Institute of Microbial Technology (सूक्ष्मजीव प्रौद्योगिकी संस्थान)  
A Council of Scientific & Industrial Research (वैज्ञानिक औद्योगिक अनुसंधान परिषद)
 
 
EpiDBase
Small molecule modulators of Epigenetic proteins
 
   
 
Search result for cancer disease
 
 
Protein NameProtein StructureCompounds
CREBBP
CREBBP  
 

Click to Expand total 14 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
500---15274229
1850---15274229
1850---15274229
ND86.6 % inhibition at 50 µM--19144517
ND79.5 % inhibition at 50 µM--19144517
ND8.8 % inhibition at 50 µM--19144517
ND81 % inhibition at 50 µM--19144517
ND6.6 % inhibition at 50 µM--19144517
ND86.8 % inhibition at 50 µM--19144517
ND--116.5 % activity at 50 µM19144517
ND85.6 % inhibition at 50 µM--19144517
5053.1 % inhibition at 50 µM-constituent of green tea19147572
ND---19380225
100--inhibits the splicing cycle of pre-mRNA in vitro; cell-permeable GCN5 inhibitor20493978
GCN5
GCN5  
 

Click to Expand total 48 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
0.3--Gcn5(Tetrahymena)12391296
0.3--Gcn5(Tetrahymena)12391296
15--Gcn5(Tetrahymena)12391296
0.3--Gcn5(Tetrahymena)12391296
100---15274229
----17154519
----17154519
----17154519
----17154519
----17154519
----17154519
----17154519
----17154519
----17154519
----17154519
----17154519
----17154519
----17154519
----17154519
----17154519
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND---19099397
ND2.6 % inhibition at 50 µM--19144517
ND2.6 % inhibition at 50 µM--19144517
ND--101.8 % activity at 50 µM19144517
ND2 % inhibition at 50 µM--19144517
ND6.6 % inhibition at 50 µM--19144517
ND4.6 % inhibition at 50 µM--19144517
ND3.2 % inhibition at 50 µM--19144517
ND85.6 % inhibition at 50 µM-103.3 % activity at 50 µM19144517
ND--inhibit yeast cell growth, Gcn5-dependent gene transcription and acetylation of histone H3 in vivo20493978
ND--inhibit yeast cell growth, Gcn5-dependent gene transcription and acetylation of histone H3 in vivo20493978
P300
P300  
 

Click to Expand total 182 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
---No inhibition22141352
200---10882143
200---10882143
30---10882143
10---10882143
0.5---24300735
8.5---12624111
---activator of p30012624111
46---17348637
21---17348637
33---17348637
233---17348637
168---17348637
5---17348637
111---17348637
400---17348637
7---17584612
7---17584612
5-7---17584612
ND---17584612
6---17584612
ND---17584612
ND---17584612
6---17584612
37---17876038
18---17876038
12---17876038
6---17876038
30---17876038
23---17876038
15---17876038
18---17876038
16---17876038
14---17876038
42---17876038
3---19101154
ND---19101154
9.9---19101154
23---19101154
28---19101154
14.4---19101154
2.88---19114310
8.15---19114310
4.35---19114310
6.62---19114310
17.35---19114310
7.54---19114310
0.98---19114310
1000---19114310
45.94---19114310
40---19114310
ND83.6 % inhibition at 50 µM--19144517
ND88.6 % inhibition at 50 µM--19144517
ND52.3 % inhibition at 50 µM--19144517
ND18 % inhibition at 50 µM--19144517
ND60.9 % inhibition at 50 µM--19144517
ND46.1 % inhibition at 50 µM--19144517
ND60.2 % inhibition at 50 µM--19144517
ND53.1 % inhibition at 50 µM--19144517
30--constituent of green tea19147572
ND---20373302
ND---20373302
ND---20373302
ND---20373302
5--compound is active in mammalian cells and leads to downregulation histone H3 acetylation of histone H3 acetylation20493978
nd--cell-permeable inhibitors of p30020493978
nd--cell-permeable inhibitors of p30020493978
3.6---21118378
0.4---21118378
0.07---21118378
0.7---21118378
0.8---21118378
0.3---21118378
1.6---21118378
0.2---21118378
0.3---21118378
20---21118378
152---21118378
28---21118378
209---21118378
150---21186043
---No inhibition22141352
---No inhibition22141352
0.75---22141352
---No inhibition22141352
---No inhibition22141352
---No inhibition22141352
3---22141352
---No inhibition22141352
0.5---24300735
0.4---24300735
-34 % inhibition at 100 µM--24835815
-31 % inhibition at 100 µM--24835815
----24835815
-30 % inhibition at 100 µM--24835815
----24835815
-30 % inhibition at 100 µM--24835815
-46 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-51 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-62 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-61 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-37 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-33 % inhibition at 100 µM--24835815
-32 % inhibition at 100 µM--24835815
-44 % inhibition at 100 µM--24835815
-40 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-31 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-34 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-42 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-33 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-30 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-31 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
-41 % inhibition at 100 µM--24835815
-20 % inhibition at 100 µM--24835815
PCAF
PCAF  
 

Click to Expand total 164 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
1---17444627
20---10882143
0.75---12391296
20---10882143
10---10882143
200---10882143
0.75---12391296
0.36---12391296
5---12391296
0.36---12391296
0.36---12391296
5---12624111
2.5---16227401
3.1---19101154
2.8---16227401
5.4---19101154
12.4---16227401
7.3---16227401
15---16227401
18.7---16227401
54.7---16227401
14.4---16227401
7.3---16227401
10.2---16227401
31.1---16227401
11---16227401
7.6---16227401
17.1---16227401
11---16227401
8.4---16227401
18.3---16227401
5---16227401
9.2---16227401
6.6---16227401
10.2---16227401
11---16227401
6.5---16227401
8.7---16227401
5.4---16227401
8.1---16227401
12.6---16227401
50---16227401
29.5---16227401
9.6---16227401
13.5---16227401
44.6---16227401
18.7---16227401
10.6---16227401
15---16227401
25---16227401
7.3---16227401
1.1---16227401
100---16227401
11---16227401
9.1---16227401
7.8---16227401
5---17584612
5---17584612
3.1---19101154
1.5---19101154
5.4---19101154
7.5---19101154
5.4---19101154
109---19101154
162---19101154
200---19101154
58---19101154
200---19101154
200---19101154
28---19101154
32---19101154
102---19101154
42.7---19101154
19.8---19101154
200---19101154
6.1---19101154
19---19101154
6.5---19101154
65.93---19114310
124.3---19114310
53.57---19114310
58.47---19114310
60.54---19114310
2.27---19114310
108.3---19114310
667.05---19114310
41.91---19114310
ND18.3 % inhibition at 50 µM--19144517
ND--104.2 % activity at 50 µM19144517
ND0 % inhibition at 50 µM--19144517
ND--102.8 % activity at 50 µM19144517
ND9.9 % inhibition at 50 µM--19144517
ND8.5 % inhibition at 50 µM--19144517
ND17.6 % inhibition at 50 µM--19144517
ND37.3 % inhibition at 50 µM--19144517
60--constituent of green tea19147572
10---19683843
10---19683843
10---19683843
10---19683843
10---19683843
10---19683843
10---19683843
10---19683843
1.8---19683843
10---19683843
10---19683843
2.4---19683843
2.6---19683843
10---19683843
662---20655754
100---21186043
10---21267493
2.5---21267493
3.9---21267493
10---21267493
2.9---21267493
1.8---21267493
2.6---21267493
10---21267493
2---21267493
2.5---21267493
10---21267493
10---21267493
10---21267493
5.6---21267493
10---21267493
10---21267493
10---21267493
10---21267493
10---21267493
10---21267493
10---21267493
10---21267493
4.2---21267493
7.8588 % at 50 µM-Ic50 measured for histone substrate 3(aa 1-21) | Inhibition measured for histone substrate 4(aa 2-24)21353783
3.5387 % at 50 µM-Ic50 measured for histone substrate 3(aa 1-21) | Inhibition measured for histone substrate 4(aa 2-24)21353783
4.5791 % at 50 µM-Ic50 measured for histone substrate 3(aa 1-21) | Inhibition measured for histone substrate 4(aa 2-24)21353783
1.64 | 0.72--Ic50 measured for histone substrate 3(aa 1-21) | Ic50 measured for histone substrate 4(aa 2-24)21353783
5.9--Ic50 measured for histone substrate 3(aa 1-21)21353783
4.6375 % at 50 µM-Ic50 measured for histone substrate 3(aa 1-21) | Inhibition measured for histone substrate 4(aa 2-24)21353783
5.03--Ic50 measured for histone substrate 3(aa 1-21)21353783
22.96--Ic50 measured for histone substrate 3(aa 1-21)21353783
17.5--Ic50 measured for histone substrate 3(aa 1-21)21353783
6.94--Ic50 measured for histone substrate 3(aa 1-21)21353783
86.3--Ic50 measured for histone substrate 3(aa 1-21)21353783
101--Ic50 measured for histone substrate 3(aa 1-21)21353783
27.9--Ic50 measured for histone substrate 3(aa 1-21)21353783
22.2--Ic50 measured for histone substrate 3(aa 1-21)21353783
130--Ic50 measured for histone substrate 3(aa 1-21)21353783
15.3 | 2.72--Ic50 measured for histone substrate 3(aa 1-21) | Ic50 measured for histone substrate 4(aa 2-24)21353783
6.51--Ic50 measured for histone substrate 3(aa 1-21)21353783
2.99--Ic50 measured for histone substrate 3(aa 1-21)21353783
4.43--Ic50 measured for histone substrate 3(aa 1-21)21353783
4.91 | 0.86--Ic50 measured for histone substrate 3(aa 1-21) | Ic50 measured for histone substrate 4(aa 2-24)21353783
4.1 | 2.99--Ic50 measured for histone substrate 3(aa 1-21) | Ic50 measured for histone substrate 4(aa 2-24)21353783
11.8 | 15.8--Ic50 measured for histone substrate 3(aa 1-21) | Ic50 measured for histone substrate 4(aa 2-24)21353783
12.9--Ic50 measured for histone substrate 3(aa 1-21)21353783
-48 % at 10 µM-Inhibition for histone substrate 3(aa 1-21)21353783
5.71--Ic50 measured for histone substrate 3(aa 1-21)21353783
3.42 | 1.83--Ic50 measured for histone substrate 3(aa 1-21) | Ic50 measured for histone substrate 4(aa 2-24)21353783
15.9--Ic50 measured for histone substrate 3(aa 1-21)21353783
-49 % at 25 µM-Inhibition for histone substrate 3(aa 1-21)21353783
-17 % inhibition at 50 µM-Inhibition for histone substrate 3(aa 1-21)21353783
TIP60
TIP60  
 

Click to Expand total 15 compounds

Ligand NameIC50(µM)InhibitionKiCommentsPubMed ID
143.35---19114310
111.7---19114310
25.87---19114310
17.59---19114310
20.91---19114310
79.62---19114310
29.75---19114310
347.59---19114310
82.27---19114310
200---19114310
70--constituent of green tea19147572
149---21186043
181---21186043
400---21186043
240---21186043
   
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