Institute of Microbial Technology (?????????? ???????????? ???????)  
A Council of Scientific & Industrial Research (????????? ???????? ???????? ?????)
 
 
EpiDBase
Small molecule modulators of Epigenetic proteins
 
   
 
Search result for cancer disease
 
 
Protein NameProtein StructureCompounds
KDM1B
KDM1B  
 

Click to Expand total 36 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
10---25014588
----20415477
----20415477
----20415477
----20415477
----20415477
----20415477
----20415477
----20415477
----20415477
----20415477
----20415477
----20415477
----20415477
ND--Inhibits the enzyme20415477
ND--Inhibits the enzyme20415477
No Inhibition---20415477
ND--Inhibits the enzyme20415477
ND--Inhibits the enzyme20415477
ND--Inhibits the enzyme20415477
ND--Inhibits the enzyme20415477
ND--Inhibits the enzyme20415477
ND--Inhibits the enzyme20415477
ND--Inhibits the enzyme20415477
ND---20415477
ND--Inhibits the enzyme20415477
ND--Inhibits the enzyme20415477
ND--Inhibits the enzyme20415477
ND--Inhibits the enzyme20415477
No Inhibition---20415477
ND--Inhibits the enzyme20415477
ND---20415477
ND--Inhibits the enzyme20415477
ND--Inhibits the enzyme20415477
49.1---24131029
36.6---24131029
KDM2A
KDM2A  
 

Click to Expand total 38 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
0.22--Binds to FBXL11 domain of KDM224325601
12.2--Binds to FBXL11 domain of KDM224325601
7.8--Binds to FBXL11 domain of KDM224325601
12--Binds to FBXL11 domain of KDM224325601
8.2--Binds to FBXL11 domain of KDM224325601
12--Binds to FBXL11 domain of KDM224325601
100--Binds to FBXL11 domain of KDM224325601
4.8--Binds to FBXL11 domain of KDM224325601
15--Binds to FBXL11 domain of KDM224325601
63---22724510
0.37---22724510
0.25---22724510
0.43---22724510
3.7---22724510
100---22724510
0.57---22724510
9.1---22724510
100---22724510
19---22724510
---No inhibition22724510
29---22724510
21---22724510
---No inhibition22724510
---No inhibition22724510
---No inhibition22724510
---No inhibition22724510
---No inhibition22724510
---No inhibition22724510
1.5---23964788
8.1---23964788
ND---23964788
9.6---23964788
6.8---23964788
16---23964788
8---23964788
15---23964788
2.9---23964788
0.2---24300735
KDM3A
KDM3A  
 

Click to Expand total 24 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
20---23683440
100---23683440
10081 % at 100 µM--23683440
100---23683440
100---23683440
100---23683440
0.14--Binds to JMJD1 domain of KDM324325601
37--Binds to JMJD1 domain of KDM324325601
31--Binds to JMJD1 domain of KDM324325601
12--Binds to JMJD1 domain of KDM324325601
9.7--Binds to JMJD1 domain of KDM324325601
9.1--Binds to JMJD1 domain of KDM324325601
100--Binds to JMJD1 domain of KDM324325601
1.1--Binds to JMJD1 domain of KDM324325601
0.17--Binds to JMJD1 domain of KDM324325601
100---22724510
100---22724510
100---22724510
3---22724510
100---22724510
100---22724510
12.7---22724510
100---22724510
100---22724510
KDM4A
KDM4A  
 

Click to Expand total 46 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
12--IC50 determined by MALDI20088513
13--IC50 determined by MALDI20088513
20--IC50 determined by MALDI20088513
14--IC50 determined by MALDI20088513
17--IC50 determined by MALDI20088513
13--IC50 determined by MALDI20088513
10--IC50 determined by MALDI20088513
33--IC50 determined by MALDI20088513
ND--IC50 determined by MALDI20088513
ND--IC50 determined by MALDI20088513
ND--IC50 determined by MALDI20088513
20---23683440
100---23683440
100---23683440
100---23683440
43---23683440
----23683440
ND---23550720
3300---23964788
92---23964788
120---23964788
100---23964788
120---23964788
120---23964788
120---23964788
99---23964788
65---23964788
250---23964788
4.2---23964788
0.8---23964788
3.4---25014588
4.2---20684604
250---20684604
14---20684604
17---20684604
8.7---20684604
6---20684604
3---20684604
5.5---20684604
11---20684604
22---20684604
120---20684604
8.1---20684604
3.2---20684604
2---20684604
4.4---20684604
KDM4C
KDM4C  
 

Click to Expand total 72 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
20---23683440
100---23683440
100---23683440
100---23683440
86---23683440
93---23683440
1---20684204
9.4---20684604
500---20684604
34---20684604
10---20684604
2.7---20684604
1.5---20684604
1---20684604
1.6---20684604
5.2---20684604
8.8---20684604
74---20684604
2---20684604
1.5---20684604
1.3---20684604
1.7---20684604
411---22917519
147---22917519
----22917519
----22917519
----22917519
----22917519
----22917519
----22917519
----22917519
0.07 | 0.42---24325601
2.7 | 16---24325601
1.2 | 3.9---24325601
4.5 | 5.5---24325601
3.1 | 3.5---24325601
2.5 | 5.1---24325601
100 |100---24325601
3.5 | 5---24325601
0.6 | 0.3---24325601
2500---23964788
55---23964788
110---23964788
32---23964788
83---23964788
78---23964788
81---23964788
120---23964788
22---23964788
430---23964788
8.2---23964788
2.2---23964788
1000---25014588
1000---25014588
1000---25014588
8.5---25014588
1000---25014588
1000---25014588
1000---25014588
1000---25014588
1000---25014588
520---25014588
97---25014588
1000---25014588
0.6---25014588
406---25014588
52---25014588
52---25014588
76---25014588
1000---25014588
1000---25014588
16---25014588
   
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