Institute of Microbial Technology (?????????? ???????????? ???????)  
A Council of Scientific & Industrial Research (????????? ???????? ???????? ?????)
 
 
EpiDBase
Small molecule modulators of Epigenetic proteins
 
   
 
Search result for cancer disease
 
 
Protein NameProtein StructureCompounds
PRMT1
PRMT1  
 

Click to Expand total 213 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
0.03---24300735
----15056663
----15056663
11.18---15056663
16.29---15056663
0.19---15056663
1.41---15056663
5.11---15056663
1.61---15056663
1.8---15056663
0.28---15056663
1.63---15056663
---no inhibition was observed at the highest concentration tested, 9 µg/ml (typically 10 µM)17289593
928---17323938
529---17323938
990---17323938
540---17323938
96---17323938
1220---17323938
440---17323938
18.1---17323938
476---17323938
1160---17323938
164---17323938
126---17323938
1.4---17323938
519---17323938
4.8---17323938
18.9---17323938
885---17323938
217---17323938
1050---17323938
34---17323938
280---17323938
92---17323938
928---17323938
529---17323938
990---17323938
540---17323938
96---17323938
1220---17323938
440---17323938
18.1---17323938
1070---17323938
476---17323938
1160---17323938
164---17323938
510---17323938
126---17323938
75---17323938
519---17323938
4.8---17323938
18.9---17323938
885---17323938
217---17323938
1050---17323938
34---17323938
280---17323938
92---17323938
1.4---17323938
1070---17323938
1825--His tagged PRMT 120666457
1150--His tagged PRMT 1; with R4 peptide substrate20666457
1.2---17432842
56.9---17432842
1.7---17432842
56.5---17432842
89---17432842
54.8---17432842
35.4---17432842
76.1---17432842
55---17570663
55.4---17570663
25---18619839
14.34---19085993
33.63---19085993
33.81---19085993
36.74---19085993
21.88---19085993
16.93---19085993
12.75---19085993
29.91---19085993
15.34---19085993
100---19131248
25---19632837
15---19739196
ND---19739196
14---19739196
13---19739196
5---19739196
100---19836951
6.2---20219369
2.9---20219369
5.6---20219369
397.3---20345902
332.5---20345902
No inhibition---20345902
4.15---20345902
56.7---20345902
-no inhibition at 2mM-His tagged PRMT 1; with R4 peptide substrate20666457
-no inhibition at 2mM-His tagged PRMT 1; with R4 peptide substrate20666457
-no inhibition at 2mM-His tagged PRMT 1; with R4 peptide substrate20666457
-no inhibition at 2mM-His tagged PRMT 1; with R4 peptide substrate20666457
1029--His tagged PRMT 120666457
12.9--GST tagged PRMT 1; with H4 peptide substrate20666457
12.9--GST tagged PRMT 1; with H4 peptide substrate20666457
12.9--GST tagged PRMT 1; with H4 peptide substrate20666457
108.4--His tagged PRMT 1; with R4 peptide substrate20666457
108.4--His tagged PRMT 1; with R4 peptide substrate20666457
108.4--His tagged PRMT 1; with R4 peptide substrate20666457
463.1--His tagged PRMT 1; with R4 peptide substrate20666457
463.1--His tagged PRMT 1; with R4 peptide substrate20666457
463.1--His tagged PRMT 1; with R4 peptide substrate20666457
-86.9 % at 500 µM-His tagged PRMT 120666457
1063--His tagged PRMT 120666457
-55.7% at 2 mM-His tagged PRMT 120666457
-71.4 % at 500 µM-His tagged PRMT 120666457
1458--His tagged PRMT 120666457
-87% at 2 mM-His tagged PRMT 120666457
227.8--His tagged PRMT 1; with R4 peptide substrate20666457
227.8--His tagged PRMT 1; with R4 peptide substrate20666457
227.8--His tagged PRMT 1; with R4 peptide substrate20666457
1200--His tagged PRMT 1; with R4 peptide substrate20666457
1200--His tagged PRMT 1; with R4 peptide substrate20666457
-no inhibition at 2mM-His tagged PRMT 120666457
595.8--His tagged PRMT 1; with R4 peptide substrate20666457
595.8--His tagged PRMT 1; with R4 peptide substrate20666457
-no inhibition at 2mM-His tagged PRMT 1; with R4 peptide substrate20666457
-no inhibition at 2mM-His tagged PRMT 1; with R4 peptide substrate20666457
1825--His tagged PRMT 120666457
1150--His tagged PRMT 1; with R4 peptide substrate20666457
1150--His tagged PRMT 1; with R4 peptide substrate20666457
1150--His tagged PRMT 1; with R4 peptide substrate20666457
1011---20666457
1011---20666457
29 | 56.5--Ic50 value through AdoHcy production measure | Ic50 value through MMA and aDMA production measure20701328
19.2 | 39.4--Ic50 value through AdoHcy production measure | Ic50 value through MMA and aDMA production measure20701328
17 | 28.5--Ic50 value through AdoHcy production measure | Ic50 value through MMA and aDMA production measure20701328
13.9 | 27.5--Ic50 value through AdoHcy production measure | Ic50 value through MMA and aDMA production measure20701328
74.4--Ic50 value through AdoHcy production measure | Ic50 value through MMA and aDMA production measure20701328
350--Ic50 value through AdoHcy production measure | Ic50 value through MMA and aDMA production measure20701328
10---21743462
----21936531
21.2---21936531
22---21936531
2.7---21936531
100---21936531
100---21936531
----21936531
6.2---21952734
2.9---21952734
5.6---21952734
3.9---21952734
14.5---21952734
100---21952734
2.2---21952734
1.5---21952734
2.1---21952734
4.1---22749641
12---22749641
15.5---22749641
284.2---22749641
160.8---22749641
6.3---22749641
20.3---22749641
18---22749641
14.3---22749641
368.3---22749641
291.7---22749641
-20% inhibition at 100 µM--22749641
-5% inhibition at 100 µM--22749641
41.7---22928876
12---22928876
-48% inhibition at 100 µM--22928876
-51% inhibition at 100 µM--22928876
-42% inhibition at 100 µM--22928876
-52% inhibition at 100 µM--22928876
1.5---24300735
0.07---24300735
9.4---24564570
----24564570
----24564570
----24564570
7.2---24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
----24564570
100---24900432
100---24900432
100---24900432
8.81---15056663
PRMT3
PRMT3  
 

Click to Expand total 61 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
25---18619839
40---20614940
40---20614940
ND---20614940
7.1--with R4 peptide substrate20666457
4.82---20701328
1.42---20701328
13.9---20701328
9.43---20701328
not tested---21743462
not significant---23272941
1---23445220
100---23445220
100---23445220
100---23445220
100---23445220
100---23445220
100---23445220
100---23445220
100---23445220
100---23445220
2.4---23445220
3.6---23445220
5.2---23445220
10---23445220
7.2---23445220
10---23445220
50---23445220
15---23445220
10---23445220
25---23445220
15---23445220
15---23445220
10---23445220
15---23445220
10---23445220
0.3---23445220
0.85---23445220
1.8---23445220
3.1---23445220
4---23445220
25---23445220
0.48---23445220
2.2---23445220
2.7---23445220
3.6---23445220
10---23445220
5.3---23445220
3.3---23445220
5.9---23445220
1.9---23445220
5---23445220
4.4---23445220
3.3---23445220
0.49---23445220
0.84---23445220
0.36---23445220
0.23---23445220
100---24900432
54---24900432
74---24900432
PRMT5
PRMT5  
 

Click to Expand total 6 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
162---18348515
166---24564570
186---24564570
100---24900432
100---24900432
100---24900432
PRMT6
PRMT6  
 

Click to Expand total 3 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
39.2--with H3 peptide substrate20666457
283---24564570
211---24564570
SETD8
SETD8  
 

Click to Expand total 29 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
40---20614940
40---20614940
ND---20614940
not tested---21743462
not significant---23272941
7.3---25032507
67---25032507
36---25032507
43---25032507
7.9---25032507
7.9---25032507
21---25032507
35---25032507
32---25032507
29---25032507
25---25032507
34---25032507
58---25032507
250---25032507
94---25032507
250---25032507
9.2---25032507
250---25032507
250---25032507
37---25032507
37---25032507
250---25032507
250---25032507
250---25032507
   
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