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employee Data
1HGNC approved symbol Pfam domains UniProt ID (mouse) HGNC approved name UniProt ID (human) Function Modification Protein complex Target entity Product
2# LEDGF PF11467 472-578 PWWP PF00855 5-87 Pfam-B_32406 PB032406 111-159 HDGR2_MOUSE # HDGR2_HUMAN Histone modification read # # H3K79me3 H4K20me3 H3K36me3 #
3A1CF DND1_DSRM PF14709 445-523 RRM_1 PF00076 58-127 138-203 RRM_6 PF14259 233-297 A1CF_MOUSE APOBEC1 complementation factor A1CF_HUMAN RNA modification RNA deamination APOB_mRNA_editosome mRNA mC U
4ACTB Actin PF00022 2-375 ACTB_MOUSE actin beta ACTB_HUMAN Chromatin remodelling cofactor # BAF nBAF npBAF PBAF SWI/SNF-like EPAFB bBAF SWI/SNF BRM-BRG1 NuA4 NuA4-related complex # #
5ACTL6A Actin PF00022 8-429 ACL6A_MOUSE actin-like 6A ACL6A_HUMAN Chromatin remodelling cofactor # BAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB SWI/SNF BRM-BRG1 Ino80 NuA4 NuA4-related complex SRCAP # #
6ACTL6B Actin PF00022 8-426 ACL6B_MOUSE actin-like 6B ACL6B_HUMAN Chromatin remodelling cofactor # BAF nBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF BRM-BRG1 # #
7ACTR3B Actin PF00022 3-412 ARP3B_MOUSE ARP3 actin-related protein 3 homolog B (yeast) ARP3B_HUMAN Chromatin remodelling # # H2A H3 H4 #
8ACTR5 Actin PF00022 30-570 ARP5_MOUSE ARP5 actin-related protein 5 homolog (yeast) ARP5_HUMAN Chromatin remodelling # Ino80 # #
9ACTR6 Actin PF00022 1-395 ARP6_MOUSE ARP6 actin-related protein 6 homolog (yeast) ARP6_HUMAN Chromatin remodelling cofactor # SRCAP # #
10ACTR8 Actin PF00022 43-621 ARP8_MOUSE ARP8 actin-related protein 8 homolog (yeast) ARP8_HUMAN Histone modification read # Ino80 # #
11ADNP Homeobox PF00046 765-813 Pfam-B_10803 PB010803 691-762 Pfam-B_21724 PB021724 921-1100 Pfam-B_29916 PB029916 615-646 ADNP_MOUSE activity-dependent neuroprotector homeobox ADNP_HUMAN Chromatin remodelling cofactor # # # #
12AEBP2 Pfam-B_22101 PB022101 1-79 Pfam-B_8048 PB008048 401-515 zf-H2C2_2 PF13465 315-341 AEBP2_MOUSE AE binding protein 2 AEBP2_HUMAN Histone modification write cofactor Histone methylation PRC2 # #
13AICDA APOBEC_N PF08210 11-181 AICDA_MOUSE activation-induced cytidine deaminase AICDA_HUMAN DNA modification DNA demethylation APOB_mRNA_editosome ssDNA hmC hmU
14AIRE PHD PF00628 298-343 Pfam-B_9104 PB009104 481-543 SAND PF01342 189-249 Sp100 PF03172 1-106 AIRE_MOUSE autoimmune regulator AIRE_HUMAN Histone modification read TF # # # H3K4 H3K4me3 DNA motif #
15ALKBH1 2OG-FeII_Oxy_2 PF13532 98-344 ALKB1_MOUSE alkB alkylation repair homolog 1 (E. coli) ALKB1_HUMAN Histone modification # # H2A #
16ANKRD32 Ank_2 PF12796 783-871 845-931 Pfam-B_101142 PB101142 932-1056 Pfam-B_12624 PB012624 231-430 Pfam-B_18156 PB018156 1-229 Pfam-B_81366 PB081366 641-782 ANR32_MOUSE ankyrin repeat domain 32 ANR32_HUMAN Histone modification read # # H2AXS139 #
17ANP32A LRR_9 PF14580 17-166 AN32A_MOUSE acidic (leucine-rich) nuclear phosphoprotein 32 family member A AN32A_HUMAN Chromatin remodelling cofactor # # # #
18ANP32B LRR_4 PF12799 88-136 Pfam-B_30686 PB030686 171-249 AN32B_MOUSE acidic (leucine-rich) nuclear phosphoprotein 32 family member B AN32B_HUMAN Histone chaperone # # H3 H4 #
19ANP32E LRR_4 PF12799 88-133 LRR_8 PF13855 65-125 Pfam-B_38005 PB038005 215-262 Pfam-B_94319 PB094319 171-200 AN32E_MOUSE acidic (leucine-rich) nuclear phosphoprotein 32 family member E AN32E_HUMAN Histone chaperone Histone modification read # # SWR H2A.Z #
20APBB1 PID PF00640 370-509 543-664 Pfam-B_23321 PB023321 1-215 WW PF00397 255-283 APBB1_MOUSE amyloid beta (A4) precursor protein-binding family B member 1 (Fe65) APBB1_HUMAN Histone modification # # H2AX #
21APEX1 Exo_endo_phos PF03372 65-309 Pfam-B_21616 PB021616 1-39 APEX1_MOUSE APEX nuclease (multifunctional DNA repair enzyme) 1 APEX1_HUMAN DNA modification cofactor DNA demethylation # # #
22APOBEC1 APOBEC_N PF08210 17-186 ABEC1_MOUSE apolipoprotein B mRNA editing enzyme catalytic polypeptide 1 ABEC1_HUMAN DNA modification RNA modification DNA demethylation mRNA editing APOB_mRNA_editosome ssDNA mRNA mC U
23APOBEC2 APOBEC_C PF05240 159-216 Pfam-B_38491 PB038491 1-39 ABEC2_MOUSE apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 2 ABEC2_HUMAN DNA modification RNA modification DNA demethylation mRNA editing # ssDNA mRNA mC hmU
24APOBEC3A APOBEC_C PF05240 133-187 # apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3A ABC3A_HUMAN DNA modification RNA modification DNA demethylation mRNA editing # ssDNA mRNA mC dhU
25APOBEC3B APOBEC_C PF05240 316-370 APOBEC_N PF08210 11-190 ABEC3_MOUSE apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3B ABC3B_HUMAN DNA modification RNA modification DNA demethylation mRNA editing # ssDNA mRNA mC dhU
26APOBEC3C APOBEC_C PF05240 128-182 # apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3C ABC3C_HUMAN DNA modification RNA modification DNA demethylation mRNA editing # ssDNA mRNA mC dhU
27APOBEC3D APOBEC_C PF05240 140-194 324-378 # apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3D ABC3D_HUMAN DNA modification RNA modification DNA demethylation mRNA editing # ssDNA mRNA mC dhU
28APOBEC3F APOBEC_N PF08210 3-189 199-373 # apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3F ABC3F_HUMAN DNA modification RNA modification DNA demethylation mRNA editing APOB_mRNA_editosome ssDNA mRNA mC dhU
29APOBEC3G APOBEC_N PF08210 3-182 202-380 # apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G ABC3G_HUMAN DNA modification RNA modification DNA demethylation mRNA editing APOB_mRNA_editosome ssDNA mRNA mC dhU
30APOBEC3H APOBEC_C PF05240 116-174 dCMP_cyt_deam_1 PF00383 24-99 # apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3H ABC3H_HUMAN DNA modification RNA modification DNA demethylation mRNA editing APOB_mRNA_editosome ssDNA mRNA mC dhU
31ARID1A ARID PF01388 1015-1104 DUF3518 PF12031 1975-2231 Pfam-B_16906 PB016906 451-499 Pfam-B_1854 PB001854 281-379 ARI1A_MOUSE AT rich interactive domain 1A (SWI-like) ARI1A_HUMAN Chromatin remodelling cofactor # BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm WINAC bBAF SWI/SNF BRM-BRG1 DNA motif #
32ARID1B ARID PF01388 1050-1140 DUF3518 PF12031 1926-2182 Pfam-B_60945 PB060945 291-369 Pfam-B_7257 PB007257 371-449 # AT rich interactive domain 1B (SWI1-like) ARI1B_HUMAN Histone modification write Histone ubiquitination BAF nBAF npBAF PBAF SWI/SNF-like_EPAFa SWI/SNF-like EPAFB SWI/SNF BRM-BRG1 H2BK120 DNA motif #
33ARID2 ARID PF01388 10-101 Pfam-B_11884 PB011884 1660-1747 Pfam-B_14804 PB014804 1051-1098 Pfam-B_649 PB000649 1529-1658 Pfam-B_6603 PB006603 1239-1268 RFX_DNA_binding PF02257 517-604 # AT rich interactive domain 2 (ARID RFX-like) ARID2_HUMAN Chromatin remodelling cofactor # PBAF DNA motif #
34ARID4A ARID PF01388 306-397 Pfam-B_1988 PB001988 1071-1111 1166-1240 RBB1NT PF08169 168-263 Tudor-knot PF11717 573-630 # AT rich interactive domain 4A (RBP1-like) ARI4A_HUMAN Histone modification write cofactor Histone acetylation mSin3A DNA motif #
35ARID4B ARID PF01388 304-394 Pfam-B_15110 PB015110 771-828 RBB1NT PF08169 166-264 Tudor-knot PF11717 569-626 ARI4B_MOUSE AT rich interactive domain 4B (RBP1-like) ARI4B_HUMAN Histone modification write cofactor Histone acetylation mSin3A DNA motif #
36ARNTL HLH PF00010 73-126 PAS PF00989 146-253 PAS_11 PF14598 337-444 Pfam-B_2781 PB002781 455-619 BMAL1_MOUSE aryl hydrocarbon receptor nuclear translocator-like BMAL1_HUMAN Histone modification write cofactor TF # TF activator # # #
37ARRB1 Arrestin_C PF02752 193-356 Arrestin_N PF00339 18-174 ARRB1_MOUSE arrestin beta 1 ARRB1_HUMAN Histone modification # # # #
38ASF1A ASF1_hist_chap PF04729 1-154 ASF1A_MOUSE anti-silencing function 1A histone chaperone ASF1A_HUMAN Histone chaperone # # H3 H4 #
39ASF1B ASF1_hist_chap PF04729 1-154 ASF1B_MOUSE anti-silencing function 1B histone chaperone ASF1B_HUMAN Histone chaperone # # H3 H4 #
40ASH1L BAH PF01426 2661-2798 Bromodomain PF00439 2453-2538 PHD PF00628 2587-2631 Pfam-B_14208 PB014208 1818-1847 Pfam-B_18246 PB018246 2310-2419 Pfam-B_25586 PB025586 1473-1507 Pfam-B_4663 PB004663 1023-1054 1180-1377 Pfam-B_6310 PB006310 1509-1554 SET PF00856 2156-2261 ASH1L_MOUSE ash1 (absent small or homeotic)-like (Drosophila) ASH1L_HUMAN Histone modification write Histone methylation # H3K36 H3K36me
41ASH2L Pfam-B_11232 PB011232 499-622 Pfam-B_12412 PB012412 361-417 SPRY PF00622 418-497 ASH2L_MOUSE ash2 (absent small or homeotic)-like (Drosophila) ASH2L_HUMAN Histone modification write cofactor Histone methylation COMPASS Menin-associated_HMT MLL-HCF CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 COMPASS-like MLL3 4 # #
42ASXL1 ASXH PF13919 231-362 HARE-HTH PF05066 11-83 PHD_3 PF13922 1475-1539 Pfam-B_4087 PB004087 970-1084 ASXL1_MOUSE additional sex combs like transcriptional regulator 1 ASXL1_HUMAN Histone modification erase Polycomb group (PcG) protein Histone deubiquitination # PR-DUB H2AK119 H2AK119ub1
43ASXL2 ASXH PF13919 249-381 HARE-HTH PF05066 11-83 PHD_3 PF13922 1370-1433 Pfam-B_4087 PB004087 944-1090 ASXL2_MOUSE additional sex combs like transcriptional regulator 2 ASXL2_HUMAN Histone modification read # # H3K4 H3K9 #
44ASXL3 ASXH PF13919 229-361 HARE-HTH PF05066 10-81 PHD_3 PF13922 2183-2246 Pfam-B_17129 PB017129 941-1279 Pfam-B_20113 PB020113 751-939 Pfam-B_27498 PB027498 1341-1411 Pfam-B_34336 PB034336 1281-1339 Pfam-B_6874 PB006874 601-669 ASXL3_MOUSE additional sex combs like transcriptional regulator 3 ASXL3_HUMAN Scaffold protein Polycomb group (PcG) protein # # # # #
45ATAD2 AAA PF00004 463-598 Bromodomain PF00439 993-1075 Pfam-B_11064 PB011064 870-958 Pfam-B_23116 PB023116 1-56 Pfam-B_40477 PB040477 57-79 ATAD2_MOUSE ATPase family AAA domain containing 2 ATAD2_HUMAN Chromatin remodelling # # # #
46ATAD2B AAA PF00004 437-572 Bromodomain PF00439 967-1050 Pfam-B_11064 PB011064 896-932 Pfam-B_130965 PB130965 330-388 # ATPase family AAA domain containing 2B ATD2B_HUMAN Histone modification read # # H1.4 H2A H2B H3 and H4 #
47ATF2 bZIP_1 PF00170 349-413 ATF2_MOUSE activating transcription factor 2 ATF2_HUMAN Histone modification write TF Histone acetylation TF activator # H2B H4 DNA motif #
48ATF7IP Pfam-B_2570 PB002570 450-518 MCAF1_MOUSE activating transcription factor 7 interacting protein MCAF1_HUMAN Histone modification write cofactor Histone methylation # # #
49ATM FAT PF02259 2096-2489 FATC PF02260 3024-3056 PI3_PI4_kinase PF00454 2711-2962 Pfam-B_10220 PB010220 1575-1713 Pfam-B_13450 PB013450 602-830 Pfam-B_16049 PB016049 1715-1818 Pfam-B_17604 PB017604 1819-1953 Pfam-B_3386 PB003386 861-1458 TAN PF11640 5-166 ATM_MOUSE ATM serine/threonine kinase ATM_HUMAN Histone modification write Histone phosphorylation # H2AXS139 #
50ATN1 Atrophin-1 PF03154 1-163 349-1190 ATN1_MOUSE atrophin 1 ATN1_HUMAN Histone modification erase cofactor # # # #
51ATR FAT PF02259 1771-2092 FATC PF02260 2612-2644 PI3_PI4_kinase PF00454 2321-2567 Pfam-B_15857 PB015857 1226-1489 Pfam-B_17853 PB017853 1-129 Pfam-B_20071 PB020071 291-659 Pfam-B_21066 PB021066 131-289 Pfam-B_21726 PB021726 661-1009 Pfam-B_22672 PB022672 1011-1079 UME PF08064 1119-1225 ATR_MOUSE ATR serine/threonine kinase ATR_HUMAN Histone modification write Histone phosphorylation # H2AX #
52ATRX Helicase_C PF00271 2076-2155 Pfam-B_12326 PB012326 1906-2016 Pfam-B_14952 PB014952 1242-1362 Pfam-B_16104 PB016104 2368-2490 Pfam-B_16400 PB016400 1424-1474 Pfam-B_17163 PB017163 1364-1422 Pfam-B_19720 PB019720 751-889 Pfam-B_24253 PB024253 1181-1239 Pfam-B_3534 PB003534 45-304 SNF2_N PF00176 1563-1889 ATRX_MOUSE alpha thalassemia/mental retardation syndrome X-linked ATRX_HUMAN Chromatin remodelling # # H3K9me2 H3K9me3 H3K4 #
53ATXN7 Pfam-B_15485 PB015485 781-879 Pfam-B_23658 PB023658 129-174 Pfam-B_6735 PB006735 491-579 SCA7 PF08313 318-397 ATX7_MOUSE ataxin 7 ATX7_HUMAN Histone modification write cofactor Histone acetylation SAGA # #
54ATXN7L3 Pfam-B_25595 PB025595 276-345 SCA7 PF08313 201-239 Sgf11 PF08209 80-112 AT7L3_MOUSE ataxin 7-like 3 AT7L3_HUMAN Histone modification erase cofactor Histone deubiquitination SAGA # #
55AURKA Pfam-B_20489 PB020489 1-59 Pkinase PF00069 133-383 AURKA_MOUSE aurora kinase A AURKA_HUMAN Histone modification write Histone phosphorylation # H3 H3S10ph
56AURKB Pfam-B_34716 PB034716 1-46 Pkinase PF00069 77-327 AURKB_MOUSE aurora kinase B AURKB_HUMAN Histone modification write Histone phosphorylation # H3S10 H3S28 #
57AURKC Pkinase PF00069 43-293 AURKC_MOUSE aurora kinase C AURKC_HUMAN Histone modification write Histone phosphorylation # H3S10 H3S28 #
58BABAM1 Pfam-B_4074 PB004074 1-327 BABA1_MOUSE BRISC and BRCA1 A complex member 1 BABA1_HUMAN Histone modification erase cofactor Histone deubiquitination BRISC BRCA1-A # #
59BAHD1 BAH PF01426 623-779 BAHD1_MOUSE bromo adjacent homology domain containing 1 BAHD1_HUMAN Chromatin remodelling # # H3K27me3 #
60BANP BEN PF10523 249-322 BANP_MOUSE BTG3 associated nuclear protein BANP_HUMAN Histone modification write Histone acetylation # H3K9 H4K8 #
61BAP1 Peptidase_C12 PF01088 4-217 Pfam-B_14567 PB014567 441-579 Pfam-B_16218 PB016218 271-439 Pfam-B_4660 PB004660 581-693 BAP1_MOUSE BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) BAP1_HUMAN Histone modification erase Polycomb group (PcG) protein Histone deubiquitination # PR-DUB H2AK119ub1 H2AK119
62BARD1 Ank PF00023 427-459 460-491 493-525 BRCT PF00533 568-640 Pfam-B_30184 PB030184 161-239 Pfam-B_32178 PB032178 241-290 Pfam-B_32432 PB032432 291-339 Pfam-B_33025 PB033025 723-775 zf-RING_6 PF14835 41-105 BARD1_MOUSE BRCA1 associated RING domain 1 BARD1_HUMAN Histone modification write Histone ubiquitination BRCC BRCA1-A H2AX H2A H2B H3 H4 H2AXub H2Aub H2Bub H3ub H4ub
63BAZ1A Bromodomain PF00439 1438-1521 DDT PF02791 422-487 PHD PF00628 1150-1198 Pfam-B_18021 PB018021 670-767 Pfam-B_18567 PB018567 769-877 Pfam-B_19398 PB019398 1210-1430 WAC_Acf1_DNA_bd PF10537 22-122 WHIM1 PF15612 592-640 BAZ1A_MOUSE bromodomain adjacent to zinc finger domain 1A BAZ1A_HUMAN Histone chaperone # ACF CHRAC # #
64BAZ1B Bromodomain PF00439 1348-1431 PHD PF00628 1186-1234 WAC_Acf1_DNA_bd PF10537 20-120 WHIM1 PF15612 724-773 WHIM2 PF15613 899-936 WHIM3 PF15614 991-1031 BAZ1B_MOUSE bromodomain adjacent to zinc finger domain 1B BAZ1B_HUMAN Histone modification write Histone phosphorylation B-WICH WINAC H2AXT142 H3 H2AXY142ph
65BAZ2A Bromodomain PF00439 1802-1885 DDT PF02791 848-910 MBD PF01429 546-620 PHD PF00628 1678-1726 Pfam-B_14139 PB014139 1518-1541 Pfam-B_1702 PB001702 2-228 Pfam-B_25722 PB025722 1211-1279 Pfam-B_3124 PB003124 701-789 1085-1136 Pfam-B_32186 PB032186 1484-1516 Pfam-B_6766 PB006766 331-489 WHIM1 PF15612 950-999 WHIM3 PF15614 1439-1480 BAZ2A_MOUSE bromodomain adjacent to zinc finger domain 2A BAZ2A_HUMAN Chromatin remodelling Histone modification erase # Histone deacetylation NoRC H4K16ac DNA motif H4K5 H4K8 H4K12
66BAZ2B Bromodomain PF00439 2069-2151 DDT PF02791 1087-1149 MBD PF01429 739-813 PHD PF00628 1933-1981 Pfam-B_10350 PB010350 521-649 Pfam-B_12038 PB012038 1200-1479 Pfam-B_13066 PB013066 91-399 Pfam-B_1587 PB001587 401-519 Pfam-B_17078 PB017078 1618-1728 Pfam-B_17427 PB017427 1-89 Pfam-B_9375 PB009375 1481-1616 # bromodomain adjacent to zinc finger domain 2B BAZ2B_HUMAN Histone modification read # # H1.4ac H2Aac H2Bac H3ac H4Kac #
67BCOR Ank_2 PF12796 1460-1560 Pfam-B_11277 PB011277 41-289 Pfam-B_26758 PB026758 300-329 Pfam-B_27995 PB027995 1241-1359 Pfam-B_30654 PB030654 1361-1419 Pfam-B_5207 PB005207 421-1239 BCOR_MOUSE BCL6 corepressor BCOR_HUMAN Polycomb group (PcG) protein # BCOR # #
68BCORL1 Ank_2 PF12796 1410-1486 1426-1519 Pfam-B_1109 PB001109 110-149 Pfam-B_16739 PB016739 560-637 Pfam-B_20248 PB020248 740-800 Pfam-B_31169 PB031169 1-76 Pfam-B_8912 PB008912 383-533 BCORL_MOUSE BCL6 corepressor-like 1 BCORL_HUMAN Histone modification erase cofactor Histone deacetylation BCOR H3K36me2 #
69BMI1 zf-C3HC4 PF00097 18-56 BMI1_MOUSE BMI1 proto-oncogene polycomb ring finger BMI1_HUMAN Polycomb group (PcG) protein # PRC1 # #
70BPTF Bromodomain PF00439 2936-3019 DDT PF02791 240-300 PHD PF00628 392-437 2869-2918 Pfam-B_14861 PB014861 2113-2229 Pfam-B_26081 PB026081 91-205 Pfam-B_911 PB000911 1922-2111 Pfam-B_94218 PB094218 1-89 WHIM1 PF15612 339-388 # bromodomain PHD finger transcription factor BPTF_HUMAN Chromatin remodelling # NuRF # #
71BRCA1 BRCT PF00533 1648-1723 1756-1842 BRCT_assoc PF12820 344-508 EIN3 PF04873 648-978 Pfam-B_17893 PB017893 1404-1493 zf-C3HC4 PF00097 24-64 BRCA1_MOUSE breast cancer 1 early onset BRCA1_HUMAN Histone modification write cofactor Histone modification write cofactor Histone modification write cofactor TF TF Histone acetylation Histone methylation Histone ubiquitination TF activator TF repressor BRCC BRCA1-A DNA motif #
72BRCA2 BRCA-2_OB1 PF09103 2670-2800 BRCA-2_OB3 PF09104 3052-3190 BRCA-2_helical PF09169 2479-2667 BRCA2 PF00634 1002-1036 1212-1246 1421-1455 1517-1551 1664-1698 1837-1871 1971-2005 2051-2085 Pfam-B_13057 PB013057 2141-2448 Pfam-B_47717 PB047717 2449-2478 Pfam-B_8258 PB008258 651-989 Tower PF09121 2831-2872 BRCA2_MOUSE breast cancer 2 early onset BRCA2_HUMAN Histone modification write Histone acetylation BRCC H3 H4 ssDNA #
73BRCC3 JAB PF01398 7-148 BRCC3_MOUSE BRCA1/BRCA2-containing complex subunit 3 BRCC3_HUMAN Histone modification erase Histone deubiquitination BRISC BRCA1-A H2AK63 H2AXK63 H2A H2AX
74BRD1 Bromodomain PF00439 571-654 EPL1 PF10513 46-196 PHD_2 PF13831 228-262 PWWP PF00855 927-1042 zf-HC5HC2H_2 PF13832 269-388 # bromodomain containing 1 BRD1_HUMAN Histone modification read # MOZ/MORF H3K36me3 H3 #
75BRD2 Bromodomain PF00439 84-168 353-441 Pfam-B_12618 PB012618 624-776 Pfam-B_14336 PB014336 541-613 BRD2_MOUSE bromodomain containing 2 BRD2_HUMAN Histone modification read # # H3K9me2 H3K14me2 H4K5ac H4K12ac #
76BRD3 Bromodomain PF00439 42-128 315-403 BRD3_MOUSE bromodomain containing 3 BRD3_HUMAN Histone modification read # # H3K9me2 H3K14me2 H4K5ac H4K12ac #
77BRD4 Bromodomain PF00439 67-152 357-445 Pfam-B_14896 PB014896 1187-1263 Pfam-B_15118 PB015118 509-647 Pfam-B_18611 PB018611 648-667 Pfam-B_24632 PB024632 833-892 Pfam-B_29595 PB029595 1283-1311 Pfam-B_35798 PB035798 1136-1185 Pfam-B_361 PB000361 1324-1357 BRD4_MOUSE bromodomain containing 4 BRD4_HUMAN Histone modification read # # H3K9 H3K14 H4K5 H4K12 #
78BRD7 Bromodomain PF00439 140-223 DUF3512 PF12024 286-534 Pfam-B_1543 PB001543 591-649 Pfam-B_64177 PB064177 1-49 BRD7_MOUSE bromodomain containing 7 BRD7_HUMAN Histone modification read # SWI/SNF BRM-BRG1 H3K9ac H3K14ac H3K8ac #
79BRD8 Bromodomain PF00439 713-799 1112-1195 Pfam-B_19676 PB019676 1-69 Pfam-B_55933 PB055933 71-109 BRD8_MOUSE bromodomain containing 8 BRD8_HUMAN Histone modification read # SWR NuA4 NuA4-related complex # #
80BRD9 Bromodomain PF00439 143-228 DUF3512 PF12024 268-505 Pfam-B_8260 PB008260 511-595 BRD9_MOUSE bromodomain containing 9 BRD9_HUMAN Histone modification read # SWI/SNF BRM-BRG1 H3 #
81BRDT Bromodomain PF00439 36-121 276-364 Pfam-B_11430 PB011430 710-791 BRDT_MOUSE bromodomain testis-specific BRDT_HUMAN Histone modification read # # H4K5ac H4K8ac #
82BRE BRE PF06113 1-333 BRE_MOUSE brain and reproductive organ-expressed (TNFRSF1A modulator) BRE_HUMAN Histone modification write cofactor Histone ubiquitination BRISC BRCC BRCA1-A # #
83BRMS1 Sds3 PF08598 58-229 BRMS1_MOUSE breast cancer metastasis suppressor 1 BRMS1_HUMAN Chromatin remodelling # mSin3A # #
84BRMS1L Sds3 PF08598 59-227 BRM1L_MOUSE breast cancer metastasis-suppressor 1-like BRM1L_HUMAN Histone modification erase Histone deacetylation mSin3A # #
85BRPF1 Bromodomain PF00439 637-720 EPL1 PF10513 105-255 PHD_2 PF13831 287-321 PWWP PF00855 1083-1198 zf-HC5HC2H_2 PF13832 328-447 # bromodomain and PHD finger containing 1 BRPF1_HUMAN Histone modification read # MOZ/MORF H3K36me3 #
86BRPF3 Bromodomain PF00439 598-681 EPL1 PF10513 47-194 PHD_2 PF13831 226-260 PWWP PF00855 1074-1189 Pfam-B_5327 PB005327 751-829 zf-HC5HC2H_2 PF13832 267-386 # bromodomain and PHD finger containing 3 BRPF3_HUMAN Histone modification write cofactor Histone acetylation MOZ/MORF # #
87BRWD1 Bromodomain PF00439 1166-1252 1322-1405 Pfam-B_18973 PB018973 859-924 Pfam-B_22078 PB022078 2089-2186 Pfam-B_27858 PB027858 1900-2087 Pfam-B_71 PB000071 2238-2318 Pfam-B_8184 PB008184 1821-1898 WD40 PF00400 177-214 218-256 260-302 358-396 458-497 BRWD1_MOUSE bromodomain and WD repeat domain containing 1 BRWD1_HUMAN Histone modification read # # H3 #
88BRWD3 Bromodomain PF00439 1147-1233 1345-1418 Pfam-B_12397 PB012397 1669-1710 Pfam-B_2569 PB002569 9-97 WD40 PF00400 171-208 212-250 254-296 352-392 455-494 507-540 BRWD3_MOUSE bromodomain and WD repeat domain containing 3 BRWD3_HUMAN Histone modification read # # H3 #
89BUB1 Mad3_BUB1_I PF08311 4-126 Pkinase PF00069 787-1033 BUB1_MOUSE BUB1 mitotic checkpoint serine/threonine kinase BUB1_HUMAN Histone modification write Histone phosphorylation # H2AS121 H2AS121ph
90C11orf30 ENT PF03735 16-88 Pfam-B_10468 PB010468 695-833 Pfam-B_10943 PB010943 985-1113 EMSY_MOUSE chromosome 11 open reading frame 30 EMSY_HUMAN Histone modification write cofactor Histone methylation # # #
91C14orf169 Cupin_4 PF08007 215-557 Pfam-B_41208 PB041208 71-139 Pfam-B_47541 PB047541 1-69 NO66_MOUSE # NO66_HUMAN Histone modification erase Histone methylation # H3K4me3 H3K4me1 H3K36me2 H3K4me2 H3K4 H3K36me1
92C17orf49 # BAP18_MOUSE chromosome 17 open reading frame 49 BAP18_HUMAN Histone modification read # CHD8 MLL2/3 MLL4/WBP7 H3K4me3 #
93CARM1 CARM1 PF11531 26-139 PRMT5 PF05185 143-446 Pfam-B_10255 PB010255 449-469 Pfam-B_13059 PB013059 511-606 CARM1_MOUSE coactivator-associated arginine methyltransferase 1 CARM1_HUMAN Histone modification write Histone methylation # H3R17 H3R17me H3R17me2a
94CBX1 Chromo PF00385 21-70 Chromo_shadow PF01393 115-172 CBX1_MOUSE chromobox homolog 1 CBX1_HUMAN Histone modification read # # H3K9me3 H3K27me3 #
95CBX2 Chromo PF00385 12-61 Pfam-B_1400 PB001400 249-295 CBX2_MOUSE chromobox homolog 2 CBX2_HUMAN Histone modification read # PRC1 H3K9me3 H3K27me3 #
96CBX3 Chromo PF00385 30-79 Chromo_shadow PF01393 119-176 CBX3_MOUSE chromobox homolog 3 CBX3_HUMAN Histone modification read # RING2-L3MBTL2 L3MBTL1 H3K9me3 #
97CBX4 Chromo PF00385 11-60 Pfam-B_16393 PB016393 481-531 Pfam-B_26041 PB026041 401-479 Pfam-B_8537 PB008537 82-281 CBX4_MOUSE chromobox homolog 4 CBX4_HUMAN Histone modification read # PRC1 H3K9me3 #
98CBX5 Chromo PF00385 20-69 Chromo_shadow PF01393 119-176 CBX5_MOUSE chromobox homolog 5 CBX5_HUMAN Histone modification read # # H3K9me H3K27me3 #
99CBX6 Chromo PF00385 11-60 Pfam-B_41557 PB041557 291-379 Pfam-B_49897 PB049897 381-410 CBX6_MOUSE chromobox homolog 6 CBX6_HUMAN Histone modification read # PRC1 H3K9me3 H3K27me3 #
100CBX7 Chromo PF00385 11-60 CBX7_MOUSE chromobox homolog 7 CBX7_HUMAN Histone modification read # PRC1 H3K9me3 H3K27me3 #
101CBX8 Chromo PF00385 11-60 CBX8_MOUSE chromobox homolog 8 CBX8_HUMAN Histone modification read # PRC1 H3K9me3 H3K27me3 #
102CCDC101 DUF1325 PF07039 157-289 SGF29_MOUSE coiled-coil domain containing 101 SGF29_HUMAN Histone modification read # ATAC H3K4me H3K4me3 #
103CDC6 AAA_22 PF13401 190-322 Cdc6_C PF09079 465-545 CDC6_MOUSE cell division cycle 6 CDC6_HUMAN Chromatin remodelling # # # #
104CDC73 CDC73 PF05179 233-525 CDC73_MOUSE cell division cycle 73 CDC73_HUMAN Histone modification write cofactor Histone methylation # # #
105CDK1 Pkinase PF00069 4-287 CDK1_MOUSE cyclin-dependent kinase 1 CDK1_HUMAN Histone modification write Histone phosphorylation # H1 H1ph
106CDK2 Pkinase PF00069 4-286 CDK2_MOUSE cyclin-dependent kinase 2 CDK2_HUMAN Histone modification write Histone phosphorylation # H1S H1T H1Sph H1Tph
107CDK3 Pkinase PF00069 4-286 CDK3_MOUSE cyclin-dependent kinase 3 CDK3_HUMAN Histone modification write Histone phosphorylation # H1 #
108CDK5 Pkinase PF00069 4-286 CDK5_MOUSE cyclin-dependent kinase 5 CDK5_HUMAN Histone modification write Histone phosphorylation # H1 #
109CDK7 Pfam-B_20206 PB020206 301-344 Pkinase PF00069 12-295 CDK7_MOUSE cyclin-dependent kinase 7 CDK7_HUMAN Histone modification write Histone phosphorylation # H1 #
110CDK9 Pkinase PF00069 19-315 CDK9_MOUSE cyclin-dependent kinase 9 CDK9_HUMAN Histone modification cofactor # # # #
111CDK17 Pkinase PF00069 192-473 CDK17_MOUSE cyclin-dependent kinase 17 CDK17_HUMAN Histone modification write Histone phosphorylation # H1 #
112CDY1 Chromo PF00385 6-57 ECH PF00378 287-535 Pfam-B_51834 PB051834 101-148 # chromodomain protein Y-linked 1 CDY1_HUMAN Histone modification write Histone acetylation # H4 #
113CDY1B Chromo PF00385 6-57 ECH PF00378 287-535 Pfam-B_51834 PB051834 101-148 # chromodomain protein Y-linked 1B CDY1_HUMAN Histone modification write Histone acetylation # H4 #
114CDY2A Chromo PF00385 6-57 ECH PF00378 288-536 Pfam-B_51834 PB051834 101-149 # chromodomain protein Y-linked 2A CDY2_HUMAN Histone modification write Histone acetylation # # #
115CDY2B Chromo PF00385 6-57 ECH PF00378 288-536 Pfam-B_51834 PB051834 101-149 # chromodomain protein Y-linked 2B CDY2_HUMAN Histone modification write Histone acetylation # # #
116CDYL Chromo PF00385 61-112 ECH PF00378 345-593 Pfam-B_14969 PB014969 136-234 CDYL_MOUSE chromodomain protein Y-like CDYL1_HUMAN Histone modification write Histone acetylation # H4 #
117CDYL2 Chromo PF00385 7-57 ECH PF00378 253-501 CDYL2_MOUSE chromodomain protein Y-like 2 CDYL2_HUMAN Histone modification read # # H3K9me3 #
118CECR2 Bromodomain PF00439 443-526 Pfam-B_13010 PB013010 1-329 Pfam-B_18245 PB018245 800-968 Pfam-B_20164 PB020164 331-419 # cat eye syndrome chromosome region candidate 2 CECR2_HUMAN Histone modification read # CERF CERF H2A H3 #
119CENPC CENP-C_C PF11699 856-940 CENP-C_mid PF15620 296-552 CENP_C_N PF15622 7-292 CENPC_MOUSE centromere protein C CENPC_HUMAN DNA modification DNA methylation # C 5mC
120CHAF1A CAF-1_p150 PF11600 266-479 CAF1-p150_C2 PF15539 665-956 CAF1-p150_N PF15557 1-229 CAF1A PF12253 557-635 CAF1A_MOUSE chromatin assembly factor 1 subunit A (p150) CAF1A_HUMAN Chromatin remodelling # CAF-1 H3 H4 #
121CHAF1B CAF-1_p60_C PF15512 381-558 WD40 PF00400 10-45 57-94 119-157 161-199 339-372 CAF1B_MOUSE chromatin assembly factor 1 subunit B (p60) CAF1B_HUMAN Chromatin remodelling # WINAC CAF-1 H3 H4 #
122CHD1 Chromo PF00385 273-355 389-443 DUF4208 PF13907 1400-1500 Helicase_C PF00271 822-902 Pfam-B_182 PB000182 1646-1708 Pfam-B_91833 PB091833 121-162 SNF2_N PF00176 484-765 CHD1_MOUSE chromodomain helicase DNA binding protein 1 CHD1_HUMAN Chromatin remodelling # # # #
123CHD1L Helicase_C PF00271 381-459 Pfam-B_2492 PB002492 468-549 SNF2_N PF00176 49-328 CHD1L_MOUSE chromodomain helicase DNA binding protein 1-like CHD1L_HUMAN Chromatin remodelling # # # #
124CHD2 Chromo PF00385 261-344 378-447 DUF4208 PF13907 1455-1555 Helicase_C PF00271 825-905 Pfam-B_19320 PB019320 1231-1309 Pfam-B_761 PB000761 1111-1229 SNF2_N PF00176 487-768 CHD2_MOUSE chromodomain helicase DNA binding protein 2 CHD2_HUMAN Chromatin remodelling # # # #
125CHD3 CHDCT2 PF08074 1735-1907 CHDNT PF08073 147-201 Chromo PF00385 539-574 631-683 DUF1086 PF06461 1363-1519 DUF1087 PF06465 1293-1357 Helicase_C PF00271 1094-1174 PHD PF00628 381-426 458-503 SNF2_N PF00176 739-1035 # chromodomain helicase DNA binding protein 3 CHD3_HUMAN Chromatin remodelling # NuRD # #
126CHD4 CHDCT2 PF08074 1724-1896 CHDNT PF08073 163-217 Chromo PF00385 531-577 622-674 DUF1086 PF06461 1366-1523 DUF1087 PF06465 1289-1353 Helicase_C PF00271 1084-1164 PHD PF00628 372-417 451-496 SNF2_N PF00176 729-1025 CHD4_MOUSE chromodomain helicase DNA binding protein 4 CHD4_HUMAN Chromatin remodelling # NuRD # #
127CHD5 CHDCT2 PF08074 1731-1903 CHDNT PF08073 146-200 Chromo PF00385 499-537 592-643 DUF1086 PF06461 1377-1531 DUF1087 PF06465 1295-1359 Helicase_C PF00271 1058-1138 PHD PF00628 345-390 418-463 Pfam-B_20089 PB020089 201-334 SNF2_N PF00176 703-999 CHD5_MOUSE chromodomain helicase DNA binding protein 5 CHD5_HUMAN Chromatin remodelling # # H3K27me3 H3K4 #
128CHD6 BRK PF07533 2400-2441 Chromo PF00385 292-354 375-429 Helicase_C PF00271 817-897 Pfam-B_18962 PB018962 1-49 Pfam-B_23619 PB023619 1691-1909 Pfam-B_71010 PB071010 1911-1953 Pfam-B_761 PB000761 1271-1333 1361-1519 SNF2_N PF00176 464-751 CHD6_MOUSE chromodomain helicase DNA binding protein 6 CHD6_HUMAN Chromatin remodelling # # # #
129CHD7 BRK PF07533 2562-2612 2640-2685 Chromo PF00385 800-862 882-935 Helicase_C PF00271 1324-1404 Pfam-B_19729 PB019729 1-188 Pfam-B_19848 PB019848 2351-2469 Pfam-B_2227 PB002227 281-449 Pfam-B_2565 PB002565 1722-1920 Pfam-B_6146 PB006146 2041-2259 Pfam-B_761 PB000761 1622-1720 1966-2035 SNF2_N PF00176 971-1258 CHD7_MOUSE chromodomain helicase DNA binding protein 7 CHD7_HUMAN Chromatin remodelling # # # #
130CHD8 BRK PF07533 2308-2353 Chromo PF00385 642-704 724-778 Helicase_C PF00271 1167-1247 Pfam-B_10410 PB010410 1-109 Pfam-B_12479 PB012479 1721-1779 Pfam-B_13819 PB013819 2211-2279 Pfam-B_20709 PB020709 2031-2169 Pfam-B_2565 PB002565 1781-2029 Pfam-B_6146 PB006146 2171-2209 Pfam-B_6192 PB006192 1481-1669 Pfam-B_7386 PB007386 311-493 Pfam-B_8182 PB008182 1411-1479 Pfam-B_8545 PB008545 111-309 SNF2_N PF00176 814-1101 CHD8_MOUSE chromodomain helicase DNA binding protein 8 CHD8_HUMAN Chromatin remodelling # CHD8 MLL2/3 MLL4/WBP7 H1 #
131CHD9 BRK PF07533 2480-2530 2554-2599 Chromo PF00385 690-752 773-827 Helicase_C PF00271 1216-1296 Pfam-B_10410 PB010410 1-89 Pfam-B_1107 PB001107 2701-2729 Pfam-B_15117 PB015117 371-579 Pfam-B_24836 PB024836 1774-1901 Pfam-B_6192 PB006192 1530-1675 Pfam-B_7386 PB007386 231-369 Pfam-B_8182 PB008182 1460-1528 Pfam-B_8545 PB008545 91-229 SNF2_N PF00176 863-1150 CHD9_MOUSE chromodomain helicase DNA binding protein 9 CHD9_HUMAN Chromatin remodelling # # # #
132CHEK1 Pkinase PF00069 9-265 CHK1_MOUSE checkpoint kinase 1 CHK1_HUMAN Histone modification write Histone phosphorylation # H3.1 H3.1ph
133CHRAC1 CBFD_NFYB_HMF PF00808 17-80 CHRC1_MOUSE chromatin accessibility complex 1 CHRC1_HUMAN Histone chaperone # CHRAC # #
134CHTOP FoP_duplication PF13865 171-245 CHTOP_MOUSE chromatin target of PRMT1 CHTOP_HUMAN # # # # #
135CHUK IKKbetaNEMObind PF12179 706-743 Pfam-B_15051 PB015051 300-415 Pkinase PF00069 15-297 IKKA_MOUSE conserved helix-loop-helix ubiquitous kinase IKKA_HUMAN Histone modification write Histone phosphorylation # H3 #
136CIR1 Cir_N PF10197 13-49 Pfam-B_16354 PB016354 52-448 CIR1_MOUSE corepressor interacting with RBPJ 1 CIR1_HUMAN Histone modification read # # # #
137CIT CNH PF00780 1597-1868 Pfam-B_11694 PB011694 483-521 Pfam-B_387 PB000387 1354-1412 Pkinase PF00069 97-360 Pkinase_C PF00433 378-424 CTRO_MOUSE citron rho-interacting serine/threonine kinase CTRO_HUMAN Histone modification write cofactor Histone modification write cofactor Histone methylation Histone phosphorylation # H3K9 H3K9me
138CLNS1A Pfam-B_77655 PB077655 1-34 Voldacs PF03517 35-165 ICLN_MOUSE chloride channel nucleotide-sensitive 1A ICLN_HUMAN Histone modification write cofactor Histone methylation methylosome # #
139CLOCK HLH PF00010 35-85 PAS PF00989 109-188 PAS_11 PF14598 273-381 Pfam-B_3081 PB003081 721-839 Pfam-B_7827 PB007827 571-719 Pfam-B_8264 PB008264 382-429 CLOCK_MOUSE clock circadian regulator CLOCK_HUMAN Histone modification write Histone acetylation # H3 H4 #
140CRB2 EGF PF00008 112-142 150-180 227-257 324-354 362-392 811-841 1060-1090 Laminin_G_2 PF02210 465-588 900-1033 Pfam-B_3557 PB003557 1199-1283 Pfam-B_79172 PB079172 1119-1197 hEGF PF12661 305-317 CRUM2_MOUSE crumbs family member 2 CRUM2_HUMAN Histone modification read # # H4K20 #
141CREBBP Bromodomain PF00439 1094-1180 Creb_binding PF09030 2016-2115 DUF902 PF06001 1191-1232 KAT11 PF08214 1342-1648 KIX PF02172 587-667 Pfam-B_2669 PB002669 2188-2217 Pfam-B_817 PB000817 2353-2401 ZZ PF00569 1701-1742 zf-TAZ PF02135 352-432 1770-1843 CBP_MOUSE CREB binding protein CBP_HUMAN Histone modification write Histone acetylation # # #
142CSNK2A1 Pkinase PF00069 39-324 CSK21_MOUSE casein kinase 2 alpha 1 polypeptide CSK21_HUMAN Histone modification # RING2-FBRS # #
143CSRP2BP Acetyltransf_1 PF00583 678-752 Pfam-B_6449 PB006449 351-435 Pfam-B_8520 PB008520 1-129 CSR2B_MOUSE CSRP2 binding protein CSR2B_HUMAN Histone modification write Histone acetylation ATAC H4 #
144CTBP1 2-Hacid_dh PF00389 30-352 2-Hacid_dh_C PF02826 133-317 CTBP1_MOUSE C-terminal binding protein 1 CTBP1_HUMAN Chromatin remodelling # LSD-CoREST # #
145CTBP2 2-Hacid_dh PF00389 36-358 2-Hacid_dh_C PF02826 139-323 CTBP2_MOUSE C-terminal binding protein 2 CTBP2_HUMAN Histone modification write cofactor Histone methylation # H3K9 H3K9me H3K9me2
146CTCF Pfam-B_18810 PB018810 671-725 zf-C2H2 PF00096 437-460 zf-C2H2_4 PF13894 555-578 zf-H2C2_2 PF13465 280-305 308-333 336-362 365-389 393-418 481-506 507-534 CTCF_MOUSE CCCTC-binding factor (zinc finger protein) CTCF_HUMAN Chromatin remodelling TF # TF activator # DNA motif #
147CTCFL Pfam-B_37192 PB037192 1-49 Pfam-B_59982 PB059982 611-659 zf-C2H2 PF00096 428-451 546-568 zf-H2C2_2 PF13465 271-296 299-324 327-353 356-380 384-409 472-497 500-525 CTCFL_MOUSE CCCTC-binding factor (zinc finger protein)-like CTCFL_HUMAN Chromatin remodelling # # # #
148CTR9 Pfam-B_9491 PB009491 5-42 TPR_1 PF00515 163-196 198-231 306-339 342-374 498-530 531-564 681-710 TPR_2 PF07719 451-483 CTR9_MOUSE CTR9 Paf1/RNA polymerase II complex component CTR9_HUMAN Histone modification cofactor # # H3K36 #
149CUL1 Cullin PF00888 21-707 Cullin_Nedd8 PF10557 703-770 CUL1_MOUSE cullin 1 CUL1_HUMAN Chromatin remodelling cofactor # # H3K9me3 H3K36me3 H1.4K26me3 H3K9 H3K36 H1.4K26
150CUL2 Cullin PF00888 14-645 Cullin_Nedd8 PF10557 672-739 CUL2_MOUSE cullin 2 CUL2_HUMAN Chromatin remodelling cofactor # # HP1 (Heterochromatin protein 1) #
151CUL3 Cullin PF00888 34-666 Cullin_Nedd8 PF10557 695-762 CUL3_MOUSE cullin 3 CUL3_HUMAN Histone modification write Histone ubiquitination # MACROH2A #
152CUL4A Cullin PF00888 63-661 Cullin_Nedd8 PF10557 688-753 CUL4A_MOUSE cullin 4A CUL4A_HUMAN Histone modification write Histone ubiquitination # H3 H4 #
153CUL4B Cullin PF00888 217-815 Cullin_Nedd8 PF10557 842-907 CUL4B_MOUSE cullin 4B CUL4B_HUMAN Histone modification write Histone ubiquitination # H3 H4 #
154CUL5 Cullin PF00888 19-673 Cullin_Nedd8 PF10557 707-774 CUL5_MOUSE cullin 5 CUL5_HUMAN DNA modification cofactor DNA methylation # # #
155CXXC1 PHD PF00628 28-76 zf-CXXC PF02008 160-208 zf-CpG_bind_C PF12269 400-636 CXXC1_MOUSE CXXC finger protein 1 CXXC1_HUMAN Chromatin remodelling TF # # COMPASS CG DNA motif #
156DAPK3 Pkinase PF00069 13-275 DAPK3_MOUSE death-associated protein kinase 3 DAPK3_HUMAN Histone modification write Histone phosphorylation # H3T11 #
157DAXX Daxx PF03344 1-740 DAXX_MOUSE death-domain associated protein DAXX_HUMAN # # # H3.3 #
158DDB1 CPSF_A PF03178 788-1099 MMS1_N PF10433 75-546 Pfam-B_431 PB000431 585-732 DDB1_MOUSE damage-specific DNA binding protein 1 127kDa DDB1_HUMAN Histone modification write Histone ubiquitination # H2A #
159DDB2 WD40 PF00400 112-140 232-271 284-316 DDB2_MOUSE damage-specific DNA binding protein 2 48kDa DDB2_HUMAN Histone modification write cofactor Histone ubiquitination # # #
160DDX21 DEAD PF00270 210-385 GUCT PF08152 620-716 Helicase_C PF00271 458-532 Pfam-B_47445 PB047445 1-39 DDX21_MOUSE DEAD (Asp-Glu-Ala-Asp) box helicase 21 DDX21_HUMAN RNA modification # B-WICH # #
161DDX50 DEAD PF00270 161-336 GUCT PF08152 571-666 Helicase_C PF00271 409-483 DDX50_MOUSE DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 DDX50_HUMAN RNA modification # # # #
162DEK DEK_C PF08766 321-375 Pfam-B_10960 PB010960 191-269 SAP PF02037 149-183 DEK_MOUSE DEK proto-oncogene DEK_HUMAN Chromatin remodelling # B-WICH H4 #
163DMAP1 DMAP1 PF05499 243-407 DMAP1_MOUSE DNA methyltransferase 1 associated protein 1 DMAP1_HUMAN Chromatin remodelling # NuA4 NuA4-related complex SRCAP # #
164DNAJC1 DnaJ PF00226 65-126 Myb_DNA-binding PF00249 494-543 Pfam-B_8255 PB008255 367-413 DNJC1_MOUSE DnaJ (Hsp40) homolog subfamily C member 1 DNJC1_HUMAN Histone modification write cofactor Histone modification erase cofactor Histone acetylation Histone deacetylation # # #
165DNAJC2 DnaJ PF00226 88-158 Myb_DNA-binding PF00249 451-506 552-600 Pfam-B_24524 PB024524 28-59 Pfam-B_30652 PB030652 1-27 DNJC2_MOUSE DnaJ (Hsp40) homolog subfamily C member 2 DNJC2_HUMAN Histone modification read # # H2A #
166DND1 DND1_DSRM PF14709 253-333 RRM_1 PF00076 60-126 DND1_MOUSE DND microRNA-mediated repression inhibitor 1 DND1_HUMAN RNA modification # # # #
167DNMT1 BAH PF01426 755-880 931-1100 DMAP_binding PF06464 16-105 DNA_methylase PF00145 1139-1594 DNMT1-RFD PF12047 399-534 zf-CXXC PF02008 645-691 DNMT1_MOUSE DNA (cytosine-5-)-methyltransferase 1 DNMT1_HUMAN DNA modification DNA methylation # dhC dhU
168DNMT3A DNA_methylase PF00145 634-776 PWWP PF00855 290-375 DNM3A_MOUSE DNA (cytosine-5-)-methyltransferase 3 alpha DNM3A_HUMAN DNA modification DNA methylation # dhC dhU
169DNMT3B DNA_methylase PF00145 575-725 PWWP PF00855 223-308 DNM3B_MOUSE DNA (cytosine-5-)-methyltransferase 3 beta DNM3B_HUMAN DNA modification DNA methylation # dhC dhU
170DNMT3L Pfam-B_139748 PB139748 181-229 Pfam-B_41249 PB041249 91-179 DNM3L_MOUSE DNA (cytosine-5-)-methyltransferase 3-like DNM3L_HUMAN Histone modification read # # H3K4 #
171DNTTIP2 Fcf2 PF08698 635-731 TDIF2_MOUSE deoxynucleotidyltransferase terminal interacting protein 2 TDIF2_HUMAN Chromatin remodelling # # H2A H2B #
172DOT1L DOT1 PF08123 115-317 Pfam-B_30738 PB030738 501-539 - DOT1-like histone H3K79 methyltransferase DOT1L_HUMAN Histone modification write Histone methylation # H3K79 #
173DPF1 PHD PF00628 256-311 310-368 Pfam-B_77905 PB077905 1-37 Requiem_N PF14051 38-111 DPF1_MOUSE D4 zinc and double PHD fingers family 1 DPF1_HUMAN Chromatin remodelling cofactor # nBAF SWI/SNF BRM-BRG1 # #
174DPF2 PHD PF00628 272-330 329-376 Requiem_N PF14051 12-85 REQU_MOUSE D4 zinc and double PHD fingers family 2 REQU_HUMAN Chromatin remodelling # SWI/SNF BRM-BRG1 # #
175DPF3 PHD PF00628 261-319 318-366 Requiem_N PF14051 12-85 DPF3_MOUSE D4 zinc and double PHD fingers family 3 DPF3_HUMAN Chromatin remodelling # BAF nBAF SWI/SNF BRM-BRG1 H3 H4 #
176DPPA3 PGC7_Stella PF15549 1-155 DPPA3_MOUSE developmental pluripotency associated 3 DPPA3_HUMAN Histone modification read # # H3K9me2 #
177DPY30 Dpy-30 PF05186 52-93 Pfam-B_28037 PB028037 1-51 DPY30_MOUSE dpy-30 homolog (C. elegans) DPY30_HUMAN Histone modification write cofactor Histone methylation COMPASS Menin-associated_HMT MLL-HCF CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 COMPASS-like MLL3 4 # #
178DR1 CBFD_NFYB_HMF PF00808 11-75 NC2B_MOUSE down-regulator of transcription 1 TBP-binding (negative cofactor 2) NC2B_HUMAN Histone chaperone # ATAC # #
179DTX3L Pfam-B_11420 PB011420 311-389 706-737 zf-RING_2 PF13639 559-600 DTX3L_MOUSE deltex 3 like E3 ubiquitin ligase DTX3L_HUMAN Histone modification write Histone ubiquitination # H4K91 #
180DZIP3 Pfam-B_10362 PB010362 531-619 Pfam-B_5525 PB005525 201-419 Pfam-B_5636 PB005636 1-199 Pfam-B_8501 PB008501 621-773 Pfam-B_8729 PB008729 421-529 zf-RING_2 PF13639 1146-1188 DZIP3_MOUSE DAZ interacting zinc finger protein 3 DZIP3_HUMAN Histone modification write Histone ubiquitination # H2AK119 H2AK119ub
181E2F6 E2F_TDP PF02319 63-128 E2F6_MOUSE E2F transcription factor 6 E2F6_HUMAN TF TF repressor RING2-L3MBTL2 CHD8 MLL2/3 MLL4/WBP7 DNA motif #
182EED Pfam-B_26038 PB026038 1-39 Pfam-B_6684 PB006684 265-359 WD40 PF00400 180-219 231-264 EED_MOUSE embryonic ectoderm development EED_HUMAN Polycomb group (PcG) protein # PRC2 # #
183EHMT1 Ank_2 PF12796 742-836 810-903 910-998 Ank_4 PF13637 773-826 839-893 Pfam-B_28560 PB028560 1-98 Pre-SET PF05033 1013-1118 SET PF00856 1137-1243 EHMT1_MOUSE euchromatic histone-lysine N-methyltransferase 1 EHMT1_HUMAN Histone modification write Histone methylation # H3K9 H3K9me1 H3K9me2
184EHMT2 Ank PF00023 684-716 717-748 750-783 784-816 818-849 850-882 Pfam-B_9355 PB009355 34-359 Pre-SET PF05033 925-1030 SET PF00856 1049-1155 EHMT2_MOUSE euchromatic histone-lysine N-methyltransferase 2 EHMT2_HUMAN Histone modification write Histone methylation # H3K9 H3K9me1 H3K9me2
185EID1 Pfam-B_5729 PB005729 1-159 EID1_MOUSE EP300 interacting inhibitor of differentiation 1 EID1_HUMAN Histone modification write cofactor Histone acetylation # # #
186EID2 Pfam-B_42536 PB042536 111-199 Pfam-B_7728 PB007728 1-109 201-234 EID2_MOUSE EP300 interacting inhibitor of differentiation 2 EID2_HUMAN Histone modification write cofactor Histone acetylation # # #
187EID2B # # EP300 interacting inhibitor of differentiation 2B EID2B_HUMAN Histone modification erase cofactor Histone acetylation # # #
188ELP2 WD40 PF00400 48-91 99-143 197-237 274-320 378-416 557-587 604-642 662-697 ELP2_MOUSE elongator acetyltransferase complex subunit 2 ELP2_HUMAN Histone modification write cofactor Histone acetylation Pol2 elongator # #
189ELP3 Acetyltransf_1 PF00583 441-536 Pfam-B_13823 PB013823 1-49 Radical_SAM PF04055 96-305 ELP3_MOUSE elongator acetyltransferase complex subunit 3 ELP3_HUMAN Histone modification write Histone acetylation Pol2 elongator H3 H4? #
190ELP4 PAXNEB PF05625 27-424 ELP4_MOUSE elongator acetyltransferase complex subunit 4 ELP4_HUMAN Histone modification write cofactor Histone acetylation Pol2 elongator # #
191ELP5 Elong_Iki1 PF10483 17-298 ELP5_MOUSE elongator acetyltransferase complex subunit 5 ELP5_HUMAN Histone modification write cofactor Histone acetylation Pol2 elongator H3K14 H4K8 #
192ELP6 DUF2348 PF09807 1-251 ELP6_MOUSE elongator acetyltransferase complex subunit 6 ELP6_HUMAN Histone modification write cofactor Histone acetylation Pol2 elongator # #
193ENY2 EnY2 PF10163 11-96 ENY2_MOUSE enhancer of yellow 2 homolog (Drosophila) ENY2_HUMAN Histone modification erase cofactor Histone ubiquitination SAGA # #
194EP300 Bromodomain PF00439 1058-1144 Creb_binding PF09030 1990-2099 DUF902 PF06001 1155-1196 KAT11 PF08214 1306-1612 KIX PF02172 566-646 Pfam-B_15526 PB015526 1-129 Pfam-B_817 PB000817 2317-2349 ZZ PF00569 1664-1705 zf-TAZ PF02135 336-416 1733-1806 EP300_MOUSE E1A binding protein p300 EP300_HUMAN Histone modification write Histone acetylation # H2A H2B H3 H4 #
195EP400 HSA PF07529 800-871 Helicase_C PF00271 1932-2014 Pfam-B_18422 PB018422 1887-1923 SNF2_N PF00176 1094-1374 EP400_MOUSE E1A binding protein p400 EP400_HUMAN Chromatin remodelling Histone modification write # Histone acetylation SWR NuA4 NuA4-related complex # #
196EPC1 EPL1 PF10513 6-149 E_Pc_C PF06752 582-836 EPC1_MOUSE enhancer of polycomb homolog 1 (Drosophila) EPC1_HUMAN Polycomb group (PcG) protein # NuA4 Piccolo_NuA4 NuA4-related complex # #
197EPC2 EPL1 PF10513 6-149 E_Pc_C PF06752 577-807 Pfam-B_18248 PB018248 432-544 Pfam-B_19406 PB019406 370-415 EPC2_MOUSE enhancer of polycomb homolog 2 (Drosophila) EPC2_HUMAN Chromatin remodelling # # # #
198ERBB4 Furin-like PF00757 176-335 GF_recep_IV PF14843 502-634 Pfam-B_10445 PB010445 1236-1306 Pkinase_Tyr PF07714 718-974 Recep_L_domain PF01030 55-167 358-478 ERBB4_MOUSE v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 ERBB4_HUMAN Histone modification cofactor # # H3K9me3 #
199ERCC6 Helicase_C PF00271 873-952 Pfam-B_58020 PB058020 1-49 SNF2_N PF00176 510-812 # excision repair cross-complementation group 6 ERCC6_HUMAN Chromatin remodelling # B-WICH # #
200EXOSC1 ECR1_N PF14382 7-41 EXOSC1 PF10447 64-135 EXOS1_MOUSE exosome component 1 EXOS1_HUMAN Scaffold protein RNA modification # RNA degradation RNA exosome # #
201EXOSC2 ECR1_N PF14382 26-64 EXOS2_MOUSE exosome component 2 EXOS2_HUMAN Scaffold protein RNA modification # RNA degradation RNA exosome # #
202EXOSC3 Pfam-B_7181 PB007181 221-267 EXOS3_MOUSE exosome component 3 EXOS3_HUMAN Scaffold protein RNA modification # RNA degradation RNA exosome # #
203EXOSC4 Pfam-B_25613 PB025613 221-243 RNase_PH PF01138 21-152 RNase_PH_C PF03725 155-220 EXOS4_MOUSE exosome component 4 EXOS4_HUMAN Scaffold protein RNA modification # RNA degradation RNA exosome # #
204EXOSC5 RNase_PH PF01138 27-147 RNase_PH_C PF03725 150-216 EXOS5_MOUSE exosome component 5 EXOS5_HUMAN Scaffold protein RNA modification # RNA degradation RNA exosome # #
205EXOSC6 RNase_PH PF01138 35-175 EXOS6_MOUSE exosome component 6 EXOS6_HUMAN Scaffold protein RNA modification # RNA degradation RNA exosome # #
206EXOSC7 RNase_PH PF01138 31-166 RNase_PH_C PF03725 196-262 EXOS7_MOUSE exosome component 7 EXOS7_HUMAN Scaffold protein RNA modification # RNA degradation RNA exosome # #
207EXOSC8 RNase_PH PF01138 31-166 RNase_PH_C PF03725 191-258 EXOS8_MOUSE exosome component 8 EXOS8_HUMAN Scaffold protein RNA modification # RNA degradation RNA exosome # #
208EXOSC9 RNase_PH PF01138 31-163 RNase_PH_C PF03725 189-256 EXOS9_MOUSE exosome component 9 EXOS9_HUMAN Scaffold protein RNA modification # RNA degradation RNA exosome # #
209EYA1 Pfam-B_10178 PB010178 530-586 Pfam-B_3150 PB003150 209-513 EYA1_MOUSE EYA transcriptional coactivator and phosphatase 1 EYA1_HUMAN Histone modification erase Histone phosphorylation # H2AXT142 #
210EYA2 # EYA2_MOUSE EYA transcriptional coactivator and phosphatase 2 EYA2_HUMAN Histone modification erase Histone phosphorylation # H2AXT142 #
211EYA3 # EYA3_MOUSE EYA transcriptional coactivator and phosphatase 3 EYA3_HUMAN Histone modification erase Histone phosphorylation # H2AXT142 #
212EYA4 Pfam-B_6035 PB006035 96-142 EYA4_MOUSE EYA transcriptional coactivator and phosphatase 4 EYA4_HUMAN Histone modification erase Histone phosphorylation # H2AXY142ph H2AXY142
213EZH1 EZH2_WD-Binding PF11616 39-68 SET PF00856 624-728 EZH1_MOUSE enhancer of zeste 1 polycomb repressive complex 2 subunit EZH1_HUMAN Histone modification write Polycomb group (PcG) protein Histone methylation # PRC2 H3K27 H3K27me1 H3K27me2 H3K27me3
214EZH2 EZH2_WD-Binding PF11616 39-68 SET PF00856 623-727 EZH2_MOUSE enhancer of zeste 2 polycomb repressive complex 2 subunit EZH2_HUMAN Histone modification write Polycomb group (PcG) protein Histone methylation # PRC2 H3K27 H3K27me1 H3K27me2 H3K27me3
215FAM175A Pfam-B_8506 PB008506 1-175 F175A_MOUSE family with sequence similarity 175 member A F175A_HUMAN Scaffold protein # BRCA1-A # #
216FAM175B Pfam-B_24421 PB024421 331-390 F175B_MOUSE family with sequence similarity 175 member B F175B_HUMAN Histone modification erase cofactor Histone ubiquitination BRISC H2AK63 H2AK63ub
217FBL Fibrillarin PF01269 88-315 FBRL_MOUSE fibrillarin FBRL_HUMAN Histone modification write Histone methylation # H2AQ104 H2AQ104me
218FBRS Auts2 PF15336 82-282 Pfam-B_58582 PB058582 283-359 FBRS_MOUSE fibrosin FBRS_HUMAN Histone modification # RING2-FBRS # #
219FBRSL1 Auts2 PF15336 587-791 Pfam-B_17807 PB017807 439-487 Pfam-B_187339 PB187339 41-131 Pfam-B_52362 PB052362 164-412 # fibrosin-like 1 FBSL_HUMAN Histone modification # RING2-FBRS # #
220FOXA1 Fork_head PF00250 170-265 Fork_head_N PF08430 17-169 HNF_C PF09354 397-461 FOXA1_MOUSE forkhead box A1 FOXA1_HUMAN Chromatin remodelling TF # # # DNA motif #
221FOXO1 Fork_head PF00250 127-268 Pfam-B_12765 PB012765 601-653 Pfam-B_39024 PB039024 1-49 FOXO1_MOUSE forkhead box O1 FOXO1_HUMAN TF # # DNA motif H3 H4 #
222FOXP1 Fork_head PF00250 465-555 Pfam-B_24123 PB024123 1-79 FOXP1_MOUSE forkhead box P1 FOXP1_HUMAN TF # # DNA motif #
223FOXP2 Fork_head PF00250 504-593 Pfam-B_4008 PB004008 240-308 FOXP2_MOUSE forkhead box P2 FOXP2_HUMAN TF # # DNA motif #
224FOXP3 Fork_head PF00250 337-426 FOXP3_MOUSE forkhead box P3 FOXP3_HUMAN TF # # DNA motif #
225FOXP4 Fork_head PF00250 467-555 Pfam-B_22084 PB022084 1-155 Pfam-B_23482 PB023482 569-647 Pfam-B_4008 PB004008 201-230 FOXP4_MOUSE forkhead box P4 FOXP4_HUMAN TF # # DNA motif #
226GADD45A Ribosomal_L7Ae PF01248 21-123 GA45A_MOUSE growth arrest and DNA-damage-inducible alpha GA45A_HUMAN Chromatin remodelling # # H2A H2B H3 H4 #
227GADD45B Ribosomal_L7Ae PF01248 21-121 GA45B_MOUSE growth arrest and DNA-damage-inducible beta GA45B_HUMAN Chromatin remodelling # # H2A H2B H3 H4 #
228GADD45G Ribosomal_L7Ae PF01248 24-113 GA45G_MOUSE growth arrest and DNA-damage-inducible gamma GA45G_HUMAN Chromatin remodelling # # H2A H2B H3 H4 #
229GATAD1 GATA PF00320 9-36 Pfam-B_13145 PB013145 175-216 Pfam-B_17231 PB017231 235-263 GATD1_MOUSE GATA zinc finger domain containing 1 GATD1_HUMAN Histone modification read # # H3K4me3 #
230GATAD2A Pfam-B_2058 PB002058 1-79 P66A_MOUSE GATA zinc finger domain containing 2A P66A_HUMAN Histone modification read # NuRD H2A H2B H3 H4 #
231GATAD2B GATA PF00320 420-454 P66B_MOUSE GATA zinc finger domain containing 2B P66B_HUMAN Histone modification read # NuRD H2A H2B H3 H4 #
232GFI1 LIM PF00412 228-283 287-342 346-401 405-460 Paxillin PF03535 6-135 GFI1_MOUSE growth factor independent 1 transcription repressor GFI1_HUMAN Chromatin remodelling # # # #
233GFI1B zf-C2H2 PF00096 220-242 zf-H2C2_2 PF13465 177-203 262-287 290-314 GFI1B_MOUSE growth factor independent 1B transcription repressor GFI1B_HUMAN Histone modification cofactor # # # #
234GLYR1 NAD_binding_11 PF14833 430-551 NAD_binding_2 PF03446 267-429 PWWP PF00855 6-89 GLYR1_MOUSE glyoxylate reductase 1 homolog (Arabidopsis) GLYR1_HUMAN Histone modification read # # H3K4me3 #
235GSE1 DUF3736 PF12540 70-203 731-874 GSE1_MOUSE Gse1 coiled-coil protein GSE1_HUMAN Histone modification erase Histone acetylation BHC LSD-CoREST # #
236GSG2 DUF3635 PF12330 708-797 Pfam-B_41097 PB041097 111-310 Pfam-B_49843 PB049843 1-109 Pkinase PF00069 484-699 HASP_MOUSE germ cell associated 2 (haspin) HASP_HUMAN Histone modification write Histone phosphorylation # H3T3 H3T3ph
237GTF2I GTF2I PF02946 112-187 361-436 466-541 571-646 733-808 868-943 GTF2I_MOUSE general transcription factor IIi GTF2I_HUMAN TF # BHC DNA motif #
238GTF3C4 TFIIIC_delta PF12657 61-254 zf-TFIIIC PF12660 733-822 TF3C4_MOUSE general transcription factor IIIC polypeptide 4 90kDa TF3C4_HUMAN Histone modification write Histone acetylation # H3 #
239HAT1 Hat1_N PF10394 26-187 HAT1_MOUSE histone acetyltransferase 1 HAT1_HUMAN Histone modification write Histone acetylation # H4 H2A #
240HCFC1 Kelch_1 PF01344 32-71 Kelch_3 PF13415 91-145 146-208 215-263 264-330 Pfam-B_49758 PB049758 381-598 HCFC1_MOUSE host cell factor C1 HCFC1_HUMAN Chromatin remodelling # NSL COMPASS MLL-HCF CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 # #
241HCFC2 Kelch_1 PF01344 244-301 Kelch_3 PF13415 205-253 Kelch_5 PF13854 312-356 HCFC2_MOUSE host cell factor C2 HCFC2_HUMAN Histone modification write cofactor Histone modification write cofactor Histone methylation Histone acetylation MLL-HCF CHD8 MLL2/3 MLL4/WBP7 H3 #
242HDAC1 Hist_deacetyl PF00850 18-320 Pfam-B_22185 PB022185 444-478 HDAC1_MOUSE histone deacetylase 1 HDAC1_HUMAN Histone modification erase Histone acetylation SWI/SNF_Brm NuRD BHC MeCP1 mSin3A core HDAC mSin3A-like complex RING2-L3MBTL2 CREST-BRG1 LSD-CoREST H3 H4 #
243HDAC2 Hist_deacetyl PF00850 19-321 Pfam-B_46198 PB046198 351-449 HDAC2_MOUSE histone deacetylase 2 HDAC2_HUMAN Histone modification erase Histone acetylation SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm NuRD BHC MeCP1 mSin3A core HDAC mSin3A-like complex RING2-L3MBTL2 LSD-CoREST H2AKac H2BKac H3Kac H4Kac H2AK H2BK H3K H4K
244HDAC3 Hist_deacetyl PF00850 11-315 Pfam-B_3137 PB003137 353-383 HDAC3_MOUSE histone deacetylase 3 HDAC3_HUMAN Histone modification erase Histone acetylation # H2AKac H2BKac H3Kac H4Kac H2AK H2BK H3K H4K
245HDAC4 Arb2 PF09757 1000-1059 HDAC4_Gln PF12203 61-152 Hist_deacetyl PF00850 664-993 HDAC4_MOUSE histone deacetylase 4 HDAC4_HUMAN Histone modification erase Histone acetylation # H2AKac H2BKac H3Kac H4Kac H2AK H2BK H3K H4K
246HDAC5 HDAC4_Gln PF12203 66-133 Hist_deacetyl PF00850 693-1023 HDAC5_MOUSE histone deacetylase 5 HDAC5_HUMAN Histone modification erase Histone acetylation # H2AKac H2BKac H3Kac H4Kac H2AK H2BK H3K H4K
247HDAC6 Hist_deacetyl PF00850 95-403 489-799 zf-UBP PF02148 1133-1195 HDAC6_MOUSE histone deacetylase 6 HDAC6_HUMAN Histone modification erase Histone acetylation # H2AKac H2BKac H3Kac H4Kac H2AK H2BK H3K H4K
248HDAC7 Hist_deacetyl PF00850 530-860 Pfam-B_5922 PB005922 1-148 HDAC7_MOUSE histone deacetylase 7 HDAC7_HUMAN Histone modification erase Histone acetylation # H2AKac H2BKac H3Kac H4Kac H2AK H2BK H3K H4K
249HDAC8 Hist_deacetyl PF00850 21-323 Pfam-B_15628 PB015628 324-375 HDAC8_MOUSE histone deacetylase 8 HDAC8_HUMAN Histone modification erase Histone acetylation # H2AKac H2BKac H3Kac H4Kac H2AK H2BK H3K H4K
250HDAC9 HDAC4_Gln PF12203 36-124 Hist_deacetyl PF00850 643-973 Pfam-B_5353 PB005353 577-624 HDAC9_MOUSE histone deacetylase 9 HDAC9_HUMAN Histone modification erase Histone acetylation # H3Kac H4Kac H3K H4K
251HDAC10 Hist_deacetyl PF00850 13-322 HDA10_MOUSE histone deacetylase 10 HDA10_HUMAN Histone modification erase Histone acetylation # H2AKac H2BKac H3Kac H4Kac H2AK H2BK H3K H4K
252HDAC11 Hist_deacetyl PF00850 23-320 HDA11_MOUSE histone deacetylase 11 HDA11_HUMAN Histone modification erase Histone acetylation # H2AKac H2BKac H3Kac H4Kac H2AK H2BK H3K H4K
253HDGF PWWP PF00855 10-92 HDGF_MOUSE hepatoma-derived growth factor HDGF_HUMAN Chromatin remodelling TF # TF repressor # DNA motif #
254HELLS Helicase_C PF00271 633-712 SNF2_N PF00176 226-577 HELLS_MOUSE helicase lymphoid-specific HELLS_HUMAN Chromatin remodelling # # # #
255HIF1AN Cupin_8 PF13621 48-302 HIF1N_MOUSE hypoxia inducible factor 1 alpha subunit inhibitor HIF1N_HUMAN Histone modification erase cofactor Histone acetylation # # #
256HINFP Pfam-B_17110 PB017110 1-103 zf-C2H2 PF00096 255-278 345-368 zf-C2H2_4 PF13894 229-254 zf-H2C2_2 PF13465 185-210 HINFP_MOUSE histone H4 transcription factor HINFP_HUMAN Histone modification read TF TF # TF activator TF repressor # H4 DNA motif #
257HIRA HIRA_B PF09453 448-471 Hira PF07569 763-962 Pfam-B_18560 PB018560 963-1015 WD40 PF00400 5-44 60-98 121-159 164-202 258-312 HIRA_MOUSE histone cell cycle regulator HIRA_HUMAN Histone modification read # # H2B H4 #
258HIRIP3 CHZ PF09649 484-520 HIRP3_MOUSE HIRA interacting protein 3 HIRP3_HUMAN Histone modification read # # H2A H3 #
259HJURP HJURP_C PF12347 409-471 554-614 HJURP_mid PF12346 271-386 Pfam-B_631 PB000631 682-746 Scm3 PF10384 16-77 HJURP_MOUSE Holliday junction recognition protein HJURP_HUMAN Histone chaperone # # H4 #
260HLCS BPL_C PF02237 669-718 BPL_LplA_LipB PF03099 471-603 Pfam-B_33359 PB033359 244-405 Pfam-B_35799 PB035799 407-469 BPL1_MOUSE holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) BPL1_HUMAN Histone modification write # # H1 H2A H2B H4 #
261HLTF HIRAN PF08797 60-155 Helicase_C PF00271 870-950 SNF2_N PF00176 243-722 zf-RING_2 PF13639 758-801 HLTF_MOUSE helicase-like transcription factor HLTF_HUMAN Chromatin remodelling cofactor # # # #
262HMG20A HMG_box PF00505 103-171 HM20A_MOUSE high mobility group 20A HM20A_HUMAN Chromatin remodelling cofactor # LSD-CoREST H3K4 #
263HMG20B HMG_box PF00505 70-138 Pfam-B_10576 PB010576 211-315 HM20B_MOUSE high mobility group 20B HM20B_HUMAN Chromatin remodelling # BHC LSD-CoREST # #
264HMGB1 HMG_box PF00505 95-163 HMG_box_2 PF09011 6-79 HMGB1_MOUSE high mobility group box 1 HMGB1_HUMAN Chromatin remodelling # # # #
265HMGN1 HMG14_17 PF01101 2-96 HMGN1_MOUSE high mobility group nucleosome binding domain 1 HMGN1_HUMAN Chromatin remodelling # # H1 #
266HMGN2 HMG14_17 PF01101 2-90 HMGN2_MOUSE high mobility group nucleosomal binding domain 2 HMGN2_HUMAN Chromatin remodelling # # H1 #
267HMGN3 HMG14_17 PF01101 2-98 HMGN3_MOUSE high mobility group nucleosomal binding domain 3 HMGN3_HUMAN Chromatin remodelling # # H1 #
268HMGN4 HMG14_17 PF01101 2-90 # high mobility group nucleosomal binding domain 4 HMGN4_HUMAN Chromatin remodelling # # H1 #
269HMGN5 HMG14_17 PF01101 2-102 HMGN5_MOUSE high mobility group nucleosome binding domain 5 HMGN5_HUMAN Chromatin remodelling # # H1 #
270HP1BP3 Linker_histone PF00538 157-232 260-330 341-412 HP1B3_MOUSE heterochromatin protein 1 binding protein 3 HP1B3_HUMAN Chromatin remodelling # # # #
271HR JmjC PF02373 1026-1140 Pfam-B_40014 PB040014 312-431 Pfam-B_80075 PB080075 181-289 HAIR_MOUSE hair growth associated HAIR_HUMAN Histone modification erase Histone methylation # H3K9me1 H3K9me2 H3K9
272HSPA1A HSP70 PF00012 6-612 HS71A_MOUSE heat shock 70kDa protein 1A HSP71_HUMAN Histone modification write cofactor Histone modification write cofactor Histone methylation Histone acetylation CHD8 MLL2/3 MLL4/WBP7 # #
273HSPA1B HSP70 PF00012 6-612 HS71A_MOUSE heat shock 70kDa protein 1B HSP71_HUMAN Histone modification write cofactor Histone modification write cofactor Histone methylation Histone acetylation CHD8 MLL2/3 MLL4/WBP7 # #
274HUWE1 DUF4414 PF14377 2968-3079 DUF908 PF06012 89-370 DUF913 PF06025 429-815 HECT PF00632 4067-4374 Pfam-B_13571 PB013571 3944-3965 Pfam-B_15798 PB015798 3091-3191 Pfam-B_20712 PB020712 2429-2459 Pfam-B_6870 PB006870 3966-4021 UBA PF00627 1317-1352 WWE PF02825 1611-1679 HUWE1_MOUSE HECT UBA and WWE domain containing 1 E3 ubiquitin protein ligase HUWE1_HUMAN Histone modification write Histone ubiquitination # H3K9 #
275IKBKAP IKI3 PF04762 1-954 Pfam-B_8846 PB008846 1048-1212 ELP1_MOUSE inhibitor of kappa light polypeptide gene enhancer in B-cells kinase complex-associated protein ELP1_HUMAN Scaffold protein # Pol2 elongator RNA #
276IKZF1 zf-H2C2_2 PF13465 131-156 159-184 187-212 IKZF1_MOUSE IKAROS family zinc finger 1 (Ikaros) IKZF1_HUMAN Chromatin remodelling TF # # # DNA motif #
277IKZF3 Pfam-B_2031 PB002031 67-110 zf-C2H2_4 PF13894 480-504 zf-H2C2_2 PF13465 132-157 160-183 188-213 IKZF3_MOUSE IKAROS family zinc finger 3 (Aiolos) IKZF3_HUMAN TF # # DNA motif #
278ING1 ING PF12998 173-256 PHD PF00628 355-402 Pfam-B_837 PB000837 51-89 ING1_MOUSE inhibitor of growth family member 1 ING1_HUMAN Histone modification read # # H3K4me3 #
279ING2 ING PF12998 26-125 PHD PF00628 214-261 ING2_MOUSE inhibitor of growth family member 2 ING2_HUMAN Histone modification read # mSin3A-like complex H3K4me3 #
280ING3 ING PF12998 2-104 PHD PF00628 362-409 ING3_MOUSE inhibitor of growth family member 3 ING3_HUMAN Chromatin remodelling Histone modification write cofactor # Histone acetylation SWR NuA4 Piccolo_NuA4 H2A H4 #
281ING4 ING PF12998 5-107 PHD PF00628 198-245 ING4_MOUSE inhibitor of growth family member 4 ING4_HUMAN Histone modification read # HBO1 H3K4me3 #
282ING5 ING PF12998 5-107 PHD PF00628 188-235 ING5_MOUSE inhibitor of growth family member 5 ING5_HUMAN Histone modification read # HBO1 MOZ/MORF H3K4me3 H3K4me2 #
283INO80 DBINO PF13892 270-410 Helicase_C PF00271 1135-1214 Pfam-B_16799 PB016799 1435-1475 SNF2_N PF00176 521-822 INO80_MOUSE INO80 complex subunit INO80_HUMAN Chromatin remodelling # Ino80 # #
284INO80B PAPA-1 PF04795 211-293 zf-HIT PF04438 305-336 IN80B_MOUSE INO80 complex subunit B IN80B_HUMAN Chromatin remodelling cofactor # Ino80 # #
285INO80C YL1_C PF08265 141-170 IN80C_MOUSE INO80 complex subunit C IN80C_HUMAN Chromatin remodelling cofactor # Ino80 CHD8 MLL2/3 MLL4/WBP7 # #
286INO80D Pfam-B_14282 PB014282 588-622 zf-C3Hc3H PF13891 16-80 446-512 IN80D_MOUSE INO80 complex subunit D IN80D_HUMAN Chromatin remodelling cofactor # Ino80 # #
287INO80E # # INO80 complex subunit E IN80E_HUMAN Chromatin remodelling cofactor # # # #
288JADE1 EPL1 PF10513 29-181 PHD_2 PF13831 217-251 zf-HC5HC2H_2 PF13832 256-368 JADE1_MOUSE jade family PHD finger 1 JADE1_HUMAN Histone modification write Histone acetylation HBO1 H3 H4 H3ac H4ac
289JADE2 EPL1 PF10513 39-177 PHD_2 PF13831 213-247 Pfam-B_23296 PB023296 631-669 zf-HC5HC2H_2 PF13832 252-364 JADE2_MOUSE jade family PHD finger 2 JADE2_HUMAN Histone modification write Histone acetylation HBO1 H3 H4 H3ac H4ac
290JADE3 EPL1 PF10513 30-178 PHD PF00628 202-249 zf-HC5HC2H_2 PF13832 253-365 JADE3_MOUSE jade family PHD finger 3 JADE3_HUMAN Histone modification write Histone acetylation HBO1 H3 H4 H3ac H4ac
291JAK2 Pkinase_Tyr PF07714 545-805 849-1123 SH2 PF00017 400-481 JAK2_MOUSE Janus kinase 2 JAK2_HUMAN Histone modification write Histone phosphorylation # H3T41 H3T41ph
292JARID2 ARID PF01388 618-709 JmjC PF02373 916-1031 JmjN PF02375 558-591 Pfam-B_728 PB000728 1-122 zf-C5HC2 PF02928 1139-1193 JARD2_MOUSE jumonji AT rich interactive domain 2 JARD2_HUMAN Histone modification write cofactor Histone methylation PRC2 H3K27 H3K9 #
293JDP2 bZIP_1 PF00170 70-131 JDP2_MOUSE Jun dimerization protein 2 JDP2_HUMAN Chromatin remodelling Histone modification erase cofactor # Histone acetylation # # #
294JMJD1C JmjC PF02373 2381-2481 Pfam-B_14856 PB014856 2090-2122 Pfam-B_15350 PB015350 2148-2224 Pfam-B_16501 PB016501 1889-1927 Pfam-B_17329 PB017329 541-947 Pfam-B_19453 PB019453 1929-2023 Pfam-B_2770 PB002770 220-524 Pfam-B_63706 PB063706 1-119 JHD2C_MOUSE jumonji domain containing 1C JHD2C_HUMAN Histone modification erase Histone methylation # H3K9me H3K9
295JMJD6 JmjC PF02373 174-288 Pfam-B_22969 PB022969 1-39 JMJD6_MOUSE jumonji domain containing 6 JMJD6_HUMAN Histone modification erase Histone methylation # H3R2me H4R3me H3R2 H4R3
296KANSL1 PEHE PF15275 885-1035 Pfam-B_14811 PB014811 571-639 Pfam-B_19390 PB019390 431-469 Pfam-B_2194 PB002194 135-403 Pfam-B_6892 PB006892 471-569 KANL1_MOUSE KAT8 regulatory NSL complex subunit 1 KANL1_HUMAN Histone modification write cofactor Histone modification write cofactor Histone methylation Histone acetylation NSL CHD8 MLL2/3 MLL4/WBP7 H4 H4ac
297KANSL2 Pfam-B_21577 PB021577 1-25 zf-C3Hc3H PF13891 27-93 300-365 KANL2_MOUSE KAT8 regulatory NSL complex subunit 2 KANL2_HUMAN Histone modification write cofactor Histone acetylation NSL H5 H4ac
298KANSL3 Abhydrolase_5 PF12695 287-436 Pfam-B_10092 PB010092 521-544 Pfam-B_8995 PB008995 545-589 KANL3_MOUSE KAT8 regulatory NSL complex subunit 3 KANL3_HUMAN Histone modification write cofactor Histone acetylation NSL H6 H4ac
299KAT2A Acetyltransf_1 PF00583 553-628 Bromodomain PF00439 737-820 PCAF_N PF06466 86-337 Pfam-B_10717 PB010717 1-67 KAT2A_MOUSE K(lysine) acetyltransferase 2A KAT2A_HUMAN Histone modification write Histone acetylation TFTC-HAT SAGA ATAC STAGA # #
300KAT2B Acetyltransf_7 PF13508 541-624 Bromodomain PF00439 732-815 PCAF_N PF06466 74-327 Pfam-B_358817 PB358817 339-381 KAT2B_MOUSE K(lysine) acetyltransferase 2B KAT2B_HUMAN Histone modification write Histone acetylation # # #
301KAT5 MOZ_SAS PF01853 285-477 Tudor-knot PF11717 7-65 KAT5_MOUSE K(lysine) acetyltransferase 5 KAT5_HUMAN Histone modification write Histone acetylation SWR NuA4 Piccolo_NuA4 H2AK5 H3K14 H4K5 H4K8 H4K12 H4K16 H2AK5ac H3K14ac H4K5ac H4K8ac H4K12ac H4K16ac
302KAT6A MOZ_SAS PF01853 562-749 PHD PF00628 208-265 264-313 Pfam-B_19382 PB019382 1-84 Pfam-B_21350 PB021350 1011-1048 Pfam-B_25985 PB025985 1056-1116 Pfam-B_3468 PB003468 1648-1699 Pfam-B_6470 PB006470 1487-1601 KAT6A_MOUSE K(lysine) acetyltransferase 6A KAT6A_HUMAN Histone modification write Histone acetylation MOZ/MORF H3 H4 H3ac H4ac
303KAT6B Linker_histone PF00538 106-175 MOZ_SAS PF01853 773-960 PHD PF00628 271-320 Pfam-B_6470 PB006470 1604-1717 KAT6B_MOUSE K(lysine) acetyltransferase 6B KAT6B_HUMAN Histone modification write Histone acetylation MOZ/MORF H3 H3ac
304KAT7 MOZ_SAS PF01853 390-577 zf-C2HC PF01530 182-212 KAT7_MOUSE K(lysine) acetyltransferase 7 KAT7_HUMAN Histone modification write Histone acetylation HBO1 H4 H4ac
305KAT8 MOZ_SAS PF01853 232-418 Tudor-knot PF11717 55-111 KAT8_MOUSE K(lysine) acetyltransferase 8 KAT8_HUMAN Histone modification write Histone acetylation NSL CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 H2A H3 H4 H2Aac H3ac H4ac
306KDM1A Amino_oxidase PF01593 288-826 SWIRM PF04433 174-264 KDM1A_MOUSE lysine (K)-specific demethylase 1A KDM1A_HUMAN Histone modification erase Histone methylation NuRD BHC SCL H3K4me1 H3K4me2 H3K9me H3K4 H3K9
307KDM1B Amino_oxidase PF01593 392-820 zf-CW PF07496 137-192 KDM1B_MOUSE lysine (K)-specific demethylase 1B KDM1B_HUMAN Histone modification erase Histone methylation # H3K4me1 H3K4me2 H3K4
308KDM2A F-box PF00646 889-935 JmjC PF02373 199-299 Pfam-B_11167 PB011167 362-470 Pfam-B_6618 PB006618 951-1149 Pfam-B_9841 PB009841 686-744 zf-CXXC PF02008 563-609 KDM2A_MOUSE lysine (K)-specific demethylase 2A KDM2A_HUMAN Histone modification erase Histone methylation # H3K36me2 H3K36
309KDM2B Cupin_8 PF13621 23-335 F-box PF00646 1050-1107 Pfam-B_23456 PB023456 441-519 Pfam-B_33113 PB033113 1235-1289 zf-CXXC PF02008 605-651 KDM2B_MOUSE lysine (K)-specific demethylase 2B KDM2B_HUMAN Histone modification erase Histone methylation BCOR H3K4me3 H3K36me2 H3K4 H3K36
310KDM3A JmjC PF02373 1151-1264 Pfam-B_14772 PB014772 851-889 Pfam-B_17027 PB017027 351-439 Pfam-B_6147 PB006147 441-539 Pfam-B_7111 PB007111 781-849 KDM3A_MOUSE lysine (K)-specific demethylase 3A KDM3A_HUMAN Histone modification erase Histone methylation # H3K9me1 H3K9me2 H3K9
311KDM3B JmjC PF02373 1594-1704 Pfam-B_16202 PB016202 1548-1593 Pfam-B_16670 PB016670 1497-1546 Pfam-B_19299 PB019299 351-469 Pfam-B_22020 PB022020 711-779 Pfam-B_3525 PB003525 571-639 Pfam-B_38652 PB038652 1-39 Pfam-B_6147 PB006147 471-569 Pfam-B_7111 PB007111 781-839 KDM3B_MOUSE lysine (K)-specific demethylase 3B KDM3B_HUMAN Histone modification erase Histone methylation # H3K9me1 H3K9me2 H3K9
312KDM4A JmjC PF02373 175-291 JmjN PF02375 15-49 PHD_2 PF13831 732-767 zf-HC5HC2H_2 PF13832 773-884 KDM4A_MOUSE lysine (K)-specific demethylase 4A KDM4A_HUMAN Histone modification erase Histone methylation # H3K4me3 H3K36me3 H3K4me2 H3K36me2
313KDM4B JmjC PF02373 176-292 JmjN PF02375 16-50 PHD_2 PF13831 754-789 Pfam-B_12059 PB012059 1021-1094 zf-HC5HC2H_2 PF13832 795-906 KDM4B_MOUSE lysine (K)-specific demethylase 4B KDM4B_HUMAN Histone modification erase Histone methylation # H3K9me3 H3K9me1 H3K9me2
314KDM4C JmjC PF02373 177-293 JmjN PF02375 17-51 PHD_2 PF13831 712-747 Pfam-B_10616 PB010616 1021-1054 Pfam-B_14467 PB014467 422-670 Pfam-B_5109 PB005109 891-1019 zf-HC5HC2H_2 PF13832 753-864 KDM4C_MOUSE lysine (K)-specific demethylase 4C KDM4C_HUMAN Histone modification erase Histone methylation # H3K9me3 H3K36me3 H3K9me1 H3K9me2
315KDM4D JmjC PF02373 179-295 JmjN PF02375 19-53 Pfam-B_45485 PB045485 324-356 Pfam-B_84013 PB084013 451-521 KDM4D_MOUSE lysine (K)-specific demethylase 4D KDM4D_HUMAN Histone modification erase Histone methylation # H3K9me3 H3K9me1 H3K9me2
316KDM4E JmjC PF02373 176-292 JmjN PF02375 16-50 # lysine (K)-specific demethylase 4E KDM4E_HUMAN Histone modification erase Histone methylation # H3K9me2 H3K9me3 H3K9
317KDM5A ARID PF01388 81-170 JmjC PF02373 470-586 JmjN PF02375 20-53 PHD PF00628 295-343 1163-1218 PLU-1 PF08429 740-1072 zf-C5HC2 PF02928 676-729 KDM5A_MOUSE lysine (K)-specific demethylase 5A KDM5A_HUMAN Histone modification erase Histone methylation # H3K4me3 H3K4
318KDM5B ARID PF01388 94-183 JmjC PF02373 486-602 JmjN PF02375 33-66 PHD PF00628 311-359 1178-1224 1486-1538 PLU-1 PF08429 756-1088 zf-C5HC2 PF02928 692-745 KDM5B_MOUSE lysine (K)-specific demethylase 5B KDM5B_HUMAN Histone modification erase Histone methylation # H3K4me3 H3K4
319KDM5C ARID PF01388 76-165 JmjC PF02373 501-617 JmjN PF02375 15-48 PHD PF00628 326-374 1187-1250 PLU-1 PF08429 771-1100 Pfam-B_12821 PB012821 1417-1482 zf-C5HC2 PF02928 707-760 KDM5C_MOUSE lysine (K)-specific demethylase 5C KDM5C_HUMAN Histone modification erase Histone methylation # H3K4me3 H3K4me2 H3K4me1
320KDM5D ARID PF01388 76-165 JmjC PF02373 491-607 JmjN PF02375 15-48 PHD PF00628 316-364 1174-1237 PLU-1 PF08429 761-1087 Pfam-B_12821 PB012821 1401-1443 zf-C5HC2 PF02928 697-750 KDM5D_MOUSE lysine (K)-specific demethylase 5D KDM5D_HUMAN Histone modification erase Histone methylation # H3K4me3 H3K4me2 H3K4
321KDM6A JmjC PF02373 1133-1241 Pfam-B_604 PB000604 631-769 Pfam-B_972 PB000972 771-1109 TPR_1 PF00515 130-163 318-351 352-380 TPR_17 PF13431 272-304 TPR_8 PF13181 205-238 KDM6A_MOUSE lysine (K)-specific demethylase 6A KDM6A_HUMAN Histone modification erase Histone methylation CHD8 MLL2/3 MLL4/WBP7 COMPASS-like MLL3 4 H3K27me2. H3K27me3 H3K27
322KDM6B JmjC PF02373 1377-1485 Pfam-B_5108 PB005108 101-843 Pfam-B_992 PB000992 1-99 KDM6B_MOUSE lysine (K)-specific demethylase 6B KDM6B_HUMAN Histone modification erase Histone methylation # H3K27me2. H3K27me4 H3K28
323KDM7A PHD PF00628 39-88 JmjC PF02373 269-369 Pfam-B_18122 PB018122 381-538 Pfam-B_13686 PB013686 541-639 Pfam-B_1060 PB001060 853-939 KDM7A_MOUSE lysine (K)-specific demethylase 7A KDM7A_HUMAN Histone modification erase Histone methylation # H3K9me2 H3K27me2 H4K20me1 H3K9 H3K27 H4K20
324KDM8 Cupin_8 PF13621 192-416 KDM8_MOUSE lysine (K)-specific demethylase 8 KDM8_HUMAN Histone modification erase Histone methylation # H3K36me2 H3K36
325KEAP1 BACK PF07707 184-286 BTB PF00651 67-179 Kelch_1 PF01344 317-359 361-410 412-457 459-504 506-551 553-598 KEAP1_MOUSE kelch-like ECH-associated protein 1 KEAP1_HUMAN Chromatin remodelling # # # #
326KMT2A FYRC PF05965 3666-3749 FYRN PF05964 2023-2073 PHD PF00628 1481-1533 1568-1627 Pfam-B_11202 PB011202 1021-1086 SET PF00856 3840-3945 zf-CXXC PF02008 1147-1194 zf-HC5HC2H PF13771 1900-1978 KMT2A_MOUSE lysine (K)-specific methyltransferase 2A KMT2A_HUMAN Histone modification write Histone methylation MLL-HCF CHD8 COMPASS-like MLL1 2 H3K4 H3K4me
327KMT2B FYRC PF05965 2411-2494 FYRN PF05964 1732-1782 PHD PF00628 1251-1303 1337-1396 Pfam-B_25060 PB025060 1783-1849 Pfam-B_25524 PB025524 1168-1202 Pfam-B_26440 PB026440 701-839 Pfam-B_27348 PB027348 2191-2289 Pfam-B_3353 PB003353 1981-2079 Pfam-B_6332 PB006332 1401-1479 Pfam-B_85509 PB085509 345-387 SET PF00856 2586-2691 zf-CXXC PF02008 958-1005 zf-HC5HC2H PF13771 1608-1686 KMT2B_MOUSE lysine (K)-specific methyltransferase 2B KMT2B_HUMAN Histone modification write Histone methylation Menin-associated_HMT MLL2/3 COMPASS-like MLL3 4 H3K4 H3K4me3
328KMT2C FYRC PF05965 4606-4693 FYRN PF05964 4550-4604 PHD PF00628 390-438 959-1010 1009-1060 Pfam-B_16694 PB016694 2536-2572 Pfam-B_19991 PB019991 1874-1906 Pfam-B_43 PB000043 3044-3095 Pfam-B_49476 PB049476 1-159 SET PF00856 4782-4887 zf-HC5HC2H PF13771 252-331 4429-4507 KMT2C_MOUSE lysine (K)-specific methyltransferase 2C KMT2C_HUMAN Histone modification write Histone methylation MLL2/3 COMPASS-like MLL3 4 H3K4 H3K4me
329KMT2D FYRC PF05965 5236-5323 FYRN PF05964 5180-5234 PHD PF00628 275-323 1379-1429 1429-1477 Pfam-B_26489 PB026489 5016-5050 Pfam-B_29065 PB029065 423-678 Pfam-B_2976 PB002976 1682-1717 Pfam-B_33020 PB033020 3681-3767 SET PF00856 5408-5513 zf-HC5HC2H PF13771 139-218 5059-5137 KMT2D_MOUSE lysine (K)-specific methyltransferase 2D KMT2D_HUMAN Histone modification write Histone methylation COMPASS-like MLL1 2 MLL4/WBP7 COMPASS-like MLL3 4 H3K4 H3K4me
330KMT2E PHD PF00628 120-166 Pfam-B_13611 PB013611 1791-1856 Pfam-B_19470 PB019470 1301-1369 Pfam-B_19601 PB019601 1131-1179 Pfam-B_20626 PB020626 961-1129 Pfam-B_22469 PB022469 871-959 Pfam-B_24586 PB024586 1261-1299 Pfam-B_7010 PB007010 1651-1789 Pfam-B_7713 PB007713 731-869 SET PF00856 342-447 KMT2E_MOUSE lysine (K)-specific methyltransferase 2E KMT2E_HUMAN Histone modification write Histone methylation # H3K4 H3K4me1 H3K4me2
331L3MBTL1 MBT PF02820 242-314 349-421 453-525 SAM_1 PF00536 681-745 zf-C2HC PF01530 551-581 LMBL1_MOUSE l(3)mbt-like 1 (Drosophila) LMBL1_HUMAN Histone modification read # L3MBTL1 H1BK26 H4K20 #
332L3MBTL2 MBT PF02820 214-290 327-395 432-508 540-610 LMBL2_MOUSE l(3)mbt-like 2 (Drosophila) LMBL2_HUMAN Histone modification read # RING2-L3MBTL2 H3K4 H3K9 H3K27 H4K20 #
333L3MBTL3 MBT PF02820 268-340 375-447 479-548 Pfam-B_29190 PB029190 1-79 SAM_1 PF00536 706-770 LMBL3_MOUSE l(3)mbt-like 3 (Drosophila) LMBL3_HUMAN Histone modification read # # H4K20me #
334L3MBTL4 MBT PF02820 88-160 196-268 300-371 SAM_1 PF00536 541-605 zf-C2HC PF01530 376-407 LMBL4_MOUSE l(3)mbt-like 4 (Drosophila) LMBL4_HUMAN Histone modification read # # HKme #
335LAS1L Las1 PF04031 42-188 Pfam-B_28535 PB028535 671-732 LAS1L_MOUSE LAS1-like (S. cerevisiae) LAS1L_HUMAN Histone modification write cofactor Histone modification write cofactor Histone methylation Histone acetylation CHD8 MLL2/3 MLL4/WBP7 H3K4 H3 H4 H2A H3K4me H3K4me2 H3Ac H4Ac H2AAc
336LBR ERG4_ERG24 PF01222 183-615 LBR_tudor PF09465 1-55 LBR_MOUSE lamin B receptor LBR_HUMAN # # # # #
337LEO1 Leo1 PF04004 373-537 Pfam-B_17842 PB017842 1-105 Pfam-B_20153 PB020153 171-239 Pfam-B_6431 PB006431 241-309 LEO1_MOUSE Leo1 Paf1/RNA polymerase II complex component homolog (S. cerevisiae) LEO1_HUMAN Histone modification write cofactor Histone ubiquitination # # #
338LRWD1 LRR_1 PF00560 48-69 Pfam-B_28625 PB028625 274-344 Pfam-B_39252 PB039252 191-239 WD40 PF00400 382-421 LRWD1_MOUSE leucine-rich repeats and WD repeat domain containing 1 LRWD1_HUMAN Chromatin remodelling # # H3K9me3 H3K27me3 #
339MAP3K7 Pfam-B_11880 PB011880 521-569 Pkinase_Tyr PF07714 36-284 M3K7_MOUSE mitogen-activated protein kinase kinase kinase 7 M3K7_HUMAN Histone modification write # # # #
340MAPKAPK3 Pkinase PF00069 44-304 MAPK3_MOUSE mitogen-activated protein kinase-activated protein kinase 3 MAPK3_HUMAN Chromatin remodelling # # # #
341MASTL Pfam-B_24677 PB024677 271-369 Pfam-B_8409 PB008409 371-489 Pkinase PF00069 35-203 733-835 GWL_MOUSE microtubule associated serine/threonine kinase-like GWL_HUMAN Histone modification write Histone phosphorylation # H1 H3 H1p H3p
342MAX HLH PF00010 24-75 MAX_MOUSE MYC associated factor X MAX_HUMAN Histone modification write cofactor Histone modification write cofactor TF TF Histone methylation Histone acetylation TF activator TF repressor CHD8 MLL2/3 MLL4/WBP7 DNA motif #
343MAZ zf-C2H2 PF00096 337-360 zf-C2H2_4 PF13894 190-213 366-388 zf-H2C2_2 PF13465 293-318 MAZ_MOUSE MYC-associated zinc finger protein (purine-binding transcription factor) MAZ_HUMAN Chromatin remodelling # # # #
344MBD1 MBD PF01429 1-85 Pfam-B_12306 PB012306 468-526 Pfam-B_9691 PB009691 528-587 zf-CXXC PF02008 168-215 217-262 330-377 MBD1_MOUSE methyl-CpG binding domain protein 1 MBD1_HUMAN Histone modification write cofactor TF Histone methylation TF repressor # mCG DNA motif #
345MBD2 MBD PF01429 145-216 MBD_C PF14048 294-387 MBD2_MOUSE methyl-CpG binding domain protein 2 MBD2_HUMAN Histone modification write cofactor Histone modification erase cofactor TF Histone methylation Histone acetylation TF repressor NuRD MeCP1 mCG DNA motif #
346MBD3 MBD PF01429 1-72 MBD_C PF14048 150-243 MBD3_MOUSE methyl-CpG binding domain protein 3 MBD3_HUMAN Histone modification erase cofactor Histone acetylation NuRD # #
347MBD4 HhH-GPD PF00730 461-575 MBD PF01429 76-151 Pfam-B_47325 PB047325 409-460 MBD4_MOUSE methyl-CpG binding domain protein 4 MBD4_HUMAN DNA modification # # G:T G:U #
348MBD5 Pfam-B_1400 PB001400 981-1140 Pfam-B_19258 PB019258 499-567 Pfam-B_41495 PB041495 438-497 Pfam-B_51737 PB051737 1-119 Pfam-B_5417 PB005417 121-219 Pfam-B_7705 PB007705 221-410 MBD5_MOUSE methyl-CpG binding domain protein 5 MBD5_HUMAN Chromatin remodelling # # # #
349MBD6 Pfam-B_28044 PB028044 161-209 MBD6_MOUSE methyl-CpG binding domain protein 6 MBD6_HUMAN Chromatin remodelling # # # #
350MBIP Pfam-B_15854 PB015854 191-249 Pfam-B_276 PB000276 251-342 MBIP1_MOUSE MAP3K12 binding inhibitory protein 1 MBIP1_HUMAN Histone modification write cofactor Histone acetylation ATAC # #
351MBTD1 MBT PF02820 183-253 289-360 388-464 496-568 Pfam-B_45320 PB045320 1-59 MBTD1_MOUSE mbt domain containing 1 MBTD1_HUMAN Polycomb group (PcG) protein # # H4K20me1 H4K20me2 #
352MCRS1 FHA PF00498 363-436 MCRS_N PF13325 134-331 MCRS1_MOUSE microspherule protein 1 MCRS1_HUMAN Histone modification write Histone acetylation Ino80 NSL CHD8 MLL2/3 MLL4/WBP7 H4K5 H4K8 H4K16 H4K5ac H4K8ac H4K16ac
353MDC1 FHA PF00498 54-124 Pfam-B_1811 PB001811 319-407 MDC1_MOUSE mediator of DNA-damage checkpoint 1 MDC1_HUMAN Histone modification read # # H2AX #
354MEAF6 NuA4 PF09340 16-97 EAF6_MOUSE MYST/Esa1-associated factor 6 EAF6_HUMAN Histone modification write cofactor Histone acetylation HBO1 NuA4 MOZ/MORF H2A H3K14 H4K5 H4K8 H4K12 H2Aac H3K14ac H4K5ac H4K8ac H4K12ac
355MECP2 MBD PF01429 90-164 MECP2_MOUSE methyl CpG binding protein 2 MECP2_HUMAN Histone modification write cofactor Histone modification write cofactor TF Histone methylation Histone acetylation TF repressor # mCG DNA motif #
356MEN1 Menin PF05053 1-615 MEN1_MOUSE multiple endocrine neoplasia I MEN1_HUMAN Histone modification write cofactor Histone methylation Menin-associated_HMT MLL-HCF CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 H3K4 H3K4me
357MGA HLH PF00010 2385-2436 Pfam-B_11518 PB011518 378-497 Pfam-B_24878 PB024878 2971-3008 Pfam-B_591 PB000591 979-1080 1332-1376 Pfam-B_7320 PB007320 1791-1938 Pfam-B_80122 PB080122 1-39 Pfam-B_8542 PB008542 653-837 T-box PF00907 76-261 MGAP_MOUSE MGA MAX dimerization protein MGAP_HUMAN Histone modification write cofactor Histone modification write cofactor TF TF Histone methylation Histone acetylation TF activator TF repressor RING2-L3MBTL2 CHD8 MLL2/3 MLL4/WBP7 DNA motif #
358MGEA5 NAGidase PF07555 62-364 Pfam-B_15148 PB015148 851-895 NCOAT_MOUSE meningioma expressed antigen 5 (hyaluronidase) NCOAT_HUMAN Histone modification write Histone acetylation # H3K14 H4K8 H3K14ac H4K8ac
359MINA Cupin_4 PF08007 51-364 MINA_MOUSE MYC induced nuclear antigen MINA_HUMAN Histone modification erase Histone methylation # H3K9me3 H3K9
360MLLT1 YEATS PF03366 29-112 # myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog Drosophila); translocated to 1 ENL_HUMAN Chromatin remodelling cofactor # SWI/SNF-like_EPAFa SWI/SNF-like EPAFB # #
361MLLT6 Pfam-B_16181 PB016181 791-1091 Pfam-B_3448 PB003448 551-789 zf-HC5HC2H_2 PF13832 63-180 # myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog Drosophila); translocated to 6 AF17_HUMAN Histone modification write cofactor Histone methylation # H3K79 H3K79me3
362MLLT10 PHD_2 PF13831 36-72 Pfam-B_12689 PB012689 541-619 Pfam-B_12729 PB012729 821-879 Pfam-B_4074 PB004074 234-538 Pfam-B_6933 PB006933 721-819 Pfam-B_9291 PB009291 621-719 zf-HC5HC2H_2 PF13832 80-197 AF10_MOUSE myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog Drosophila); translocated to 10 AF10_HUMAN Histone modification write cofactor Histone methylation # H3K79 H3K79me3
363MORF4L1 MRG PF05712 166-350 Tudor-knot PF11717 11-53 MO4L1_MOUSE mortality factor 4 like 1 MO4L1_HUMAN Histone modification read # NuA4 H4 #
364MORF4L2 MRG PF05712 93-276 Pfam-B_26706 PB026706 1-39 MO4L2_MOUSE mortality factor 4 like 2 MO4L2_HUMAN Histone modification erase cofactor Histone acetylation NuA4 # #
365MOV10 AAA_11 PF13086 498-605 599-691 AAA_12 PF13087 698-923 Pfam-B_18178 PB018178 1-114 MOV10_MOUSE Mov10 RISC complex RNA helicase MOV10_HUMAN # # # # #
366MPHOSPH8 Ank_2 PF12796 570-664 647-730 Chromo PF00385 59-109 MPP8_MOUSE M-phase phosphoprotein 8 MPP8_HUMAN Histone modification read # # H3K9me3 H3K9me2 #
367MRGBP Eaf7 PF07904 34-114 MRGBP_MOUSE MRG/MORF4L binding protein MRGBP_HUMAN Histone modification write cofactor Histone acetylation NuA4 # #
368MSH6 MutS_I PF01624 407-526 MutS_II PF05188 537-703 MutS_III PF05192 737-1065 MutS_IV PF05190 932-1024 MutS_V PF00488 1074-1326 PWWP PF00855 90-182 MSH6_MOUSE mutS homolog 6 MSH6_HUMAN Histone modification read # # H3K36me3 #
369MSL1 PEHE PF15275 473-591 Pfam-B_41610 PB041610 41-129 Pfam-B_70275 PB070275 1-39 MSL1_MOUSE male-specific lethal 1 homolog (Drosophila) MSL1_HUMAN Histone modification write Histone ubiquitination # H2BK34 H2BK34ub
370MSL2 Pfam-B_16851 PB016851 461-575 Pfam-B_19348 PB019348 1-89 Pfam-B_20099 PB020099 211-459 Pfam-B_22844 PB022844 91-209 MSL2_MOUSE male-specific lethal 2 homolog (Drosophila) MSL2_HUMAN Histone modification write Histone ubiquitination # H2BK34 H2BK34ub
371MSL3 MRG PF05712 136-504 Tudor-knot PF11717 11-74 MS3L1_MOUSE male-specific lethal 3 homolog (Drosophila) MS3L1_HUMAN Histone modification read # # H4K20me1 #
372MST1 Kringle PF00051 110-186 191-268 283-361 370-448 PAN_1 PF00024 16-106 Trypsin PF00089 484-704 HGFL_MOUSE macrophage stimulating 1 (hepatocyte growth factor-like) HGFL_HUMAN Histone modification # # # #
373MTA1 BAH PF01426 4-164 ELM2 PF01448 167-221 GATA PF00320 393-430 MTA1_MOUSE metastasis associated 1 MTA1_HUMAN Chromatin remodelling cofactor # NuRD # #
374MTA2 BAH PF01426 4-144 ELM2 PF01448 147-201 GATA PF00320 367-404 Pfam-B_3593 PB003593 571-637 MTA2_MOUSE metastasis associated 1 family member 2 MTA2_HUMAN Histone modification erase cofactor Histone acetylation NuRD # #
375MTA3 BAH PF01426 4-147 ELM2 PF01448 150-204 GATA PF00320 379-416 Pfam-B_11869 PB011869 421-489 Pfam-B_22870 PB022870 491-520 MTA3_MOUSE metastasis associated 1 family member 3 MTA3_HUMAN Chromatin remodelling cofactor # NuRD # #
376MTF2 Mtf2_C PF14061 542-592 PHD PF00628 104-157 MTF2_MOUSE metal response element binding transcription factor 2 MTF2_HUMAN Polycomb group (PcG) protein # PRC2 H3K36me3 #
377MUM1 Pfam-B_7774 PB007774 1-232 MUM1_MOUSE melanoma associated antigen (mutated) 1 MUM1_HUMAN Histone modification read # # H3K36me K3K79me H4K20me #
378MYBBP1A DNA_pol_phi PF04931 70-836 MBB1A_MOUSE MYB binding protein (P160) 1a MBB1A_HUMAN Chromatin remodelling cofactor # B-WICH # #
379MYO1C IQ PF00612 735-755 758-777 Myosin_TH1 PF06017 873-1059 Myosin_head PF00063 48-718 MYO1C_MOUSE myosin IC MYO1C_HUMAN Chromatin remodelling cofactor # B-WICH # #
380MYSM1 JAB PF01398 572-682 Myb_DNA-binding PF00249 118-163 Pfam-B_30622 PB030622 691-736 SWIRM PF04433 372-461 MYSM1_MOUSE Myb-like SWIRM and MPN domains 1 MYSM1_HUMAN Histone modification erase Histone ubiquitination # H2Aub H2A
381NAA60 Acetyltransf_1 PF00583 57-156 NAA60_MOUSE N(alpha)-acetyltransferase 60 NatF catalytic subunit NAA60_HUMAN Histone modification write Histone acetylation # H4K20 H4K79 H4K91 H4K20ac H4K79ac H4K91ac
382NAP1L1 NAP PF00956 75-346 NP1L1_MOUSE nucleosome assembly protein 1-like 1 NP1L1_HUMAN Histone chaperone # # # #
383NAP1L2 NAP PF00956 109-412 NP1L2_MOUSE nucleosome assembly protein 1-like 2 NP1L2_HUMAN Histone modification cofactor # # H3 H4 #
384NAP1L4 NAP PF00956 64-339 NP1L4_MOUSE nucleosome assembly protein 1-like 4 NP1L4_HUMAN Histone modification cofactor # # H3 H4 #
385NASP SHNi-TPR PF10516 542-579 TPR_1 PF00515 584-617 NASP_MOUSE nuclear autoantigenic sperm protein (histone-binding) NASP_HUMAN Chromatin remodelling # # H1 #
386NAT10 DUF1726 PF08351 107-201 GNAT_acetyltr_2 PF13718 528-753 Helicase_RecD PF05127 281-488 tRNA_bind_2 PF13725 771-892 NAT10_MOUSE N-acetyltransferase 10 (GCN5-related) NAT10_HUMAN Histone modification write Histone acetylation # # #
387NBN FHA PF00498 24-100 Nbs1_C PF08599 682-746 NBN_MOUSE nibrin NBN_HUMAN Chromatin remodelling # # H2AX #
388NCL Pfam-B_12581 PB012581 1-59 RRM_1 PF00076 309-377 395-460 488-554 574-641 NUCL_MOUSE nucleolin NUCL_HUMAN Histone chaperone # # DNA motif RNA motif #
389NCOA1 DUF1518 PF07469 1149-1205 1212-1268 Nuc_rec_co-act PF08815 924-973 PAS PF00989 112-183 PAS_11 PF14598 259-370 SRC-1 PF08832 625-708 NCOA1_MOUSE nuclear receptor coactivator 1 NCOA1_HUMAN Histone modification write Histone acetylation # H3 H4 #
390NCOA2 DUF1518 PF07469 1281-1338 Nuc_rec_co-act PF08815 1071-1117 PAS PF00989 115-215 PAS_11 PF14598 267-379 SRC-1 PF08832 636-709 NCOA2_MOUSE nuclear receptor coactivator 2 NCOA2_HUMAN Chromatin remodelling cofactor # # # #
391NCOA3 DUF1518 PF07469 1291-1348 Nuc_rec_co-act PF08815 1045-1095 PAS PF00989 113-210 PAS_11 PF14598 264-375 Pfam-B_10879 PB010879 1096-1195 Pfam-B_14009 PB014009 794-924 SRC-1 PF08832 616-704 NCOA3_MOUSE nuclear receptor coactivator 3 NCOA3_HUMAN Histone modification write Histone acetylation # # #
392NCOA6 Nucleic_acid_bd PF13820 45-195 Pfam-B_14375 PB014375 987-1511 Pfam-B_3537 PB003537 407-669 NCOA6_MOUSE nuclear receptor coactivator 6 NCOA6_HUMAN Histone modification write cofactor Histone methylation CHD8 MLL2/3 COMPASS-like MLL3 4 # #
393NCOR1 Myb_DNA-binding PF00249 625-670 Pfam-B_4054 PB004054 1242-1723 Pfam-B_670 PB000670 1725-1983 Pfam-B_7837 PB007837 1-159 NCOR1_MOUSE nuclear receptor corepressor 1 NCOR1_HUMAN Histone modification erase cofactor Histone acetylation # # #
394NCOR2 Myb_DNA-binding PF00249 612-657 Pfam-B_1539 PB001539 271-430 NCOR2_MOUSE nuclear receptor corepressor 2 NCOR2_HUMAN Histone modification erase cofactor Histone acetylation # # #
395NEK6 Pkinase PF00069 45-306 NEK6_MOUSE NIMA-related kinase 6 NEK6_HUMAN Histone modification write Histone phosphorylation # H1 H3 H1ph H3ph
396NEK9 Pfam-B_22064 PB022064 309-349 Pkinase PF00069 52-308 RCC1 PF00415 390-441 444-495 499-547 615-665 NEK9_MOUSE NIMA-related kinase 9 NEK9_HUMAN Histone modification write Histone phosphorylation # H1 H1ph
397NFRKB NFRKB_winged PF14465 379-478 Pfam-B_18306 PB018306 610-661 NFRKB_MOUSE nuclear factor related to kappaB binding protein NFRKB_HUMAN Chromatin remodelling cofactor TF # # Ino80 DNA motif #
398NFYB CBFD_NFYB_HMF PF00808 57-122 Pfam-B_17851 PB017851 1-39 NFYB_MOUSE nuclear transcription factor Y beta NFYB_HUMAN Chromatin remodelling TF # TF activator # DNA motif #
399NFYC CBFD_NFYB_HMF PF00808 41-105 Pfam-B_8767 PB008767 141-201 NFYC_MOUSE nuclear transcription factor Y gamma NFYC_HUMAN Histone modification # # # #
400NIPBL Cohesin_HEAT PF12765 1794-1835 Nipped-B_C PF12830 2274-2457 Pfam-B_338 PB000338 1292-1355 Pfam-B_4450 PB004450 1859-2018 Pfam-B_5032 PB005032 2020-2194 NIPBL_MOUSE Nipped-B homolog (Drosophila) NIPBL_HUMAN Histone modification erase cofactor Histone acetylation # # #
401NOC2L Noc2 PF03715 325-623 Pfam-B_22168 PB022168 62-101 Pfam-B_2429 PB002429 644-713 Pfam-B_50064 PB050064 1-31 NOC2L_MOUSE nucleolar complex associated 2 homolog (S. cerevisiae) NOC2L_HUMAN Chromatin remodelling TF # TF repressor # H3 #
402NPAS2 HLH PF00010 10-59 PAS PF00989 84-176 PAS_11 PF14598 248-356 NPAS2_MOUSE neuronal PAS domain protein 2 NPAS2_HUMAN Chromatin remodelling TF # TF activator # DNA motif #
403NPM1 Nucleoplasmin PF03066 13-196 NPM_MOUSE nucleophosmin (nucleolar phosphoprotein B23 numatrin) NPM_HUMAN Histone chaperone # # H3 H2B H4 #
404NPM2 TSP_1 PF00090 161-209 213-267 271-316 319-374 NPM2_MOUSE nucleophosmin/nucleoplasmin 2 NPM2_HUMAN Histone chaperone # # H2A H2B #
405NSD1 PHD PF00628 1709-1751 PWWP PF00855 321-419 1754-1844 Pfam-B_7228 PB007228 821-937 SET PF00856 1953-2059 NSD1_MOUSE nuclear receptor binding SET domain protein 1 NSD1_HUMAN Histone modification write Histone methylation # H3K36 H4K20 H3K36me H4K20me
406NSL1 Mis14 PF08641 67-211 NSL1_MOUSE NSL1 MIS12 kinetochore complex component NSL1_HUMAN Histone modification write cofactor Histone acetylation # H4K16 H4K16ac
407OGT Glyco_transf_41 PF13844 556-1024 TPR_1 PF00515 89-122 191-224 225-258 259-292 293-326 327-360 361-394 395-428 429-462 TPR_11 PF13414 87-154 TPR_8 PF13181 160-190 OGT1_MOUSE O-linked N-acetylglucosamine (GlcNAc) transferase OGT1_HUMAN Histone modification write Histone GlcNAcylation NSL H2BS112 H2BS112GlcNa
408PADI1 PAD PF03068 276-663 PAD_M PF08527 115-273 PAD_N PF08526 1-113 PADI1_MOUSE peptidyl arginine deiminase type I PADI1_HUMAN Histone modification Histone citrullination # H2AR H3R H4R H2ARci H3Rci H4Rci
409PADI2 PAD PF03068 279-665 PAD_M PF08527 116-274 PAD_N PF08526 1-114 PADI2_MOUSE peptidyl arginine deiminase type II PADI2_HUMAN Histone modification Histone citrullination # H2AR H3R H4R H2ARci H3Rci H4Rci
410PADI3 PAD PF03068 278-664 PAD_M PF08527 115-273 PAD_N PF08526 1-113 PADI3_MOUSE peptidyl arginine deiminase type III PADI3_HUMAN Histone modification Histone citrullination # H2AR H3R H4R H2ARci H3Rci H4Rci
411PADI4 PAD PF03068 278-663 PAD_M PF08527 113-273 PAD_N PF08526 1-111 PADI4_MOUSE peptidyl arginine deiminase type IV PADI4_HUMAN Histone modification Histone citrullination # H2AR H3R2 H3R8 H3R17 H3R26 H4R H2ARci H3R2ci H3R8ci H3R17ci H3R26ci H4Rci
412PAF1 Paf1 PF03985 27-446 PAF1_MOUSE Paf1 RNA polymerase II associated factor homolog (S. cerevisiae) PAF1_HUMAN Histone modification write cofactor Histone ubiquitination # H2 H3 #
413PAGR1 PAXIP1_C PF15364 86-221 PAGR1_MOUSE PAXIP1 associated glutamate-rich protein 1 PAGR1_HUMAN Histone modification write cofactor Histone modification write cofactor Histone methylation Histone acetylation CHD8 MLL2/3 MLL4/WBP7 COMPASS-like MLL3 4 # #
414PAK2 PBD PF00786 73-131 Pkinase PF00069 249-500 PAK2_MOUSE p21 protein (Cdc42/Rac)-activated kinase 2 PAK2_HUMAN Histone modification write Histone phosphorylation # H4S47 H4S47ph
415PARG PARG_cat PF05028 577-912 Pfam-B_14007 PB014007 925-955 PARG_MOUSE poly (ADP-ribose) glycohydrolase PARG_HUMAN Chromatin remodelling # # H3K9 #
416PARP1 BRCT PF00533 385-462 PADR1 PF08063 279-332 PARP PF00644 797-1007 PARP_reg PF02877 662-795 WGR PF05406 549-633 zf-PARP PF00645 12-90 116-200 PARP1_MOUSE poly (ADP-ribose) polymerase 1 PARP1_HUMAN Chromatin remodelling # # H1 #
417PARP2 PARP PF00644 365-577 PARP_reg PF02877 231-363 WGR PF05406 111-195 PARP2_MOUSE poly (ADP-ribose) polymerase 2 PARP2_HUMAN Chromatin remodelling cofactor # # # #
418PARP3 PARP PF00644 322-533 PARP_reg PF02877 182-320 WGR PF05406 62-144 # poly (ADP-ribose) polymerase family member 3 PARP3_HUMAN Polycomb group (PcG) protein # # # #
419PAXIP1 BRCT PF00533 601-681 701-776 867-934 PTCB-BRCT PF12738 102-165 Pfam-B_13490 PB013490 1009-1064 Pfam-B_16838 PB016838 485-548 PAXI1_MOUSE PAX interacting (with transcription-activation domain) protein 1 PAXI1_HUMAN Histone modification write cofactor Histone methylation CHD8 MLL2/3 MLL4/WBP7 COMPASS-like MLL3 4 H3K4 H3K4me3
420PBK Pkinase PF00069 33-318 TOPK_MOUSE PDZ binding kinase TOPK_HUMAN Histone modification write Histone phosphorylation # H3S10 H3S10ph
421PBRM1 BAH PF01426 956-1074 1156-1272 Bromodomain PF00439 54-139 186-275 392-475 532-613 666-750 785-867 HMG_box PF00505 1379-1446 PB1_MOUSE polybromo 1 PB1_HUMAN Histone modification read # PBAF SWI/SNF BRM-BRG1 H3 #
422PCGF1 zf-C3HC4 PF00097 47-85 PCGF1_MOUSE polycomb group ring finger 1 PCGF1_HUMAN Polycomb group (PcG) protein # PRC1 BCOR # #
423PCGF2 zf-C3HC4 PF00097 18-56 PCGF2_MOUSE polycomb group ring finger 2 PCGF2_HUMAN Polycomb group (PcG) protein # PRC1 # #
424PCGF3 zf-C3HC4 PF00097 17-55 PCGF3_MOUSE polycomb group ring finger 3 PCGF3_HUMAN Polycomb group (PcG) protein # PRC1 RING2-FBRS # #
425PCGF5 zf-C3HC4 PF00097 18-56 PCGF5_MOUSE polycomb group ring finger 5 PCGF5_HUMAN Polycomb group (PcG) protein # PRC1 RING2-FBRS # #
426PCGF6 zf-C3HC4 PF00097 134-172 PCGF6_MOUSE polycomb group ring finger 6 PCGF6_HUMAN Polycomb group (PcG) protein # PRC1 RING2-L3MBTL2 # #
427PCNA PCNA_C PF02747 127-254 PCNA_N PF00705 1-125 PCNA_MOUSE proliferating cell nuclear antigen PCNA_HUMAN Chromatin remodelling # # H2A H2B #
428PDP1 PP2C PF00481 194-487 Pfam-B_13776 PB013776 99-163 PDP1_MOUSE pyruvate dehyrogenase phosphatase catalytic subunit 1 PDP1_HUMAN Histone modification read # # H4K20me3 #
429PELP1 NUC202 PF08166 423-489 569-642 RIX1 PF08167 66-226 PELP1_MOUSE proline glutamate and leucine rich protein 1 PELP1_HUMAN Histone modification read Histone modification write cofactor Histone methylation Histone acetylation CHD8 MLL2/3 MLL4/WBP7 H1 H3 H4 #
430PHC1 Pfam-B_4954 PB004954 615-678 Pfam-B_5821 PB005821 430-536 SAM_1 PF00536 938-1002 zf-FCS PF06467 792-827 PHC1_MOUSE polyhomeotic homolog 1 (Drosophila) PHC1_HUMAN Polycomb group (PcG) protein # PRC1 # #
431PHC2 Pfam-B_5669 PB005669 651-679 Pfam-B_6832 PB006832 1-198 SAM_1 PF00536 792-856 PHC2_MOUSE polyhomeotic homolog 2 (Drosophila) PHC2_HUMAN Polycomb group (PcG) protein # PRC1 # #
432PHC3 Pfam-B_12208 PB012208 689-724 Pfam-B_17091 PB017091 431-487 Pfam-B_19383 PB019383 780-822 Pfam-B_19396 PB019396 1-39 SAM_1 PF00536 917-981 PHC3_MOUSE polyhomeotic homolog 3 (Drosophila) PHC3_HUMAN Polycomb group (PcG) protein # PRC1 # #
433PHF1 Mtf2_C PF14061 525-566 PHD PF00628 89-142 Pfam-B_18040 PB018040 1-30 Pfam-B_24844 PB024844 331-384 PHF1_MOUSE PHD finger protein 1 PHF1_HUMAN Polycomb group (PcG) protein # PRC2 # #
434PHF2 JmjC PF02373 236-336 PHD PF00628 7-56 Pfam-B_3847 PB003847 851-988 PHF2_MOUSE PHD finger protein 2 PHF2_HUMAN Histone modification erase Histone methylation # H3K9me2 H3K9
435PHF8 JmjC PF02373 270-370 PHD PF00628 43-92 Pfam-B_22520 PB022520 499-557 Pfam-B_5629 PB005629 779-877 PHF8_MOUSE PHD finger protein 8 PHF8_HUMAN Histone modification erase Histone methylation # H3K9me1 H3K9me2 H3K27me2 H4K20me1 H3K36me2 H3K36me3 H3K4me3 H3K9 H3K27 H4K20 H3K36 H3K4
436PHF10 PHD PF00628 379-436 435-481 Pfam-B_1316 PB001316 15-230 PHF10_MOUSE PHD finger protein 10 PHF10_HUMAN Chromatin remodelling # npBAF SWI/SNF BRM-BRG1 # #
437PHF12 PHD PF00628 58-105 273-318 PHF12_MOUSE PHD finger protein 12 PHF12_HUMAN Histone modification erase cofactor Histone acetylation # # #
438PHF13 PHD PF00628 234-280 Pfam-B_28476 PB028476 1-49 PHF13_MOUSE PHD finger protein 13 PHF13_HUMAN Histone modification read # # H3K4me3 #
439PHF14 PHD PF00628 321-380 727-779 Pfam-B_16803 PB016803 175-216 Pfam-B_19012 PB019012 218-295 zf-HC5HC2H_2 PF13832 383-498 PHF14_MOUSE PHD finger protein 14 PHF14_HUMAN Histone modification read # # H2A H2B H3 H2Aac H2Bac H3ac
440PHF19 Mtf2_C PF14061 529-579 PHD PF00628 98-151 Pfam-B_31053 PB031053 1-59 PHF19_MOUSE PHD finger protein 19 PHF19_HUMAN Chromatin remodelling Histone modification write cofactor # Histone acetylation PRC2 # #
441PHF20 DUF3776 PF12618 173-279 PHD PF00628 654-700 Pfam-B_21846 PB021846 511-589 Pfam-B_23453 PB023453 280-309 PHF20_MOUSE PHD finger protein 20 PHF20_HUMAN Histone modification write Histone acetylation NSL CHD8 MLL2/3 MLL4/WBP7 H4 H4ac
442PHF20L1 DUF3776 PF12618 210-317 415-518 PHD PF00628 683-729 Pfam-B_37699 PB037699 791-849 P20L1_MOUSE PHD finger protein 20-like 1 P20L1_HUMAN Histone modification read # # H3K4me #
443PHF21A AT_hook PF02178 425-436 PHD PF00628 490-535 Pfam-B_15568 PB015568 536-649 Pfam-B_7050 PB007050 1-349 PF21A_MOUSE PHD finger protein 21A PF21A_HUMAN Histone modification erase cofactor Histone methylation BHC LSD-CoREST # #
444PHIP Bromodomain PF00439 1165-1251 1325-1409 Pfam-B_15784 PB015784 743-864 Pfam-B_60538 PB060538 1-77 WD40 PF00400 174-211 215-253 257-298 355-393 456-495 PHIP_MOUSE pleckstrin homology domain interacting protein PHIP_HUMAN Histone modification read # # H3 #
445PIWIL4 PAZ PF02170 271-407 Pfam-B_2782 PB002782 101-219 Pfam-B_34294 PB034294 1-99 Piwi PF02171 546-838 PIWL4_MOUSE piwi-like RNA-mediated gene silencing 4 PIWL4_HUMAN Chromatin remodelling Histone modification erase cofactor # Histone methylation # H3K9 #
446PKM PK PF00224 42-395 PK_C PF02887 409-529 KPYM_MOUSE pyruvate kinase muscle KPYM_HUMAN Histone modification write cofactor Histone phosphorylation # H3S10 H3S28 H2BS32 H3S10ph H3S28ph H2BS32ph H3T11ph
447PKN1 HR1 PF02185 37-105 126-198 213-285 Pfam-B_33979 PB033979 8-36 Pkinase PF00069 615-874 Pkinase_C PF00433 894-940 PKN1_MOUSE protein kinase N1 PKN1_HUMAN Histone modification write Histone phosphorylation # H3T11 H3T11ph
448POGZ DDE_1 PF03184 1117-1304 HTH_Tnp_Tc5 PF03221 1024-1085 Pfam-B_10413 PB010413 693-771 Pfam-B_10981 PB010981 1-69 Pfam-B_5179 PB005179 796-843 Pfam-B_6754 PB006754 773-795 POGZ_MOUSE pogo transposable element with ZNF domain POGZ_HUMAN Histone modification read Histone methylation # H3K9me3 #
449POLE3 CBFD_NFYB_HMF PF00808 8-73 Pfam-B_35841 PB035841 74-135 DPOE3_MOUSE polymerase (DNA directed) epsilon 3 accessory subunit DPOE3_HUMAN Histone chaperone # CHRAC # #
450PPARGC1A Pfam-B_19319 PB019319 241-286 RRM_1 PF00076 679-742 PRGC1_MOUSE peroxisome proliferator-activated receptor gamma coactivator 1 alpha PRGC1_HUMAN Histone modification cofactor # # # #
451PPM1G PP2C PF00481 25-120 264-492 PPM1G_MOUSE protein phosphatase Mg2+/Mn2+ dependent 1G PPM1G_HUMAN Chromatin remodelling # # # #
452PPP2CA Metallophos PF00149 50-245 PP2AA_MOUSE protein phosphatase 2 catalytic subunit alpha isozyme PP2AA_HUMAN Histone modification write Histone phosphorylation # H2AX H2AXph
453PPP4C Metallophos PF00149 47-242 PP4C_MOUSE protein phosphatase 4 catalytic subunit PP4C_HUMAN Histone modification erase Histone phosphorylation PPP4C-PPP4R2-PPP4R3A H2AXS139ph H2AXS139
454PPP4R2 PPP4R2 PF09184 2-267 PP4R2_MOUSE protein phosphatase 4 regulatory subunit 2 PP4R2_HUMAN Histone modification cofactor # PPP4C-PPP4R2-PPP4R3A # #
455PRDM1 SET PF00856 99-201 zf-H2C2_2 PF13465 589-614 617-642 645-670 PRDM1_MOUSE PR domain containing 1 with ZNF domain PRDM1_HUMAN Histone modification write cofactor Histone methylation # H3K9 H3K9me
456PRDM2 Pfam-B_29325 PB029325 1053-1085 SET PF00856 41-141 zf-C2H2 PF00096 390-412 zf-C2H2_4 PF13894 360-383 483-506 1134-1157 1191-1214 1455-1475 # PR domain containing 2 with ZNF domain PRDM2_HUMAN Histone modification write Histone methylation # H3K9 H3K9me
457PRDM4 Pfam-B_13260 PB013260 461-509 zf-C2H2 PF00096 730-752 zf-H2C2_2 PF13465 632-657 660-683 688-713 PRDM4_MOUSE PR domain containing 4 PRDM4_HUMAN Histone modification write Histone methylation # H4R3 H4R3me2s
458PRDM5 zf-C2H2 PF00096 199-221 262-287 603-625 zf-C2H2_4 PF13894 167-190 zf-C2H2_jaz PF12171 375-399 zf-H2C2_2 PF13465 334-359 418-443 446-472 475-500 503-528 531-556 559-583 zf-met PF12874 234-254 295-317 PRDM5_MOUSE PR domain containing 5 PRDM5_HUMAN Histone modification write Histone methylation # H3K9 H3K9me
459PRDM6 SET PF00856 259-365 zf-C2H2 PF00096 501-523 zf-C2H2_4 PF13894 473-495 zf-H2C2_2 PF13465 543-568 PRDM6_MOUSE PR domain containing 6 PRDM6_HUMAN Histone modification write Histone methylation # H3R2 H4K20 H3R2me1 H3R2me2 H4K20me1
460PRDM7 KRAB PF01352 27-65 SSXRD PF09514 170-202 # PR domain containing 7 PRDM7_HUMAN Histone modification write Histone methylation # # #
461PRDM8 zf-C2H2 PF00096 627-648 666-688 PRDM8_MOUSE PR domain containing 8 PRDM8_HUMAN Histone modification write Histone methylation # # #
462PRDM9 KRAB PF01352 27-65 SSXRD PF09514 170-202 zf-C2H2 PF00096 860-882 zf-H2C2_2 PF13465 540-562 566-590 594-619 622-647 650-674 678-702 706-731 734-758 762-786 790-815 818-843 846-871 PRDM9_MOUSE PR domain containing 9 PRDM9_HUMAN Histone modification write Histone methylation # H3K4 H3K4me3
463PRDM11 Pfam-B_3219 PB003219 1-353 PRD11_MOUSE PR domain containing 11 PRD11_HUMAN Histone modification write Histone methylation # # #
464PRDM12 Pfam-B_39033 PB039033 1-49 zf-H2C2_2 PF13465 257-282 285-310 PRD12_MOUSE PR domain containing 12 PRD12_HUMAN Histone modification write cofactor Histone methylation # H3K9 H3K9me
465PRDM13 zf-C2H2 PF00096 137-160 zf-H2C2_2 PF13465 587-611 615-641 PRD13_MOUSE PR domain containing 13 PRD13_HUMAN Histone modification write Histone methylation # # #
466PRDM14 SET PF00856 265-367 zf-C2H2 PF00096 546-568 zf-C2H2_4 PF13894 400-421 432-455 zf-H2C2_2 PF13465 475-500 504-528 PRD14_MOUSE PR domain containing 14 PRD14_HUMAN DNA modification DNA demethylation # mC #
467PRDM16 Pfam-B_2662 PB002662 14-127 zf-C2H2 PF00096 337-360 366-388 394-416 423-445 979-1002 1008-1032 zf-C2H2_6 PF13912 229-255 zf-H2C2_2 PF13465 295-319 965-989 PRD16_MOUSE PR domain containing 16 PRD16_HUMAN Histone modification write cofactor TF Histone methylation TF repressor # H3K9 DNA motif H3K9me
468PRKAA1 Pfam-B_8588 PB008588 351-524 Pkinase PF00069 27-279 AAPK1_MOUSE protein kinase AMP-activated alpha 1 catalytic subunit AAPK1_HUMAN Histone modification write Histone phosphorylation # H2BS36 H2BS36ph
469PRKAA2 Pkinase PF00069 16-268 AAPK2_MOUSE protein kinase AMP-activated alpha 2 catalytic subunit AAPK2_HUMAN Histone modification write Histone phosphorylation # H2BS36 H2BS36ph
470PRKAB1 AMPKBI PF04739 149-270 AAKB1_MOUSE protein kinase AMP-activated beta 1 non-catalytic subunit AAKB1_HUMAN Histone modification write cofactor Histone phosphorylation # # #
471PRKAB2 AMPKBI PF04739 155-272 AAKB2_MOUSE protein kinase AMP-activated beta 2 non-catalytic subunit AAKB2_HUMAN Histone modification write cofactor Histone phosphorylation # # #
472PRKAG1 CBS PF00571 39-97 118-178 187-252 263-324 AAKG1_MOUSE protein kinase AMP-activated gamma 1 non-catalytic subunit AAKG1_HUMAN Histone modification write cofactor Histone phosphorylation # # #
473PRKAG2 CBS PF00571 350-410 428-484 494-556 Pfam-B_5182 PB005182 268-349 AAKG2_MOUSE protein kinase AMP-activated gamma 2 non-catalytic subunit AAKG2_HUMAN Histone modification write cofactor Histone phosphorylation # # #
474PRKAG3 CBS PF00571 273-333 350-406 414-479 AAKG3_MOUSE protein kinase AMP-activated gamma 3 non-catalytic subunit AAKG3_HUMAN Histone modification write cofactor Histone phosphorylation # # #
475PRKCA C1_1 PF00130 37-89 102-154 C2 PF00168 173-260 Pkinase PF00069 339-597 Pkinase_C PF00433 622-662 KPCA_MOUSE protein kinase C alpha KPCA_HUMAN Histone modification write cofactor Histone phosphorylation # H3 #
476PRKCB C1_1 PF00130 37-89 102-154 C2 PF00168 173-260 Pkinase PF00069 342-600 Pkinase_C PF00433 620-666 KPCB_MOUSE protein kinase C beta KPCB_HUMAN Histone modification write Histone methylation # H3T6 H3T6ph
477PRKCD C1_1 PF00130 159-211 231-283 Pkinase PF00069 349-603 Pkinase_C PF00433 623-669 KPCD_MOUSE protein kinase C delta KPCD_HUMAN Histone modification # # # #
478PRKDC FAT PF02259 3023-3470 FATC PF02260 4096-4128 NUC194 PF08163 1813-2210 PI3_PI4_kinase PF00454 3747-4015 Pfam-B_14440 PB014440 411-472 Pfam-B_1565 PB001565 131-345 Pfam-B_9125 PB009125 2650-2694 PRKDC_MOUSE protein kinase DNA-activated catalytic polypeptide PRKDC_HUMAN Histone modification write Histone phosphorylation # H2AXS139 H2AFXS139 H2AXS139ph H2AFXS139ph
479PRMT1 Methyltransf_31 PF13847 76-216 ANM1_MOUSE protein arginine methyltransferase 1 ANM1_HUMAN Histone modification write Histone methylation # H4R3 H4R3me1 H4R3me2a
480PRMT2 PRMT5 PF05185 114-415 SH3_9 PF14604 37-84 ANM2_MOUSE protein arginine methyltransferase 2 ANM2_HUMAN Histone modification write Histone methylation # H4 H4me
481PRMT5 PRMT5 PF05185 181-619 Pfam-B_18578 PB018578 1-49 ANM5_MOUSE protein arginine methyltransferase 5 ANM5_HUMAN Histone modification write Histone methylation methylosome H3R8 H4R3 H3R8me H4R3me
482PRMT6 Methyltransf_18 PF12847 82-189 ANM6_MOUSE protein arginine methyltransferase 6 ANM6_HUMAN Histone modification write Histone methylation # H2AR3 H3R2 H4R4 H2AR3me H4R3me H3R2me2a
483PRMT7 Pfam-B_13426 PB013426 301-359 PrmA PF06325 54-149 ANM7_MOUSE protein arginine methyltransferase 7 ANM7_HUMAN Histone modification write Histone methylation # H2A H4R3 H2A H4R3me2
484PRMT8 PrmA PF06325 102-200 ANM8_MOUSE protein arginine methyltransferase 8 ANM8_HUMAN Histone modification write Histone methylation # H4R H4Rme
485PRMT9 PrmA PF06325 167-257 TPR_11 PF13414 67-132 ANM9_MOUSE protein arginine methyltransferase 9 ANM9_HUMAN Histone modification write Histone methylation # H4R3 H4R3me2
486PRPF31 NOSIC PF08060 92-144 Nop PF01798 186-334 Pfam-B_23523 PB023523 1-44 Prp31_C PF09785 336-465 PRP31_MOUSE pre-mRNA processing factor 31 PRP31_HUMAN Histone modification write cofactor Histone modification write cofactor Histone methylation Histone acetylation CHD8 MLL2/3 MLL4/WBP7 # #
487PRR14 Tantalus PF15386 457-517 PRR14_MOUSE proline rich 14 PRR14_HUMAN Histone modification write Histone phosphorylation # H3K9me2 H3K9me3 #
488PSIP1 LEDGF PF11467 349-455 PWWP PF00855 5-87 PSIP1_MOUSE PC4 and SFRS1 interacting protein 1 PSIP1_HUMAN Chromatin remodelling # # # #
489RAD51 HHH_5 PF14520 28-80 Rad51 PF08423 83-338 RAD51_MOUSE RAD51 recombinase RAD51_HUMAN Histone modification erase Histone ubiquitination BRCC histone #
490RAD54B Helicase_C PF00271 678-758 Pfam-B_10171 PB010171 772-829 SNF2_N PF00176 299-598 RA54B_MOUSE RAD54 homolog B (S. cerevisiae) RA54B_HUMAN Chromatin remodelling # # # #
491RAD54L Helicase_C PF00271 531-611 Pfam-B_14570 PB014570 674-743 Rad54_N PF08658 33-138 SNF2_N PF00176 156-463 RAD54_MOUSE RAD54-like (S. cerevisiae) RAD54_HUMAN Chromatin remodelling # # # #
492RAD54L2 Helicase_C PF00271 774-854 Pfam-B_2830 PB002830 105-259 SNF2_N PF00176 274-625 ARIP4_MOUSE RAD54-like 2 (S. cerevisiae) ARIP4_HUMAN Chromatin remodelling # # # #
493RAG1 Pfam-B_793 PB000793 1-89 RAG1 PF12940 513-953 zf-C3HC4 PF00097 293-331 zf-RAG1 PF10426 354-383 RAG1_MOUSE recombination activating gene 1 RAG1_HUMAN Histone modification write Histone ubiquitination # H3.3K DNA motif H3.3Kub
494RAG2 RAG2 PF03089 51-389 RAG2_PHD PF13341 414-491 RAG2_MOUSE recombination activating gene 2 RAG2_HUMAN Histone modification read # # H3K4me3 #
495RAI1 Pfam-B_11259 PB011259 438-596 Pfam-B_27361 PB027361 388-436 Pfam-B_6090 PB006090 1665-1710 zf-HC5HC2H PF13771 1825-1903 RAI1_MOUSE retinoic acid induced 1 RAI1_HUMAN Chromatin remodelling # # # #
496RARA Hormone_recep PF00104 207-409 zf-C4 PF00105 86-155 RARA_MOUSE retinoic acid receptor alpha RARA_HUMAN Histone modification write cofactor TF TF Histone methylation TF activator TF repressor # H3K4 H3K4me H3K4me2
497RB1 DUF3452 PF11934 105-229 RB_A PF01858 373-573 RB_B PF01857 645-766 Rb_C PF08934 768-927 RB_MOUSE retinoblastoma 1 RB_HUMAN Chromatin remodelling Histone modification write # Histone ubiquitination CREST-BRG1 L3MBTL1 # #
498RBBP4 CAF1C_H4-bd PF12265 18-89 WD40 PF00400 167-206 218-256 263-302 307-346 364-403 RBBP4_MOUSE retinoblastoma binding protein 4 RBBP4_HUMAN Histone chaperone # NuRF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm NuRD mSin3A core HDAC mSin3A-like complex PRC2 CAF-1 H4 #
499RBBP5 Pfam-B_3428 PB003428 121-325 WD40 PF00400 23-52 58-94 RBBP5_MOUSE retinoblastoma binding protein 5 RBBP5_HUMAN Histone modification write cofactor Histone methylation COMPASS Menin-associated_HMT MLL-HCF CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 COMPASS-like MLL3 4 H3K4 H3K4me1 H3K4me2 H3K4me3
500RBBP7 CAF1C_H4-bd PF12265 17-88 WD40 PF00400 166-205 217-255 262-301 306-345 363-402 RBBP7_MOUSE retinoblastoma binding protein 7 RBBP7_HUMAN Histone chaperone # NuRF NuRD mSin3A core HDAC mSin3A-like complex PRC2 H4 #
501RBX1 zf-rbx1 PF12678 21-98 RBX1_MOUSE ring-box 1 E3 ubiquitin protein ligase RBX1_HUMAN Histone modification write cofactor Histone ubiquitination # H3 H4 H3ub H4ub
502RCC1 RCC1 PF00415 34-82 85-134 137-187 190-255 258-309 312-360 363-414 RCC1_MOUSE regulator of chromosome condensation 1 RCC1_HUMAN Chromatin remodelling # # H2A H2B #
503RCOR1 ELM2 PF01448 102-157 Myb_DNA-binding PF00249 381-425 RCOR1_MOUSE REST corepressor 1 RCOR1_HUMAN Histone modification erase cofactor Histone modification erase cofactor Histone acetylation Histone methylation BHC SCL LSD-CoREST # #
504RCOR3 ELM2 PF01448 1-54 Myb_DNA-binding PF00249 288-332 RCOR3_MOUSE REST corepressor 3 RCOR3_HUMAN Histone modification erase cofactor Histone acetylation LSD-CoREST # #
505REST Pfam-B_2325 PB002325 821-909 Pfam-B_9727 PB009727 1001-1095 zf-C2H2_4 PF13894 216-238 zf-H2C2_2 PF13465 290-315 318-343 346-372 REST_MOUSE RE1-silencing transcription factor REST_HUMAN Histone modification erase cofactor TF TF Histone acetylation TF activator TF repressor # DNA motif #
506RING1 Pfam-B_11743 PB011743 292-404 Pfam-B_13488 PB013488 241-291 Pfam-B_23468 PB023468 191-239 zf-C3HC4 PF00097 48-87 RING1_MOUSE ring finger protein 1 RING1_HUMAN Histone modification write Polycomb group (PcG) protein Histone ubiquitination # PRC1 BCOR RING2-L3MBTL2 RING2-FBRS H2AK119 H2AK119ub
507RLIM zf-RING_2 PF13639 568-611 RNF12_MOUSE ring finger protein LIM domain interacting RNF12_HUMAN Histone modification erase cofactor Histone acetylation # # #
508RMI1 DUF1767 PF08585 12-104 Pfam-B_227 PB000227 590-623 RMI1_MOUSE RecQ mediated genome instability 1 RMI1_HUMAN DNA modification # # # #
509RNF2 zf-C3HC4 PF00097 51-90 RING2_MOUSE ring finger protein 2 RING2_HUMAN Histone modification write Histone ubiquitination PRC1 BCOR RING2-L3MBTL2 RING2-FBRS CHD8 MLL2/3 MLL4/WBP7 H2AK119 H2AK119ub
510RNF8 FHA PF00498 38-109 zf-RING_2 PF13639 401-441 RNF8_MOUSE ring finger protein 8 E3 ubiquitin protein ligase RNF8_HUMAN Histone modification write Histone ubiquitination # H2AK63 H2AXK63 H2AK48 H2AXK48 H2AK63ub H2AXK63ub H2AK48ub H2AXK48ub
511RNF20 Pfam-B_13436 PB013436 97-179 Pfam-B_14933 PB014933 35-95 Pfam-B_6844 PB006844 735-892 zf-C3HC4 PF00097 922-960 BRE1A_MOUSE ring finger protein 20 E3 ubiquitin protein ligase BRE1A_HUMAN Histone modification write Histone ubiquitination # H2BK120 H2BK120ub1
512RNF40 Pfam-B_21314 PB021314 191-299 Pfam-B_9159 PB009159 1-189 zf-C3HC4 PF00097 948-986 BRE1B_MOUSE ring finger protein 40 E3 ubiquitin protein ligase BRE1B_HUMAN Histone modification write cofactor Histone ubiquitination # H2BK121 H2BK120ub2
513RNF168 Pfam-B_30754 PB030754 528-566 zf-C3HC4_2 PF13923 16-54 RN168_MOUSE ring finger protein 168 E3 ubiquitin protein ligase RN168_HUMAN Histone modification write Histone ubiquitination # H2AK13 H2AK15 H2AXK13 H2AXK15 H2AK13ub H2AK15ub H2AXK13ub H2AXK15ub
514RPS6KA3 Pkinase PF00069 68-327 422-679 Pkinase_C PF00433 349-389 KS6A3_MOUSE ribosomal protein S6 kinase 90kDa polypeptide 3 KS6A3_HUMAN Histone modification write cofactor Histone phosphorylation # H3S10 H3S10ph
515RPS6KA4 Pkinase PF00069 33-301 413-674 Pkinase_C PF00433 321-365 KS6A4_MOUSE ribosomal protein S6 kinase 90kDa polypeptide 4 KS6A4_HUMAN Histone modification write Histone phosphorylation # H3S10 H3S28 H3S10ph H3S28ph
516RPS6KA5 Pkinase PF00069 49-318 427-687 Pkinase_C PF00433 338-381 KS6A5_MOUSE ribosomal protein S6 kinase 90kDa polypeptide 5 KS6A5_HUMAN Histone modification write Histone phosphorylation # H2AS1 H3S10 H3S28 H2AS1ph H3S10ph H3S28ph
517RRP8 Methyltransf_8 PF05148 237-456 RRP8_MOUSE ribosomal RNA processing 8 methyltransferase homolog (yeast) RRP8_HUMAN Histone modification cofactor # eNoSc H3ac H3K9me2
518RSF1 PHD PF00628 893-941 WHIM1 PF15612 98-148 WHIM2 PF15613 150-182 WHIM3 PF15614 188-409 # remodeling and spacing factor 1 RSF1_HUMAN Histone modification read # RSF # #
519RUVBL1 TIP49 PF06068 14-416 RUVB1_MOUSE RuvB-like AAA ATPase 1 RUVB1_HUMAN Chromatin remodelling Histone modification write # Histone phosphorylation Ino80 SWR NuA4 NuA4-related complex CHD8 MLL2/3 MLL4/WBP7 SRCAP # #
520RUVBL2 TIP49 PF06068 21-412 RUVB2_MOUSE RuvB-like AAA ATPase 2 RUVB2_HUMAN Chromatin remodelling cofactor # Ino80 SWR NuA4 NuA4-related complex CHD8 MLL2/3 MLL4/WBP7 SRCAP # #
521RYBP Pfam-B_18067 PB018067 49-226 zf-RanBP PF00641 22-48 RYBP_MOUSE RING1 and YY1 binding protein RYBP_HUMAN Polycomb group (PcG) protein # BCOR RING2-L3MBTL2 RING2-FBRS # #
522SAFB Pfam-B_12198 PB012198 66-89 RRM_6 PF14259 409-478 SAP PF02037 31-65 SAFB1_MOUSE scaffold attachment factor B SAFB1_HUMAN Chromatin remodelling # # # #
523SAP18 SAP18 PF06487 16-137 SAP18_MOUSE Sin3A-associated protein 18kDa SAP18_HUMAN Histone modification erase cofactor Histone acetylation mSin3A # #
524SAP25 SAP25 PF15476 1-199 SAP25_MOUSE Sin3A-associated protein 25kDa SAP25_HUMAN Histone modification erase cofactor Histone acetylation # # #
525SAP30 SAP30_Sin3_bdg PF13867 153-205 zf-SAP30 PF13866 56-134 SAP30_MOUSE Sin3A-associated protein 30kDa SAP30_HUMAN Histone modification erase cofactor Histone acetylation mSin3A mSin3A-like complex # #
526SAP30L SAP30_Sin3_bdg PF13867 114-166 zf-SAP30 PF13866 18-95 SP30L_MOUSE SAP30-like SP30L_HUMAN Histone modification erase cofactor Histone acetylation # # #
527SAP130 Pfam-B_10398 PB010398 431-719 Pfam-B_13351 PB013351 101-249 Pfam-B_17122 PB017122 781-837 Pfam-B_18714 PB018714 721-779 Pfam-B_237 PB000237 949-984 SP130_MOUSE Sin3A-associated protein 130kDa SP130_HUMAN Histone modification erase cofactor Histone acetylation # # #
528SATB1 CUT PF02376 362-448 485-571 Homeobox PF00046 645-702 Pfam-B_9146 PB009146 141-299 SATB1_MOUSE SATB homeobox 1 SATB1_HUMAN Chromatin remodelling cofactor # # # #
529SATB2 CUT PF02376 352-437 474-560 Homeobox PF00046 615-672 Pfam-B_8103 PB008103 1-268 SATB2_MOUSE SATB homeobox 2 SATB2_HUMAN Chromatin remodelling cofactor # # # #
530SCMH1 DUF3588 PF12140 355-469 MBT PF02820 62-134 171-239 SAM_1 PF00536 591-656 SCMH1_MOUSE sex comb on midleg homolog 1 (Drosophila) SCMH1_HUMAN Polycomb group (PcG) protein # PRC1 # #
531SCML2 DUF3588 PF12140 353-468 MBT PF02820 67-139 176-244 SAM_1 PF00536 629-695 # sex comb on midleg-like 2 (Drosophila) SCML2_HUMAN Polycomb group (PcG) protein # PRC1 # #
532SCML4 DUF3588 PF12140 92-208 SAM_1 PF00536 344-410 SCML4_MOUSE sex comb on midleg-like 4 (Drosophila) SCML4_HUMAN Polycomb group (PcG) protein # # # #
533SENP1 Peptidase_C48 PF02902 464-642 Pfam-B_2161 PB002161 1-189 Pfam-B_34931 PB034931 191-249 SENP1_MOUSE SUMO1/sentrin specific peptidase 1 SENP1_HUMAN Histone modification erase cofactor Histone sumoylation # H4 #
534SENP3 Peptidase_C48 PF02902 400-572 Pfam-B_2161 PB002161 1-349 SENP3_MOUSE SUMO1/sentrin/SMT3 specific peptidase 3 SENP3_HUMAN Histone modification erase Histone modification write cofactor Histone sumoylation Histone acetylation CHD8 MLL2/3 MLL4/WBP7 H3 H3ac
535SET NAP PF00956 42-237 SET_MOUSE SET nuclear proto-oncogene SET_HUMAN Histone modification # # # #
536SETD1A N-SET PF11764 1418-1558 Pfam-B_24657 PB024657 752-1010 Pfam-B_24930 PB024930 331-410 Pfam-B_41492 PB041492 622-680 RRM_1 PF00076 99-166 SET PF00856 1579-1685 # SET domain containing 1A SET1A_HUMAN Histone modification write Histone methylation COMPASS H3K4 H3K4me
537SETD1B N-SET PF11764 1629-1774 Pfam-B_1367 PB001367 1017-1148 Pfam-B_14013 PB014013 887-1015 RRM_1 PF00076 108-175 SET PF00856 1795-1901 SET1B_MOUSE SET domain containing 1B SET1B_HUMAN Histone modification write Histone methylation COMPASS H3K4 H3K4me
538SETD2 Pfam-B_18604 PB018604 305-521 Pfam-B_22486 PB022486 541-599 Pfam-B_2796 PB002796 2146-2339 Pfam-B_3607 PB003607 1826-2144 Pfam-B_67824 PB067824 31-77 SET PF00856 1561-1667 SRI PF08236 2465-2559 WW PF00397 2391-2420 SETD2_MOUSE SET domain containing 2 SETD2_HUMAN Histone modification write Histone methylation # H3K36me2 H3K36me3
539SETD3 Rubis-subs-bind PF09273 343-475 SET PF00856 105-314 SETD3_MOUSE SET domain containing 3 SETD3_HUMAN Histone modification write Histone methylation # H3K36 H3K36me
540SETD5 Pfam-B_7713 PB007713 700-789 SET PF00856 285-390 SETD5_MOUSE SET domain containing 5 SETD5_HUMAN Histone modification write Histone methylation # # #
541SETD6 Pfam-B_25912 PB025912 1-69 Rubis-subs-bind PF09273 329-465 SET PF00856 74-286 SETD6_MOUSE SET domain containing 6 SETD6_HUMAN Chromatin remodelling Histone modification write # Histone methylation # # #
542SETD7 MORN PF02493 13-35 36-58 60-81 106-128 SET PF00856 227-336 SETD7_MOUSE SET domain containing (lysine methyltransferase) 7 SETD7_HUMAN Histone modification write Histone methylation # H3K4 H3K4me1
543SETD8 SET PF00856 268-378 SETD8_MOUSE SET domain containing (lysine methyltransferase) 8 SETD8_HUMAN Histone modification write Histone methylation # H4K20 H4K20me1
544SETDB1 MBD PF01429 594-668 Pfam-B_23747 PB023747 365-520 Pfam-B_27578 PB027578 341-364 Pre-SET PF05033 681-795 SET PF00856 814-1266 SETB1_MOUSE SET domain bifurcated 1 SETB1_HUMAN Histone modification write Histone methylation # H3K9 H3K9me3
545SETDB2 MBD PF01429 160-232 Pre-SET PF05033 245-359 SET PF00856 378-694 SETB2_MOUSE SET domain bifurcated 2 SETB2_HUMAN Histone modification write Histone methylation # H3K9 H3K9me3
546SETMAR HTH_Tnp_Tc3_2 PF01498 401-466 Pre-SET PF05033 16-118 SET PF00856 137-250 Transposase_1 PF01359 488-568 SETMR_MOUSE SET domain and mariner transposase fusion gene SETMR_HUMAN Histone modification write Histone methylation # H3K4 H3K36 H3K4me H3K36me
547SF3B1 Pfam-B_1720 PB001720 1099-1147 SF3b1 PF08920 282-457 SF3B1_MOUSE splicing factor 3b subunit 1 155kDa SF3B1_HUMAN RNA modification # B-WICH # #
548SF3B3 CPSF_A PF03178 863-1184 MMS1_N PF10433 76-597 SF3B3_MOUSE splicing factor 3b subunit 3 130kDa SF3B3_HUMAN RNA modification # # # #
549SFMBT1 DUF3588 PF12140 501-620 MBT PF02820 54-128 167-240 279-356 388-461 Pfam-B_19576 PB019576 672-751 SAM_1 PF00536 794-857 SMBT1_MOUSE Scm-like with four mbt domains 1 SMBT1_HUMAN Polycomb group (PcG) protein # SCL H4K20 #
550SFMBT2 DUF3588 PF12140 527-646 MBT PF02820 78-152 191-263 304-380 412-485 SAM_1 PF00536 822-885 SMBT2_MOUSE Scm-like with four mbt domains 2 SMBT2_HUMAN Histone modification read Polycomb group (PcG) protein TF # # TF repressor # H3K9me2 H3K9me3 H3K27me3 H4K20me2 H4K20me3 H3 H4
551SFPQ NOPS PF08075 444-495 RRM_1 PF00076 299-363 373-440 SFPQ_MOUSE splicing factor proline/glutamine-rich SFPQ_HUMAN Chromatin remodelling cofactor RNA modification TF # # TF repressor # # #
552SHPRH Helicase_C PF00271 1545-1622 Linker_histone PF00538 438-512 Pfam-B_11163 PB011163 1-248 SNF2_N PF00176 307-987 zf-C3HC4_2 PF13923 1432-1478 SHPRH_MOUSE SNF2 histone linker PHD RING helicase E3 ubiquitin protein ligase SHPRH_HUMAN Histone modification write cofactor Histone ubiquitination # # #
553SIN3A PAH PF02671 141-187 322-381 477-523 Pfam-B_10250 PB010250 1-99 Pfam-B_10714 PB010714 1098-1128 Pfam-B_8471 PB008471 1055-1090 Sin3_corepress PF08295 550-650 SIN3A_MOUSE SIN3 transcription regulator family member A SIN3A_HUMAN Histone modification erase cofactor TF TF Histone acetylation TF activator TF repressor SWI/SNF_Brg1(I) SWI/SNF_Brm mSin3A mSin3A-like complex DNA motif #
554SIN3B PAH PF02671 59-105 180-236 321-367 Sin3_corepress PF08295 393-448 450-525 SIN3B_MOUSE SIN3 transcription regulator family member B SIN3B_HUMAN Histone modification erase cofactor TF Histone acetylation TF repressor mSin3A DNA motif #
555SIRT1 Pfam-B_28511 PB028511 1-109 Pfam-B_5913 PB005913 111-189 Pfam-B_8042 PB008042 611-745 SIR2 PF02146 261-447 SIR1_MOUSE sirtuin 1 SIR1_HUMAN Histone modification erase Histone modification write cofactor Histone acetylation Histone methylation eNoSc H1K26ac H3K9ac H4K16ac H1K26 H3K9 H4K16
556SIRT2 SIR2 PF02146 84-268 SIR2_MOUSE sirtuin 2 SIR2_HUMAN Histone modification erase Histone modification write cofactor Histone acetylation Histone methylation # H3K18ac H3K56ac H4K16ac H4K20me1 H3K18 H3K56 H4K16 H4K20me2 H4K20me3
557SIRT6 SIR2 PF02146 52-89 80-221 SIR6_MOUSE sirtuin 6 SIR6_HUMAN Histone modification erase Histone acetylation # H3K9ac H3K56ac H3K9 H3K56
558SIRT7 SIR2 PF02146 133-275 SIR7_MOUSE sirtuin 7 SIR7_HUMAN Histone modification erase Histone acetylation B-WICH H3K18ac H3K18
559SKP1 Skp1 PF01466 85-162 Skp1_POZ PF03931 2-67 SKP1_MOUSE S-phase kinase-associated protein 1 SKP1_HUMAN Histone modification write cofactor Histone ubiquitination BCOR # #
560SMARCA1 DBINO PF13892 42-119 HAND PF09110 758-856 Helicase_C PF00271 520-612 SLIDE PF09111 912-1028 SNF2_N PF00176 186-466 SMCA1_MOUSE SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 1 SMCA1_HUMAN Chromatin remodelling Histone modification erase # Histone acetylation NuRF CERF CERF # #
561SMARCA2 BRK PF07533 588-633 Bromodomain PF00439 1411-1493 HSA PF07529 436-508 Helicase_C PF00271 1084-1164 Pfam-B_17897 PB017897 1369-1398 Pfam-B_2366 PB002366 333-414 QLQ PF08880 172-208 SNF2_N PF00176 727-1022 SnAC PF14619 1257-1326 SMCA2_MOUSE SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 2 SMCA2_HUMAN Histone modification read TF # TF activator BAF nBAF npBAF WINAC bBAF SWI/SNF BRM-BRG1 H3 DNA motif #
562SMARCA4 BRK PF07533 610-655 Bromodomain PF00439 1462-1551 HSA PF07529 460-532 Helicase_C PF00271 1114-1194 QLQ PF08880 170-206 SNF2_N PF00176 757-1052 SnAC PF14619 1321-1389 SMCA4_MOUSE SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 4 SMCA4_HUMAN Histone modification read TF # TF activator BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB bBAF SWI/SNF BRM-BRG1 CREST-BRG1 H3 H4 #
563SMARCA5 DBINO PF13892 58-116 HAND PF09110 743-841 Helicase_C PF00271 517-597 Pfam-B_36230 PB036230 1-39 SLIDE PF09111 897-1013 SNF2_N PF00176 183-463 SMCA5_MOUSE SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 5 SMCA5_HUMAN Chromatin remodelling # ACF B-WICH RSF CHRAC NoRC # #
564SMARCAD1 Helicase_C PF00271 888-967 Pfam-B_295 PB000295 41-308 SNF2_N PF00176 500-788 SMRCD_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily a containing DEAD/H box 1 SMRCD_HUMAN Chromatin remodelling # # # #
565SMARCAL1 HARP PF07443 248-302 343-397 Helicase_C PF00271 743-822 Pfam-B_7889 PB007889 1-159 SNF2_N PF00176 434-716 SMAL1_MOUSE SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a-like 1 SMAL1_HUMAN Chromatin remodelling # # # #
566SMARCB1 Pfam-B_9879 PB009879 2-146 SNF5 PF04855 178-373 SNF5_MOUSE SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily b member 1 SNF5_HUMAN Histone modification read # BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB bBAF SWI/SNF BRM-BRG1 H3K56 #
567SMARCC1 Myb_DNA-binding PF00249 620-665 SWIRM PF04433 449-537 SMRC1_MOUSE SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 1 SMRC1_HUMAN Chromatin remodelling cofactor # BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB bBAF SWI/SNF BRM-BRG1 # #
568SMARCC2 Myb_DNA-binding PF00249 598-643 Pfam-B_1849 PB001849 1-168 SWIRM PF04433 424-512 SMRC2_MOUSE SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 2 SMRC2_HUMAN Chromatin remodelling cofactor # BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB bBAF SWI/SNF BRM-BRG1 # #
569SMARCD1 Pfam-B_13759 PB013759 1-79 Pfam-B_3130 PB003130 378-473 SWIB PF02201 291-366 SMRD1_MOUSE SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 1 SMRD1_HUMAN Chromatin remodelling # BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB SWI/SNF BRM-BRG1 # #
570SMARCD2 Pfam-B_13705 PB013705 420-516 Pfam-B_7929 PB007929 141-287 SWIB PF02201 307-382 SMRD2_MOUSE SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 2 SMRD2_HUMAN Chromatin remodelling cofactor # BAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brm SWI/SNF-like EPAFB bBAF SWI/SNF BRM-BRG1 # #
571SMARCD3 Pfam-B_18257 PB018257 7-73 Pfam-B_3130 PB003130 346-441 SWIB PF02201 259-334 SMRD3_MOUSE SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 3 SMRD3_HUMAN Chromatin remodelling cofactor # BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brm SWI/SNF BRM-BRG1 # #
572SMARCE1 HMG_box PF00505 66-134 Pfam-B_14199 PB014199 371-409 SMCE1_MOUSE SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily e member 1 SMCE1_HUMAN Chromatin remodelling cofactor # BAF nBAF npBAF PBAF SWI/SNF_Brg1(I) SWI/SNF_Brg1(II) SWI/SNF_Brm SWI/SNF-like_EPAFa WINAC SWI/SNF-like EPAFB bBAF # #
573SMEK1 Pfam-B_1700 PB001700 381-501 Pfam-B_334 PB000334 506-611 SMK-1 PF04802 164-357 P4R3A_MOUSE SMEK homolog 1 suppressor of mek1 (Dictyostelium) P4R3A_HUMAN Histone modification erase cofactor Histone phosphorylation PPP4C-PPP4R2-PPP4R3A H2AFX #
574SMEK2 Pfam-B_2986 PB002986 536-638 SMK-1 PF04802 166-359 P4R3B_MOUSE SMEK homolog 2 suppressor of mek1 (Dictyostelium) P4R3B_HUMAN Histone modification erase cofactor Histone phosphorylation # H2AFX #
575SMYD1 SET PF00856 18-253 zf-MYND PF01753 52-90 SMYD1_MOUSE SET and MYND domain containing 1 SMYD1_HUMAN Histone modification write Histone methylation # H3K4 H3K4me
576SMYD2 SET PF00856 18-241 zf-MYND PF01753 52-90 SMYD2_MOUSE SET and MYND domain containing 2 SMYD2_HUMAN Histone modification write Histone methylation # H3K4 H3K36 H3K4me H3K36me2
577SMYD3 Pfam-B_27974 PB027974 391-422 SET PF00856 15-240 zf-MYND PF01753 47-87 SMYD3_MOUSE SET and MYND domain containing 3 SMYD3_HUMAN Histone modification write Histone methylation # H3K4 H3K5 H3K4me2 H3K4me3 H3K5me2 H3K5me3
578SMYD4 Pfam-B_24699 PB024699 740-795 Pfam-B_50317 PB050317 1-65 SET PF00856 244-574 TPR_11 PF13414 66-135 zf-MYND PF01753 296-335 SMYD4_MOUSE SET and MYND domain containing 4 SMYD4_HUMAN Histone modification erase cofactor Histone acetylation # # #
579SNAI2 zf-C2H2 PF00096 159-181 zf-C2H2_6 PF13912 127-153 zf-H2C2_2 PF13465 199-224 227-252 SNAI2_MOUSE snail family zinc finger 2 SNAI2_HUMAN Histone modification erase cofactor # # # #
580SP1 Pfam-B_20467 PB020467 61-148 Pfam-B_7620 PB007620 371-482 zf-C2H2 PF00096 626-650 686-708 zf-H2C2_2 PF13465 672-695 SP1_MOUSE Sp1 transcription factor SP1_HUMAN Chromatin remodelling TF TF # TF activator TF repressor CREST-BRG1 DNA motif #
581SP100 HMG_box PF00505 769-837 HMG_box_2 PF09011 684-753 Pfam-B_182547 PB182547 845-873 Pfam-B_41802 PB041802 151-337 SAND PF01342 595-676 Sp100 PF03172 47-150 SP100_MOUSE SP100 nuclear antigen SP100_HUMAN Chromatin remodelling cofactor # # # #
582SP140 Bromodomain PF00439 775-842 PHD PF00628 692-736 SAND PF01342 580-661 Sp100 PF03172 36-139 # SP140 nuclear body protein SP140_HUMAN Histone modification read TF # # # H3 #
583SPEN Pfam-B_1253 PB001253 981-1331 Pfam-B_17673 PB017673 621-899 Pfam-B_17985 PB017985 901-979 Pfam-B_2825 PB002825 1826-1859 RRM_1 PF00076 8-74 337-407 440-507 RRM_5 PF13893 533-587 SPOC PF07744 3509-3630 MINT_MOUSE spen family transcriptional repressor MINT_HUMAN Histone modification erase cofactor TF TF Histone acetylation TF activator TF repressor # # #
584SPOP BTB PF00651 190-297 MATH PF00917 38-163 SPOP_MOUSE speckle-type POZ protein SPOP_HUMAN Histone modification write Histone ubiquitination # MacroH2A1 MacroH2A1ub
585SRCAP HSA PF07529 125-196 Helicase_C PF00271 2077-2156 SNF2_N PF00176 621-907 # Snf2-related CREBBP activator protein SRCAP_HUMAN Chromatin remodelling Histone modification erase # Histone acetylation NuA4-related complex SRCAP H2A.Z #
586SRSF1 Pfam-B_5206 PB005206 192-246 RRM_1 PF00076 18-85 123-186 SRSF1_MOUSE serine/arginine-rich splicing factor 1 SRSF1_HUMAN RNA modification # # # #
587SRSF3 Pfam-B_13909 PB013909 131-162 RRM_1 PF00076 12-77 SRSF3_MOUSE serine/arginine-rich splicing factor 3 SRSF3_HUMAN RNA modification # # # #
588SS18L1 Pfam-B_16193 PB016193 365-394 Pfam-B_22298 PB022298 315-363 SSXT PF05030 11-76 CREST_MOUSE synovial sarcoma translocation gene on chromosome 18-like 1 CREST_HUMAN Chromatin remodelling # CREST-BRG1 # #
589SS18L2 SSXT PF05030 11-76 S18L2_MOUSE synovial sarcoma translocation gene on chromosome 18-like 2 S18L2_HUMAN Chromatin remodelling # # # #
590SSRP1 HMG_box PF00505 547-615 Pfam-B_9245 PB009245 1-73 Rtt106 PF08512 338-428 SSrecog PF03531 74-285 SSRP1_MOUSE structure specific recognition protein 1 SSRP1_HUMAN Chromatin remodelling # FACT H3 H4 #
591STK4 Mst1_SARAH PF11629 432-480 Pfam-B_12195 PB012195 341-431 Pkinase PF00069 30-281 STK4_MOUSE serine/threonine kinase 4 STK4_HUMAN Histone modification write Histone phosphorylation # H2AS14 H2BS14ph
592SUDS3 Sds3 PF08598 53-223 SDS3_MOUSE suppressor of defective silencing 3 homolog (S. cerevisiae) SDS3_HUMAN Histone modification erase cofactor Histone acetylation mSin3A # #
593SUPT3H TFIID-18kDa PF02269 106-198 # suppressor of Ty 3 homolog (S. cerevisiae) SUPT3_HUMAN Histone modification write cofactor Histone acetylation PCAF SAGA STAGA # #
594SUPT6H DLD PF14878 1050-1160 HHH_7 PF14635 935-1038 HTH_44 PF14641 300-437 Pfam-B_17741 PB017741 172-225 Pfam-B_27919 PB027919 129-149 S1 PF00575 1226-1282 SH2_2 PF14633 1295-1515 SPT6_acidic PF14632 35-128 YqgF PF14639 775-931 SPT6H_MOUSE suppressor of Ty 6 homolog (S. cerevisiae) SPT6H_HUMAN Histone modification erase cofactor Histone methylation # # #
595SUPT7L Bromo_TP PF07524 151-230 Pfam-B_18361 PB018361 301-379 Pfam-B_18885 PB018885 1-69 ST65G_MOUSE suppressor of Ty 7 (S. cerevisiae)-like ST65G_HUMAN Histone chaperone # TFTC-HAT STAGA # #
596SUPT16H FACT-Spt16_Nlob PF14826 5-168 Peptidase_M24 PF00557 181-411 Pfam-B_18241 PB018241 958-1024 Rtt106 PF08512 806-896 SPT16 PF08644 529-689 SP16H_MOUSE suppressor of Ty 16 homolog (S. cerevisiae) SP16H_HUMAN Histone modification read # WINAC FACT H2A H2B #
597SUV39H1 Chromo PF00385 43-92 Pre-SET PF05033 135-235 SET PF00856 255-366 SUV91_MOUSE suppressor of variegation 3-9 homolog 1 (Drosophila) SUV91_HUMAN Histone modification write Histone modification write Histone methylation Histone phosphorylation eNoSc H3S10 H3K9me1 H4 H3K9me3
598SUV39H2 Chromo PF00385 47-96 Pre-SET PF05033 144-242 SET PF00856 262-373 SUV92_MOUSE suppressor of variegation 3-9 homolog 2 (Drosophila) SUV92_HUMAN Histone modification write Histone methylation # H3K9me1 H3K9me3
599SUV420H1 Pfam-B_23340 PB023340 771-839 Pfam-B_24134 PB024134 711-769 Pfam-B_32221 PB032221 551-609 Pfam-B_49669 PB049669 841-883 SET PF00856 99-308 SV421_MOUSE suppressor of variegation 4-20 homolog 1 (Drosophila) SV421_HUMAN Histone modification write Histone methylation # H4K20 H4K20me3
600SUV420H2 Pfam-B_18005 PB018005 261-379 Pfam-B_59617 PB059617 1-39 Pfam-B_6511 PB006511 381-460 SET PF00856 121-218 SV422_MOUSE suppressor of variegation 4-20 homolog 2 (Drosophila) SV422_HUMAN Histone modification write Histone methylation # H4K20 H4K20me3
601SUZ12 VEFS-Box PF09733 544-681 SUZ12_MOUSE SUZ12 polycomb repressive complex 2 subunit SUZ12_HUMAN Histone modification write cofactor Histone modification write cofactor Polycomb group (PcG) protein TF Histone methylation Histone ubiquitination # TF repressor PRC2 DNA motif #
602SYNCRIP RRM_1 PF00076 164-232 245-312 340-402 HNRPQ_MOUSE synaptotagmin binding cytoplasmic RNA interacting protein HNRPQ_HUMAN RNA modification mRNA editing APOB_mRNA_editosome mRNA #
603TADA1 SAGA-Tad1 PF12767 3-195 TADA1_MOUSE transcriptional adaptor 1 TADA1_HUMAN Histone chaperone # STAGA H2A #
604TADA2A Myb_DNA-binding PF00249 72-118 SWIRM PF04433 362-442 TAD2A_MOUSE transcriptional adaptor 2A TAD2A_HUMAN Histone modification read TF # TF activator PCAF ATAC H3 #
605TADA2B Myb_DNA-binding PF00249 67-113 ZZ PF00569 6-47 # transcriptional adaptor 2B TAD2B_HUMAN Histone modification write cofactor Histone acetylation TFTC-HAT # #
606TADA3 Ada3 PF10198 308-432 TADA3_MOUSE transcriptional adaptor 3 TADA3_HUMAN Histone modification write cofactor Histone acetylation PCAF TFTC-HAT ATAC STAGA # #
607TAF1 Bromodomain PF00439 1389-1472 1509-1595 DUF3591 PF12157 565-1028 Pfam-B_10720 PB010720 311-366 TBP-binding PF09247 22-87 zf-CCHC_6 PF15288 1261-1300 TAF1_MOUSE TAF1 RNA polymerase II TATA box binding protein (TBP)-associated factor 250kDa TAF1_HUMAN Histone modification write Histone acetylation CHD8 MLL2/3 MLL4/WBP7 H3 H4 H3ac H4ac
608TAF1L Bromodomain PF00439 1408-1491 1528-1614 DUF3591 PF12157 584-1047 Pfam-B_10720 PB010720 330-385 TBP-binding PF09247 21-86 zf-CCHC_6 PF15288 1280-1319 # TAF1 RNA polymerase II TATA box binding protein (TBP)-associated factor 210kDa-like TAF1L_HUMAN Histone modification read # # H1.4ac H2Aac H2Bac H3ac H4ac #
609TAF2 Peptidase_M1 PF01433 21-406 Pfam-B_2101 PB002101 661-979 Pfam-B_21717 PB021717 1111-1159 Pfam-B_6210 PB006210 1161-1197 Pfam-B_8840 PB008840 981-1109 TAF2_MOUSE TAF2 RNA polymerase II TATA box binding protein (TBP)-associated factor 150kDa TAF2_HUMAN TF # TFTC-HAT DNA motif #
610TAF3 Bromo_TP PF07524 3-79 PHD PF00628 867-915 TAF3_MOUSE TAF3 RNA polymerase II TATA box binding protein (TBP)-associated factor 140kDa TAF3_HUMAN Histone modification read # # H3K4me #
611TAF4 Pfam-B_41790 PB041790 141-219 Pfam-B_7817 PB007817 411-499 Pfam-B_906 PB000906 1-139 TAF4 PF05236 834-1084 TAFH PF07531 590-688 # TAF4 RNA polymerase II TATA box binding protein (TBP)-associated factor 135kDa TAF4_HUMAN Histone chaperone # TFTC-HAT CHD8 MLL2/3 MLL4/WBP7 # #
612TAF5 Pfam-B_22190 PB022190 61-159 Pfam-B_34937 PB034937 1-59 TFIID_90kDa PF04494 199-338 WD40 PF00400 461-498 533-571 575-613 617-655 659-697 701-739 TAF5_MOUSE TAF5 RNA polymerase II TATA box binding protein (TBP)-associated factor 100kDa TAF5_HUMAN Histone modification write cofactor Histone acetylation TFTC-HAT # #
613TAF5L TFIID_90kDa PF04494 55-196 WD40 PF00400 259-296 332-370 375-412 416-454 458-496 500-538 TAF5L_MOUSE TAF5-like RNA polymerase II p300/CBP-associated factor (PCAF)-associated factor 65kDa TAF5L_HUMAN Histone modification write cofactor Histone acetylation PCAF TFTC-HAT STAGA # #
614TAF6 DUF1546 PF07571 308-399 Pfam-B_25920 PB025920 618-675 TAF PF02969 11-76 TAF6_MOUSE TAF6 RNA polymerase II TATA box binding protein (TBP)-associated factor 80kDa TAF6_HUMAN Histone chaperone # TFTC-HAT CHD8 MLL2/3 MLL4/WBP7 # #
615TAF6L DUF1546 PF07571 242-333 Pfam-B_32143 PB032143 200-239 Pfam-B_32396 PB032396 161-199 TAF PF02969 9-73 TAF6L_MOUSE TAF6-like RNA polymerase II p300/CBP-associated factor (PCAF)-associated factor 65kDa TAF6L_HUMAN Histone chaperone # PCAF TFTC-HAT STAGA # #
616TAF7 TAFII55_N PF04658 12-178 TAF7_MOUSE TAF7 RNA polymerase II TATA box binding protein (TBP)-associated factor 55kDa TAF7_HUMAN Histone modification write cofactor Histone modification write cofactor Histone methylation Histone acetylation CHD8 MLL2/3 MLL4/WBP7 # #
617TAF8 Bromo_TP PF07524 29-106 TAF8_C PF10406 144-194 TAF8_MOUSE TAF8 RNA polymerase II TATA box binding protein (TBP)-associated factor 43kDa TAF8_HUMAN Histone chaperone # # # #
618TAF9 TFIID-31kDa PF02291 2-130 TAF9_MOUSE TAF9 RNA polymerase II TATA box binding protein (TBP)-associated factor 32kDa TAF9_HUMAN Histone chaperone # PCAF STAGA CHD8 MLL2/3 MLL4/WBP7 # #
619TAF9B TFIID-31kDa PF02291 2-130 TAF9B_MOUSE TAF9B RNA polymerase II TATA box binding protein (TBP)-associated factor 31kDa TAF9B_HUMAN Histone chaperone # TFTC-HAT # #
620TAF10 TFIID_30kDa PF03540 128-178 TAF10_MOUSE TAF10 RNA polymerase II TATA box binding protein (TBP)-associated factor 30kDa TAF10_HUMAN Histone chaperone Histone modification write # Histone acetylation PCAF TFTC-HAT SAGA STAGA H3 H4 #
621TAF12 Pfam-B_25018 PB025018 1-58 TFIID_20kDa PF03847 59-126 TAF12_MOUSE TAF12 RNA polymerase II TATA box binding protein (TBP)-associated factor 20kDa TAF12_HUMAN Histone chaperone Histone modification write # Histone acetylation PCAF STAGA # #
622TBL1XR1 LisH PF08513 6-32 Pfam-B_2526 PB002526 471-510 WD40 PF00400 160-197 224-253 256-294 298-335 339-377 381-428 432-470 TBL1R_MOUSE transducin (beta)-like 1 X-linked receptor 1 TBL1R_HUMAN # # # # #
623TDG UDG PF03167 125-293 TDG_MOUSE thymine-DNA glycosylase TDG_HUMAN DNA modification DNA hydroxymethylation # G:U G:T G:hmU C 5mC 5hmC
624TDRD3 TUDOR PF00567 542-615 UBA PF00627 194-230 TDRD3_MOUSE tudor domain containing 3 TDRD3_HUMAN Histone modification read # # H3R17me2a H4R3me2a #
625TDRD7 OST-HTH PF12872 5-73 Pfam-B_27056 PB027056 101-149 TUDOR PF00567 459-581 648-775 908-1026 TDRD7_MOUSE tudor domain containing 7 TDRD7_HUMAN Histone modification read # # H3K9 #
626TDRKH KH_1 PF00013 54-115 126-190 Pfam-B_19308 PB019308 201-301 TUDOR PF00567 302-423 TDRKH_MOUSE tudor and KH domain containing TDRKH_HUMAN RNA modification # # piRNA #
627TET1 Pfam-B_12165 PB012165 2056-2134 Pfam-B_35074 PB035074 1-139 Pfam-B_6123 PB006123 782-815 Tet_JBP PF12851 1580-2052 zf-CXXC PF02008 583-624 TET1_MOUSE tet methylcytosine dioxygenase 1 TET1_HUMAN DNA modification DNA hydroxymethylation # mC hmC
628TET2 Pfam-B_32546 PB032546 930-1046 Pfam-B_34477 PB034477 1927-1975 Tet_JBP PF12851 1290-1905 TET2_MOUSE tet methylcytosine dioxygenase 2 TET2_HUMAN DNA modification DNA hydroxymethylation # mC hmC
629TET3 Pfam-B_188 PB000188 1613-1658 Pfam-B_19260 PB019260 1-109 Tet_JBP PF12851 850-1562 TET3_MOUSE tet methylcytosine dioxygenase 3 TET3_HUMAN DNA modification DNA hydroxymethylation # mC hmC
630TEX10 Ipi1_N PF12333 130-235 Pfam-B_18291 PB018291 611-869 TEX10_MOUSE testis expressed 10 TEX10_HUMAN Histone modification write cofactor Histone modification write cofactor Histone methylation Histone acetylation CHD8 MLL2/3 MLL4/WBP7 # #
631TFDP1 DP PF08781 200-344 E2F_TDP PF02319 111-193 TFDP1_MOUSE transcription factor Dp-1 TFDP1_HUMAN Histone modification # RING2-L3MBTL2 # #
632TFPT Pfam-B_10240 PB010240 10-162 Pfam-B_26015 PB026015 181-212 TFPT_MOUSE TCF3 (E2A) fusion partner (in childhood Leukemia) TFPT_HUMAN Chromatin remodelling cofactor DNA modification # DNA hydroxymethylation Ino80 # #
633TLE1 TLE_N PF03920 1-136 WD40 PF00400 477-511 523-558 565-602 606-644 689-726 736-767 TLE1_MOUSE transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) TLE1_HUMAN Chromatin remodelling Histone modification cofactor # # # H3 #
634TLE2 TLE_N PF03920 1-132 WD40 PF00400 450-484 538-575 579-617 661-699 709-740 TLE2_MOUSE transducin-like enhancer of split 2 TLE2_HUMAN Histone modification cofactor # # H3 H3K4 H3K9 H3K27me
635TLE4 TLE_N PF03920 8-141 WD40 PF00400 480-514 526-561 568-605 609-647 692-729 739-770 TLE4_MOUSE transducin-like enhancer of split 4 TLE4_HUMAN Histone modification erase cofactor TF # # # H3ac H4ac #
636TLK1 Pfam-B_2740 PB002740 1-109 Pfam-B_9699 PB009699 111-179 Pkinase PF00069 456-734 TLK1_MOUSE tousled-like kinase 1 TLK1_HUMAN Histone modification write Histone phosphorylation # H3S10 H3S10ph
637TLK2 Pfam-B_24604 PB024604 91-129 Pfam-B_3701 PB003701 1-89 Pkinase PF00069 462-741 TLK2_MOUSE tousled-like kinase 2 TLK2_HUMAN Histone modification write Histone phosphorylation # # #
638TNP1 TP1 PF02079 2-55 STP1_MOUSE transition protein 1 (during histone to protamine replacement) STP1_HUMAN Chromatin remodelling # # # #
639TNP2 TP2 PF01254 1-138 STP2_MOUSE transition protein 2 (during histone to protamine replacement) STP2_HUMAN Chromatin remodelling # # # #
640TONSL Ank PF00023 528-560 561-591 597-629 LRR_6 PF13516 1097-1121 Pfam-B_27656 PB027656 642-670 Pfam-B_51992 PB051992 204-263 TPR_11 PF13414 350-422 TONSL_MOUSE tonsoku-like DNA repair protein TONSL_HUMAN Chromatin remodelling # # # #
641TOP2A DNA_gyraseB PF00204 266-430 DNA_topoisoIV PF00521 713-1172 DTHCT PF08070 1435-1523 HATPase_c PF02518 77-224 Toprim PF01751 456-572 TOP2A_MOUSE topoisomerase (DNA) II alpha 170kDa TOP2A_HUMAN Chromatin remodelling # # DNA #
642TOP2B DNA_gyraseB PF00204 287-450 DNA_topoisoIV PF00521 734-1190 DTHCT PF08070 1508-1611 HATPase_c PF02518 98-245 Toprim PF01751 477-593 TOP2B_MOUSE topoisomerase (DNA) II beta 180kDa TOP2B_HUMAN Chromatin remodelling # WINAC # #
643TP53 P53 PF00870 95-289 P53_TAD PF08563 5-29 P53_tetramer PF07710 318-359 P53_MOUSE tumor protein p53 P53_HUMAN Histone modification write cofactor TF TF Histone acetylation TF activator TF repressor # H3 #
644TP53BP1 53-BP1_Tudor PF09038 1483-1604 Pfam-B_14288 PB014288 1213-1356 Pfam-B_21507 PB021507 1-59 Pfam-B_24656 PB024656 1358-1386 Pfam-B_24892 PB024892 970-1000 Pfam-B_44 PB000044 528-565 Pfam-B_689 PB000689 567-698 Pfam-B_9132 PB009132 902-939 Pfam-B_9249 PB009249 1611-1967 TP53B_MOUSE tumor protein p53 binding protein 1 TP53B_HUMAN Histone modification read # # H4K79me2 H4K20me2 #
645TRIM16 PRY PF13765 375-424 Pfam-B_10855 PB010855 281-339 SPRY PF00622 426-551 zf-B_box PF00643 126-165 TRI16_MOUSE tripartite motif containing 16 TRI16_HUMAN Histone modification write Histone acetylation # # #
646TRIM24 Bromodomain PF00439 908-992 PHD PF00628 828-873 Pfam-B_14213 PB014213 595-656 Pfam-B_4946 PB004946 372-591 zf-B_box PF00643 158-205 218-259 TIF1A_MOUSE tripartite motif containing 24 TIF1A_HUMAN Histone modification read # # H3K4 H3K23ac #
647TRIM27 PRY PF13765 318-366 SPRY PF00622 368-493 zf-B_box PF00643 91-132 zf-C3HC4 PF00097 16-56 TRI27_MOUSE tripartite motif containing 27 TRI27_HUMAN Histone modification erase cofactor Histone acetylation # # #
648TRIM28 PHD PF00628 627-672 zf-B_box PF00643 148-195 204-245 zf-RING_5 PF14634 64-122 TIF1B_MOUSE tripartite motif containing 28 TIF1B_HUMAN Histone modification read # # H3 #
649TRIM33 Bromodomain PF00439 966-1051 PHD PF00628 889-933 Pfam-B_10963 PB010963 664-696 Pfam-B_11449 PB011449 608-663 Pfam-B_11628 PB011628 535-606 zf-B_box PF00643 212-258 271-312 zf-RING_2 PF13639 123-185 TRI33_MOUSE tripartite motif containing 33 TRI33_HUMAN Histone modification read # # H3K9me3 H3K18ac #
650TRRAP FAT PF02259 2849-3204 PI3_PI4_kinase PF00454 3526-3783 Pfam-B_11387 PB011387 1471-1587 Pfam-B_12811 PB012811 141-238 Pfam-B_15427 PB015427 1-139 Pfam-B_3253 PB003253 1858-1890 1946-2001 Pfam-B_6491 PB006491 1589-1667 Pfam-B_6680 PB006680 2445-2544 TRRAP_MOUSE transformation/transcription domain-associated protein TRRAP_HUMAN Histone modification write cofactor Histone acetylation SWR PCAF TFTC-HAT NuA4 SAGA NuA4-related complex STAGA # #
651TSSK6 Pkinase PF00069 12-267 TSSK6_MOUSE testis-specific serine kinase 6 TSSK6_HUMAN Histone modification write Histone phosphorylation # H1 H2A H2AX H3 #
652TTK Pfam-B_2743 PB002743 1-291 Pkinase PF00069 525-791 TTK_MOUSE TTK protein kinase TTK_HUMAN Histone modification write cofactor Histone phosphorylation # H2AT120 H2AT120ph
653TYW5 Cupin_8 PF13621 16-256 TYW5_MOUSE tRNA-yW synthesizing protein 5 TYW5_HUMAN RNA modification # # # #
654UBE2A UQ_con PF00179 8-145 UBE2A_MOUSE ubiquitin-conjugating enzyme E2A UBE2A_HUMAN Histone modification write Histone ubiquitination # H2A H2BK120 H2BK120ub1
655UBE2B UQ_con PF00179 8-145 UBE2B_MOUSE ubiquitin-conjugating enzyme E2B UBE2B_HUMAN Histone modification write Histone ubiquitination # H2A H2BK121 H2BK120ub2
656UBE2D1 UQ_con PF00179 5-142 UB2D1_MOUSE ubiquitin-conjugating enzyme E2D 1 UB2D1_HUMAN Histone modification write Histone ubiquitination # H2BK48 H2BK48ub
657UBE2D3 UQ_con PF00179 5-142 UB2D3_MOUSE ubiquitin-conjugating enzyme E2D 3 UB2D3_HUMAN Histone modification write Histone ubiquitination # H2AK119 H2AK119ub
658UBE2E1 UQ_con PF00179 51-188 UB2E1_MOUSE ubiquitin-conjugating enzyme E2E 1 UB2E1_HUMAN Histone modification write Histone ubiquitination # H2BK120 H2BK120ub
659UBE2H UQ_con PF00179 9-145 UBE2H_MOUSE ubiquitin-conjugating enzyme E2H UBE2H_HUMAN Histone modification write Histone ubiquitination # H2A H2B H2Aub H2Bub
660UBE2N UQ_con PF00179 7-144 UBE2N_MOUSE ubiquitin-conjugating enzyme E2N UBE2N_HUMAN Histone modification write Histone ubiquitination # H2AX H2AXub
661UBE2T UQ_con PF00179 6-147 UBE2T_MOUSE ubiquitin-conjugating enzyme E2T (putative) UBE2T_HUMAN Histone modification write Histone ubiquitination # # #
662UBN1 HUN PF08729 115-169 UBN_AB PF14075 353-575 UBN1_MOUSE ubinuclein 1 UBN1_HUMAN Histone modification write cofactor Histone methylation # # #
663UBR2 ClpS PF02617 221-302 Pfam-B_10464 PB010464 668-730 Pfam-B_14814 PB014814 1413-1491 Pfam-B_15951 PB015951 1298-1365 Pfam-B_2665 PB002665 1020-1065 zf-UBR PF02207 97-167 UBR2_MOUSE ubiquitin protein ligase E3 component n-recognin 2 UBR2_HUMAN Histone modification write Histone ubiquitination # H2A #
664UBR5 E3_UbLigase_EDD PF11547 178-230 HECT PF00632 2497-2799 PABP PF00658 2376-2449 Pfam-B_10556 PB010556 1381-1499 Pfam-B_14783 PB014783 601-649 Pfam-B_18259 PB018259 22-174 Pfam-B_5733 PB005733 1011-1149 Pfam-B_664 PB000664 651-1009 Pfam-B_8293 PB008293 1591-1748 Pfam-B_8878 PB008878 1249-1379 zf-UBR PF02207 1177-1248 UBR5_MOUSE ubiquitin protein ligase E3 component n-recognin 5 UBR5_HUMAN Chromatin remodelling Histone modification write cofactor # Histone ubiquitination # H2A H2AX H2Aub H2AXub
665UBR7 Pfam-B_38998 PB038998 361-423 zf-UBR PF02207 44-115 UBR7_MOUSE ubiquitin protein ligase E3 component n-recognin 7 (putative) UBR7_HUMAN DNA modification cofactor DNA methylation # # #
666UCHL5 Peptidase_C12 PF01088 7-211 UCHL5_MOUSE ubiquitin carboxyl-terminal hydrolase L5 UCHL5_HUMAN Histone modification erase cofactor Histone ubiquitination Ino80 # #
667UHRF1 DUF3590 PF12148 140-236 PHD PF00628 317-366 SAD_SRA PF02182 415-586 ubiquitin PF00240 6-76 UHRF1_MOUSE ubiquitin-like with PHD and ring finger domains 1 UHRF1_HUMAN Histone modification read Histone modification write cofactor Histone ubiquitination # # H3K9me3 H3R2 H3 mCG H3ub
668UHRF2 DUF3590 PF12148 177-261 PHD PF00628 346-395 SAD_SRA PF02182 444-616 ubiquitin PF00240 6-76 UHRF2_MOUSE ubiquitin-like with PHD and ring finger domains 2 E3 ubiquitin protein ligase UHRF2_HUMAN Histone modification read # # H3K9me3 mCG #
669UIMC1 Pfam-B_20901 PB020901 471-524 UIMC1_MOUSE ubiquitin interaction motif containing 1 UIMC1_HUMAN Histone modification read # BRCA1-A H2AK63ub H2AXK63ub H2BK63ub #
670USP3 UCH PF00443 158-508 zf-UBP PF02148 29-107 UBP3_MOUSE ubiquitin specific peptidase 3 UBP3_HUMAN Histone modification write Histone ubiquitination # H2Aub H2Bub H2A H2B
671USP7 MATH PF00917 56-197 Pfam-B_12182 PB012182 591-618 Pfam-B_45828 PB045828 1-39 UCH PF00443 213-518 USP7_C2 PF14533 874-1088 USP7_ICP0_bdg PF12436 619-865 UBP7_MOUSE ubiquitin specific peptidase 7 (herpes virus-associated) UBP7_HUMAN Histone modification erase DNA modification cofactor Histone ubiquitination DNA methylation BCOR H2Bub H2B
672USP11 DUSP PF06337 99-185 Pfam-B_176820 PB176820 1-47 UCH PF00443 308-927 Ubiquitin_3 PF14836 198-285 UBP11_MOUSE ubiquitin specific peptidase 11 UBP11_HUMAN Histone modification erase cofactor Histone ubiquitination # # #
673USP12 UCH PF00443 38-366 UBP12_MOUSE ubiquitin specific peptidase 12 UBP12_HUMAN Histone modification erase Histone ubiquitination # H2Aub H2A
674USP15 DUSP PF06337 27-119 UCH PF00443 288-930 USP7_C2 PF14533 459-614 Ubiquitin_3 PF14836 135-222 UBP15_MOUSE ubiquitin specific peptidase 15 UBP15_HUMAN Histone modification erase Histone ubiquitination # H2BK120ub H2BK120
675USP16 UCH PF00443 195-819 zf-UBP PF02148 48-128 UBP16_MOUSE ubiquitin specific peptidase 16 UBP16_HUMAN Histone modification erase Histone ubiquitination # H2Aub H2A
676USP17L2 HABP4_PAI-RBP1 PF04774 374-458 Pfam-B_24444 PB024444 1-39 UCH PF00443 79-372 U17PE_MOUSE ubiquitin specific peptidase 17-like family member 2 U17L2_HUMAN Histone modification erase cofactor Histone ubiquitination # # #
677USP21 UCH PF00443 211-555 UBP21_MOUSE ubiquitin specific peptidase 21 UBP21_HUMAN Histone modification erase Histone ubiquitination # H2Aub H2A
678USP22 UCH PF00443 175-517 zf-UBP PF02148 63-124 UBP22_MOUSE ubiquitin specific peptidase 22 UBP22_HUMAN Histone modification write cofactor Histone ubiquitination SAGA H2Aub H2Bub H2A H2B
679USP36 Pfam-B_17191 PB017191 1088-1118 Pfam-B_20267 PB020267 1065-1087 UCH PF00443 121-420 UBP36_MOUSE ubiquitin specific peptidase 36 UBP36_HUMAN Histone modification write cofactor Histone ubiquitination # H2Bub H2B
680USP44 UCH PF00443 272-675 zf-UBP PF02148 29-91 UBP44_MOUSE ubiquitin specific peptidase 44 UBP44_HUMAN Histone modification erase Histone ubiquitination # H2Bub1 H2B
681USP46 UCH PF00443 34-362 UBP46_MOUSE ubiquitin specific peptidase 46 UBP46_HUMAN Histone modification erase Histone ubiquitination # H2Aub H2A
682USP49 UCH PF00443 252-654 zf-UBP PF02148 20-88 UBP49_MOUSE ubiquitin specific peptidase 49 UBP49_HUMAN Histone modification erase Histone ubiquitination # H2Bub H2B
683UTY JmjC PF02373 1080-1188 Pfam-B_2066 PB002066 1-49 Pfam-B_604 PB000604 580-716 Pfam-B_972 PB000972 718-1056 TPR_1 PF00515 127-160 315-348 349-377 TPR_17 PF13431 269-301 TPR_8 PF13181 202-233 UTY_MOUSE ubiquitously transcribed tetratricopeptide repeat containing Y-linked UTY_HUMAN Histone modification erase Histone ubiquitination # H3K27me #
684VDR Hormone_recep PF00104 209-418 zf-C4 PF00105 22-91 VDR_MOUSE vitamin D (1 25- dihydroxyvitamin D3) receptor VDR_HUMAN Chromatin remodelling cofactor TF # # # H2BK12ac H3K14ac H4K16ac #
685VPS72 YL1 PF05764 4-218 YL1_C PF08265 290-319 VPS72_MOUSE vacuolar protein sorting 72 homolog (S. cerevisiae) VPS72_HUMAN Histone modification write cofactor Histone acetylation NuA4 NuA4-related complex # #
686VRK1 Pkinase PF00069 37-325 VRK1_MOUSE vaccinia related kinase 1 VRK1_HUMAN Histone modification write Histone phosphorylation # H3S10 H3T3 H3S10ph H3T3ph
687WAC WW PF00397 131-160 WAC_MOUSE WW domain containing adaptor with coiled-coil WAC_HUMAN Histone modification write cofactor Histone ubiquitination # # #
688WDR5 WD40 PF00400 36-73 77-115 119-157 161-199 203-242 246-287 291-331 WDR5_MOUSE WD repeat domain 5 WDR5_HUMAN Histone modification read # ATAC NSL RING2-L3MBTL2 COMPASS Menin-associated_HMT MLL-HCF CHD8 MLL2/3 COMPASS-like MLL1 2 MLL4/WBP7 COMPASS-like MLL3 4 H3K4 H3K4me1 H3K4me2 H3K4me3 #
689WDR77 Pfam-B_26289 PB026289 1-49 WD40 PF00400 117-153 157-196 245-284 MEP50_MOUSE WD repeat domain 77 MEP50_HUMAN Histone modification write Histone methylation methylosome H2A H4 H2Ame H4me
690WDR82 WD40 PF00400 12-49 97-135 245-267 273-304 WDR82_MOUSE WD repeat domain 82 WDR82_HUMAN Histone modification write cofactor Histone methylation COMPASS # #
691WHSC1 HMG_box PF00505 455-508 PHD PF00628 833-875 PWWP PF00855 220-332 878-968 SET PF00856 1074-1180 NSD2_MOUSE Wolf-Hirschhorn syndrome candidate 1 NSD2_HUMAN Histone modification write Histone methylation # H3K27 H3K27me
692WHSC1L1 PWWP PF00855 268-378 958-1047 Pfam-B_7848 PB007848 619-671 SET PF00856 1156-1262 NSD3_MOUSE Wolf-Hirschhorn syndrome candidate 1-like 1 NSD3_HUMAN Chromatin remodelling cofactor TF # # # H3K4 H3K27 #
693WSB2 Pfam-B_17306 PB017306 1-52 SOCS_box PF07525 366-402 WD40 PF00400 83-139 143-182 187-225 229-267 288-321 337-361 WSB2_MOUSE WD repeat and SOCS box containing 2 WSB2_HUMAN Histone modification write Histone ubiquitination # # #
694YAF2 zf-RanBP PF00641 20-46 YAF2_MOUSE YY1 associated factor 2 YAF2_HUMAN Chromatin remodelling cofactor # BCOR RING2-L3MBTL2 RING2-FBRS # #
695YEATS2 Pfam-B_10841 PB010841 976-1072 Pfam-B_13347 PB013347 678-756 Pfam-B_19332 PB019332 758-854 YEATS PF03366 231-314 YETS2_MOUSE YEATS domain containing 2 YETS2_HUMAN Histone chaperone # ATAC # #
696YEATS4 YEATS PF03366 44-126 YETS4_MOUSE YEATS domain containing 4 YETS4_HUMAN Histone modification write cofactor Histone acetylation NuA4 NuA4-related complex SRCAP # #
697YWHAB 14-3-3 PF00244 5-238 1433B_MOUSE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 1433B_HUMAN Histone modification erase cofactor Histone acetylation # # #
698YWHAE 14-3-3 PF00244 4-239 1433E_MOUSE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 1433E_HUMAN Histone modification erase cofactor Histone acetylation # # #
699YWHAZ 14-3-3 PF00244 3-236 1433Z_MOUSE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 1433Z_HUMAN Histone modification read # # H3 #
700YY1 zf-C2H2 PF00096 383-407 zf-H2C2_2 PF13465 339-365 TYY1_MOUSE YY1 transcription factor TYY1_HUMAN Chromatin remodelling cofactor TF # TF repressor Ino80 DNA motif #
701ZBTB7C BTB PF00651 24-130 zf-H2C2_2 PF13465 379-403 406-431 434-459 ZBT7C_MOUSE zinc finger and BTB domain containing 7C ZBT7C_HUMAN Histone modification cofactor # # # #
702ZBTB16 BTB PF00651 24-126 zf-C2H2 PF00096 491-512 630-652 zf-C2H2_4 PF13894 432-455 zf-C2H2_6 PF13912 460-486 zf-H2C2_2 PF13465 532-556 560-584 588-612 # zinc finger and BTB domain containing 16 ZBT16_HUMAN Histone modification erase cofactor Histone acetylation # # #
703ZBTB33 BTB PF00651 22-118 zf-H2C2_2 PF13465 508-532 537-561 KAISO_MOUSE zinc finger and BTB domain containing 33 KAISO_HUMAN Histone modification write cofactor Histone modification erase cofactor TF Histone acetylation Histone methylation TF repressor # CG mCG DNA motif #
704ZCWPW1 PWWP PF00855 315-411 Pfam-B_36867 PB036867 512-557 zf-CW PF07496 254-303 ZCPW1_MOUSE zinc finger CW type with PWWP domain 1 ZCPW1_HUMAN Histone modification read # # H3K4me #
705ZFP57 KRAB PF01352 16-56 zf-C2H2 PF00096 91-113 175-197 zf-C2H2_4 PF13894 300-323 329-351 356-377 zf-H2C2_2 PF13465 133-156 ZFP57_MOUSE ZFP57 zinc finger protein ZFP57_HUMAN TF TF repressor # mC DNA motif #
706ZGPAT G-patch PF01585 333-376 ZGPAT_MOUSE zinc finger CCCH-type with G patch domain ZGPAT_HUMAN TF TF repressor # DNA motif #
707ZHX1 Homeobox PF00046 297-339 467-521 573-623 665-717 Homez PF11569 776-827 Pfam-B_22595 PB022595 1-37 ZHX1_MOUSE zinc fingers and homeoboxes 1 ZHX1_HUMAN Chromatin remodelling Histone modification write cofactor Histone modification write cofactor # Histone acetylation Histone methylation # # #
708ZMYM2 DUF3504 PF12012 1190-1361 Pfam-B_10252 PB010252 941-1179 Pfam-B_2297 PB002297 1-159 zf-FCS PF06467 323-363 365-409 417-456 459-502 528-570 576-616 631-671 719-758 760-799 ZMYM2_MOUSE zinc finger MYM-type 2 ZMYM2_HUMAN Histone modification erase cofactor TF Histone acetylation # BHC LSD-CoREST DNA motif #
709ZMYM3 DUF3504 PF12012 1183-1354 Pfam-B_2297 PB002297 1-189 Pfam-B_24258 PB024258 191-229 Pfam-B_5192 PB005192 1100-1142 zf-FCS PF06467 304-343 345-389 402-440 443-488 490-532 538-578 583-623 626-664 671-710 712-751 ZMYM3_MOUSE zinc finger MYM-type 3 ZMYM3_HUMAN Histone modification erase cofactor Histone acetylation BHC # #
710ZMYND8 Bromodomain PF00439 157-240 DUF3544 PF12064 412-622 PHD PF00628 90-133 PWWP PF00855 275-349 zf-MYND PF01753 1028-1062 # zinc finger MYND-type containing 8 PKCB1_HUMAN Histone modification erase cofactor Histone acetylation # # #
711ZMYND11 Bromodomain PF00439 122-203 PWWP PF00855 238-313 Pfam-B_7883 PB007883 342-530 Pfam-B_8532 PB008532 532-560 ZMY11_MOUSE zinc finger MYND-type containing 11 ZMY11_HUMAN Histone modification read Histone methylation # H3.3K36me3 #
712ZNF217 Pfam-B_30131 PB030131 913-979 zf-C2H2 PF00096 128-150 156-178 zf-C2H2_4 PF13894 65-88 216-239 375-398 zf-H2C2_2 PF13465 485-510 # zinc finger protein 217 ZN217_HUMAN Histone modification erase cofactor TF Histone acetylation TF repressor BHC LSD-CoREST # #
713ZNF516 zf-C2H2 PF00096 248-270 276-298 1098-1120 zf-C2H2_4 PF13894 174-197 zf-H2C2_2 PF13465 48-73 ZN516_MOUSE zinc finger protein 516 ZN516_HUMAN Histone modification erase cofactor TF Histone acetylation TF repressor LSD-CoREST # #
714ZNF532 Pfam-B_17557 PB017557 601-719 Pfam-B_19362 PB019362 831-959 zf-C2H2 PF00096 1265-1286 ZN532_MOUSE zinc finger protein 532 ZN532_HUMAN Histone modification erase cofactor Histone acetylation # # #
715ZNF541 ELM2 PF01448 1074-1131 Pfam-B_17081 PB017081 567-665 Pfam-B_27795 PB027795 956-1034 Pfam-B_3685 PB003685 772-954 Pfam-B_40457 PB040457 1171-1225 zf-C2H2 PF00096 168-190 zf-C2H2_4 PF13894 140-163 196-221 ZN541_MOUSE zinc finger protein 541 ZN541_HUMAN Chromatin remodelling # # # #
716ZNF592 Pfam-B_21220 PB021220 499-547 Pfam-B_27046 PB027046 771-913 Pfam-B_379 PB000379 1-97 zf-C2H2 PF00096 1013-1036 1043-1069 ZN592_MOUSE zinc finger protein 592 ZN592_HUMAN Histone modification erase cofactor Histone acetylation # # #
717ZNF687 zf-C2H2 PF00096 1200-1222 zf-C2H2_4 PF13894 858-881 963-986 993-1016 ZN687_MOUSE zinc finger protein 687 ZN687_HUMAN Histone modification erase cofactor Histone acetylation # # #
718ZNF711 Pfam-B_16491 PB016491 1-63 Zfx_Zfy_act PF04704 64-368 zf-C2H2 PF00096 383-405 zf-C2H2_4 PF13894 562-583 733-756 zf-H2C2_2 PF13465 490-516 519-543 604-630 690-715 zf-H2C2_5 PF13909 414-437 647-671 ZN711_MOUSE zinc finger protein 711 ZN711_HUMAN Histone modification erase cofactor Histone acetylation # # #
719ZNHIT1 zf-HIT PF04438 113-142 ZNHI1_MOUSE zinc finger HIT-type containing 1 ZNHI1_HUMAN Chromatin remodelling cofactor Histone modification erase cofactor # Histone acetylation SRCAP # #
720ZRANB3 HNH PF01844 1009-1051 Helicase_C PF00271 357-435 Pfam-B_14328 PB014328 729-854 SNF2_N PF00176 40-326 zf-RanBP PF00641 621-650 ZRAB3_MOUSE zinc finger RAN-binding domain containing 3 ZRAB3_HUMAN Chromatin remodelling Histone modification read cofactor # Histone methylation # # #
721ZZZ3 Myb_DNA-binding PF00249 652-703 Pfam-B_19065 PB019065 361-439 Pfam-B_22505 PB022505 211-359 ZZ PF00569 817-865 ZZZ3_MOUSE zinc finger ZZ-type containing 3 ZZZ3_HUMAN Histone modification read # ATAC # #