl-CpG binding domain protein 5 | MBD5_HUMAN | Chromatin remodelling | # | # | # | # |
| MBD6 | Pfam-B_28044 PB028044 161-209 | MBD6_MOUSE | methyl-CpG binding domain protein 6 | MBD6_HUMAN | Chromatin remodelling | # | # | # | # |
| MBIP | Pfam-B_15854 PB015854 191-249 Pfam-B_276 PB000276 251-342 | MBIP1_MOUSE | MAP3K12 binding inhibitory protein 1 | MBIP1_HUMAN | Histone modification write cofactor | Histone acetylation | ATAC | # | # |
| MBTD1 | MBT PF02820 183-253 289-360 388-464 496-568 Pfam-B_45320 PB045320 1-59 | MBTD1_MOUSE | mbt domain containing 1 | MBTD1_HUMAN | Polycomb group (PcG) protein | # | # | H4K20me1 H4K20me2 | # |
| MCRS1 | FHA PF00498 363-436 MCRS_N PF13325 134-331 | MCRS1_MOUSE | microspherule protein 1 | MCRS1_HUMAN | Histone modification write | Histone acetylation | Ino80 NSL CHD8 MLL2/3 MLL4/WBP7 | H4K5 H4K8 H4K16 | H4K5ac H4K8ac H4K16ac |
| MDC1 | FHA PF00498 54-124 Pfam-B_1811 PB001811 319-407 | MDC1_MOUSE | mediator of DNA-damage checkpoint 1 | MDC1_HUMAN | Histone modification read | # | # | H2AX | # |
| MEAF6 | NuA4 PF09340 16-97 | EAF6_MOUSE | MYST/Esa1-associated factor 6 | EAF6_HUMAN | Histone modification write cofactor | Histone acetylation | HBO1 NuA4 MOZ/MORF | H2A H3K14 H4K5 H4K8 H4K12 | H2Aac H3K14ac H4K5ac H4K8ac H4K12ac |
| MECP2 | MBD PF01429 90-164 | MECP2_MOUSE | methyl CpG binding protein 2 | MECP2_HUMAN | Histone modification write cofactor Histone modification write cofactor TF | Histone methylation Histone acetylation TF repressor | # | mCG DNA motif | # |
| MEN1 | Menin PF05053 1-615 | MEN1_MOUSE | multiple endocrine neoplasia I | MEN1_HUMAN | Histone modification write cofactor | Histone methylation | Menin-associated_HMT MLL-HCF CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 | H3K4 | H3K4me |
| MGA | HLH PF00010 2385-2436 Pfam-B_11518 PB011518 378-497 Pfam-B_24878 PB024878 2971-3008 Pfam-B_591 PB000591 979-1080 1332-1376 Pfam-B_7320 PB007320 1791-1938 Pfam-B_80122 PB080122 1-39 Pfam-B_8542 PB008542 653-837 T-box PF00907 76-261 | MGAP_MOUSE | MGA MAX dimerization protein | MGAP_HUMAN | Histone modification write cofactor Histone modification write cofactor TF TF | Histone methylation Histone acetylation TF activator TF repressor | RING2-L3MBTL2 CHD8 MLL2/3 MLL4/WBP7 | DNA motif | # |
| MGEA5 | NAGidase PF07555 62-364 Pfam-B_15148 PB015148 851-895 | NCOAT_MOUSE | meningioma expressed antigen 5 (hyaluronidase) | NCOAT_HUMAN | Histone modification write | Histone acetylation | # | H3K14 H4K8 | H3K14ac H4K8ac |
| MINA | Cupin_4 PF08007 51-364 | MINA_MOUSE | MYC induced nuclear antigen | MINA_HUMAN | Histone modification erase | Histone methylation | # | H3K9me3 | H3K9 |
| MLLT1 | YEATS PF03366 29-112 | # | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog Drosophila); translocated to 1 | ENL_HUMAN | Chromatin remodelling cofactor | # | SWI/SNF-like_EPAFa SWI/SNF-like EPAFB | # | # |
| MLLT6 | Pfam-B_16181 PB016181 791-1091 Pfam-B_3448 PB003448 551-789 zf-HC5HC2H_2 PF13832 63-180 | # | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog Drosophila); translocated to 6 | AF17_HUMAN | Histone modification write cofactor | Histone methylation | # | H3K79 | H3K79me3 |
| MLLT10 | PHD_2 PF13831 36-72 Pfam-B_12689 PB012689 541-619 Pfam-B_12729 PB012729 821-879 Pfam-B_4074 PB004074 234-538 Pfam-B_6933 PB006933 721-819 Pfam-B_9291 PB009291 621-719 zf-HC5HC2H_2 PF13832 80-197 | AF10_MOUSE | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog Drosophila); translocated to 10 | AF10_HUMAN | Histone modification write cofactor | Histone methylation | # | H3K79 | H3K79me3 |
| MORF4L1 | MRG PF05712 166-350 Tudor-knot PF11717 11-53 | MO4L1_MOUSE | mortality factor 4 like 1 | MO4L1_HUMAN | Histone modification read | # | NuA4 | H4 | # |
| MORF4L2 | MRG PF05712 93-276 Pfam-B_26706 PB026706 1-39 | MO4L2_MOUSE | mortality factor 4 like 2 | MO4L2_HUMAN | Histone modification erase cofactor | Histone acetylation | NuA4 | # | # |
| MOV10 | AAA_11 PF13086 498-605 599-691 AAA_12 PF13087 698-923 Pfam-B_18178 PB018178 1-114 | MOV10_MOUSE | Mov10 RISC complex RNA helicase | MOV10_HUMAN | # | # | # | # | # |
| MPHOSPH8 | Ank_2 PF12796 570-664 647-730 Chromo PF00385 59-109 | MPP8_MOUSE | M-phase phosphoprotein 8 | MPP8_HUMAN | Histone modification read | # | # | H3K9me3 H3K9me2 | # |
| MRGBP | Eaf7 PF07904 34-114 | MRGBP_MOUSE | MRG/MORF4L binding protein | MRGBP_HUMAN | Histone modification write cofactor | Histone acetylation | NuA4 | # | # |
| MSH6 | MutS_I PF01624 407-526 MutS_II PF05188 537-703 MutS_III PF05192 737-1065 MutS_IV PF05190 932-1024 MutS_V PF00488 1074-1326 PWWP PF00855 90-182 | MSH6_MOUSE | mutS homolog 6 | MSH6_HUMAN | Histone modification read | # | # | H3K36me3 | # |
| MSL1 | PEHE PF15275 473-591 Pfam-B_41610 PB041610 41-129 Pfam-B_70275 PB070275 1-39 | MSL1_MOUSE | male-specific lethal 1 homolog (Drosophila) | MSL1_HUMAN | Histone modification write | Histone ubiquitination | # | H2BK34 | H2BK34ub |
| MSL2 | Pfam-B_16851 PB016851 461-575 Pfam-B_19348 PB019348 1-89 Pfam-B_20099 PB020099 211-459 Pfam-B_22844 PB022844 91-209 | MSL2_MOUSE | male-specific lethal 2 homolog (Drosophila) | MSL2_HUMAN | Histone modification write | Histone ubiquitination | # | H2BK34 | H2BK34ub |
| MSL3 | MRG PF05712 136-504 Tudor-knot PF11717 11-74 | MS3L1_MOUSE | male-specific lethal 3 homolog (Drosophila) | MS3L1_HUMAN | Histone modification read | # | # | H4K20me1 | # |
| MST1 | Kringle PF00051 110-186 191-268 283-361 370-448 PAN_1 PF00024 16-106 Trypsin PF00089 484-704 | HGFL_MOUSE | macrophage stimulating 1 (hepatocyte growth factor-like) | HGFL_HUMAN | Histone modification | # | # | # | # |
| MTA1 | BAH PF01426 4-164 ELM2 PF01448 167-221 GATA PF00320 393-430 | MTA1_MOUSE | metastasis associated 1 | MTA1_HUMAN | Chromatin remodelling cofactor | # | NuRD | # | # |
| MTA2 | BAH PF01426 4-144 ELM2 PF01448 147-201 GATA PF00320 367-404 Pfam-B_3593 PB003593 571-637 | MTA2_MOUSE | metastasis associated 1 family member 2 | MTA2_HUMAN | Histone modification erase cofactor | Histone acetylation | NuRD | # | # |
| MTA3 | BAH PF01426 4-147 ELM2 PF01448 150-204 GATA PF00320 379-416 Pfam-B_11869 PB011869 421-489 Pfam-B_22870 PB022870 491-520 | MTA3_MOUSE | metastasis associated 1 family member 3 | MTA3_HUMAN | Chromatin remodelling cofactor | # | NuRD | # | # |
| MTF2 | Mtf2_C PF14061 542-592 PHD PF00628 104-157 | MTF2_MOUSE | metal response element binding transcription factor 2 | MTF2_HUMAN | Polycomb group (PcG) protein | # | PRC2 | H3K36me3 | # |
| MUM1 | Pfam-B_7774 PB007774 1-232 | MUM1_MOUSE | melanoma associated antigen (mutated) 1 | MUM1_HUMAN | Histone modification read | # | # | H3K36me K3K79me H4K20me | # |
| MYBBP1A | DNA_pol_phi PF04931 70-836 | MBB1A_MOUSE | MYB binding protein (P160) 1a | MBB1A_HUMAN | Chromatin remodelling cofactor | # | B-WICH | # | # |
| MYO1C | IQ PF00612 735-755 758-777 Myosin_TH1 PF06017 873-1059 Myosin_head PF00063 48-718 | MYO1C_MOUSE | myosin IC | MYO1C_HUMAN | Chromatin remodelling cofactor | # | B-WICH | # | # |
| MYSM1 | JAB PF01398 572-682 Myb_DNA-binding PF00249 118-163 Pfam-B_30622 PB030622 691-736 SWIRM PF04433 372-461 | MYSM1_MOUSE | Myb-like SWIRM and MPN domains 1 | MYSM1_HUMAN | Histone modification erase | Histone ubiquitination | # | H2Aub | H2A |
| NAA60 | Acetyltransf_1 PF00583 57-156 | NAA60_MOUSE | N(alpha)-acetyltransferase 60 NatF catalytic subunit | NAA60_HUMAN | Histone modification write | Histone acetylation | # | H4K20 H4K79 H4K91 | H4K20ac H4K79ac H4K91ac |
| NAP1L1 | NAP PF00956 75-346 | NP1L1_MOUSE | nucleosome assembly protein 1-like 1 | NP1L1_HUMAN | Histone chaperone | # | # | # | # |
| NAP1L2 | NAP PF00956 109-412 | NP1L2_MOUSE | nucleosome assembly protein 1-like 2 | NP1L2_HUMAN | Histone modification cofactor | # | # | H3 H4 | # |
| NAP1L4 | NAP PF00956 64-339 | NP1L4_MOUSE | nucleosome assembly protein 1-like 4 | NP1L4_HUMAN | Histone modification cofactor | # | # | H3 H4 | # |
| NASP | SHNi-TPR PF10516 542-579 TPR_1 PF00515 584-617 | NASP_MOUSE | nuclear autoantigenic sperm protein (histone-binding) | NASP_HUMAN | Chromatin remodelling | # | # | H1 | # |
| NAT10 | DUF1726 PF08351 107-201 GNAT_acetyltr_2 PF13718 528-753 Helicase_RecD PF05127 281-488 tRNA_bind_2 PF13725 771-892 | NAT10_MOUSE | N-acetyltransferase 10 (GCN5-related) | NAT10_HUMAN | Histone modification write | Histone acetylation | # | # | # |
| NBN | FHA PF00498 24-100 Nbs1_C PF08599 682-746 | NBN_MOUSE | nibrin | NBN_HUMAN | Chromatin remodelling | # | # | H2AX | # |
| NCL | Pfam-B_12581 PB012581 1-59 RRM_1 PF00076 309-377 395-460 488-554 574-641 | NUCL_MOUSE | nucleolin | NUCL_HUMAN | Histone chaperone | # | # | DNA motif RNA motif | # |
| NCOA1 | DUF1518 PF07469 1149-1205 1212-1268 Nuc_rec_co-act PF08815 924-973 PAS PF00989 112-183 PAS_11 PF14598 259-370 SRC-1 PF08832 625-708 | NCOA1_MOUSE | nuclear receptor coactivator 1 | NCOA1_HUMAN | Histone modification write | Histone acetylation | # | H3 H4 | # |
| NCOA2 | DUF1518 PF07469 1281-1338 Nuc_rec_co-act PF08815 1071-1117 PAS PF00989 115-215 PAS_11 PF14598 267-379 SRC-1 PF08832 636-709 | NCOA2_MOUSE | nuclear receptor coactivator 2 | NCOA2_HUMAN | Chromatin remodelling cofactor | # | # | # | # |
| NCOA3 | DUF1518 PF07469 1291-1348 Nuc_rec_co-act PF08815 1045-1095 PAS PF00989 113-210 PAS_11 PF14598 264-375 Pfam-B_10879 PB010879 1096-1195 Pfam-B_14009 PB014009 794-924 SRC-1 PF08832 616-704 | NCOA3_MOUSE | nuclear receptor coactivator 3 | NCOA3_HUMAN | Histone modification write | Histone acetylation | # | # | # |
| NCOA6 | Nucleic_acid_bd PF13820 45-195 Pfam-B_14375 PB014375 987-1511 Pfam-B_3537 PB003537 407-669 | NCOA6_MOUSE | nuclear receptor coactivator 6 | NCOA6_HUMAN | Histone modification write cofactor | Histone methylation | CHD8 MLL2/3 COMPASS-like MLL3 4 | # | # |
| NCOR1 | Myb_DNA-binding PF00249 625-670 Pfam-B_4054 PB004054 1242-1723 Pfam-B_670 PB000670 1725-1983 Pfam-B_7837 PB007837 1-159 | NCOR1_MOUSE | nuclear receptor corepressor 1 | NCOR1_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| NCOR2 | Myb_DNA-binding PF00249 612-657 Pfam-B_1539 PB001539 271-430 | NCOR2_MOUSE | nuclear receptor corepressor 2 | NCOR2_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| NEK6 | Pkinase PF00069 45-306 | NEK6_MOUSE | NIMA-related kinase 6 | NEK6_HUMAN | Histone modification write | Histone phosphorylation | # | H1 H3 | H1ph H3ph |
| NEK9 | Pfam-B_22064 PB022064 309-349 Pkinase PF00069 52-308 RCC1 PF00415 390-441 444-495 499-547 615-665 | NEK9_MOUSE | NIMA-related kinase 9 | NEK9_HUMAN | Histone modification write | Histone phosphorylation | # | H1 | H1ph |
| NFRKB | NFRKB_winged PF14465 379-478 Pfam-B_18306 PB018306 610-661 | NFRKB_MOUSE | nuclear factor related to kappaB binding protein | NFRKB_HUMAN | Chromatin remodelling cofactor TF | # # | Ino80 | DNA motif | # |
| NFYB | CBFD_NFYB_HMF PF00808 57-122 Pfam-B_17851 PB017851 1-39 | NFYB_MOUSE | nuclear transcription factor Y beta | NFYB_HUMAN | Chromatin remodelling TF | # TF activator | # | DNA motif | # |
| NFYC | CBFD_NFYB_HMF PF00808 41-105 Pfam-B_8767 PB008767 141-201 | NFYC_MOUSE | nuclear transcription factor Y gamma | NFYC_HUMAN | Histone modification | # | # | # | # |
| NIPBL | Cohesin_HEAT PF12765 1794-1835 Nipped-B_C PF12830 2274-2457 Pfam-B_338 PB000338 1292-1355 Pfam-B_4450 PB004450 1859-2018 Pfam-B_5032 PB005032 2020-2194 | NIPBL_MOUSE | Nipped-B homolog (Drosophila) | NIPBL_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| NOC2L | Noc2 PF03715 325-623 Pfam-B_22168 PB022168 62-101 Pfam-B_2429 PB002429 644-713 Pfam-B_50064 PB050064 1-31 | NOC2L_MOUSE | nucleolar complex associated 2 homolog (S. cerevisiae) | NOC2L_HUMAN | Chromatin remodelling TF | # TF repressor | # | H3 | # |
| NPAS2 | HLH PF00010 10-59 PAS PF00989 84-176 PAS_11 PF14598 248-356 | NPAS2_MOUSE | neuronal PAS domain protein 2 | NPAS2_HUMAN | Chromatin remodelling TF | # TF activator | # | DNA motif | # |
| NPM1 | Nucleoplasmin PF03066 13-196 | NPM_MOUSE | nucleophosmin (nucleolar phosphoprotein B23 numatrin) | NPM_HUMAN | Histone chaperone | # | # | H3 H2B H4 | # |
| NPM2 | TSP_1 PF00090 161-209 213-267 271-316 319-374 | NPM2_MOUSE | nucleophosmin/nucleoplasmin 2 | NPM2_HUMAN | Histone chaperone | # | # | H2A H2B | # |
| NSD1 | PHD PF00628 1709-1751 PWWP PF00855 321-419 1754-1844 Pfam-B_7228 PB007228 821-937 SET PF00856 1953-2059 | NSD1_MOUSE | nuclear receptor binding SET domain protein 1 | NSD1_HUMAN | Histone modification write | Histone methylation | # | H3K36 H4K20 | H3K36me H4K20me |
| NSL1 | Mis14 PF08641 67-211 | NSL1_MOUSE | NSL1 MIS12 kinetochore complex component | NSL1_HUMAN | Histone modification write cofactor | Histone acetylation | # | H4K16 | H4K16ac |
| OGT | Glyco_transf_41 PF13844 556-1024 TPR_1 PF00515 89-122 191-224 225-258 259-292 293-326 327-360 361-394 395-428 429-462 TPR_11 PF13414 87-154 TPR_8 PF13181 160-190 | OGT1_MOUSE | O-linked N-acetylglucosamine (GlcNAc) transferase | OGT1_HUMAN | Histone modification write | Histone GlcNAcylation | NSL | H2BS112 | H2BS112GlcNa |
| PADI1 | PAD PF03068 276-663 PAD_M PF08527 115-273 PAD_N PF08526 1-113 | PADI1_MOUSE | peptidyl arginine deiminase type I | PADI1_HUMAN | Histone modification | Histone citrullination | # | H2AR H3R H4R | H2ARci H3Rci H4Rci |
| PADI2 | PAD PF03068 279-665 PAD_M PF08527 116-274 PAD_N PF08526 1-114 | PADI2_MOUSE | peptidyl arginine deiminase type II | PADI2_HUMAN | Histone modification | Histone citrullination | # | H2AR H3R H4R | H2ARci H3Rci H4Rci |
| PADI3 | PAD PF03068 278-664 PAD_M PF08527 115-273 PAD_N PF08526 1-113 | PADI3_MOUSE | peptidyl arginine deiminase type III | PADI3_HUMAN | Histone modification | Histone citrullination | # | H2AR H3R H4R | H2ARci H3Rci H4Rci |
| PADI4 | PAD PF03068 278-663 PAD_M PF08527 113-273 PAD_N PF08526 1-111 | PADI4_MOUSE | peptidyl arginine deiminase type IV | PADI4_HUMAN | Histone modification | Histone citrullination | # | H2AR H3R2 H3R8 H3R17 H3R26 H4R | H2ARci H3R2ci H3R8ci H3R17ci H3R26ci H4Rci |
| PAF1 | Paf1 PF03985 27-446 | PAF1_MOUSE | Paf1 RNA polymerase II associated factor homolog (S. cerevisiae) | PAF1_HUMAN | Histone modification write cofactor | Histone ubiquitination | # | H2 H3 | # |
| PAGR1 | PAXIP1_C PF15364 86-221 | PAGR1_MOUSE | PAXIP1 associated glutamate-rich protein 1 | PAGR1_HUMAN | Histone modification write cofactor Histone modification write cofactor | Histone methylation Histone acetylation | CHD8 MLL2/3 MLL4/WBP7 COMPASS-like MLL3 4 | # | # |
| PAK2 | PBD PF00786 73-131 Pkinase PF00069 249-500 | PAK2_MOUSE | p21 protein (Cdc42/Rac)-activated kinase 2 | PAK2_HUMAN | Histone modification write | Histone phosphorylation | # | H4S47 | H4S47ph |
| PARG | PARG_cat PF05028 577-912 Pfam-B_14007 PB014007 925-955 | PARG_MOUSE | poly (ADP-ribose) glycohydrolase | PARG_HUMAN | Chromatin remodelling | # | # | H3K9 | # |
| PARP1 | BRCT PF00533 385-462 PADR1 PF08063 279-332 PARP PF00644 797-1007 PARP_reg PF02877 662-795 WGR PF05406 549-633 zf-PARP PF00645 12-90 116-200 | PARP1_MOUSE | poly (ADP-ribose) polymerase 1 | PARP1_HUMAN | Chromatin remodelling | # | # | H1 | # |
| PARP2 | PARP PF00644 365-577 PARP_reg PF02877 231-363 WGR PF05406 111-195 | PARP2_MOUSE | poly (ADP-ribose) polymerase 2 | PARP2_HUMAN | Chromatin remodelling cofactor | # | # | # | # |
| PARP3 | PARP PF00644 322-533 PARP_reg PF02877 182-320 WGR PF05406 62-144 | # | poly (ADP-ribose) polymerase family member 3 | PARP3_HUMAN | Polycomb group (PcG) protein | # | # | # | # |
| PAXIP1 | BRCT PF00533 601-681 701-776 867-934 PTCB-BRCT PF12738 102-165 Pfam-B_13490 PB013490 1009-1064 Pfam-B_16838 PB016838 485-548 | PAXI1_MOUSE | PAX interacting (with transcription-activation domain) protein 1 | PAXI1_HUMAN | Histone modification write cofactor | Histone methylation | CHD8 MLL2/3 MLL4/WBP7 COMPASS-like MLL3 4 | H3K4 | H3K4me3 |
| PBK | Pkinase PF00069 33-318 | TOPK_MOUSE | PDZ binding kinase | TOPK_HUMAN | Histone modification write | Histone phosphorylation | # | H3S10 | H3S10ph |
| PBRM1 | BAH PF01426 956-1074 1156-1272 Bromodomain PF00439 54-139 186-275 392-475 532-613 666-750 785-867 HMG_box PF00505 1379-1446 | PB1_MOUSE | polybromo 1 | PB1_HUMAN | Histone modification read | # | PBAF SWI/SNF BRM-BRG1 | H3 | # |
| PCGF1 | zf-C3HC4 PF00097 47-85 | PCGF1_MOUSE | polycomb group ring finger 1 | PCGF1_HUMAN | Polycomb group (PcG) protein | # | PRC1 BCOR | # | # |
| PCGF2 | zf-C3HC4 PF00097 18-56 | PCGF2_MOUSE | polycomb group ring finger 2 | PCGF2_HUMAN | Polycomb group (PcG) protein | # | PRC1 | # | # |
| PCGF3 | zf-C3HC4 PF00097 17-55 | PCGF3_MOUSE | polycomb group ring finger 3 | PCGF3_HUMAN | Polycomb group (PcG) protein | # | PRC1 RING2-FBRS | # | # |
| PCGF5 | zf-C3HC4 PF00097 18-56 | PCGF5_MOUSE | polycomb group ring finger 5 | PCGF5_HUMAN | Polycomb group (PcG) protein | # | PRC1 RING2-FBRS | # | # |
| PCGF6 | zf-C3HC4 PF00097 134-172 | PCGF6_MOUSE | polycomb group ring finger 6 | PCGF6_HUMAN | Polycomb group (PcG) protein | # | PRC1 RING2-L3MBTL2 | # | # |
| PCNA | PCNA_C PF02747 127-254 PCNA_N PF00705 1-125 | PCNA_MOUSE | proliferating cell nuclear antigen | PCNA_HUMAN | Chromatin remodelling | # | # | H2A H2B | # |
| PDP1 | PP2C PF00481 194-487 Pfam-B_13776 PB013776 99-163 | PDP1_MOUSE | pyruvate dehyrogenase phosphatase catalytic subunit 1 | PDP1_HUMAN | Histone modification read | # | # | H4K20me3 | # |
| PELP1 | NUC202 PF08166 423-489 569-642 RIX1 PF08167 66-226 | PELP1_MOUSE | proline glutamate and leucine rich protein 1 | PELP1_HUMAN | Histone modification read Histone modification write cofactor | Histone methylation Histone acetylation | CHD8 MLL2/3 MLL4/WBP7 | H1 H3 H4 | # |
| PHC1 | Pfam-B_4954 PB004954 615-678 Pfam-B_5821 PB005821 430-536 SAM_1 PF00536 938-1002 zf-FCS PF06467 792-827 | PHC1_MOUSE | polyhomeotic homolog 1 (Drosophila) | PHC1_HUMAN | Polycomb group (PcG) protein | # | PRC1 | # | # |
| PHC2 | Pfam-B_5669 PB005669 651-679 Pfam-B_6832 PB006832 1-198 SAM_1 PF00536 792-856 | PHC2_MOUSE | polyhomeotic homolog 2 (Drosophila) | PHC2_HUMAN | Polycomb group (PcG) protein | # | PRC1 | # | # |
| PHC3 | Pfam-B_12208 PB012208 689-724 Pfam-B_17091 PB017091 431-487 Pfam-B_19383 PB019383 780-822 Pfam-B_19396 PB019396 1-39 SAM_1 PF00536 917-981 | PHC3_MOUSE | polyhomeotic homolog 3 (Drosophila) | PHC3_HUMAN | Polycomb group (PcG) protein | # | PRC1 | # | # |
| PHF1 | Mtf2_C PF14061 525-566 PHD PF00628 89-142 Pfam-B_18040 PB018040 1-30 Pfam-B_24844 PB024844 331-384 | PHF1_MOUSE | PHD finger protein 1 | PHF1_HUMAN | Polycomb group (PcG) protein | # | PRC2 | # | # |
| PHF2 | JmjC PF02373 236-336 PHD PF00628 7-56 Pfam-B_3847 PB003847 851-988 | PHF2_MOUSE | PHD finger protein 2 | PHF2_HUMAN | Histone modification erase | Histone methylation | # | H3K9me2 | H3K9 |
| PHF8 | JmjC PF02373 270-370 PHD PF00628 43-92 Pfam-B_22520 PB022520 499-557 Pfam-B_5629 PB005629 779-877 | PHF8_MOUSE | PHD finger protein 8 | PHF8_HUMAN | Histone modification erase | Histone methylation | # | H3K9me1 H3K9me2 H3K27me2 H4K20me1 H3K36me2 H3K36me3 H3K4me3 | H3K9 H3K27 H4K20 H3K36 H3K4 |
| PHF10 | PHD PF00628 379-436 435-481 Pfam-B_1316 PB001316 15-230 | PHF10_MOUSE | PHD finger protein 10 | PHF10_HUMAN | Chromatin remodelling | # | npBAF SWI/SNF BRM-BRG1 | # | # |
| PHF12 | PHD PF00628 58-105 273-318 | PHF12_MOUSE | PHD finger protein 12 | PHF12_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| PHF13 | PHD PF00628 234-280 Pfam-B_28476 PB028476 1-49 | PHF13_MOUSE | PHD finger protein 13 | PHF13_HUMAN | Histone modification read | # | # | H3K4me3 | # |
| PHF14 | PHD PF00628 321-380 727-779 Pfam-B_16803 PB016803 175-216 Pfam-B_19012 PB019012 218-295 zf-HC5HC2H_2 PF13832 383-498 | PHF14_MOUSE | PHD finger protein 14 | PHF14_HUMAN | Histone modification read | # | # | H2A H2B H3 | H2Aac H2Bac H3ac |
| PHF19 | Mtf2_C PF14061 529-579 PHD PF00628 98-151 Pfam-B_31053 PB031053 1-59 | PHF19_MOUSE | PHD finger protein 19 | PHF19_HUMAN | Chromatin remodelling Histone modification write cofactor | # Histone acetylation | PRC2 | # | # |
| PHF20 | DUF3776 PF12618 173-279 PHD PF00628 654-700 Pfam-B_21846 PB021846 511-589 Pfam-B_23453 PB023453 280-309 | PHF20_MOUSE | PHD finger protein 20 | PHF20_HUMAN | Histone modification write | Histone acetylation | NSL CHD8 MLL2/3 MLL4/WBP7 | H4 | H4ac |
| PHF20L1 | DUF3776 PF12618 210-317 415-518 PHD PF00628 683-729 Pfam-B_37699 PB037699 791-849 | P20L1_MOUSE | PHD finger protein 20-like 1 | P20L1_HUMAN | Histone modification read | # | # | H3K4me | # |
| PHF21A | AT_hook PF02178 425-436 PHD PF00628 490-535 Pfam-B_15568 PB015568 536-649 Pfam-B_7050 PB007050 1-349 | PF21A_MOUSE | PHD finger protein 21A | PF21A_HUMAN | Histone modification erase cofactor | Histone methylation | BHC LSD-CoREST | # | # |
| PHIP | Bromodomain PF00439 1165-1251 1325-1409 Pfam-B_15784 PB015784 743-864 Pfam-B_60538 PB060538 1-77 WD40 PF00400 174-211 215-253 257-298 355-393 456-495 | PHIP_MOUSE | pleckstrin homology domain interacting protein | PHIP_HUMAN | Histone modification read | # | # | H3 | # |
| PIWIL4 | PAZ PF02170 271-407 Pfam-B_2782 PB002782 101-219 Pfam-B_34294 PB034294 1-99 Piwi PF02171 546-838 | PIWL4_MOUSE | piwi-like RNA-mediated gene silencing 4 | PIWL4_HUMAN | Chromatin remodelling Histone modification erase cofactor | # Histone methylation | # | H3K9 | # |
| PKM | PK PF00224 42-395 PK_C PF02887 409-529 | KPYM_MOUSE | pyruvate kinase muscle | KPYM_HUMAN | Histone modification write cofactor | Histone phosphorylation | # | H3S10 H3S28 H2BS32 | H3S10ph H3S28ph H2BS32ph H3T11ph |
| PKN1 | HR1 PF02185 37-105 126-198 213-285 Pfam-B_33979 PB033979 8-36 Pkinase PF00069 615-874 Pkinase_C PF00433 894-940 | PKN1_MOUSE | protein kinase N1 | PKN1_HUMAN | Histone modification write | Histone phosphorylation | # | H3T11 | H3T11ph |
| POGZ | DDE_1 PF03184 1117-1304 HTH_Tnp_Tc5 PF03221 1024-1085 Pfam-B_10413 PB010413 693-771 Pfam-B_10981 PB010981 1-69 Pfam-B_5179 PB005179 796-843 Pfam-B_6754 PB006754 773-795 | POGZ_MOUSE | pogo transposable element with ZNF domain | POGZ_HUMAN | Histone modification read | Histone methylation | # | H3K9me3 | # |
| POLE3 | CBFD_NFYB_HMF PF00808 8-73 Pfam-B_35841 PB035841 74-135 | DPOE3_MOUSE | polymerase (DNA directed) epsilon 3 accessory subunit | DPOE3_HUMAN | Histone chaperone | # | CHRAC | # | # |
| PPARGC1A | Pfam-B_19319 PB019319 241-286 RRM_1 PF00076 679-742 | PRGC1_MOUSE | peroxisome proliferator-activated receptor gamma coactivator 1 alpha | PRGC1_HUMAN | Histone modification cofactor | # | # | # | # |
| PPM1G | PP2C PF00481 25-120 264-492 | PPM1G_MOUSE | protein phosphatase Mg2+/Mn2+ dependent 1G | PPM1G_HUMAN | Chromatin remodelling | # | # | # | # |
| PPP2CA | Metallophos PF00149 50-245 | PP2AA_MOUSE | protein phosphatase 2 catalytic subunit alpha isozyme | PP2AA_HUMAN | Histone modification write | Histone phosphorylation | # | H2AX | H2AXph |
| PPP4C | Metallophos PF00149 47-242 | PP4C_MOUSE | protein phosphatase 4 catalytic subunit | PP4C_HUMAN | Histone modification erase | Histone phosphorylation | PPP4C-PPP4R2-PPP4R3A | H2AXS139ph | H2AXS139 |
| PPP4R2 | PPP4R2 PF09184 2-267 | PP4R2_MOUSE | protein phosphatase 4 regulatory subunit 2 | PP4R2_HUMAN | Histone modification cofactor | # | PPP4C-PPP4R2-PPP4R3A | # | # |
| PRDM1 | SET PF00856 99-201 zf-H2C2_2 PF13465 589-614 617-642 645-670 | PRDM1_MOUSE | PR domain containing 1 with ZNF domain | PRDM1_HUMAN | Histone modification write cofactor | Histone methylation | # | H3K9 | H3K9me |
| PRDM2 | Pfam-B_29325 PB029325 1053-1085 SET PF00856 41-141 zf-C2H2 PF00096 390-412 zf-C2H2_4 PF13894 360-383 483-506 1134-1157 1191-1214 1455-1475 | # | PR domain containing 2 with ZNF domain | PRDM2_HUMAN | Histone modification write | Histone methylation | # | H3K9 | H3K9me |
| PRDM4 | Pfam-B_13260 PB013260 461-509 zf-C2H2 PF00096 730-752 zf-H2C2_2 PF13465 632-657 660-683 688-713 | PRDM4_MOUSE | PR domain containing 4 | PRDM4_HUMAN | Histone modification write | Histone methylation | # | H4R3 | H4R3me2s |
| PRDM5 | zf-C2H2 PF00096 199-221 262-287 603-625 zf-C2H2_4 PF13894 167-190 zf-C2H2_jaz PF12171 375-399 zf-H2C2_2 PF13465 334-359 418-443 446-472 475-500 503-528 531-556 559-583 zf-met PF12874 234-254 295-317 | PRDM5_MOUSE | PR domain containing 5 | PRDM5_HUMAN | Histone modification write | Histone methylation | # | H3K9 | H3K9me |
| PRDM6 | SET PF00856 259-365 zf-C2H2 PF00096 501-523 zf-C2H2_4 PF13894 473-495 zf-H2C2_2 PF13465 543-568 | PRDM6_MOUSE | PR domain containing 6 | PRDM6_HUMAN | Histone modification write | Histone methylation | # | H3R2 H4K20 | H3R2me1 H3R2me2 H4K20me1 |
| PRDM7 | KRAB PF01352 27-65 SSXRD PF09514 170-202 | # | PR domain containing 7 | PRDM7_HUMAN | Histone modification write | Histone methylation | # | # | # |
| PRDM8 | zf-C2H2 PF00096 627-648 666-688 | PRDM8_MOUSE | PR domain containing 8 | PRDM8_HUMAN | Histone modification write | Histone methylation | # | # | # |
| PRDM9 | KRAB PF01352 27-65 SSXRD PF09514 170-202 zf-C2H2 PF00096 860-882 zf-H2C2_2 PF13465 540-562 566-590 594-619 622-647 650-674 678-702 706-731 734-758 762-786 790-815 818-843 846-871 | PRDM9_MOUSE | PR domain containing 9 | PRDM9_HUMAN | Histone modification write | Histone methylation | # | H3K4 | H3K4me3 |
| PRDM11 | Pfam-B_3219 PB003219 1-353 | PRD11_MOUSE | PR domain containing 11 | PRD11_HUMAN | Histone modification write | Histone methylation | # | # | # |
| PRDM12 | Pfam-B_39033 PB039033 1-49 zf-H2C2_2 PF13465 257-282 285-310 | PRD12_MOUSE | PR domain containing 12 | PRD12_HUMAN | Histone modification write cofactor | Histone methylation | # | H3K9 | H3K9me |
| PRDM13 | zf-C2H2 PF00096 137-160 zf-H2C2_2 PF13465 587-611 615-641 | PRD13_MOUSE | PR domain containing 13 | PRD13_HUMAN | Histone modification write | Histone methylation | # | # | # |
| PRDM14 | SET PF00856 265-367 zf-C2H2 PF00096 546-568 zf-C2H2_4 PF13894 400-421 432-455 zf-H2C2_2 PF13465 475-500 504-528 | PRD14_MOUSE | PR domain containing 14 | PRD14_HUMAN | DNA modification | DNA demethylation | # | mC | # |
| PRDM16 | Pfam-B_2662 PB002662 14-127 zf-C2H2 PF00096 337-360 366-388 394-416 423-445 979-1002 1008-1032 zf-C2H2_6 PF13912 229-255 zf-H2C2_2 PF13465 295-319 965-989 | PRD16_MOUSE | PR domain containing 16 | PRD16_HUMAN | Histone modification write cofactor TF | Histone methylation TF repressor | # | H3K9 DNA motif | H3K9me |
| PRKAA1 | Pfam-B_8588 PB008588 351-524 Pkinase PF00069 27-279 | AAPK1_MOUSE | protein kinase AMP-activated alpha 1 catalytic subunit | AAPK1_HUMAN | Histone modification write | Histone phosphorylation | # | H2BS36 | H2BS36ph |
| PRKAA2 | Pkinase PF00069 16-268 | AAPK2_MOUSE | protein kinase AMP-activated alpha 2 catalytic subunit | AAPK2_HUMAN | Histone modification write | Histone phosphorylation | # | H2BS36 | H2BS36ph |
| PRKAB1 | AMPKBI PF04739 149-270 | AAKB1_MOUSE | protein kinase AMP-activated beta 1 non-catalytic subunit | AAKB1_HUMAN | Histone modification write cofactor | Histone phosphorylation | # | # | # |
| PRKAB2 | AMPKBI PF04739 155-272 | AAKB2_MOUSE | protein kinase AMP-activated beta 2 non-catalytic subunit | AAKB2_HUMAN | Histone modification write cofactor | Histone phosphorylation | # | # | # |
| PRKAG1 | CBS PF00571 39-97 118-178 187-252 263-324 | AAKG1_MOUSE | protein kinase AMP-activated gamma 1 non-catalytic subunit | AAKG1_HUMAN | Histone modification write cofactor | Histone phosphorylation | # | # | # |
| PRKAG2 | CBS PF00571 350-410 428-484 494-556 Pfam-B_5182 PB005182 268-349 | AAKG2_MOUSE | protein kinase AMP-activated gamma 2 non-catalytic subunit | AAKG2_HUMAN | Histone modification write cofactor | Histone phosphorylation | # | # | # |
| PRKAG3 | CBS PF00571 273-333 350-406 414-479 | AAKG3_MOUSE | protein kinase AMP-activated gamma 3 non-catalytic subunit | AAKG3_HUMAN | Histone modification write cofactor | Histone phosphorylation | # | # | # |
| PRKCA | C1_1 PF00130 37-89 102-154 C2 PF00168 173-260 Pkinase PF00069 339-597 Pkinase_C PF00433 622-662 | KPCA_MOUSE | protein kinase C alpha | KPCA_HUMAN | Histone modification write cofactor | Histone phosphorylation | # | H3 | # |
| PRKCB | C1_1 PF00130 37-89 102-154 C2 PF00168 173-260 Pkinase PF00069 342-600 Pkinase_C PF00433 620-666 | KPCB_MOUSE | protein kinase C beta | KPCB_HUMAN | Histone modification write | Histone methylation | # | H3T6 | H3T6ph |
| PRKCD | C1_1 PF00130 159-211 231-283 Pkinase PF00069 349-603 Pkinase_C PF00433 623-669 | KPCD_MOUSE | protein kinase C delta | KPCD_HUMAN | Histone modification | # | # | # | # |
| PRKDC | FAT PF02259 3023-3470 FATC PF02260 4096-4128 NUC194 PF08163 1813-2210 PI3_PI4_kinase PF00454 3747-4015 Pfam-B_14440 PB014440 411-472 Pfam-B_1565 PB001565 131-345 Pfam-B_9125 PB009125 2650-2694 | PRKDC_MOUSE | protein kinase DNA-activated catalytic polypeptide | PRKDC_HUMAN | Histone modification write | Histone phosphorylation | # | H2AXS139 H2AFXS139 | H2AXS139ph H2AFXS139ph |
| PRMT1 | Methyltransf_31 PF13847 76-216 | ANM1_MOUSE | protein arginine methyltransferase 1 | ANM1_HUMAN | Histone modification write | Histone methylation | # | H4R3 | H4R3me1 H4R3me2a |
| PRMT2 | PRMT5 PF05185 114-415 SH3_9 PF14604 37-84 | ANM2_MOUSE | protein arginine methyltransferase 2 | ANM2_HUMAN | Histone modification write | Histone methylation | # | H4 | H4me |
| PRMT5 | PRMT5 PF05185 181-619 Pfam-B_18578 PB018578 1-49 | ANM5_MOUSE | protein arginine methyltransferase 5 | ANM5_HUMAN | Histone modification write | Histone methylation | methylosome | H3R8 H4R3 | H3R8me H4R3me |
| PRMT6 | Methyltransf_18 PF12847 82-189 | ANM6_MOUSE | protein arginine methyltransferase 6 | ANM6_HUMAN | Histone modification write | Histone methylation | # | H2AR3 H3R2 H4R4 | H2AR3me H4R3me H3R2me2a |
| PRMT7 | Pfam-B_13426 PB013426 301-359 PrmA PF06325 54-149 | ANM7_MOUSE | protein arginine methyltransferase 7 | ANM7_HUMAN | Histone modification write | Histone methylation | # | H2A H4R3 | H2A H4R3me2 |
| PRMT8 | PrmA PF06325 102-200 | ANM8_MOUSE | protein arginine methyltransferase 8 | ANM8_HUMAN | Histone modification write | Histone methylation | # | H4R | H4Rme |
| PRMT9 | PrmA PF06325 167-257 TPR_11 PF13414 67-132 | ANM9_MOUSE | protein arginine methyltransferase 9 | ANM9_HUMAN | Histone modification write | Histone methylation | # | H4R3 | H4R3me2 |
| PRPF31 | NOSIC PF08060 92-144 Nop PF01798 186-334 Pfam-B_23523 PB023523 1-44 Prp31_C PF09785 336-465 | PRP31_MOUSE | pre-mRNA processing factor 31 | PRP31_HUMAN | Histone modification write cofactor Histone modification write cofactor | Histone methylation Histone acetylation | CHD8 MLL2/3 MLL4/WBP7 | # | # |
| PRR14 | Tantalus PF15386 457-517 | PRR14_MOUSE | proline rich 14 | PRR14_HUMAN | Histone modification write | Histone phosphorylation | # | H3K9me2 H3K9me3 | # |
| PSIP1 | LEDGF PF11467 349-455 PWWP PF00855 5-87 | PSIP1_MOUSE | PC4 and SFRS1 interacting protein 1 | PSIP1_HUMAN | Chromatin remodelling | # | # | # | # |
| RAD51 | HHH_5 PF14520 28-80 Rad51 PF08423 83-338 | RAD51_MOUSE | RAD51 recombinase | RAD51_HUMAN | Histone modification erase | Histone ubiquitination | BRCC | histone | # |
| RAD54B | Helicase_C PF00271 678-758 Pfam-B_10171 PB010171 772-829 SNF2_N PF00176 299-598 | RA54B_MOUSE | RAD54 homolog B (S. cerevisiae) | RA54B_HUMAN | Chromatin remodelling | # | # | # | # |
| RAD54L | Helicase_C PF00271 531-611 Pfam-B_14570 PB014570 674-743 Rad54_N PF08658 33-138 SNF2_N PF00176 156-463 | RAD54_MOUSE | RAD54-like (S. cerevisiae) | RAD54_HUMAN | Chromatin remodelling | # | # | # | # |
| RAD54L2 | Helicase_C PF00271 774-854 Pfam-B_2830 PB002830 105-259 SNF2_N PF00176 274-625 | ARIP4_MOUSE | RAD54-like 2 (S. cerevisiae) | ARIP4_HUMAN | Chromatin remodelling | # | # | # | # |
| RAG1 | Pfam-B_793 PB000793 1-89 RAG1 PF12940 513-953 zf-C3HC4 PF00097 293-331 zf-RAG1 PF10426 354-383 | RAG1_MOUSE | recombination activating gene 1 | RAG1_HUMAN | Histone modification write | Histone ubiquitination | # | H3.3K DNA motif | H3.3Kub |
| RAG2 | RAG2 PF03089 51-389 RAG2_PHD PF13341 414-491 | RAG2_MOUSE | recombination activating gene 2 | RAG2_HUMAN | Histone modification read | # | # | H3K4me3 | # |
| RAI1 | Pfam-B_11259 PB011259 438-596 Pfam-B_27361 PB027361 388-436 Pfam-B_6090 PB006090 1665-1710 zf-HC5HC2H PF13771 1825-1903 | RAI1_MOUSE | retinoic acid induced 1 | RAI1_HUMAN | Chromatin remodelling | # | # | # | # |
| RARA | Hormone_recep PF00104 207-409 zf-C4 PF00105 86-155 | RARA_MOUSE | retinoic acid receptor alpha | RARA_HUMAN | Histone modification write cofactor TF TF | Histone methylation TF activator TF repressor | # | H3K4 | H3K4me H3K4me2 |
| RB1 | DUF3452 PF11934 105-229 RB_A PF01858 373-573 RB_B PF01857 645-766 Rb_C PF08934 768-927 | RB_MOUSE | retinoblastoma 1 | RB_HUMAN | Chromatin remodelling Histone modification write | # Histone ubiquitination | CREST-BRG1 L3MBTL1 | # | # |
| RBBP4 | CAF1C_H4-bd PF12265 18-89 WD40 PF00400 167-206 218-256 263-302 307-346 364-403 | RBBP4_MOUSE | retinoblastoma binding protein 4 | RBBP4_HUMAN | Histone chaperone | # | NuRF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm NuRD mSin3A core HDAC mSin3A-like complex PRC2 CAF-1 | H4 | # |
| RBBP5 | Pfam-B_3428 PB003428 121-325 WD40 PF00400 23-52 58-94 | RBBP5_MOUSE | retinoblastoma binding protein 5 | RBBP5_HUMAN | Histone modification write cofactor | Histone methylation | COMPASS Menin-associated_HMT MLL-HCF CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 COMPASS-like MLL3 4 | H3K4 | H3K4me1 H3K4me2 H3K4me3 |
| RBBP7 | CAF1C_H4-bd PF12265 17-88 WD40 PF00400 166-205 217-255 262-301 306-345 363-402 | RBBP7_MOUSE | retinoblastoma binding protein 7 | RBBP7_HUMAN | Histone chaperone | # | NuRF NuRD mSin3A core HDAC mSin3A-like complex PRC2 | H4 | # |
| RBX1 | zf-rbx1 PF12678 21-98 | RBX1_MOUSE | ring-box 1 E3 ubiquitin protein ligase | RBX1_HUMAN | Histone modification write cofactor | Histone ubiquitination | # | H3 H4 | H3ub H4ub |
| RCC1 | RCC1 PF00415 34-82 85-134 137-187 190-255 258-309 312-360 363-414 | RCC1_MOUSE | regulator of chromosome condensation 1 | RCC1_HUMAN | Chromatin remodelling | # | # | H2A H2B | # |
| RCOR1 | ELM2 PF01448 102-157 Myb_DNA-binding PF00249 381-425 | RCOR1_MOUSE | REST corepressor 1 | RCOR1_HUMAN | Histone modification erase cofactor Histone modification erase cofactor | Histone acetylation Histone methylation | BHC SCL LSD-CoREST | # | # |
| RCOR3 | ELM2 PF01448 1-54 Myb_DNA-binding PF00249 288-332 | RCOR3_MOUSE | REST corepressor 3 | RCOR3_HUMAN | Histone modification erase cofactor | Histone acetylation | LSD-CoREST | # | # |
| REST | Pfam-B_2325 PB002325 821-909 Pfam-B_9727 PB009727 1001-1095 zf-C2H2_4 PF13894 216-238 zf-H2C2_2 PF13465 290-315 318-343 346-372 | REST_MOUSE | RE1-silencing transcription factor | REST_HUMAN | Histone modification erase cofactor TF TF | Histone acetylation TF activator TF repressor | # | DNA motif | # |
| RING1 | Pfam-B_11743 PB011743 292-404 Pfam-B_13488 PB013488 241-291 Pfam-B_23468 PB023468 191-239 zf-C3HC4 PF00097 48-87 | RING1_MOUSE | ring finger protein 1 | RING1_HUMAN | Histone modification write Polycomb group (PcG) protein | Histone ubiquitination # | PRC1 BCOR RING2-L3MBTL2 RING2-FBRS | H2AK119 | H2AK119ub |
| RLIM | zf-RING_2 PF13639 568-611 | RNF12_MOUSE | ring finger protein LIM domain interacting | RNF12_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| RMI1 | DUF1767 PF08585 12-104 Pfam-B_227 PB000227 590-623 | RMI1_MOUSE | RecQ mediated genome instability 1 | RMI1_HUMAN | DNA modification | # | # | # | # |
| RNF2 | zf-C3HC4 PF00097 51-90 | RING2_MOUSE | ring finger protein 2 | RING2_HUMAN | Histone modification write | Histone ubiquitination | PRC1 BCOR RING2-L3MBTL2 RING2-FBRS CHD8 MLL2/3 MLL4/WBP7 | H2AK119 | H2AK119ub |
| RNF8 | FHA PF00498 38-109 zf-RING_2 PF13639 401-441 | RNF8_MOUSE | ring finger protein 8 E3 ubiquitin protein ligase | RNF8_HUMAN | Histone modification write | Histone ubiquitination | # | H2AK63 H2AXK63 H2AK48 H2AXK48 | H2AK63ub H2AXK63ub H2AK48ub H2AXK48ub |
| RNF20 | Pfam-B_13436 PB013436 97-179 Pfam-B_14933 PB014933 35-95 Pfam-B_6844 PB006844 735-892 zf-C3HC4 PF00097 922-960 | BRE1A_MOUSE | ring finger protein 20 E3 ubiquitin protein ligase | BRE1A_HUMAN | Histone modification write | Histone ubiquitination | # | H2BK120 | H2BK120ub1 |
| RNF40 | Pfam-B_21314 PB021314 191-299 Pfam-B_9159 PB009159 1-189 zf-C3HC4 PF00097 948-986 | BRE1B_MOUSE | ring finger protein 40 E3 ubiquitin protein ligase | BRE1B_HUMAN | Histone modification write cofactor | Histone ubiquitination | # | H2BK121 | H2BK120ub2 |
| RNF168 | Pfam-B_30754 PB030754 528-566 zf-C3HC4_2 PF13923 16-54 | RN168_MOUSE | ring finger protein 168 E3 ubiquitin protein ligase | RN168_HUMAN | Histone modification write | Histone ubiquitination | # | H2AK13 H2AK15 H2AXK13 H2AXK15 | H2AK13ub H2AK15ub H2AXK13ub H2AXK15ub |
| RPS6KA3 | Pkinase PF00069 68-327 422-679 Pkinase_C PF00433 349-389 | KS6A3_MOUSE | ribosomal protein S6 kinase 90kDa polypeptide 3 | KS6A3_HUMAN | Histone modification write cofactor | Histone phosphorylation | # | H3S10 | H3S10ph |
| RPS6KA4 | Pkinase PF00069 33-301 413-674 Pkinase_C PF00433 321-365 | KS6A4_MOUSE | ribosomal protein S6 kinase 90kDa polypeptide 4 | KS6A4_HUMAN | Histone modification write | Histone phosphorylation | # | H3S10 H3S28 | H3S10ph H3S28ph |
| RPS6KA5 | Pkinase PF00069 49-318 427-687 Pkinase_C PF00433 338-381 | KS6A5_MOUSE | ribosomal protein S6 kinase 90kDa polypeptide 5 | KS6A5_HUMAN | Histone modification write | Histone phosphorylation | # | H2AS1 H3S10 H3S28 | H2AS1ph H3S10ph H3S28ph |
| RRP8 | Methyltransf_8 PF05148 237-456 | RRP8_MOUSE | ribosomal RNA processing 8 methyltransferase homolog (yeast) | RRP8_HUMAN | Histone modification cofactor | # | eNoSc | H3ac | H3K9me2 |
| RSF1 | PHD PF00628 893-941 WHIM1 PF15612 98-148 WHIM2 PF15613 150-182 WHIM3 PF15614 188-409 | # | remodeling and spacing factor 1 | RSF1_HUMAN | Histone modification read | # | RSF | # | # |
| RUVBL1 | TIP49 PF06068 14-416 | RUVB1_MOUSE | RuvB-like AAA ATPase 1 | RUVB1_HUMAN | Chromatin remodelling Histone modification write | # Histone phosphorylation | Ino80 SWR NuA4 NuA4-related complex CHD8 MLL2/3 MLL4/WBP7 SRCAP | # | # |
| RUVBL2 | TIP49 PF06068 21-412 | RUVB2_MOUSE | RuvB-like AAA ATPase 2 | RUVB2_HUMAN | Chromatin remodelling cofactor | # | Ino80 SWR NuA4 NuA4-related complex CHD8 MLL2/3 MLL4/WBP7 SRCAP | # | # |
| RYBP | Pfam-B_18067 PB018067 49-226 zf-RanBP PF00641 22-48 | RYBP_MOUSE | RING1 and YY1 binding protein | RYBP_HUMAN | Polycomb group (PcG) protein | # | BCOR RING2-L3MBTL2 RING2-FBRS | # | # |
| SAFB | Pfam-B_12198 PB012198 66-89 RRM_6 PF14259 409-478 SAP PF02037 31-65 | SAFB1_MOUSE | scaffold attachment factor B | SAFB1_HUMAN | Chromatin remodelling | # | # | # | # |
| SAP18 | SAP18 PF06487 16-137 | SAP18_MOUSE | Sin3A-associated protein 18kDa | SAP18_HUMAN | Histone modification erase cofactor | Histone acetylation | mSin3A | # | # |
| SAP25 | SAP25 PF15476 1-199 | SAP25_MOUSE | Sin3A-associated protein 25kDa | SAP25_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| SAP30 | SAP30_Sin3_bdg PF13867 153-205 zf-SAP30 PF13866 56-134 | SAP30_MOUSE | Sin3A-associated protein 30kDa | SAP30_HUMAN | Histone modification erase cofactor | Histone acetylation | mSin3A mSin3A-like complex | # | # |
| SAP30L | SAP30_Sin3_bdg PF13867 114-166 zf-SAP30 PF13866 18-95 | SP30L_MOUSE | SAP30-like | SP30L_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| SAP130 | Pfam-B_10398 PB010398 431-719 Pfam-B_13351 PB013351 101-249 Pfam-B_17122 PB017122 781-837 Pfam-B_18714 PB018714 721-779 Pfam-B_237 PB000237 949-984 | SP130_MOUSE | Sin3A-associated protein 130kDa | SP130_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| SATB1 | CUT PF02376 362-448 485-571 Homeobox PF00046 645-702 Pfam-B_9146 PB009146 141-299 | SATB1_MOUSE | SATB homeobox 1 | SATB1_HUMAN | Chromatin remodelling cofactor | # | # | # | # |
| SATB2 | CUT PF02376 352-437 474-560 Homeobox PF00046 615-672 Pfam-B_8103 PB008103 1-268 | SATB2_MOUSE | SATB homeobox 2 | SATB2_HUMAN | Chromatin remodelling cofactor | # | # | # | # |
| SCMH1 | DUF3588 PF12140 355-469 MBT PF02820 62-134 171-239 SAM_1 PF00536 591-656 | SCMH1_MOUSE | sex comb on midleg homolog 1 (Drosophila) | SCMH1_HUMAN | Polycomb group (PcG) protein | # | PRC1 | # | # |
| SCML2 | DUF3588 PF12140 353-468 MBT PF02820 67-139 176-244 SAM_1 PF00536 629-695 | # | sex comb on midleg-like 2 (Drosophila) | SCML2_HUMAN | Polycomb group (PcG) protein | # | PRC1 | # | # |
| SCML4 | DUF3588 PF12140 92-208 SAM_1 PF00536 344-410 | SCML4_MOUSE | sex comb on midleg-like 4 (Drosophila) | SCML4_HUMAN | Polycomb group (PcG) protein | # | # | # | # |
| SENP1 | Peptidase_C48 PF02902 464-642 Pfam-B_2161 PB002161 1-189 Pfam-B_34931 PB034931 191-249 | SENP1_MOUSE | SUMO1/sentrin specific peptidase 1 | SENP1_HUMAN | Histone modification erase cofactor | Histone sumoylation | # | H4 | # |
| SENP3 | Peptidase_C48 PF02902 400-572 Pfam-B_2161 PB002161 1-349 | SENP3_MOUSE | SUMO1/sentrin/SMT3 specific peptidase 3 | SENP3_HUMAN | Histone modification erase Histone modification write cofactor | Histone sumoylation Histone acetylation | CHD8 MLL2/3 MLL4/WBP7 | H3 | H3ac |
| SET | NAP PF00956 42-237 | SET_MOUSE | SET nuclear proto-oncogene | SET_HUMAN | Histone modification | # | # | # | # |
| SETD1A | N-SET PF11764 1418-1558 Pfam-B_24657 PB024657 752-1010 Pfam-B_24930 PB024930 331-410 Pfam-B_41492 PB041492 622-680 RRM_1 PF00076 99-166 SET PF00856 1579-1685 | # | SET domain containing 1A | SET1A_HUMAN | Histone modification write | Histone methylation | COMPASS | H3K4 | H3K4me |
| SETD1B | N-SET PF11764 1629-1774 Pfam-B_1367 PB001367 1017-1148 Pfam-B_14013 PB014013 887-1015 RRM_1 PF00076 108-175 SET PF00856 1795-1901 | SET1B_MOUSE | SET domain containing 1B | SET1B_HUMAN | Histone modification write | Histone methylation | COMPASS | H3K4 | H3K4me |
| SETD2 | Pfam-B_18604 PB018604 305-521 Pfam-B_22486 PB022486 541-599 Pfam-B_2796 PB002796 2146-2339 Pfam-B_3607 PB003607 1826-2144 Pfam-B_67824 PB067824 31-77 SET PF00856 1561-1667 SRI PF08236 2465-2559 WW PF00397 2391-2420 | SETD2_MOUSE | SET domain containing 2 | SETD2_HUMAN | Histone modification write | Histone methylation | # | H3K36me2 | H3K36me3 |
| SETD3 | Rubis-subs-bind PF09273 343-475 SET PF00856 105-314 | SETD3_MOUSE | SET domain containing 3 | SETD3_HUMAN | Histone modification write | Histone methylation | # | H3K36 | H3K36me |
| SETD5 | Pfam-B_7713 PB007713 700-789 SET PF00856 285-390 | SETD5_MOUSE | SET domain containing 5 | SETD5_HUMAN | Histone modification write | Histone methylation | # | # | # |
| SETD6 | Pfam-B_25912 PB025912 1-69 Rubis-subs-bind PF09273 329-465 SET PF00856 74-286 | SETD6_MOUSE | SET domain containing 6 | SETD6_HUMAN | Chromatin remodelling Histone modification write | # Histone methylation | # | # | # |
| SETD7 | MORN PF02493 13-35 36-58 60-81 106-128 SET PF00856 227-336 | SETD7_MOUSE | SET domain containing (lysine methyltransferase) 7 | SETD7_HUMAN | Histone modification write | Histone methylation | # | H3K4 | H3K4me1 |
| SETD8 | SET PF00856 268-378 | SETD8_MOUSE | SET domain containing (lysine methyltransferase) 8 | SETD8_HUMAN | Histone modification write | Histone methylation | # | H4K20 | H4K20me1 |
| SETDB1 | MBD PF01429 594-668 Pfam-B_23747 PB023747 365-520 Pfam-B_27578 PB027578 341-364 Pre-SET PF05033 681-795 SET PF00856 814-1266 | SETB1_MOUSE | SET domain bifurcated 1 | SETB1_HUMAN | Histone modification write | Histone methylation | # | H3K9 | H3K9me3 |
| SETDB2 | MBD PF01429 160-232 Pre-SET PF05033 245-359 SET PF00856 378-694 | SETB2_MOUSE | SET domain bifurcated 2 | SETB2_HUMAN | Histone modification write | Histone methylation | # | H3K9 | H3K9me3 |
| SETMAR | HTH_Tnp_Tc3_2 PF01498 401-466 Pre-SET PF05033 16-118 SET PF00856 137-250 Transposase_1 PF01359 488-568 | SETMR_MOUSE | SET domain and mariner transposase fusion gene | SETMR_HUMAN | Histone modification write | Histone methylation | # | H3K4 H3K36 | H3K4me H3K36me |
| SF3B1 | Pfam-B_1720 PB001720 1099-1147 SF3b1 PF08920 282-457 | SF3B1_MOUSE | splicing factor 3b subunit 1 155kDa | SF3B1_HUMAN | RNA modification | # | B-WICH | # | # |
| SF3B3 | CPSF_A PF03178 863-1184 MMS1_N PF10433 76-597 | SF3B3_MOUSE | splicing factor 3b subunit 3 130kDa | SF3B3_HUMAN | RNA modification | # | # | # | # |
| SFMBT1 | DUF3588 PF12140 501-620 MBT PF02820 54-128 167-240 279-356 388-461 Pfam-B_19576 PB019576 672-751 SAM_1 PF00536 794-857 | SMBT1_MOUSE | Scm-like with four mbt domains 1 | SMBT1_HUMAN | Polycomb group (PcG) protein | # | SCL | H4K20 | # |
| SFMBT2 | DUF3588 PF12140 527-646 MBT PF02820 78-152 191-263 304-380 412-485 SAM_1 PF00536 822-885 | SMBT2_MOUSE | Scm-like with four mbt domains 2 | SMBT2_HUMAN | Histone modification read Polycomb group (PcG) protein TF | # # TF repressor | # | H3K9me2 H3K9me3 H3K27me3 H4K20me2 H4K20me3 | H3 H4 |
| SFPQ | NOPS PF08075 444-495 RRM_1 PF00076 299-363 373-440 | SFPQ_MOUSE | splicing factor proline/glutamine-rich | SFPQ_HUMAN | Chromatin remodelling cofactor RNA modification TF | # # TF repressor | # | # | # |
| SHPRH | Helicase_C PF00271 1545-1622 Linker_histone PF00538 438-512 Pfam-B_11163 PB011163 1-248 SNF2_N PF00176 307-987 zf-C3HC4_2 PF13923 1432-1478 | SHPRH_MOUSE | SNF2 histone linker PHD RING helicase E3 ubiquitin protein ligase | SHPRH_HUMAN | Histone modification write cofactor | Histone ubiquitination | # | # | # |
| SIN3A | PAH PF02671 141-187 322-381 477-523 Pfam-B_10250 PB010250 1-99 Pfam-B_10714 PB010714 1098-1128 Pfam-B_8471 PB008471 1055-1090 Sin3_corepress PF08295 550-650 | SIN3A_MOUSE | SIN3 transcription regulator family member A | SIN3A_HUMAN | Histone modification erase cofactor TF TF | Histone acetylation TF activator TF repressor | SWI/SNF_Brg1(I) SWI/SNF_Brm mSin3A mSin3A-like complex | DNA motif | # |
| SIN3B | PAH PF02671 59-105 180-236 321-367 Sin3_corepress PF08295 393-448 450-525 | SIN3B_MOUSE | SIN3 transcription regulator family member B | SIN3B_HUMAN | Histone modification erase cofactor TF | Histone acetylation TF repressor | mSin3A | DNA motif | # |
| SIRT1 | Pfam-B_28511 PB028511 1-109 Pfam-B_5913 PB005913 111-189 Pfam-B_8042 PB008042 611-745 SIR2 PF02146 261-447 | SIR1_MOUSE | sirtuin 1 | SIR1_HUMAN | Histone modification erase Histone modification write cofactor | Histone acetylation Histone methylation | eNoSc | H1K26ac H3K9ac H4K16ac | H1K26 H3K9 H4K16 |
| SIRT2 | SIR2 PF02146 84-268 | SIR2_MOUSE | sirtuin 2 | SIR2_HUMAN | Histone modification erase Histone modification write cofactor | Histone acetylation Histone methylation | # | H3K18ac H3K56ac H4K16ac H4K20me1 | H3K18 H3K56 H4K16 H4K20me2 H4K20me3 |
| SIRT6 | SIR2 PF02146 52-89 80-221 | SIR6_MOUSE | sirtuin 6 | SIR6_HUMAN | Histone modification erase | Histone acetylation | # | H3K9ac H3K56ac | H3K9 H3K56 |
| SIRT7 | SIR2 PF02146 133-275 | SIR7_MOUSE | sirtuin 7 | SIR7_HUMAN | Histone modification erase | Histone acetylation | B-WICH | H3K18ac | H3K18 |
| SKP1 | Skp1 PF01466 85-162 Skp1_POZ PF03931 2-67 | SKP1_MOUSE | S-phase kinase-associated protein 1 | SKP1_HUMAN | Histone modification write cofactor | Histone ubiquitination | BCOR | # | # |
| SMARCA1 | DBINO PF13892 42-119 HAND PF09110 758-856 Helicase_C PF00271 520-612 SLIDE PF09111 912-1028 SNF2_N PF00176 186-466 | SMCA1_MOUSE | SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 1 | SMCA1_HUMAN | Chromatin remodelling Histone modification erase | # Histone acetylation | NuRF CERF CERF | # | # |
| SMARCA2 | BRK PF07533 588-633 Bromodomain PF00439 1411-1493 HSA PF07529 436-508 Helicase_C PF00271 1084-1164 Pfam-B_17897 PB017897 1369-1398 Pfam-B_2366 PB002366 333-414 QLQ PF08880 172-208 SNF2_N PF00176 727-1022 SnAC PF14619 1257-1326 | SMCA2_MOUSE | SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 2 | SMCA2_HUMAN | Histone modification read TF | # TF activator | BAF nBAF npBAF WINAC bBAF SWI/SNF BRM-BRG1 | H3 DNA motif | # |
| SMARCA4 | BRK PF07533 610-655 Bromodomain PF00439 1462-1551 HSA PF07529 460-532 Helicase_C PF00271 1114-1194 QLQ PF08880 170-206 SNF2_N PF00176 757-1052 SnAC PF14619 1321-1389 | SMCA4_MOUSE | SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 4 | SMCA4_HUMAN | Histone modification read TF | # TF activator | BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB bBAF SWI/SNF BRM-BRG1 CREST-BRG1 | H3 H4 | # |
| SMARCA5 | DBINO PF13892 58-116 HAND PF09110 743-841 Helicase_C PF00271 517-597 Pfam-B_36230 PB036230 1-39 SLIDE PF09111 897-1013 SNF2_N PF00176 183-463 | SMCA5_MOUSE | SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 5 | SMCA5_HUMAN | Chromatin remodelling | # | ACF B-WICH RSF CHRAC NoRC | # | # |
| SMARCAD1 | Helicase_C PF00271 888-967 Pfam-B_295 PB000295 41-308 SNF2_N PF00176 500-788 | SMRCD_MOUSE | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily a containing DEAD/H box 1 | SMRCD_HUMAN | Chromatin remodelling | # | # | # | # |
| SMARCAL1 | HARP PF07443 248-302 343-397 Helicase_C PF00271 743-822 Pfam-B_7889 PB007889 1-159 SNF2_N PF00176 434-716 | SMAL1_MOUSE | SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a-like 1 | SMAL1_HUMAN | Chromatin remodelling | # | # | # | # |
| SMARCB1 | Pfam-B_9879 PB009879 2-146 SNF5 PF04855 178-373 | SNF5_MOUSE | SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily b member 1 | SNF5_HUMAN | Histone modification read | # | BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB bBAF SWI/SNF BRM-BRG1 | H3K56 | # |
| SMARCC1 | Myb_DNA-binding PF00249 620-665 SWIRM PF04433 449-537 | SMRC1_MOUSE | SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 1 | SMRC1_HUMAN | Chromatin remodelling cofactor | # | BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB bBAF SWI/SNF BRM-BRG1 | # | # |
| SMARCC2 | Myb_DNA-binding PF00249 598-643 Pfam-B_1849 PB001849 1-168 SWIRM PF04433 424-512 | SMRC2_MOUSE | SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 2 | SMRC2_HUMAN | Chromatin remodelling cofactor | # | BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB bBAF SWI/SNF BRM-BRG1 | # | # |
| SMARCD1 | Pfam-B_13759 PB013759 1-79 Pfam-B_3130 PB003130 378-473 SWIB PF02201 291-366 | SMRD1_MOUSE | SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 1 | SMRD1_HUMAN | Chromatin remodelling | # | BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB SWI/SNF BRM-BRG1 | # | # |
| SMARCD2 | Pfam-B_13705 PB013705 420-516 Pfam-B_7929 PB007929 141-287 SWIB PF02201 307-382 | SMRD2_MOUSE | SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 2 | SMRD2_HUMAN | Chromatin remodelling cofactor | # | BAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brm SWI/SNF-like EPAFB bBAF SWI/SNF BRM-BRG1 | # | # |
| SMARCD3 | Pfam-B_18257 PB018257 7-73 Pfam-B_3130 PB003130 346-441 SWIB PF02201 259-334 | SMRD3_MOUSE | SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 3 | SMRD3_HUMAN | Chromatin remodelling cofactor | # | BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brm SWI/SNF BRM-BRG1 | # | # |
| SMARCE1 | HMG_box PF00505 66-134 Pfam-B_14199 PB014199 371-409 | SMCE1_MOUSE | SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily e member 1 | SMCE1_HUMAN | Chromatin remodelling cofactor | # | BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB bBAF | # | # |
| SMEK1 | Pfam-B_1700 PB001700 381-501 Pfam-B_334 PB000334 506-611 SMK-1 PF04802 164-357 | P4R3A_MOUSE | SMEK homolog 1 suppressor of mek1 (Dictyostelium) | P4R3A_HUMAN | Histone modification erase cofactor | Histone phosphorylation | PPP4C-PPP4R2-PPP4R3A | H2AFX | # |
| SMEK2 | Pfam-B_2986 PB002986 536-638 SMK-1 PF04802 166-359 | P4R3B_MOUSE | SMEK homolog 2 suppressor of mek1 (Dictyostelium) | P4R3B_HUMAN | Histone modification erase cofactor | Histone phosphorylation | # | H2AFX | # |
| SMYD1 | SET PF00856 18-253 zf-MYND PF01753 52-90 | SMYD1_MOUSE | SET and MYND domain containing 1 | SMYD1_HUMAN | Histone modification write | Histone methylation | # | H3K4 | H3K4me |
| SMYD2 | SET PF00856 18-241 zf-MYND PF01753 52-90 | SMYD2_MOUSE | SET and MYND domain containing 2 | SMYD2_HUMAN | Histone modification write | Histone methylation | # | H3K4 H3K36 | H3K4me H3K36me2 |
| SMYD3 | Pfam-B_27974 PB027974 391-422 SET PF00856 15-240 zf-MYND PF01753 47-87 | SMYD3_MOUSE | SET and MYND domain containing 3 | SMYD3_HUMAN | Histone modification write | Histone methylation | # | H3K4 H3K5 | H3K4me2 H3K4me3 H3K5me2 H3K5me3 |
| SMYD4 | Pfam-B_24699 PB024699 740-795 Pfam-B_50317 PB050317 1-65 SET PF00856 244-574 TPR_11 PF13414 66-135 zf-MYND PF01753 296-335 | SMYD4_MOUSE | SET and MYND domain containing 4 | SMYD4_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| SNAI2 | zf-C2H2 PF00096 159-181 zf-C2H2_6 PF13912 127-153 zf-H2C2_2 PF13465 199-224 227-252 | SNAI2_MOUSE | snail family zinc finger 2 | SNAI2_HUMAN | Histone modification erase cofactor | # | # | # | # |
| SP1 | Pfam-B_20467 PB020467 61-148 Pfam-B_7620 PB007620 371-482 zf-C2H2 PF00096 626-650 686-708 zf-H2C2_2 PF13465 672-695 | SP1_MOUSE | Sp1 transcription factor | SP1_HUMAN | Chromatin remodelling TF TF | # TF activator TF repressor | CREST-BRG1 | DNA motif | # |
| SP100 | HMG_box PF00505 769-837 HMG_box_2 PF09011 684-753 Pfam-B_182547 PB182547 845-873 Pfam-B_41802 PB041802 151-337 SAND PF01342 595-676 Sp100 PF03172 47-150 | SP100_MOUSE | SP100 nuclear antigen | SP100_HUMAN | Chromatin remodelling cofactor | # | # | # | # |
| SP140 | Bromodomain PF00439 775-842 PHD PF00628 692-736 SAND PF01342 580-661 Sp100 PF03172 36-139 | # | SP140 nuclear body protein | SP140_HUMAN | Histone modification read TF | # # | # | H3 | # |
| SPEN | Pfam-B_1253 PB001253 981-1331 Pfam-B_17673 PB017673 621-899 Pfam-B_17985 PB017985 901-979 Pfam-B_2825 PB002825 1826-1859 RRM_1 PF00076 8-74 337-407 440-507 RRM_5 PF13893 533-587 SPOC PF07744 3509-3630 | MINT_MOUSE | spen family transcriptional repressor | MINT_HUMAN | Histone modification erase cofactor TF TF | Histone acetylation TF activator TF repressor | # | # | # |
| SPOP | BTB PF00651 190-297 MATH PF00917 38-163 | SPOP_MOUSE | speckle-type POZ protein | SPOP_HUMAN | Histone modification write | Histone ubiquitination | # | MacroH2A1 | MacroH2A1ub |
| SRCAP | HSA PF07529 125-196 Helicase_C PF00271 2077-2156 SNF2_N PF00176 621-907 | # | Snf2-related CREBBP activator protein | SRCAP_HUMAN | Chromatin remodelling Histone modification erase | # Histone acetylation | NuA4-related complex SRCAP | H2A.Z | # |
| SRSF1 | Pfam-B_5206 PB005206 192-246 RRM_1 PF00076 18-85 123-186 | SRSF1_MOUSE | serine/arginine-rich splicing factor 1 | SRSF1_HUMAN | RNA modification | # | # | # | # |
| SRSF3 | Pfam-B_13909 PB013909 131-162 RRM_1 PF00076 12-77 | SRSF3_MOUSE | serine/arginine-rich splicing factor 3 | SRSF3_HUMAN | RNA modification | # | # | # | # |
| SS18L1 | Pfam-B_16193 PB016193 365-394 Pfam-B_22298 PB022298 315-363 SSXT PF05030 11-76 | CREST_MOUSE | synovial sarcoma translocation gene on chromosome 18-like 1 | CREST_HUMAN | Chromatin remodelling | # | CREST-BRG1 | # | # |
| SS18L2 | SSXT PF05030 11-76 | S18L2_MOUSE | synovial sarcoma translocation gene on chromosome 18-like 2 | S18L2_HUMAN | Chromatin remodelling | # | # | # | # |
| SSRP1 | HMG_box PF00505 547-615 Pfam-B_9245 PB009245 1-73 Rtt106 PF08512 338-428 SSrecog PF03531 74-285 | SSRP1_MOUSE | structure specific recognition protein 1 | SSRP1_HUMAN | Chromatin remodelling | # | FACT | H3 H4 | # |
| STK4 | Mst1_SARAH PF11629 432-480 Pfam-B_12195 PB012195 341-431 Pkinase PF00069 30-281 | STK4_MOUSE | serine/threonine kinase 4 | STK4_HUMAN | Histone modification write | Histone phosphorylation | # | H2AS14 | H2BS14ph |
| SUDS3 | Sds3 PF08598 53-223 | SDS3_MOUSE | suppressor of defective silencing 3 homolog (S. cerevisiae) | SDS3_HUMAN | Histone modification erase cofactor | Histone acetylation | mSin3A | # | # |
| SUPT3H | TFIID-18kDa PF02269 106-198 | # | suppressor of Ty 3 homolog (S. cerevisiae) | SUPT3_HUMAN | Histone modification write cofactor | Histone acetylation | PCAF SAGA STAGA | # | # |
| SUPT6H | DLD PF14878 1050-1160 HHH_7 PF14635 935-1038 HTH_44 PF14641 300-437 Pfam-B_17741 PB017741 172-225 Pfam-B_27919 PB027919 129-149 S1 PF00575 1226-1282 SH2_2 PF14633 1295-1515 SPT6_acidic PF14632 35-128 YqgF PF14639 775-931 | SPT6H_MOUSE | suppressor of Ty 6 homolog (S. cerevisiae) | SPT6H_HUMAN | Histone modification erase cofactor | Histone methylation | # | # | # |
| SUPT7L | Bromo_TP PF07524 151-230 Pfam-B_18361 PB018361 301-379 Pfam-B_18885 PB018885 1-69 | ST65G_MOUSE | suppressor of Ty 7 (S. cerevisiae)-like | ST65G_HUMAN | Histone chaperone | # | TFTC-HAT STAGA | # | # |
| SUPT16H | FACT-Spt16_Nlob PF14826 5-168 Peptidase_M24 PF00557 181-411 Pfam-B_18241 PB018241 958-1024 Rtt106 PF08512 806-896 SPT16 PF08644 529-689 | SP16H_MOUSE | suppressor of Ty 16 homolog (S. cerevisiae) | SP16H_HUMAN | Histone modification read | # | WINAC FACT | H2A H2B | # |
| SUV39H1 | Chromo PF00385 43-92 Pre-SET PF05033 135-235 SET PF00856 255-366 | SUV91_MOUSE | suppressor of variegation 3-9 homolog 1 (Drosophila) | SUV91_HUMAN | Histone modification write Histone modification write | Histone methylation Histone phosphorylation | eNoSc | H3S10 H3K9me1 H4 | H3K9me3 |
| SUV39H2 | Chromo PF00385 47-96 Pre-SET PF05033 144-242 SET PF00856 262-373 | SUV92_MOUSE | suppressor of variegation 3-9 homolog 2 (Drosophila) | SUV92_HUMAN | Histone modification write | Histone methylation | # | H3K9me1 | H3K9me3 |
| SUV420H1 | Pfam-B_23340 PB023340 771-839 Pfam-B_24134 PB024134 711-769 Pfam-B_32221 PB032221 551-609 Pfam-B_49669 PB049669 841-883 SET PF00856 99-308 | SV421_MOUSE | suppressor of variegation 4-20 homolog 1 (Drosophila) | SV421_HUMAN | Histone modification write | Histone methylation | # | H4K20 | H4K20me3 |
| SUV420H2 | Pfam-B_18005 PB018005 261-379 Pfam-B_59617 PB059617 1-39 Pfam-B_6511 PB006511 381-460 SET PF00856 121-218 | SV422_MOUSE | suppressor of variegation 4-20 homolog 2 (Drosophila) | SV422_HUMAN | Histone modification write | Histone methylation | # | H4K20 | H4K20me3 |
| SUZ12 | VEFS-Box PF09733 544-681 | SUZ12_MOUSE | SUZ12 polycomb repressive complex 2 subunit | SUZ12_HUMAN | Histone modification write cofactor Histone modification write cofactor Polycomb group (PcG) protein TF | Histone methylation Histone ubiquitination # TF repressor | PRC2 | DNA motif | # |
| SYNCRIP | RRM_1 PF00076 164-232 245-312 340-402 | HNRPQ_MOUSE | synaptotagmin binding cytoplasmic RNA interacting protein | HNRPQ_HUMAN | RNA modification | mRNA editing | APOB_mRNA_editosome | mRNA | # |
| TADA1 | SAGA-Tad1 PF12767 3-195 | TADA1_MOUSE | transcriptional adaptor 1 | TADA1_HUMAN | Histone chaperone | # | STAGA | H2A | # |
| TADA2A | Myb_DNA-binding PF00249 72-118 SWIRM PF04433 362-442 | TAD2A_MOUSE | transcriptional adaptor 2A | TAD2A_HUMAN | Histone modification read TF | # TF activator | PCAF ATAC | H3 | # |
| TADA2B | Myb_DNA-binding PF00249 67-113 ZZ PF00569 6-47 | # | transcriptional adaptor 2B | TAD2B_HUMAN | Histone modification write cofactor | Histone acetylation | TFTC-HAT | # | # |
| TADA3 | Ada3 PF10198 308-432 | TADA3_MOUSE | transcriptional adaptor 3 | TADA3_HUMAN | Histone modification write cofactor | Histone acetylation | PCAF TFTC-HAT ATAC STAGA | # | # |
| TAF1 | Bromodomain PF00439 1389-1472 1509-1595 DUF3591 PF12157 565-1028 Pfam-B_10720 PB010720 311-366 TBP-binding PF09247 22-87 zf-CCHC_6 PF15288 1261-1300 | TAF1_MOUSE | TAF1 RNA polymerase II TATA box binding protein (TBP)-associated factor 250kDa | TAF1_HUMAN | Histone modification write | Histone acetylation | CHD8 MLL2/3 MLL4/WBP7 | H3 H4 | H3ac H4ac |
| TAF1L | Bromodomain PF00439 1408-1491 1528-1614 DUF3591 PF12157 584-1047 Pfam-B_10720 PB010720 330-385 TBP-binding PF09247 21-86 zf-CCHC_6 PF15288 1280-1319 | # | TAF1 RNA polymerase II TATA box binding protein (TBP)-associated factor 210kDa-like | TAF1L_HUMAN | Histone modification read | # | # | H1.4ac H2Aac H2Bac H3ac H4ac | # |
| TAF2 | Peptidase_M1 PF01433 21-406 Pfam-B_2101 PB002101 661-979 Pfam-B_21717 PB021717 1111-1159 Pfam-B_6210 PB006210 1161-1197 Pfam-B_8840 PB008840 981-1109 | TAF2_MOUSE | TAF2 RNA polymerase II TATA box binding protein (TBP)-associated factor 150kDa | TAF2_HUMAN | TF | # | TFTC-HAT | DNA motif | # |
| TAF3 | Bromo_TP PF07524 3-79 PHD PF00628 867-915 | TAF3_MOUSE | TAF3 RNA polymerase II TATA box binding protein (TBP)-associated factor 140kDa | TAF3_HUMAN | Histone modification read | # | # | H3K4me | # |
| TAF4 | Pfam-B_41790 PB041790 141-219 Pfam-B_7817 PB007817 411-499 Pfam-B_906 PB000906 1-139 TAF4 PF05236 834-1084 TAFH PF07531 590-688 | # | TAF4 RNA polymerase II TATA box binding protein (TBP)-associated factor 135kDa | TAF4_HUMAN | Histone chaperone | # | TFTC-HAT CHD8 MLL2/3 MLL4/WBP7 | # | # |
| TAF5 | Pfam-B_22190 PB022190 61-159 Pfam-B_34937 PB034937 1-59 TFIID_90kDa PF04494 199-338 WD40 PF00400 461-498 533-571 575-613 617-655 659-697 701-739 | TAF5_MOUSE | TAF5 RNA polymerase II TATA box binding protein (TBP)-associated factor 100kDa | TAF5_HUMAN | Histone modification write cofactor | Histone acetylation | TFTC-HAT | # | # |
| TAF5L | TFIID_90kDa PF04494 55-196 WD40 PF00400 259-296 332-370 375-412 416-454 458-496 500-538 | TAF5L_MOUSE | TAF5-like RNA polymerase II p300/CBP-associated factor (PCAF)-associated factor 65kDa | TAF5L_HUMAN | Histone modification write cofactor | Histone acetylation | PCAF TFTC-HAT STAGA | # | # |
| TAF6 | DUF1546 PF07571 308-399 Pfam-B_25920 PB025920 618-675 TAF PF02969 11-76 | TAF6_MOUSE | TAF6 RNA polymerase II TATA box binding protein (TBP)-associated factor 80kDa | TAF6_HUMAN | Histone chaperone | # | TFTC-HAT CHD8 MLL2/3 MLL4/WBP7 | # | # |
| TAF6L | DUF1546 PF07571 242-333 Pfam-B_32143 PB032143 200-239 Pfam-B_32396 PB032396 161-199 TAF PF02969 9-73 | TAF6L_MOUSE | TAF6-like RNA polymerase II p300/CBP-associated factor (PCAF)-associated factor 65kDa | TAF6L_HUMAN | Histone chaperone | # | PCAF TFTC-HAT STAGA | # | # |
| TAF7 | TAFII55_N PF04658 12-178 | TAF7_MOUSE | TAF7 RNA polymerase II TATA box binding protein (TBP)-associated factor 55kDa | TAF7_HUMAN | Histone modification write cofactor Histone modification write cofactor | Histone methylation Histone acetylation | CHD8 MLL2/3 MLL4/WBP7 | # | # |
| TAF8 | Bromo_TP PF07524 29-106 TAF8_C PF10406 144-194 | TAF8_MOUSE | TAF8 RNA polymerase II TATA box binding protein (TBP)-associated factor 43kDa | TAF8_HUMAN | Histone chaperone | # | # | # | # |
| TAF9 | TFIID-31kDa PF02291 2-130 | TAF9_MOUSE | TAF9 RNA polymerase II TATA box binding protein (TBP)-associated factor 32kDa | TAF9_HUMAN | Histone chaperone | # | PCAF STAGA CHD8 MLL2/3 MLL4/WBP7 | # | # |
| TAF9B | TFIID-31kDa PF02291 2-130 | TAF9B_MOUSE | TAF9B RNA polymerase II TATA box binding protein (TBP)-associated factor 31kDa | TAF9B_HUMAN | Histone chaperone | # | TFTC-HAT | # | # |
| TAF10 | TFIID_30kDa PF03540 128-178 | TAF10_MOUSE | TAF10 RNA polymerase II TATA box binding protein (TBP)-associated factor 30kDa | TAF10_HUMAN | Histone chaperone Histone modification write | # Histone acetylation | PCAF TFTC-HAT SAGA STAGA | H3 H4 | # |
| TAF12 | Pfam-B_25018 PB025018 1-58 TFIID_20kDa PF03847 59-126 | TAF12_MOUSE | TAF12 RNA polymerase II TATA box binding protein (TBP)-associated factor 20kDa | TAF12_HUMAN | Histone chaperone Histone modification write | # Histone acetylation | PCAF STAGA | # | # |
| TBL1XR1 | LisH PF08513 6-32 Pfam-B_2526 PB002526 471-510 WD40 PF00400 160-197 224-253 256-294 298-335 339-377 381-428 432-470 | TBL1R_MOUSE | transducin (beta)-like 1 X-linked receptor 1 | TBL1R_HUMAN | # | # | # | # | # |
| TDG | UDG PF03167 125-293 | TDG_MOUSE | thymine-DNA glycosylase | TDG_HUMAN | DNA modification | DNA hydroxymethylation | # | G:U G:T G:hmU | C 5mC 5hmC |
| TDRD3 | TUDOR PF00567 542-615 UBA PF00627 194-230 | TDRD3_MOUSE | tudor domain containing 3 | TDRD3_HUMAN | Histone modification read | # | # | H3R17me2a H4R3me2a | # |
| TDRD7 | OST-HTH PF12872 5-73 Pfam-B_27056 PB027056 101-149 TUDOR PF00567 459-581 648-775 908-1026 | TDRD7_MOUSE | tudor domain containing 7 | TDRD7_HUMAN | Histone modification read | # | # | H3K9 | # |
| TDRKH | KH_1 PF00013 54-115 126-190 Pfam-B_19308 PB019308 201-301 TUDOR PF00567 302-423 | TDRKH_MOUSE | tudor and KH domain containing | TDRKH_HUMAN | RNA modification | # | # | piRNA | # |
| TET1 | Pfam-B_12165 PB012165 2056-2134 Pfam-B_35074 PB035074 1-139 Pfam-B_6123 PB006123 782-815 Tet_JBP PF12851 1580-2052 zf-CXXC PF02008 583-624 | TET1_MOUSE | tet methylcytosine dioxygenase 1 | TET1_HUMAN | DNA modification | DNA hydroxymethylation | # | mC | hmC |
| TET2 | Pfam-B_32546 PB032546 930-1046 Pfam-B_34477 PB034477 1927-1975 Tet_JBP PF12851 1290-1905 | TET2_MOUSE | tet methylcytosine dioxygenase 2 | TET2_HUMAN | DNA modification | DNA hydroxymethylation | # | mC | hmC |
| TET3 | Pfam-B_188 PB000188 1613-1658 Pfam-B_19260 PB019260 1-109 Tet_JBP PF12851 850-1562 | TET3_MOUSE | tet methylcytosine dioxygenase 3 | TET3_HUMAN | DNA modification | DNA hydroxymethylation | # | mC | hmC |
| TEX10 | Ipi1_N PF12333 130-235 Pfam-B_18291 PB018291 611-869 | TEX10_MOUSE | testis expressed 10 | TEX10_HUMAN | Histone modification write cofactor Histone modification write cofactor | Histone methylation Histone acetylation | CHD8 MLL2/3 MLL4/WBP7 | # | # |
| TFDP1 | DP PF08781 200-344 E2F_TDP PF02319 111-193 | TFDP1_MOUSE | transcription factor Dp-1 | TFDP1_HUMAN | Histone modification | # | RING2-L3MBTL2 | # | # |
| TFPT | Pfam-B_10240 PB010240 10-162 Pfam-B_26015 PB026015 181-212 | TFPT_MOUSE | TCF3 (E2A) fusion partner (in childhood Leukemia) | TFPT_HUMAN | Chromatin remodelling cofactor DNA modification | # DNA hydroxymethylation | Ino80 | # | # |
| TLE1 | TLE_N PF03920 1-136 WD40 PF00400 477-511 523-558 565-602 606-644 689-726 736-767 | TLE1_MOUSE | transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) | TLE1_HUMAN | Chromatin remodelling Histone modification cofactor | # # | # | H3 | # |
| TLE2 | TLE_N PF03920 1-132 WD40 PF00400 450-484 538-575 579-617 661-699 709-740 | TLE2_MOUSE | transducin-like enhancer of split 2 | TLE2_HUMAN | Histone modification cofactor | # | # | H3 | H3K4 H3K9 H3K27me |
| TLE4 | TLE_N PF03920 8-141 WD40 PF00400 480-514 526-561 568-605 609-647 692-729 739-770 | TLE4_MOUSE | transducin-like enhancer of split 4 | TLE4_HUMAN | Histone modification erase cofactor TF | # # | # | H3ac H4ac | # |
| TLK1 | Pfam-B_2740 PB002740 1-109 Pfam-B_9699 PB009699 111-179 Pkinase PF00069 456-734 | TLK1_MOUSE | tousled-like kinase 1 | TLK1_HUMAN | Histone modification write | Histone phosphorylation | # | H3S10 | H3S10ph |
| TLK2 | Pfam-B_24604 PB024604 91-129 Pfam-B_3701 PB003701 1-89 Pkinase PF00069 462-741 | TLK2_MOUSE | tousled-like kinase 2 | TLK2_HUMAN | Histone modification write | Histone phosphorylation | # | # | # |
| TNP1 | TP1 PF02079 2-55 | STP1_MOUSE | transition protein 1 (during histone to protamine replacement) | STP1_HUMAN | Chromatin remodelling | # | # | # | # |
| TNP2 | TP2 PF01254 1-138 | STP2_MOUSE | transition protein 2 (during histone to protamine replacement) | STP2_HUMAN | Chromatin remodelling | # | # | # | # |
| TONSL | Ank PF00023 528-560 561-591 597-629 LRR_6 PF13516 1097-1121 Pfam-B_27656 PB027656 642-670 Pfam-B_51992 PB051992 204-263 TPR_11 PF13414 350-422 | TONSL_MOUSE | tonsoku-like DNA repair protein | TONSL_HUMAN | Chromatin remodelling | # | # | # | # |
| TOP2A | DNA_gyraseB PF00204 266-430 DNA_topoisoIV PF00521 713-1172 DTHCT PF08070 1435-1523 HATPase_c PF02518 77-224 Toprim PF01751 456-572 | TOP2A_MOUSE | topoisomerase (DNA) II alpha 170kDa | TOP2A_HUMAN | Chromatin remodelling | # | # | DNA | # |
| TOP2B | DNA_gyraseB PF00204 287-450 DNA_topoisoIV PF00521 734-1190 DTHCT PF08070 1508-1611 HATPase_c PF02518 98-245 Toprim PF01751 477-593 | TOP2B_MOUSE | topoisomerase (DNA) II beta 180kDa | TOP2B_HUMAN | Chromatin remodelling | # | WINAC | # | # |
| TP53 | P53 PF00870 95-289 P53_TAD PF08563 5-29 P53_tetramer PF07710 318-359 | P53_MOUSE | tumor protein p53 | P53_HUMAN | Histone modification write cofactor TF TF | Histone acetylation TF activator TF repressor | # | H3 | # |
| TP53BP1 | 53-BP1_Tudor PF09038 1483-1604 Pfam-B_14288 PB014288 1213-1356 Pfam-B_21507 PB021507 1-59 Pfam-B_24656 PB024656 1358-1386 Pfam-B_24892 PB024892 970-1000 Pfam-B_44 PB000044 528-565 Pfam-B_689 PB000689 567-698 Pfam-B_9132 PB009132 902-939 Pfam-B_9249 PB009249 1611-1967 | TP53B_MOUSE | tumor protein p53 binding protein 1 | TP53B_HUMAN | Histone modification read | # | # | H4K79me2 H4K20me2 | # |
| TRIM16 | PRY PF13765 375-424 Pfam-B_10855 PB010855 281-339 SPRY PF00622 426-551 zf-B_box PF00643 126-165 | TRI16_MOUSE | tripartite motif containing 16 | TRI16_HUMAN | Histone modification write | Histone acetylation | # | # | # |
| TRIM24 | Bromodomain PF00439 908-992 PHD PF00628 828-873 Pfam-B_14213 PB014213 595-656 Pfam-B_4946 PB004946 372-591 zf-B_box PF00643 158-205 218-259 | TIF1A_MOUSE | tripartite motif containing 24 | TIF1A_HUMAN | Histone modification read | # | # | H3K4 H3K23ac | # |
| TRIM27 | PRY PF13765 318-366 SPRY PF00622 368-493 zf-B_box PF00643 91-132 zf-C3HC4 PF00097 16-56 | TRI27_MOUSE | tripartite motif containing 27 | TRI27_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| TRIM28 | PHD PF00628 627-672 zf-B_box PF00643 148-195 204-245 zf-RING_5 PF14634 64-122 | TIF1B_MOUSE | tripartite motif containing 28 | TIF1B_HUMAN | Histone modification read | # | # | H3 | # |
| TRIM33 | Bromodomain PF00439 966-1051 PHD PF00628 889-933 Pfam-B_10963 PB010963 664-696 Pfam-B_11449 PB011449 608-663 Pfam-B_11628 PB011628 535-606 zf-B_box PF00643 212-258 271-312 zf-RING_2 PF13639 123-185 | TRI33_MOUSE | tripartite motif containing 33 | TRI33_HUMAN | Histone modification read | # | # | H3K9me3 H3K18ac | # |
| TRRAP | FAT PF02259 2849-3204 PI3_PI4_kinase PF00454 3526-3783 Pfam-B_11387 PB011387 1471-1587 Pfam-B_12811 PB012811 141-238 Pfam-B_15427 PB015427 1-139 Pfam-B_3253 PB003253 1858-1890 1946-2001 Pfam-B_6491 PB006491 1589-1667 Pfam-B_6680 PB006680 2445-2544 | TRRAP_MOUSE | transformation/transcription domain-associated protein | TRRAP_HUMAN | Histone modification write cofactor | Histone acetylation | SWR PCAF TFTC-HAT NuA4 SAGA NuA4-related complex STAGA | # | # |
| TSSK6 | Pkinase PF00069 12-267 | TSSK6_MOUSE | testis-specific serine kinase 6 | TSSK6_HUMAN | Histone modification write | Histone phosphorylation | # | H1 H2A H2AX H3 | # |
| TTK | Pfam-B_2743 PB002743 1-291 Pkinase PF00069 525-791 | TTK_MOUSE | TTK protein kinase | TTK_HUMAN | Histone modification write cofactor | Histone phosphorylation | # | H2AT120 | H2AT120ph |
| TYW5 | Cupin_8 PF13621 16-256 | TYW5_MOUSE | tRNA-yW synthesizing protein 5 | TYW5_HUMAN | RNA modification | # | # | # | # |
| UBE2A | UQ_con PF00179 8-145 | UBE2A_MOUSE | ubiquitin-conjugating enzyme E2A | UBE2A_HUMAN | Histone modification write | Histone ubiquitination | # | H2A H2BK120 | H2BK120ub1 |
| UBE2B | UQ_con PF00179 8-145 | UBE2B_MOUSE | ubiquitin-conjugating enzyme E2B | UBE2B_HUMAN | Histone modification write | Histone ubiquitination | # | H2A H2BK121 | H2BK120ub2 |
| UBE2D1 | UQ_con PF00179 5-142 | UB2D1_MOUSE | ubiquitin-conjugating enzyme E2D 1 | UB2D1_HUMAN | Histone modification write | Histone ubiquitination | # | H2BK48 | H2BK48ub |
| UBE2D3 | UQ_con PF00179 5-142 | UB2D3_MOUSE | ubiquitin-conjugating enzyme E2D 3 | UB2D3_HUMAN | Histone modification write | Histone ubiquitination | # | H2AK119 | H2AK119ub |
| UBE2E1 | UQ_con PF00179 51-188 | UB2E1_MOUSE | ubiquitin-conjugating enzyme E2E 1 | UB2E1_HUMAN | Histone modification write | Histone ubiquitination | # | H2BK120 | H2BK120ub |
| UBE2H | UQ_con PF00179 9-145 | UBE2H_MOUSE | ubiquitin-conjugating enzyme E2H | UBE2H_HUMAN | Histone modification write | Histone ubiquitination | # | H2A H2B | H2Aub H2Bub |
| UBE2N | UQ_con PF00179 7-144 | UBE2N_MOUSE | ubiquitin-conjugating enzyme E2N | UBE2N_HUMAN | Histone modification write | Histone ubiquitination | # | H2AX | H2AXub |
| UBE2T | UQ_con PF00179 6-147 | UBE2T_MOUSE | ubiquitin-conjugating enzyme E2T (putative) | UBE2T_HUMAN | Histone modification write | Histone ubiquitination | # | # | # |
| UBN1 | HUN PF08729 115-169 UBN_AB PF14075 353-575 | UBN1_MOUSE | ubinuclein 1 | UBN1_HUMAN | Histone modification write cofactor | Histone methylation | # | # | # |
| UBR2 | ClpS PF02617 221-302 Pfam-B_10464 PB010464 668-730 Pfam-B_14814 PB014814 1413-1491 Pfam-B_15951 PB015951 1298-1365 Pfam-B_2665 PB002665 1020-1065 zf-UBR PF02207 97-167 | UBR2_MOUSE | ubiquitin protein ligase E3 component n-recognin 2 | UBR2_HUMAN | Histone modification write | Histone ubiquitination | # | H2A | # |
| UBR5 | E3_UbLigase_EDD PF11547 178-230 HECT PF00632 2497-2799 PABP PF00658 2376-2449 Pfam-B_10556 PB010556 1381-1499 Pfam-B_14783 PB014783 601-649 Pfam-B_18259 PB018259 22-174 Pfam-B_5733 PB005733 1011-1149 Pfam-B_664 PB000664 651-1009 Pfam-B_8293 PB008293 1591-1748 Pfam-B_8878 PB008878 1249-1379 zf-UBR PF02207 1177-1248 | UBR5_MOUSE | ubiquitin protein ligase E3 component n-recognin 5 | UBR5_HUMAN | Chromatin remodelling Histone modification write cofactor | # Histone ubiquitination | # | H2A H2AX | H2Aub H2AXub |
| UBR7 | Pfam-B_38998 PB038998 361-423 zf-UBR PF02207 44-115 | UBR7_MOUSE | ubiquitin protein ligase E3 component n-recognin 7 (putative) | UBR7_HUMAN | DNA modification cofactor | DNA methylation | # | # | # |
| UCHL5 | Peptidase_C12 PF01088 7-211 | UCHL5_MOUSE | ubiquitin carboxyl-terminal hydrolase L5 | UCHL5_HUMAN | Histone modification erase cofactor | Histone ubiquitination | Ino80 | # | # |
| UHRF1 | DUF3590 PF12148 140-236 PHD PF00628 317-366 SAD_SRA PF02182 415-586 ubiquitin PF00240 6-76 | UHRF1_MOUSE | ubiquitin-like with PHD and ring finger domains 1 | UHRF1_HUMAN | Histone modification read Histone modification write cofactor | Histone ubiquitination # | # | H3K9me3 H3R2 H3 mCG | H3ub |
| UHRF2 | DUF3590 PF12148 177-261 PHD PF00628 346-395 SAD_SRA PF02182 444-616 ubiquitin PF00240 6-76 | UHRF2_MOUSE | ubiquitin-like with PHD and ring finger domains 2 E3 ubiquitin protein ligase | UHRF2_HUMAN | Histone modification read | # | # | H3K9me3 mCG | # |
| UIMC1 | Pfam-B_20901 PB020901 471-524 | UIMC1_MOUSE | ubiquitin interaction motif containing 1 | UIMC1_HUMAN | Histone modification read | # | BRCA1-A | H2AK63ub H2AXK63ub H2BK63ub | # |
| USP3 | UCH PF00443 158-508 zf-UBP PF02148 29-107 | UBP3_MOUSE | ubiquitin specific peptidase 3 | UBP3_HUMAN | Histone modification write | Histone ubiquitination | # | H2Aub H2Bub | H2A H2B |
| USP7 | MATH PF00917 56-197 Pfam-B_12182 PB012182 591-618 Pfam-B_45828 PB045828 1-39 UCH PF00443 213-518 USP7_C2 PF14533 874-1088 USP7_ICP0_bdg PF12436 619-865 | UBP7_MOUSE | ubiquitin specific peptidase 7 (herpes virus-associated) | UBP7_HUMAN | Histone modification erase DNA modification cofactor | Histone ubiquitination DNA methylation | BCOR | H2Bub | H2B |
| USP11 | DUSP PF06337 99-185 Pfam-B_176820 PB176820 1-47 UCH PF00443 308-927 Ubiquitin_3 PF14836 198-285 | UBP11_MOUSE | ubiquitin specific peptidase 11 | UBP11_HUMAN | Histone modification erase cofactor | Histone ubiquitination | # | # | # |
| USP12 | UCH PF00443 38-366 | UBP12_MOUSE | ubiquitin specific peptidase 12 | UBP12_HUMAN | Histone modification erase | Histone ubiquitination | # | H2Aub | H2A |
| USP15 | DUSP PF06337 27-119 UCH PF00443 288-930 USP7_C2 PF14533 459-614 Ubiquitin_3 PF14836 135-222 | UBP15_MOUSE | ubiquitin specific peptidase 15 | UBP15_HUMAN | Histone modification erase | Histone ubiquitination | # | H2BK120ub | H2BK120 |
| USP16 | UCH PF00443 195-819 zf-UBP PF02148 48-128 | UBP16_MOUSE | ubiquitin specific peptidase 16 | UBP16_HUMAN | Histone modification erase | Histone ubiquitination | # | H2Aub | H2A |
| USP17L2 | HABP4_PAI-RBP1 PF04774 374-458 Pfam-B_24444 PB024444 1-39 UCH PF00443 79-372 | U17PE_MOUSE | ubiquitin specific peptidase 17-like family member 2 | U17L2_HUMAN | Histone modification erase cofactor | Histone ubiquitination | # | # | # |
| USP21 | UCH PF00443 211-555 | UBP21_MOUSE | ubiquitin specific peptidase 21 | UBP21_HUMAN | Histone modification erase | Histone ubiquitination | # | H2Aub | H2A |
| USP22 | UCH PF00443 175-517 zf-UBP PF02148 63-124 | UBP22_MOUSE | ubiquitin specific peptidase 22 | UBP22_HUMAN | Histone modification write cofactor | Histone ubiquitination | SAGA | H2Aub H2Bub | H2A H2B |
| USP36 | Pfam-B_17191 PB017191 1088-1118 Pfam-B_20267 PB020267 1065-1087 UCH PF00443 121-420 | UBP36_MOUSE | ubiquitin specific peptidase 36 | UBP36_HUMAN | Histone modification write cofactor | Histone ubiquitination | # | H2Bub | H2B |
| USP44 | UCH PF00443 272-675 zf-UBP PF02148 29-91 | UBP44_MOUSE | ubiquitin specific peptidase 44 | UBP44_HUMAN | Histone modification erase | Histone ubiquitination | # | H2Bub1 | H2B |
| USP46 | UCH PF00443 34-362 | UBP46_MOUSE | ubiquitin specific peptidase 46 | UBP46_HUMAN | Histone modification erase | Histone ubiquitination | # | H2Aub | H2A |
| USP49 | UCH PF00443 252-654 zf-UBP PF02148 20-88 | UBP49_MOUSE | ubiquitin specific peptidase 49 | UBP49_HUMAN | Histone modification erase | Histone ubiquitination | # | H2Bub | H2B |
| UTY | JmjC PF02373 1080-1188 Pfam-B_2066 PB002066 1-49 Pfam-B_604 PB000604 580-716 Pfam-B_972 PB000972 718-1056 TPR_1 PF00515 127-160 315-348 349-377 TPR_17 PF13431 269-301 TPR_8 PF13181 202-233 | UTY_MOUSE | ubiquitously transcribed tetratricopeptide repeat containing Y-linked | UTY_HUMAN | Histone modification erase | Histone ubiquitination | # | H3K27me | # |
| VDR | Hormone_recep PF00104 209-418 zf-C4 PF00105 22-91 | VDR_MOUSE | vitamin D (1 25- dihydroxyvitamin D3) receptor | VDR_HUMAN | Chromatin remodelling cofactor TF | # # | # | H2BK12ac H3K14ac H4K16ac | # |
| VPS72 | YL1 PF05764 4-218 YL1_C PF08265 290-319 | VPS72_MOUSE | vacuolar protein sorting 72 homolog (S. cerevisiae) | VPS72_HUMAN | Histone modification write cofactor | Histone acetylation | NuA4 NuA4-related complex | # | # |
| VRK1 | Pkinase PF00069 37-325 | VRK1_MOUSE | vaccinia related kinase 1 | VRK1_HUMAN | Histone modification write | Histone phosphorylation | # | H3S10 H3T3 | H3S10ph H3T3ph |
| WAC | WW PF00397 131-160 | WAC_MOUSE | WW domain containing adaptor with coiled-coil | WAC_HUMAN | Histone modification write cofactor | Histone ubiquitination | # | # | # |
| WDR5 | WD40 PF00400 36-73 77-115 119-157 161-199 203-242 246-287 291-331 | WDR5_MOUSE | WD repeat domain 5 | WDR5_HUMAN | Histone modification read | # | ATAC NSL RING2-L3MBTL2 COMPASS Menin-associated_HMT MLL-HCF CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 COMPASS-like MLL3 4 | H3K4 H3K4me1 H3K4me2 H3K4me3 | # |
| WDR77 | Pfam-B_26289 PB026289 1-49 WD40 PF00400 117-153 157-196 245-284 | MEP50_MOUSE | WD repeat domain 77 | MEP50_HUMAN | Histone modification write | Histone methylation | methylosome | H2A H4 | H2Ame H4me |
| WDR82 | WD40 PF00400 12-49 97-135 245-267 273-304 | WDR82_MOUSE | WD repeat domain 82 | WDR82_HUMAN | Histone modification write cofactor | Histone methylation | COMPASS | # | # |
| WHSC1 | HMG_box PF00505 455-508 PHD PF00628 833-875 PWWP PF00855 220-332 878-968 SET PF00856 1074-1180 | NSD2_MOUSE | Wolf-Hirschhorn syndrome candidate 1 | NSD2_HUMAN | Histone modification write | Histone methylation | # | H3K27 | H3K27me |
| WHSC1L1 | PWWP PF00855 268-378 958-1047 Pfam-B_7848 PB007848 619-671 SET PF00856 1156-1262 | NSD3_MOUSE | Wolf-Hirschhorn syndrome candidate 1-like 1 | NSD3_HUMAN | Chromatin remodelling cofactor TF | # # | # | H3K4 H3K27 | # |
| WSB2 | Pfam-B_17306 PB017306 1-52 SOCS_box PF07525 366-402 WD40 PF00400 83-139 143-182 187-225 229-267 288-321 337-361 | WSB2_MOUSE | WD repeat and SOCS box containing 2 | WSB2_HUMAN | Histone modification write | Histone ubiquitination | # | # | # |
| YAF2 | zf-RanBP PF00641 20-46 | YAF2_MOUSE | YY1 associated factor 2 | YAF2_HUMAN | Chromatin remodelling cofactor | # | BCOR RING2-L3MBTL2 RING2-FBRS | # | # |
| YEATS2 | Pfam-B_10841 PB010841 976-1072 Pfam-B_13347 PB013347 678-756 Pfam-B_19332 PB019332 758-854 YEATS PF03366 231-314 | YETS2_MOUSE | YEATS domain containing 2 | YETS2_HUMAN | Histone chaperone | # | ATAC | # | # |
| YEATS4 | YEATS PF03366 44-126 | YETS4_MOUSE | YEATS domain containing 4 | YETS4_HUMAN | Histone modification write cofactor | Histone acetylation | NuA4 NuA4-related complex SRCAP | # | # |
| YWHAB | 14-3-3 PF00244 5-238 | 1433B_MOUSE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta | 1433B_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| YWHAE | 14-3-3 PF00244 4-239 | 1433E_MOUSE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon | 1433E_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| YWHAZ | 14-3-3 PF00244 3-236 | 1433Z_MOUSE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | 1433Z_HUMAN | Histone modification read | # | # | H3 | # |
| YY1 | zf-C2H2 PF00096 383-407 zf-H2C2_2 PF13465 339-365 | TYY1_MOUSE | YY1 transcription factor | TYY1_HUMAN | Chromatin remodelling cofactor TF | # TF repressor | Ino80 | DNA motif | # |
| ZBTB7C | BTB PF00651 24-130 zf-H2C2_2 PF13465 379-403 406-431 434-459 | ZBT7C_MOUSE | zinc finger and BTB domain containing 7C | ZBT7C_HUMAN | Histone modification cofactor | # | # | # | # |
| ZBTB16 | BTB PF00651 24-126 zf-C2H2 PF00096 491-512 630-652 zf-C2H2_4 PF13894 432-455 zf-C2H2_6 PF13912 460-486 zf-H2C2_2 PF13465 532-556 560-584 588-612 | # | zinc finger and BTB domain containing 16 | ZBT16_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| ZBTB33 | BTB PF00651 22-118 zf-H2C2_2 PF13465 508-532 537-561 | KAISO_MOUSE | zinc finger and BTB domain containing 33 | KAISO_HUMAN | Histone modification write cofactor Histone modification erase cofactor TF | Histone acetylation Histone methylation TF repressor | # | CG mCG DNA motif | # |
| ZCWPW1 | PWWP PF00855 315-411 Pfam-B_36867 PB036867 512-557 zf-CW PF07496 254-303 | ZCPW1_MOUSE | zinc finger CW type with PWWP domain 1 | ZCPW1_HUMAN | Histone modification read | # | # | H3K4me | # |
| ZFP57 | KRAB PF01352 16-56 zf-C2H2 PF00096 91-113 175-197 zf-C2H2_4 PF13894 300-323 329-351 356-377 zf-H2C2_2 PF13465 133-156 | ZFP57_MOUSE | ZFP57 zinc finger protein | ZFP57_HUMAN | TF | TF repressor | # | mC DNA motif | # |
| ZGPAT | G-patch PF01585 333-376 | ZGPAT_MOUSE | zinc finger CCCH-type with G patch domain | ZGPAT_HUMAN | TF | TF repressor | # | DNA motif | # |
| ZHX1 | Homeobox PF00046 297-339 467-521 573-623 665-717 Homez PF11569 776-827 Pfam-B_22595 PB022595 1-37 | ZHX1_MOUSE | zinc fingers and homeoboxes 1 | ZHX1_HUMAN | Chromatin remodelling Histone modification write cofactor Histone modification write cofactor | # Histone acetylation Histone methylation | # | # | # |
| ZMYM2 | DUF3504 PF12012 1190-1361 Pfam-B_10252 PB010252 941-1179 Pfam-B_2297 PB002297 1-159 zf-FCS PF06467 323-363 365-409 417-456 459-502 528-570 576-616 631-671 719-758 760-799 | ZMYM2_MOUSE | zinc finger MYM-type 2 | ZMYM2_HUMAN | Histone modification erase cofactor TF | Histone acetylation # | BHC LSD-CoREST | DNA motif | # |
| ZMYM3 | DUF3504 PF12012 1183-1354 Pfam-B_2297 PB002297 1-189 Pfam-B_24258 PB024258 191-229 Pfam-B_5192 PB005192 1100-1142 zf-FCS PF06467 304-343 345-389 402-440 443-488 490-532 538-578 583-623 626-664 671-710 712-751 | ZMYM3_MOUSE | zinc finger MYM-type 3 | ZMYM3_HUMAN | Histone modification erase cofactor | Histone acetylation | BHC | # | # |
| ZMYND8 | Bromodomain PF00439 157-240 DUF3544 PF12064 412-622 PHD PF00628 90-133 PWWP PF00855 275-349 zf-MYND PF01753 1028-1062 | # | zinc finger MYND-type containing 8 | PKCB1_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| ZMYND11 | Bromodomain PF00439 122-203 PWWP PF00855 238-313 Pfam-B_7883 PB007883 342-530 Pfam-B_8532 PB008532 532-560 | ZMY11_MOUSE | zinc finger MYND-type containing 11 | ZMY11_HUMAN | Histone modification read | Histone methylation | # | H3.3K36me3 | # |
| ZNF217 | Pfam-B_30131 PB030131 913-979 zf-C2H2 PF00096 128-150 156-178 zf-C2H2_4 PF13894 65-88 216-239 375-398 zf-H2C2_2 PF13465 485-510 | # | zinc finger protein 217 | ZN217_HUMAN | Histone modification erase cofactor TF | Histone acetylation TF repressor | BHC LSD-CoREST | # | # |
| ZNF516 | zf-C2H2 PF00096 248-270 276-298 1098-1120 zf-C2H2_4 PF13894 174-197 zf-H2C2_2 PF13465 48-73 | ZN516_MOUSE | zinc finger protein 516 | ZN516_HUMAN | Histone modification erase cofactor TF | Histone acetylation TF repressor | LSD-CoREST | # | # |
| ZNF532 | Pfam-B_17557 PB017557 601-719 Pfam-B_19362 PB019362 831-959 zf-C2H2 PF00096 1265-1286 | ZN532_MOUSE | zinc finger protein 532 | ZN532_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| ZNF541 | ELM2 PF01448 1074-1131 Pfam-B_17081 PB017081 567-665 Pfam-B_27795 PB027795 956-1034 Pfam-B_3685 PB003685 772-954 Pfam-B_40457 PB040457 1171-1225 zf-C2H2 PF00096 168-190 zf-C2H2_4 PF13894 140-163 196-221 | ZN541_MOUSE | zinc finger protein 541 | ZN541_HUMAN | Chromatin remodelling | # | # | # | # |
| ZNF592 | Pfam-B_21220 PB021220 499-547 Pfam-B_27046 PB027046 771-913 Pfam-B_379 PB000379 1-97 zf-C2H2 PF00096 1013-1036 1043-1069 | ZN592_MOUSE | zinc finger protein 592 | ZN592_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| ZNF687 | zf-C2H2 PF00096 1200-1222 zf-C2H2_4 PF13894 858-881 963-986 993-1016 | ZN687_MOUSE | zinc finger protein 687 | ZN687_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| ZNF711 | Pfam-B_16491 PB016491 1-63 Zfx_Zfy_act PF04704 64-368 zf-C2H2 PF00096 383-405 zf-C2H2_4 PF13894 562-583 733-756 zf-H2C2_2 PF13465 490-516 519-543 604-630 690-715 zf-H2C2_5 PF13909 414-437 647-671 | ZN711_MOUSE | zinc finger protein 711 | ZN711_HUMAN | Histone modification erase cofactor | Histone acetylation | # | # | # |
| ZNHIT1 | zf-HIT PF04438 113-142 | ZNHI1_MOUSE | zinc finger HIT-type containing 1 | ZNHI1_HUMAN | Chromatin remodelling cofactor Histone modification erase cofactor | # Histone acetylation | SRCAP | # | # |
| ZRANB3 | HNH PF01844 1009-1051 Helicase_C PF00271 357-435 Pfam-B_14328 PB014328 729-854 SNF2_N PF00176 40-326 zf-RanBP PF00641 621-650 | ZRAB3_MOUSE | zinc finger RAN-binding domain containing 3 | ZRAB3_HUMAN | Chromatin remodelling Histone modification read cofactor | # Histone methylation | # | # | # |
| ZZZ3 | Myb_DNA-binding PF00249 652-703 Pfam-B_19065 PB019065 361-439 Pfam-B_22505 PB022505 211-359 ZZ PF00569 817-865 | ZZZ3_MOUSE | zinc finger ZZ-type containing 3 | ZZZ3_HUMAN | Histone modification read | # | ATAC | # | # |
